Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APQ0_LEIMU

TriTrypDb:

LmxM.14.0560

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9APQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.667
CLV_NRD_NRD_1	225	227	PF00675	0.665
CLV_NRD_NRD_1	330	332	PF00675	0.439
CLV_NRD_NRD_1	40	42	PF00675	0.719
CLV_NRD_NRD_1	423	425	PF00675	0.466
CLV_NRD_NRD_1	434	436	PF00675	0.468
CLV_PCSK_KEX2_1	225	227	PF00082	0.665
CLV_PCSK_KEX2_1	328	330	PF00082	0.429
CLV_PCSK_KEX2_1	40	42	PF00082	0.719
CLV_PCSK_KEX2_1	423	425	PF00082	0.446
CLV_PCSK_KEX2_1	457	459	PF00082	0.588
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.478
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.569
CLV_PCSK_SKI1_1	125	129	PF00082	0.722
CLV_PCSK_SKI1_1	166	170	PF00082	0.632
CLV_PCSK_SKI1_1	298	302	PF00082	0.359
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DEG_SCF_FBW7_1	339	346	PF00400	0.650
DEG_SPOP_SBC_1	348	352	PF00917	0.598
DOC_CDC14_PxL_1	266	274	PF14671	0.393
DOC_CKS1_1	238	243	PF01111	0.351
DOC_CYCLIN_yCln2_LP_2	271	277	PF00134	0.392
DOC_MAPK_gen_1	222	230	PF00069	0.466
DOC_MAPK_MEF2A_6	265	273	PF00069	0.381
DOC_MAPK_MEF2A_6	50	57	PF00069	0.487
DOC_PP1_RVXF_1	164	171	PF00149	0.431
DOC_PP1_SILK_1	453	458	PF00149	0.767
DOC_PP2B_LxvP_1	107	110	PF13499	0.497
DOC_PP2B_LxvP_1	271	274	PF13499	0.392
DOC_PP4_FxxP_1	477	480	PF00568	0.706
DOC_USP7_MATH_1	201	205	PF00917	0.476
DOC_USP7_MATH_1	343	347	PF00917	0.690
DOC_USP7_MATH_1	395	399	PF00917	0.716
DOC_USP7_MATH_1	413	417	PF00917	0.662
DOC_USP7_MATH_1	451	455	PF00917	0.669
DOC_USP7_MATH_1	62	66	PF00917	0.493
DOC_USP7_UBL2_3	298	302	PF12436	0.636
DOC_USP7_UBL2_3	324	328	PF12436	0.600
DOC_WW_Pin1_4	237	242	PF00397	0.426
DOC_WW_Pin1_4	29	34	PF00397	0.527
DOC_WW_Pin1_4	339	344	PF00397	0.663
DOC_WW_Pin1_4	353	358	PF00397	0.666
DOC_WW_Pin1_4	366	371	PF00397	0.642
DOC_WW_Pin1_4	435	440	PF00397	0.754
DOC_WW_Pin1_4	470	475	PF00397	0.725
LIG_14-3-3_CanoR_1	149	155	PF00244	0.456
LIG_14-3-3_CanoR_1	192	198	PF00244	0.363
LIG_14-3-3_CanoR_1	331	337	PF00244	0.654
LIG_14-3-3_CanoR_1	361	370	PF00244	0.644
LIG_14-3-3_CanoR_1	435	439	PF00244	0.721
LIG_14-3-3_CanoR_1	458	465	PF00244	0.694
LIG_14-3-3_CanoR_1	484	488	PF00244	0.748
LIG_BIR_III_2	30	34	PF00653	0.512
LIG_BIR_III_4	216	220	PF00653	0.530
LIG_BRCT_BRCA1_1	120	124	PF00533	0.452
LIG_BRCT_BRCA1_1	64	68	PF00533	0.490
LIG_EH1_1	8	16	PF00400	0.378
