Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APQ5_LEIMU

TriTrypDb:

LmxM.14.0610

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.577
CLV_C14_Caspase3-7	432	436	PF00656	0.657
CLV_NRD_NRD_1	263	265	PF00675	0.465
CLV_NRD_NRD_1	271	273	PF00675	0.450
CLV_NRD_NRD_1	389	391	PF00675	0.551
CLV_NRD_NRD_1	452	454	PF00675	0.760
CLV_NRD_NRD_1	474	476	PF00675	0.712
CLV_PCSK_FUR_1	450	454	PF00082	0.571
CLV_PCSK_KEX2_1	263	265	PF00082	0.465
CLV_PCSK_KEX2_1	271	273	PF00082	0.450
CLV_PCSK_KEX2_1	389	391	PF00082	0.551
CLV_PCSK_KEX2_1	450	452	PF00082	0.717
CLV_PCSK_KEX2_1	466	468	PF00082	0.531
CLV_PCSK_KEX2_1	474	476	PF00082	0.798
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.660
CLV_PCSK_PC7_1	447	453	PF00082	0.560
CLV_PCSK_SKI1_1	281	285	PF00082	0.409
CLV_PCSK_SKI1_1	372	376	PF00082	0.505
CLV_PCSK_SKI1_1	390	394	PF00082	0.544
CLV_PCSK_SKI1_1	397	401	PF00082	0.562
CLV_Separin_Metazoa	317	321	PF03568	0.412
DEG_Nend_UBRbox_3	1	3	PF02207	0.441
DEG_SCF_FBW7_2	348	355	PF00400	0.571
DOC_CDC14_PxL_1	373	381	PF14671	0.578
DOC_CKS1_1	77	82	PF01111	0.468
DOC_CYCLIN_RxL_1	363	371	PF00134	0.486
DOC_MAPK_gen_1	263	269	PF00069	0.494
DOC_MAPK_HePTP_8	369	381	PF00069	0.581
DOC_MAPK_MEF2A_6	372	381	PF00069	0.504
DOC_PP1_RVXF_1	305	311	PF00149	0.493
DOC_PP2B_LxvP_1	10	13	PF13499	0.437
DOC_PP2B_LxvP_1	265	268	PF13499	0.395
DOC_PP2B_LxvP_1	374	377	PF13499	0.577
DOC_USP7_MATH_1	134	138	PF00917	0.627
DOC_USP7_MATH_1	230	234	PF00917	0.534
DOC_USP7_MATH_2	329	335	PF00917	0.589
DOC_WW_Pin1_4	167	172	PF00397	0.616
DOC_WW_Pin1_4	184	189	PF00397	0.634
DOC_WW_Pin1_4	256	261	PF00397	0.473
DOC_WW_Pin1_4	276	281	PF00397	0.409
DOC_WW_Pin1_4	348	353	PF00397	0.576
DOC_WW_Pin1_4	468	473	PF00397	0.652
DOC_WW_Pin1_4	76	81	PF00397	0.467
LIG_14-3-3_CanoR_1	307	315	PF00244	0.450
LIG_14-3-3_CanoR_1	31	38	PF00244	0.472
LIG_14-3-3_CanoR_1	440	446	PF00244	0.534
LIG_14-3-3_CanoR_1	455	464	PF00244	0.576
LIG_14-3-3_CanoR_1	467	472	PF00244	0.528
LIG_14-3-3_CanoR_1	67	77	PF00244	0.626
LIG_APCC_ABBAyCdc20_2	204	210	PF00400	0.437
LIG_BRCT_BRCA1_1	257	261	PF00533	0.531
LIG_eIF4E_1	277	283	PF01652	0.477
LIG_EVH1_1	10	14	PF00568	0.434
LIG_FHA_1	107	113	PF00498	0.624
LIG_FHA_1	168	174	PF00498	0.518
LIG_FHA_1	271	277	PF00498	0.458
LIG_FHA_1	365	371	PF00498	0.510
