Elongation of fatty acids protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania mexicana

UniProt:

E9APQ8_LEIMU

TriTrypDb:

LmxM.14.0630

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 54

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 41
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	37
GO:0110165	cellular anatomical entity	1	38
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9APQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	42
GO:0006629	lipid metabolic process	3	42
GO:0006631	fatty acid metabolic process	4	42
GO:0006633	fatty acid biosynthetic process	5	42
GO:0008152	metabolic process	1	42
GO:0008610	lipid biosynthetic process	4	42
GO:0009058	biosynthetic process	2	42
GO:0009987	cellular process	1	42
GO:0016053	organic acid biosynthetic process	4	42
GO:0019752	carboxylic acid metabolic process	5	42
GO:0032787	monocarboxylic acid metabolic process	6	42
GO:0043436	oxoacid metabolic process	4	42
GO:0044237	cellular metabolic process	2	42
GO:0044238	primary metabolic process	2	42
GO:0044249	cellular biosynthetic process	3	42
GO:0044255	cellular lipid metabolic process	3	42
GO:0044281	small molecule metabolic process	2	42
GO:0044283	small molecule biosynthetic process	3	42
GO:0046394	carboxylic acid biosynthetic process	5	42
GO:0071704	organic substance metabolic process	2	42
GO:0072330	monocarboxylic acid biosynthetic process	6	42
GO:1901576	organic substance biosynthetic process	3	42
GO:0000038	very long-chain fatty acid metabolic process	5	5
GO:0001676	long-chain fatty acid metabolic process	5	2
GO:0006643	membrane lipid metabolic process	4	5
GO:0006665	sphingolipid metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0019367	fatty acid elongation, saturated fatty acid	7	5
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	5
GO:0030148	sphingolipid biosynthetic process	5	5
GO:0030497	fatty acid elongation	6	5
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	5
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	5
GO:0042759	long-chain fatty acid biosynthetic process	6	2
GO:0042761	very long-chain fatty acid biosynthetic process	6	5
GO:0046467	membrane lipid biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	42
GO:0004312	fatty acid synthase activity	5	42
GO:0009922	fatty acid elongase activity	6	42
GO:0016740	transferase activity	2	42
GO:0016746	acyltransferase activity	3	42
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	42
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.350
CLV_NRD_NRD_1	298	300	PF00675	0.526
CLV_NRD_NRD_1	50	52	PF00675	0.282
CLV_PCSK_KEX2_1	167	169	PF00082	0.353
CLV_PCSK_KEX2_1	50	52	PF00082	0.294
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.186
CLV_PCSK_SKI1_1	209	213	PF00082	0.421
CLV_PCSK_SKI1_1	272	276	PF00082	0.424
CLV_PCSK_SKI1_1	299	303	PF00082	0.350
DOC_MAPK_gen_1	122	130	PF00069	0.317
DOC_USP7_MATH_1	72	76	PF00917	0.536
DOC_USP7_MATH_1	78	82	PF00917	0.536
DOC_USP7_MATH_1	92	96	PF00917	0.158
DOC_WW_Pin1_4	155	160	PF00397	0.523
LIG_14-3-3_CanoR_1	262	268	PF00244	0.396
LIG_14-3-3_CterR_2	299	304	PF00244	0.548
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_BRCT_BRCA1_1	180	184	PF00533	0.296
LIG_FHA_1	112	118	PF00498	0.301
LIG_FHA_1	144	150	PF00498	0.472
LIG_FHA_1	185	191	PF00498	0.316
LIG_FHA_1	200	206	PF00498	0.279
LIG_FHA_1	278	284	PF00498	0.433
LIG_FHA_1	80	86	PF00498	0.407
LIG_LIR_Gen_1	110	117	PF02991	0.297
LIG_LIR_Gen_1	145	156	PF02991	0.477
LIG_LIR_Gen_1	192	203	PF02991	0.258
LIG_LIR_Gen_1	32	38	PF02991	0.316
LIG_LIR_Gen_1	81	90	PF02991	0.281
LIG_LIR_LC3C_4	82	87	PF02991	0.182
LIG_LIR_Nem_3	145	151	PF02991	0.482
LIG_LIR_Nem_3	172	178	PF02991	0.369
LIG_LIR_Nem_3	192	198	PF02991	0.261
LIG_LIR_Nem_3	250	255	PF02991	0.330
