Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APP9_LEIMU

TriTrypDb:

LmxM.14.0550

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9APP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.477
CLV_C14_Caspase3-7	295	299	PF00656	0.456
CLV_C14_Caspase3-7	451	455	PF00656	0.637
CLV_PCSK_SKI1_1	150	154	PF00082	0.659
CLV_PCSK_SKI1_1	235	239	PF00082	0.637
CLV_PCSK_SKI1_1	275	279	PF00082	0.562
CLV_PCSK_SKI1_1	371	375	PF00082	0.566
CLV_PCSK_SKI1_1	403	407	PF00082	0.356
DEG_Nend_UBRbox_1	1	4	PF02207	0.644
DEG_SCF_FBW7_1	15	22	PF00400	0.641
DOC_ANK_TNKS_1	449	456	PF00023	0.640
DOC_CYCLIN_RxL_1	403	417	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.587
DOC_MAPK_gen_1	407	416	PF00069	0.640
DOC_MAPK_HePTP_8	108	120	PF00069	0.477
DOC_MAPK_MEF2A_6	111	120	PF00069	0.477
DOC_MAPK_MEF2A_6	409	418	PF00069	0.637
DOC_PP1_RVXF_1	273	280	PF00149	0.369
DOC_PP1_RVXF_1	60	66	PF00149	0.613
DOC_PP2B_LxvP_1	135	138	PF13499	0.451
DOC_USP7_MATH_1	19	23	PF00917	0.640
DOC_WW_Pin1_4	129	134	PF00397	0.435
DOC_WW_Pin1_4	15	20	PF00397	0.639
DOC_WW_Pin1_4	21	26	PF00397	0.623
DOC_WW_Pin1_4	3	8	PF00397	0.638
DOC_WW_Pin1_4	302	307	PF00397	0.409
DOC_WW_Pin1_4	345	350	PF00397	0.454
LIG_14-3-3_CanoR_1	156	162	PF00244	0.447
LIG_14-3-3_CanoR_1	266	270	PF00244	0.482
LIG_Actin_WH2_2	253	268	PF00022	0.466
LIG_APCC_ABBA_1	65	70	PF00400	0.609
LIG_BIR_III_4	319	323	PF00653	0.464
LIG_BRCT_BRCA1_1	127	131	PF00533	0.598
LIG_Clathr_ClatBox_1	413	417	PF01394	0.631
LIG_deltaCOP1_diTrp_1	323	326	PF00928	0.448
LIG_EVH1_2	28	32	PF00568	0.602
LIG_FAT_LD_1	381	389	PF03623	0.356
LIG_FHA_1	309	315	PF00498	0.386
LIG_FHA_1	330	336	PF00498	0.449
LIG_FHA_1	372	378	PF00498	0.311
LIG_FHA_1	381	387	PF00498	0.307
LIG_FHA_1	413	419	PF00498	0.643
LIG_FHA_2	332	338	PF00498	0.443
LIG_GBD_Chelix_1	195	203	PF00786	0.631
LIG_LIR_Gen_1	323	333	PF02991	0.433
LIG_LIR_Nem_3	160	166	PF02991	0.497
LIG_LIR_Nem_3	181	186	PF02991	0.436
LIG_LIR_Nem_3	231	237	PF02991	0.449
LIG_LIR_Nem_3	323	329	PF02991	0.441
LIG_LIR_Nem_3	331	336	PF02991	0.398
LIG_LIR_Nem_3	76	81	PF02991	0.613
LIG_LYPXL_yS_3	183	186	PF13949	0.442
LIG_NRBOX	115	121	PF00104	0.337
LIG_NRBOX	383	389	PF00104	0.356
LIG_Pex14_2	288	292	PF04695	0.448
LIG_Pex14_2	81	85	PF04695	0.614
LIG_SH2_CRK	370	374	PF00017	0.312
LIG_SH2_GRB2like	289	292	PF00017	0.411
LIG_SH2_SRC	296	299	PF00017	0.455
LIG_SH2_STAT5	163	166	PF00017	0.443
LIG_SH2_STAT5	185	188	PF00017	0.558
LIG_SH2_STAT5	289	292	PF00017	0.463
LIG_SH2_STAT5	296	299	PF00017	0.430
LIG_SH2_STAT5	333	336	PF00017	0.434
LIG_SH2_STAT5	376	379	PF00017	0.392
LIG_SH2_STAT5	77	80	PF00017	0.633
LIG_SH3_3	11	17	PF00018	0.650
LIG_SH3_3	22	28	PF00018	0.610
LIG_SH3_3	392	398	PF00018	0.356
LIG_Sin3_3	115	122	PF02671	0.308
LIG_SUMO_SIM_anti_2	382	389	PF11976	0.415
LIG_SUMO_SIM_anti_2	415	420	PF11976	0.628
LIG_SUMO_SIM_par_1	412	417	PF11976	0.637