LIG_FHA_1	471	477	PF00498	0.654
LIG_FHA_2	113	119	PF00498	0.534
LIG_FHA_2	120	126	PF00498	0.572
LIG_FHA_2	141	147	PF00498	0.717
LIG_FHA_2	311	317	PF00498	0.480
LIG_FHA_2	349	355	PF00498	0.572
LIG_FHA_2	391	397	PF00498	0.548
LIG_GBD_Chelix_1	289	297	PF00786	0.395
LIG_LIR_Gen_1	149	158	PF02991	0.663
LIG_LIR_Gen_1	193	203	PF02991	0.419
LIG_LIR_Gen_1	41	50	PF02991	0.486
LIG_LIR_Nem_3	193	197	PF02991	0.366
LIG_LIR_Nem_3	349	353	PF02991	0.642
LIG_LIR_Nem_3	41	47	PF02991	0.486
LIG_Pex14_2	3	7	PF04695	0.434
LIG_RPA_C_Fungi	282	294	PF08784	0.411
LIG_SH2_CRK	277	281	PF00017	0.415
LIG_SH2_NCK_1	350	354	PF00017	0.572
LIG_SH2_PTP2	194	197	PF00017	0.347
LIG_SH2_SRC	292	295	PF00017	0.412
LIG_SH2_STAT3	107	110	PF00017	0.620
LIG_SH2_STAT3	322	325	PF00017	0.495
LIG_SH2_STAT5	194	197	PF00017	0.347
LIG_SH2_STAT5	292	295	PF00017	0.397
LIG_SH2_STAT5	309	312	PF00017	0.433
LIG_SH2_STAT5	350	353	PF00017	0.605
LIG_SH2_STAT5	373	376	PF00017	0.490
LIG_SH2_STAT5	498	501	PF00017	0.597
LIG_SH3_3	155	161	PF00018	0.608
LIG_SH3_3	185	191	PF00018	0.700
LIG_SH3_3	224	230	PF00018	0.485
LIG_SH3_3	254	260	PF00018	0.434
LIG_SH3_3	8	14	PF00018	0.438
LIG_SUMO_SIM_par_1	366	371	PF11976	0.510
LIG_TRAF2_1	115	118	PF00917	0.515
LIG_TRAF2_1	237	240	PF00917	0.583
LIG_TRAF2_1	352	355	PF00917	0.561
LIG_TYR_ITIM	192	197	PF00017	0.385
LIG_TYR_ITIM	348	353	PF00017	0.576
LIG_UBA3_1	379	385	PF00899	0.506
MOD_CDC14_SPxK_1	471	474	PF00782	0.514
MOD_CDK_SPK_2	276	281	PF00069	0.409
MOD_CDK_SPxK_1	468	474	PF00069	0.517
MOD_CDK_SPxxK_3	256	263	PF00069	0.537
MOD_CDK_SPxxK_3	468	475	PF00069	0.639
MOD_CK1_1	128	134	PF00069	0.693
MOD_CK1_1	175	181	PF00069	0.626
MOD_CK1_1	22	28	PF00069	0.551
MOD_CK1_1	232	238	PF00069	0.587
MOD_CK1_1	429	435	PF00069	0.677
MOD_CK1_1	470	476	PF00069	0.678
MOD_CK1_1	49	55	PF00069	0.593
MOD_CK2_1	112	118	PF00069	0.544
MOD_CK2_1	310	316	PF00069	0.463
MOD_CK2_1	348	354	PF00069	0.574
MOD_CK2_1	390	396	PF00069	0.546
MOD_CK2_1	407	413	PF00069	0.607
MOD_Cter_Amidation	269	272	PF01082	0.475
MOD_Cter_Amidation	464	467	PF01082	0.590
MOD_GlcNHglycan	103	106	PF01048	0.619
MOD_GlcNHglycan	122	125	PF01048	0.533
MOD_GlcNHglycan	130	133	PF01048	0.581
MOD_GlcNHglycan	15	18	PF01048	0.556
MOD_GlcNHglycan	234	237	PF01048	0.829
MOD_GlcNHglycan	251	254	PF01048	0.601