LIG_FHA_1	115	121	PF00498	0.451
LIG_FHA_1	14	20	PF00498	0.484
LIG_FHA_1	171	177	PF00498	0.409
LIG_FHA_1	210	216	PF00498	0.457
LIG_FHA_1	23	29	PF00498	0.600
LIG_FHA_1	350	356	PF00498	0.618
LIG_FHA_1	416	422	PF00498	0.667
LIG_FHA_2	230	236	PF00498	0.562
LIG_FHA_2	92	98	PF00498	0.470
LIG_IRF3_LxIS_1	281	288	PF10401	0.344
LIG_LIR_Apic_2	476	480	PF02991	0.706
LIG_LIR_Gen_1	22	31	PF02991	0.526
LIG_LIR_Gen_1	6	15	PF02991	0.455
LIG_LIR_Nem_3	121	127	PF02991	0.539
LIG_LIR_Nem_3	22	27	PF02991	0.523
LIG_LIR_Nem_3	224	230	PF02991	0.503
LIG_LIR_Nem_3	6	11	PF02991	0.463
LIG_MYND_1	270	274	PF01753	0.256
LIG_NRBOX	13	19	PF00104	0.611
LIG_PDZ_Class_2	484	489	PF00595	0.747
LIG_Pex14_1	114	118	PF04695	0.498
LIG_Pex14_2	179	183	PF04695	0.414
LIG_Pex14_2	68	72	PF04695	0.479
LIG_RPA_C_Fungi	412	424	PF08784	0.598
LIG_SH2_GRB2like	180	183	PF00017	0.483
LIG_SH2_SRC	233	236	PF00017	0.592
LIG_SH2_STAP1	223	227	PF00017	0.568
LIG_SH2_STAT3	187	190	PF00017	0.447
LIG_SH2_STAT5	118	121	PF00017	0.543
LIG_SH2_STAT5	180	183	PF00017	0.492
LIG_SH2_STAT5	223	226	PF00017	0.616
LIG_SH2_STAT5	233	236	PF00017	0.616
LIG_SH2_STAT5	293	296	PF00017	0.447
LIG_SH2_STAT5	35	38	PF00017	0.531
LIG_SH3_3	1	7	PF00018	0.568
LIG_SH3_3	235	241	PF00018	0.542
LIG_SH3_3	444	450	PF00018	0.662
LIG_SH3_4	298	305	PF00018	0.539
LIG_Sin3_3	24	31	PF02671	0.523
LIG_SUMO_SIM_anti_2	288	293	PF11976	0.428
LIG_SUMO_SIM_par_1	15	20	PF11976	0.400
LIG_SUMO_SIM_par_1	211	216	PF11976	0.468
LIG_SUMO_SIM_par_1	273	278	PF11976	0.332
LIG_SUMO_SIM_par_1	350	356	PF11976	0.483
LIG_SUMO_SIM_par_1	51	58	PF11976	0.611
LIG_UBA3_1	290	298	PF00899	0.392
LIG_WRPW_2	197	200	PF00400	0.533
MOD_CDK_SPK_2	366	371	PF00069	0.594
MOD_CDK_SPxxK_3	237	244	PF00069	0.557
MOD_CK1_1	193	199	PF00069	0.446
MOD_CK1_1	22	28	PF00069	0.548
MOD_CK1_1	335	341	PF00069	0.668
MOD_CK1_1	351	357	PF00069	0.497
MOD_CK1_1	364	370	PF00069	0.608
MOD_CK1_1	431	437	PF00069	0.698
MOD_CK1_1	438	444	PF00069	0.619
MOD_CK1_1	461	467	PF00069	0.840
MOD_CK1_1	470	476	PF00069	0.608
MOD_CK2_1	229	235	PF00069	0.561
MOD_CK2_1	91	97	PF00069	0.609
MOD_DYRK1A_RPxSP_1	237	241	PF00069	0.542
MOD_GlcNHglycan	120	123	PF01048	0.557
MOD_GlcNHglycan	21	24	PF01048	0.469
MOD_GlcNHglycan	255	258	PF01048	0.488
MOD_GlcNHglycan	277	280	PF01048	0.332
MOD_GlcNHglycan	371	374	PF01048	0.647
MOD_GlcNHglycan	378	381	PF01048	0.712
MOD_GlcNHglycan	466	469	PF01048	0.729
