Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APQ6_LEIMU

TriTrypDb:

LmxM.14.0620

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.597
CLV_C14_Caspase3-7	316	320	PF00656	0.420
CLV_C14_Caspase3-7	397	401	PF00656	0.563
CLV_C14_Caspase3-7	42	46	PF00656	0.644
CLV_C14_Caspase3-7	7	11	PF00656	0.612
CLV_NRD_NRD_1	185	187	PF00675	0.489
CLV_NRD_NRD_1	192	194	PF00675	0.473
CLV_NRD_NRD_1	312	314	PF00675	0.458
CLV_NRD_NRD_1	339	341	PF00675	0.699
CLV_NRD_NRD_1	356	358	PF00675	0.580
CLV_NRD_NRD_1	450	452	PF00675	0.589
CLV_NRD_NRD_1	457	459	PF00675	0.593
CLV_PCSK_FUR_1	310	314	PF00082	0.465
CLV_PCSK_FUR_1	354	358	PF00082	0.599
CLV_PCSK_KEX2_1	185	187	PF00082	0.489
CLV_PCSK_KEX2_1	197	199	PF00082	0.471
CLV_PCSK_KEX2_1	312	314	PF00082	0.458
CLV_PCSK_KEX2_1	328	330	PF00082	0.506
CLV_PCSK_KEX2_1	339	341	PF00082	0.560
CLV_PCSK_KEX2_1	356	358	PF00082	0.734
CLV_PCSK_KEX2_1	450	452	PF00082	0.589
CLV_PCSK_KEX2_1	457	459	PF00082	0.595
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.507
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.506
CLV_PCSK_PC7_1	193	199	PF00082	0.429
CLV_PCSK_SKI1_1	153	157	PF00082	0.615
CLV_PCSK_SKI1_1	185	189	PF00082	0.527
CLV_PCSK_SKI1_1	194	198	PF00082	0.480
CLV_PCSK_SKI1_1	357	361	PF00082	0.750
CLV_PCSK_SKI1_1	420	424	PF00082	0.594
CLV_PCSK_SKI1_1	450	454	PF00082	0.589
CLV_PCSK_SKI1_1	457	461	PF00082	0.494
DEG_SCF_FBW7_1	421	427	PF00400	0.575
DOC_CKS1_1	421	426	PF01111	0.453
DOC_CYCLIN_RxL_1	179	192	PF00134	0.460
DOC_MAPK_gen_1	218	226	PF00069	0.574
DOC_MAPK_gen_1	339	348	PF00069	0.582
DOC_MAPK_MEF2A_6	218	226	PF00069	0.574
DOC_MAPK_MEF2A_6	339	348	PF00069	0.678
DOC_PP2B_LxvP_1	294	297	PF13499	0.529
DOC_USP7_MATH_1	253	257	PF00917	0.690
DOC_USP7_MATH_1	452	456	PF00917	0.548
DOC_USP7_MATH_1	60	64	PF00917	0.646
DOC_WW_Pin1_4	127	132	PF00397	0.748
DOC_WW_Pin1_4	172	177	PF00397	0.573
DOC_WW_Pin1_4	276	281	PF00397	0.731
DOC_WW_Pin1_4	32	37	PF00397	0.715
DOC_WW_Pin1_4	366	371	PF00397	0.613
DOC_WW_Pin1_4	401	406	PF00397	0.797
DOC_WW_Pin1_4	420	425	PF00397	0.593
DOC_WW_Pin1_4	56	61	PF00397	0.677
LIG_14-3-3_CanoR_1	122	127	PF00244	0.661
LIG_14-3-3_CanoR_1	132	139	PF00244	0.648
LIG_14-3-3_CanoR_1	185	190	PF00244	0.626
LIG_14-3-3_CanoR_1	242	250	PF00244	0.632
LIG_14-3-3_CanoR_1	266	274	PF00244	0.671
LIG_14-3-3_CanoR_1	436	440	PF00244	0.520