LIG_LIR_Nem_3	81	86	PF02991	0.316
LIG_MLH1_MIPbox_1	180	184	PF16413	0.164
LIG_PALB2_WD40_1	171	179	PF16756	0.536
LIG_PTB_Apo_2	106	113	PF02174	0.336
LIG_SH2_CRK	83	87	PF00017	0.340
LIG_SH2_GRB2like	255	258	PF00017	0.322
LIG_SH2_NCK_1	77	81	PF00017	0.395
LIG_SH2_STAP1	252	256	PF00017	0.335
LIG_SH2_STAT3	14	17	PF00017	0.376
LIG_SH2_STAT3	213	216	PF00017	0.417
LIG_SH2_STAT5	127	130	PF00017	0.321
LIG_SH2_STAT5	154	157	PF00017	0.536
LIG_SH2_STAT5	183	186	PF00017	0.335
LIG_SH2_STAT5	19	22	PF00017	0.281
LIG_SH2_STAT5	258	261	PF00017	0.294
LIG_SH2_STAT5	278	281	PF00017	0.322
LIG_SH2_STAT5	29	32	PF00017	0.308
LIG_SH2_STAT5	34	37	PF00017	0.306
LIG_SH2_STAT5	7	10	PF00017	0.336
LIG_SH3_3	153	159	PF00018	0.536
LIG_SH3_3	290	296	PF00018	0.496
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.232
LIG_SUMO_SIM_par_1	234	239	PF11976	0.577
LIG_TRAF2_1	159	162	PF00917	0.522
LIG_WRC_WIRS_1	144	149	PF05994	0.497
LIG_WRC_WIRS_1	198	203	PF05994	0.182
MOD_CK1_1	110	116	PF00069	0.282
MOD_CK1_1	189	195	PF00069	0.261
MOD_CK1_1	247	253	PF00069	0.316
MOD_CK1_1	66	72	PF00069	0.490
MOD_GlcNHglycan	132	135	PF01048	0.442
MOD_GlcNHglycan	205	208	PF01048	0.408
MOD_GlcNHglycan	217	220	PF01048	0.284
MOD_GlcNHglycan	246	249	PF01048	0.378
MOD_GSK3_1	107	114	PF00069	0.308
MOD_GSK3_1	186	193	PF00069	0.361
MOD_GSK3_1	199	206	PF00069	0.377
MOD_GSK3_1	247	254	PF00069	0.330
MOD_N-GLC_1	256	261	PF02516	0.534
MOD_NEK2_1	102	107	PF00069	0.319
MOD_NEK2_1	111	116	PF00069	0.286
MOD_NEK2_1	130	135	PF00069	0.317
MOD_NEK2_1	184	189	PF00069	0.301
MOD_NEK2_1	197	202	PF00069	0.343
MOD_NEK2_1	203	208	PF00069	0.288
MOD_NEK2_1	277	282	PF00069	0.302
MOD_NEK2_2	29	34	PF00069	0.408
MOD_NEK2_2	72	77	PF00069	0.512
MOD_OFUCOSY	91	96	PF10250	0.281
MOD_PKA_2	169	175	PF00069	0.585
MOD_Plk_4	102	108	PF00069	0.278
MOD_Plk_4	143	149	PF00069	0.457
MOD_Plk_4	247	253	PF00069	0.282
MOD_Plk_4	29	35	PF00069	0.355
MOD_Plk_4	43	49	PF00069	0.492
MOD_ProDKin_1	155	161	PF00069	0.523
MOD_SUMO_rev_2	158	166	PF00179	0.386
TRG_ENDOCYTIC_2	127	130	PF00928	0.306
TRG_ENDOCYTIC_2	34	37	PF00928	0.312
TRG_ENDOCYTIC_2	83	86	PF00928	0.349
TRG_ER_diArg_1	166	168	PF00400	0.536
TRG_ER_diLys_1	300	304	PF00400	0.697
TRG_NLS_MonoExtC_3	49	54	PF00514	0.386
TRG_NLS_MonoExtN_4	296	303	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9H5	Leptomonas seymouri	26%	100%
A0A0N1IIZ8	Leptomonas seymouri	68%	99%
A0A0N1ILQ4	Leptomonas seymouri	25%	100%
A0A0N1IM10	Leptomonas seymouri	24%	100%
A0A0S4IS29	Bodo saltans	23%	100%
A0A0S4IVS6	Bodo saltans	23%	100%
A0A0S4IW98	Bodo saltans	23%	96%
A0A1X0NNL0	Trypanosomatidae	24%	100%
A0A1X0NNM4	Trypanosomatidae	25%	100%
A0A1X0NP89	Trypanosomatidae	22%	95%
A0A3Q8I9X8	Leishmania donovani	22%	91%
A0A3Q8IIA9	Leishmania donovani	25%	100%
A0A3R7KG78	Trypanosoma rangeli	25%	100%
A0A3R7MJR2	Trypanosoma rangeli	26%	100%
A0A3R7NSQ3	Trypanosoma rangeli	23%	100%
A0A3S5H6R7	Leishmania donovani	22%	100%
A0A3S5H6R8	Leishmania donovani	25%	100%
A0A3S7WT05	Leishmania donovani	93%	100%
A4H7M1	Leishmania braziliensis	78%	100%
A4H7M2	Leishmania braziliensis	25%	100%
A4H7M3	Leishmania braziliensis	22%	98%
A4H7M4	Leishmania braziliensis	24%	100%
A4H7M5	Leishmania braziliensis	24%	100%
A4HW06	Leishmania infantum	93%	100%
A4HW08	Leishmania infantum	22%	100%
A4HW09	Leishmania infantum	25%	100%
A4HW10	Leishmania infantum	25%	100%
A4HW12	Leishmania infantum	22%	91%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	99%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QFR3	Leishmania major	24%	100%
Q4QFR7	Leishmania major	24%	100%
Q4QFR8	Leishmania major	26%	100%
Q4QFR9	Leishmania major	24%	100%
Q4QFS1	Leishmania major	90%	100%
V5BIX9	Trypanosoma cruzi	25%	100%
V5DF68	Trypanosoma cruzi	25%	100%