MOD_GlcNHglycan	333	336	PF01048	0.595
MOD_GlcNHglycan	34	37	PF01048	0.466
MOD_GlcNHglycan	40	43	PF01048	0.462
MOD_GlcNHglycan	428	431	PF01048	0.619
MOD_GlcNHglycan	71	74	PF01048	0.620
MOD_GlcNHglycan	87	90	PF01048	0.601
MOD_GSK3_1	101	108	PF00069	0.623
MOD_GSK3_1	130	137	PF00069	0.747
MOD_GSK3_1	180	187	PF00069	0.748
MOD_GSK3_1	243	250	PF00069	0.680
MOD_GSK3_1	27	34	PF00069	0.499
MOD_GSK3_1	48	55	PF00069	0.581
MOD_GSK3_1	92	99	PF00069	0.632
MOD_N-GLC_1	85	90	PF02516	0.480
MOD_NEK2_1	112	117	PF00069	0.705
MOD_NEK2_1	150	155	PF00069	0.526
MOD_NEK2_1	166	171	PF00069	0.549
MOD_NEK2_1	282	287	PF00069	0.381
MOD_NEK2_1	310	315	PF00069	0.523
MOD_NEK2_1	38	43	PF00069	0.473
MOD_NEK2_1	59	64	PF00069	0.611
MOD_NEK2_1	6	11	PF00069	0.440
MOD_NEK2_2	485	490	PF00069	0.606
MOD_OFUCOSY	78	83	PF10250	0.480
MOD_PIKK_1	106	112	PF00454	0.654
MOD_PIKK_1	113	119	PF00454	0.655
MOD_PIKK_1	477	483	PF00454	0.622
MOD_PKA_2	175	181	PF00069	0.614
MOD_PKA_2	230	236	PF00069	0.613
MOD_PKA_2	270	276	PF00069	0.559
MOD_PKA_2	30	36	PF00069	0.471
MOD_PKA_2	456	462	PF00069	0.665
MOD_PKA_2	485	491	PF00069	0.601
MOD_PKA_2	68	74	PF00069	0.598
MOD_PKA_2	84	90	PF00069	0.483
MOD_PKB_1	455	463	PF00069	0.640
MOD_PKB_1	475	483	PF00069	0.495
MOD_PKB_1	67	75	PF00069	0.582
MOD_Plk_1	295	301	PF00069	0.324
MOD_Plk_1	353	359	PF00069	0.538
MOD_Plk_2-3	141	147	PF00069	0.658
MOD_Plk_2-3	407	413	PF00069	0.683
MOD_Plk_4	190	196	PF00069	0.426
MOD_ProDKin_1	167	173	PF00069	0.612
MOD_ProDKin_1	184	190	PF00069	0.629
MOD_ProDKin_1	256	262	PF00069	0.460
MOD_ProDKin_1	276	282	PF00069	0.403
MOD_ProDKin_1	348	354	PF00069	0.574
MOD_ProDKin_1	468	474	PF00069	0.637
MOD_ProDKin_1	76	82	PF00069	0.467
TRG_ENDOCYTIC_2	194	197	PF00928	0.347
TRG_ENDOCYTIC_2	350	353	PF00928	0.576
TRG_ER_diArg_1	262	264	PF00400	0.568
TRG_ER_diArg_1	304	307	PF00400	0.446
TRG_ER_diArg_1	389	391	PF00400	0.551
TRG_ER_diArg_1	450	453	PF00400	0.667
TRG_ER_diArg_1	474	477	PF00400	0.807
TRG_ER_diArg_1	66	69	PF00400	0.696
TRG_NLS_Bipartite_1	450	470	PF00514	0.578
TRG_NLS_MonoExtN_4	464	470	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF5	Leptomonas seymouri	48%	100%
A0A3Q8I8S7	Leishmania donovani	83%	100%
A4H7L8	Leishmania braziliensis	71%	99%
A4HW03	Leishmania infantum	83%	100%
Q4QFS4	Leishmania major	79%	99%