LIG_14-3-3_CanoR_1	450	459	PF00244	0.496
LIG_14-3-3_CanoR_1	86	92	PF00244	0.649
LIG_BRCT_BRCA1_1	129	133	PF00533	0.714
LIG_FHA_1	24	30	PF00498	0.708
LIG_FHA_1	269	275	PF00498	0.669
LIG_FHA_1	282	288	PF00498	0.511
LIG_FHA_1	341	347	PF00498	0.749
LIG_FHA_1	451	457	PF00498	0.596
LIG_FHA_2	106	112	PF00498	0.481
LIG_FHA_2	300	306	PF00498	0.644
LIG_FHA_2	395	401	PF00498	0.560
LIG_FHA_2	40	46	PF00498	0.650
LIG_LIR_Gen_1	130	141	PF02991	0.752
LIG_LIR_Gen_1	425	435	PF02991	0.587
LIG_LIR_Gen_1	77	87	PF02991	0.504
LIG_LIR_Nem_3	130	136	PF02991	0.714
LIG_LIR_Nem_3	410	416	PF02991	0.706
LIG_LIR_Nem_3	425	431	PF02991	0.599
LIG_LIR_Nem_3	77	82	PF02991	0.500
LIG_MYND_1	292	296	PF01753	0.527
LIG_SH2_PTP2	79	82	PF00017	0.502
LIG_SH2_SRC	290	293	PF00017	0.524
LIG_SH2_STAT5	290	293	PF00017	0.563
LIG_SH2_STAT5	79	82	PF00017	0.502
LIG_SH3_3	133	139	PF00018	0.663
LIG_SH3_3	170	176	PF00018	0.527
LIG_SH3_3	247	253	PF00018	0.563
LIG_SH3_3	294	300	PF00018	0.609
LIG_SH3_3	341	347	PF00018	0.633
LIG_SH3_3	402	408	PF00018	0.590
LIG_SH3_3	418	424	PF00018	0.471
LIG_TRAF2_1	314	317	PF00917	0.351
LIG_WW_3	404	408	PF00397	0.573
MOD_CDC14_SPxK_1	279	282	PF00782	0.488
MOD_CDC14_SPxK_1	369	372	PF00782	0.650
MOD_CDK_SPK_2	127	132	PF00069	0.663
MOD_CDK_SPxK_1	276	282	PF00069	0.495
MOD_CDK_SPxK_1	366	372	PF00069	0.655
MOD_CDK_SPxK_1	401	407	PF00069	0.584
MOD_CDK_SPxxK_3	172	179	PF00069	0.579
MOD_CDK_SPxxK_3	32	39	PF00069	0.613
MOD_CK1_1	124	130	PF00069	0.642
MOD_CK1_1	254	260	PF00069	0.681
MOD_CK1_1	262	268	PF00069	0.549
MOD_CK1_1	269	275	PF00069	0.565
MOD_CK1_1	278	284	PF00069	0.514
MOD_CK1_1	46	52	PF00069	0.662
MOD_CK1_1	63	69	PF00069	0.499
MOD_CK1_1	81	87	PF00069	0.574
MOD_CK2_1	1	7	PF00069	0.475
MOD_CK2_1	105	111	PF00069	0.413
MOD_CK2_1	457	463	PF00069	0.556
MOD_GlcNHglycan	143	146	PF01048	0.596
MOD_GlcNHglycan	147	150	PF01048	0.608
MOD_GlcNHglycan	244	247	PF01048	0.595
MOD_GlcNHglycan	253	256	PF01048	0.651
MOD_GlcNHglycan	271	274	PF01048	0.662
MOD_GlcNHglycan	3	6	PF01048	0.595
MOD_GlcNHglycan	388	391	PF01048	0.616
MOD_GlcNHglycan	65	68	PF01048	0.546
MOD_GSK3_1	12	19	PF00069	0.539
MOD_GSK3_1	121	128	PF00069	0.639
MOD_GSK3_1	141	148	PF00069	0.581
MOD_GSK3_1	159	166	PF00069	0.648
MOD_GSK3_1	23	30	PF00069	0.643
MOD_GSK3_1	256	263	PF00069	0.590
MOD_GSK3_1	268	275	PF00069	0.632
MOD_GSK3_1	295	302	PF00069	0.555