MOD_GSK3_1	114	121	PF00069	0.614
MOD_GSK3_1	13	20	PF00069	0.481
MOD_GSK3_1	335	342	PF00069	0.602
MOD_GSK3_1	343	350	PF00069	0.596
MOD_GSK3_1	362	369	PF00069	0.633
MOD_GSK3_1	400	407	PF00069	0.680
MOD_GSK3_1	431	438	PF00069	0.634
MOD_GSK3_1	457	464	PF00069	0.825
MOD_N-GLC_1	114	119	PF02516	0.569
MOD_N-GLC_1	181	186	PF02516	0.517
MOD_N-GLC_1	209	214	PF02516	0.554
MOD_N-GLC_1	62	67	PF02516	0.630
MOD_NEK2_1	17	22	PF00069	0.498
MOD_NEK2_1	251	256	PF00069	0.611
MOD_NEK2_1	285	290	PF00069	0.344
MOD_NEK2_1	83	88	PF00069	0.699
MOD_PIKK_1	356	362	PF00454	0.481
MOD_PIKK_1	395	401	PF00454	0.703
MOD_PKA_1	423	429	PF00069	0.593
MOD_PKA_1	457	463	PF00069	0.659
MOD_PKA_2	221	227	PF00069	0.470
MOD_PKA_2	407	413	PF00069	0.719
MOD_PKA_2	423	429	PF00069	0.533
MOD_PKA_2	434	440	PF00069	0.581
MOD_PKA_2	457	463	PF00069	0.826
MOD_PKA_2	483	489	PF00069	0.616
MOD_Plk_1	114	120	PF00069	0.567
MOD_Plk_1	201	207	PF00069	0.536
MOD_Plk_1	209	215	PF00069	0.504
MOD_Plk_4	123	129	PF00069	0.669
MOD_Plk_4	13	19	PF00069	0.490
MOD_Plk_4	229	235	PF00069	0.574
MOD_Plk_4	343	349	PF00069	0.598
MOD_Plk_4	407	413	PF00069	0.695
MOD_Plk_4	423	429	PF00069	0.505
MOD_Plk_4	442	448	PF00069	0.613
MOD_Plk_4	451	457	PF00069	0.703
MOD_Plk_4	64	70	PF00069	0.536
MOD_Plk_4	84	90	PF00069	0.406
MOD_ProDKin_1	237	243	PF00069	0.524
MOD_ProDKin_1	29	35	PF00069	0.528
MOD_ProDKin_1	339	345	PF00069	0.573
MOD_ProDKin_1	353	359	PF00069	0.579
MOD_ProDKin_1	366	372	PF00069	0.544
MOD_ProDKin_1	435	441	PF00069	0.703
MOD_ProDKin_1	470	476	PF00069	0.658
MOD_SUMO_for_1	301	304	PF00179	0.637
MOD_SUMO_for_1	309	312	PF00179	0.481
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.494
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.477
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.631
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.499
TRG_ENDOCYTIC_2	180	183	PF00928	0.483
TRG_ENDOCYTIC_2	227	230	PF00928	0.704
TRG_ER_diArg_1	225	227	PF00400	0.576
TRG_ER_diArg_1	329	331	PF00400	0.574
TRG_ER_diArg_1	423	425	PF00400	0.610
TRG_NLS_MonoCore_2	327	332	PF00514	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W9	Leptomonas seymouri	35%	100%
A0A3Q8I9R5	Leishmania donovani	31%	100%
A0A3S7WSX8	Leishmania donovani	88%	100%
A4H7L3	Leishmania braziliensis	70%	100%
A4HVZ7	Leishmania infantum	29%	100%
A4HVZ8	Leishmania infantum	88%	100%
Q4QFS9	Leishmania major	83%	94%