LIG_TRAF2_1	436	439	PF00917	0.654
LIG_TRAF2_1	52	55	PF00917	0.602
LIG_TYR_ITSM	179	186	PF00017	0.450
MOD_CK1_1	127	133	PF00069	0.636
MOD_CK1_1	169	175	PF00069	0.518
MOD_CK1_1	205	211	PF00069	0.564
MOD_CK1_1	301	307	PF00069	0.401
MOD_CK1_1	309	315	PF00069	0.373
MOD_CK1_1	343	349	PF00069	0.485
MOD_CK1_1	44	50	PF00069	0.593
MOD_CK2_1	331	337	PF00069	0.514
MOD_CK2_1	432	438	PF00069	0.701
MOD_CK2_1	49	55	PF00069	0.602
MOD_GlcNHglycan	166	169	PF01048	0.768
MOD_GlcNHglycan	187	190	PF01048	0.672
MOD_GlcNHglycan	192	195	PF01048	0.595
MOD_GlcNHglycan	204	207	PF01048	0.560
MOD_GlcNHglycan	342	345	PF01048	0.717
MOD_GlcNHglycan	424	428	PF01048	0.482
MOD_GlcNHglycan	438	443	PF01048	0.517
MOD_GlcNHglycan	46	49	PF01048	0.400
MOD_GSK3_1	125	132	PF00069	0.520
MOD_GSK3_1	15	22	PF00069	0.641
MOD_GSK3_1	157	164	PF00069	0.450
MOD_GSK3_1	175	182	PF00069	0.379
MOD_GSK3_1	201	208	PF00069	0.468
MOD_GSK3_1	229	236	PF00069	0.412
MOD_GSK3_1	298	305	PF00069	0.373
MOD_GSK3_1	331	338	PF00069	0.513
MOD_GSK3_1	434	441	PF00069	0.748
MOD_GSK3_1	444	451	PF00069	0.762
MOD_N-GLC_1	161	166	PF02516	0.649
MOD_N-GLC_1	290	295	PF02516	0.662
MOD_N-GLC_1	301	306	PF02516	0.605
MOD_N-GLC_1	340	345	PF02516	0.710
MOD_N-GLC_1	360	365	PF02516	0.598
MOD_N-GLC_1	444	449	PF02516	0.438
MOD_N-GLC_1	73	78	PF02516	0.403
MOD_NEK2_1	202	207	PF00069	0.523
MOD_NEK2_1	265	270	PF00069	0.502
MOD_NEK2_1	292	297	PF00069	0.473
MOD_NEK2_1	307	312	PF00069	0.372
MOD_NEK2_1	32	37	PF00069	0.714
MOD_NEK2_1	329	334	PF00069	0.490
MOD_NEK2_1	335	340	PF00069	0.484
MOD_NEK2_1	342	347	PF00069	0.525
MOD_NEK2_1	41	46	PF00069	0.666
MOD_NEK2_1	85	90	PF00069	0.605
MOD_NEK2_2	161	166	PF00069	0.439
MOD_PIKK_1	259	265	PF00454	0.470
MOD_PIKK_1	290	296	PF00454	0.365
MOD_PIKK_1	362	368	PF00454	0.486
MOD_PIKK_1	417	423	PF00454	0.698
MOD_PK_1	49	55	PF00069	0.602
MOD_PKA_2	104	110	PF00069	0.616
MOD_PKA_2	265	271	PF00069	0.473
MOD_PKB_1	446	454	PF00069	0.724
MOD_Plk_1	161	167	PF00069	0.452
MOD_Plk_1	73	79	PF00069	0.604
MOD_Plk_4	161	167	PF00069	0.443
MOD_Plk_4	233	239	PF00069	0.440
MOD_Plk_4	292	298	PF00069	0.391
MOD_Plk_4	309	315	PF00069	0.376
MOD_Plk_4	32	38	PF00069	0.719
MOD_Plk_4	331	337	PF00069	0.460
MOD_Plk_4	380	386	PF00069	0.282
MOD_Plk_4	73	79	PF00069	0.604
MOD_ProDKin_1	129	135	PF00069	0.437
MOD_ProDKin_1	15	21	PF00069	0.639
MOD_ProDKin_1	3	9	PF00069	0.639
MOD_ProDKin_1	302	308	PF00069	0.409
MOD_ProDKin_1	345	351	PF00069	0.456
TRG_ENDOCYTIC_2	183	186	PF00928	0.442
TRG_ENDOCYTIC_2	289	292	PF00928	0.418
TRG_ENDOCYTIC_2	333	336	PF00928	0.434
TRG_ENDOCYTIC_2	370	373	PF00928	0.497
TRG_ENDOCYTIC_2	77	80	PF00928	0.617
TRG_ER_diArg_1	1	4	PF00400	0.672
TRG_ER_diArg_1	86	89	PF00400	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9R5	Leishmania donovani	89%	100%
A4HVZ7	Leishmania infantum	90%	100%
Q4QFT0	Leishmania major	76%	100%