MOD_GSK3_1	39	46	PF00069	0.754
MOD_GSK3_1	420	427	PF00069	0.624
MOD_GSK3_1	56	63	PF00069	0.533
MOD_GSK3_1	74	81	PF00069	0.533
MOD_GSK3_1	87	94	PF00069	0.680
MOD_LATS_1	120	126	PF00433	0.507
MOD_LATS_1	240	246	PF00433	0.553
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	12	17	PF00069	0.594
MOD_NEK2_1	126	131	PF00069	0.580
MOD_NEK2_1	165	170	PF00069	0.649
MOD_NEK2_1	23	28	PF00069	0.637
MOD_NEK2_1	350	355	PF00069	0.594
MOD_NEK2_2	452	457	PF00069	0.549
MOD_PIKK_1	131	137	PF00454	0.627
MOD_PIKK_1	27	33	PF00454	0.708
MOD_PIKK_1	295	301	PF00454	0.525
MOD_PIKK_1	444	450	PF00454	0.389
MOD_PKA_1	185	191	PF00069	0.467
MOD_PKA_1	450	456	PF00069	0.593
MOD_PKA_1	457	463	PF00069	0.543
MOD_PKA_2	121	127	PF00069	0.694
MOD_PKA_2	131	137	PF00069	0.655
MOD_PKA_2	185	191	PF00069	0.545
MOD_PKA_2	259	265	PF00069	0.766
MOD_PKA_2	435	441	PF00069	0.563
MOD_PKA_2	450	456	PF00069	0.439
MOD_PKA_2	457	463	PF00069	0.533
MOD_PKA_2	85	91	PF00069	0.645
MOD_PKB_1	264	272	PF00069	0.503
MOD_Plk_1	104	110	PF00069	0.542
MOD_Plk_1	211	217	PF00069	0.506
MOD_Plk_1	340	346	PF00069	0.584
MOD_Plk_1	424	430	PF00069	0.611
MOD_Plk_2-3	105	111	PF00069	0.488
MOD_Plk_4	105	111	PF00069	0.475
MOD_Plk_4	12	18	PF00069	0.512
MOD_Plk_4	185	191	PF00069	0.507
MOD_Plk_4	226	232	PF00069	0.604
MOD_Plk_4	424	430	PF00069	0.611
MOD_Plk_4	435	441	PF00069	0.450
MOD_ProDKin_1	127	133	PF00069	0.749
MOD_ProDKin_1	172	178	PF00069	0.564
MOD_ProDKin_1	276	282	PF00069	0.729
MOD_ProDKin_1	32	38	PF00069	0.717
MOD_ProDKin_1	366	372	PF00069	0.614
MOD_ProDKin_1	401	407	PF00069	0.799
MOD_ProDKin_1	420	426	PF00069	0.590
MOD_ProDKin_1	56	62	PF00069	0.678
MOD_SUMO_rev_2	192	199	PF00179	0.505
MOD_SUMO_rev_2	323	330	PF00179	0.502
MOD_SUMO_rev_2	415	422	PF00179	0.626
TRG_DiLeu_BaEn_4	101	107	PF01217	0.577
TRG_DiLeu_BaEn_4	325	331	PF01217	0.502
TRG_ENDOCYTIC_2	203	206	PF00928	0.440
TRG_ENDOCYTIC_2	79	82	PF00928	0.502
TRG_ER_diArg_1	184	186	PF00400	0.487
TRG_ER_diArg_1	310	313	PF00400	0.475
TRG_ER_diArg_1	338	340	PF00400	0.677
TRG_ER_diArg_1	354	357	PF00400	0.572
TRG_ER_diArg_1	449	451	PF00400	0.587
TRG_ER_diArg_1	456	458	PF00400	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X0	Leptomonas seymouri	37%	89%
A0A3S7WSY4	Leishmania donovani	84%	78%
A4H7L9	Leishmania braziliensis	60%	100%
A4HW04	Leishmania infantum	85%	78%
Q4QFS3	Leishmania major	83%	100%