Ion transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein-like protein

Species:

Leishmania mexicana

UniProt:

E9APP8_LEIMU

TriTrypDb:

LmxM.14.0540

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9APP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005227	calcium activated cation channel activity	6	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0005267	potassium channel activity	6	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015079	potassium ion transmembrane transporter activity	6	11
GO:0015267	channel activity	4	11
GO:0015269	calcium-activated potassium channel activity	7	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0016286	small conductance calcium-activated potassium channel activity	8	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022836	gated channel activity	5	11
GO:0022839	monoatomic ion gated channel activity	6	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0046873	metal ion transmembrane transporter activity	5	11
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.334
CLV_NRD_NRD_1	377	379	PF00675	0.461
CLV_NRD_NRD_1	408	410	PF00675	0.370
CLV_NRD_NRD_1	49	51	PF00675	0.441
CLV_NRD_NRD_1	69	71	PF00675	0.499
CLV_PCSK_KEX2_1	408	410	PF00082	0.366
CLV_PCSK_KEX2_1	47	49	PF00082	0.489
CLV_PCSK_KEX2_1	57	59	PF00082	0.509
CLV_PCSK_KEX2_1	69	71	PF00082	0.504
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.481
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.536
CLV_PCSK_PC7_1	65	71	PF00082	0.485
CLV_PCSK_SKI1_1	131	135	PF00082	0.466
CLV_PCSK_SKI1_1	172	176	PF00082	0.293
CLV_PCSK_SKI1_1	467	471	PF00082	0.513
CLV_PCSK_SKI1_1	50	54	PF00082	0.457
CLV_PCSK_SKI1_1	58	62	PF00082	0.475
CLV_PCSK_SKI1_1	69	73	PF00082	0.435
CLV_PCSK_SKI1_1	95	99	PF00082	0.440
DEG_SPOP_SBC_1	244	248	PF00917	0.586
DEG_SPOP_SBC_1	500	504	PF00917	0.758
DOC_CKS1_1	192	197	PF01111	0.360
DOC_MAPK_gen_1	259	268	PF00069	0.515
DOC_MAPK_gen_1	361	370	PF00069	0.626
DOC_MAPK_gen_1	388	396	PF00069	0.594
DOC_MAPK_gen_1	453	462	PF00069	0.691
DOC_MAPK_HePTP_8	256	268	PF00069	0.564
DOC_MAPK_MEF2A_6	215	223	PF00069	0.378
DOC_MAPK_MEF2A_6	259	268	PF00069	0.564
DOC_MAPK_MEF2A_6	455	464	PF00069	0.686
DOC_MAPK_MEF2A_6	76	83	PF00069	0.626
DOC_PP1_RVXF_1	311	318	PF00149	0.296
DOC_PP4_FxxP_1	175	178	PF00568	0.358
DOC_USP7_MATH_1	20	24	PF00917	0.695
DOC_USP7_MATH_1	486	490	PF00917	0.712
DOC_USP7_MATH_1	500	504	PF00917	0.660
DOC_USP7_UBL2_3	72	76	PF12436	0.681
DOC_WW_Pin1_4	174	179	PF00397	0.320
DOC_WW_Pin1_4	191	196	PF00397	0.327
DOC_WW_Pin1_4	28	33	PF00397	0.736
DOC_WW_Pin1_4	303	308	PF00397	0.283
LIG_14-3-3_CanoR_1	172	178	PF00244	0.484
LIG_14-3-3_CanoR_1	215	220	PF00244	0.426
LIG_14-3-3_CanoR_1	235	244	PF00244	0.430
LIG_14-3-3_CanoR_1	261	267	PF00244	0.442
LIG_14-3-3_CanoR_1	28	32	PF00244	0.747
LIG_14-3-3_CanoR_1	361	370	PF00244	0.584
LIG_14-3-3_CanoR_1	48	56	PF00244	0.641
LIG_14-3-3_CanoR_1	530	538	PF00244	0.632
LIG_Actin_WH2_2	96	113	PF00022	0.556
LIG_APCC_ABBAyCdc20_2	76	82	PF00400	0.594
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	176	180	PF00533	0.408
LIG_BRCT_BRCA1_1	245	249	PF00533	0.579
LIG_CaM_IQ_9	365	381	PF13499	0.588
LIG_CtBP_PxDLS_1	546	550	PF00389	0.689
LIG_deltaCOP1_diTrp_1	288	294	PF00928	0.283
LIG_EH1_1	181	189	PF00400	0.481
LIG_EH1_1	344	352	PF00400	0.664
LIG_EH1_1	476	484	PF00400	0.499
LIG_FHA_1	118	124	PF00498	0.345
LIG_FHA_1	137	143	PF00498	0.419
LIG_FHA_1	152	158	PF00498	0.480
LIG_FHA_1	245	251	PF00498	0.559
LIG_FHA_1	258	264	PF00498	0.460
LIG_FHA_1	279	285	PF00498	0.353
LIG_FHA_1	391	397	PF00498	0.601
LIG_FHA_1	399	405	PF00498	0.531
LIG_FHA_1	530	536	PF00498	0.670
LIG_FHA_2	347	353	PF00498	0.622
LIG_FHA_2	96	102	PF00498	0.539
LIG_KLC1_Yacidic_2	77	82	PF13176	0.613
LIG_LIR_Gen_1	177	188	PF02991	0.481
LIG_LIR_Gen_1	293	302	PF02991	0.317
LIG_LIR_Gen_1	323	332	PF02991	0.355
LIG_LIR_Gen_1	333	340	PF02991	0.433
LIG_LIR_Gen_1	51	60	PF02991	0.635
LIG_LIR_Gen_1	77	88	PF02991	0.646
LIG_LIR_Nem_3	194	200	PF02991	0.452
LIG_LIR_Nem_3	288	294	PF02991	0.350
LIG_LIR_Nem_3	299	305	PF02991	0.271
LIG_LIR_Nem_3	333	338	PF02991	0.496
LIG_LIR_Nem_3	77	83	PF02991	0.643
LIG_NRBOX	395	401	PF00104	0.584
LIG_Pex14_1	320	324	PF04695	0.345
LIG_Pex14_2	13	17	PF04695	0.584
LIG_PTB_Apo_2	163	170	PF02174	0.588
LIG_PTB_Apo_2	222	229	PF02174	0.400
LIG_PTB_Phospho_1	222	228	PF10480	0.432
LIG_SH2_CRK	217	221	PF00017	0.378
LIG_SH2_CRK	335	339	PF00017	0.597
LIG_SH2_GRB2like	222	225	PF00017	0.475
LIG_SH2_PTP2	204	207	PF00017	0.360
LIG_SH2_PTP2	80	83	PF00017	0.661
LIG_SH2_SRC	80	83	PF00017	0.646
LIG_SH2_SRC	85	88	PF00017	0.645
LIG_SH2_STAP1	217	221	PF00017	0.378
LIG_SH2_STAP1	392	396	PF00017	0.629
LIG_SH2_STAT5	204	207	PF00017	0.361
LIG_SH2_STAT5	210	213	PF00017	0.318
LIG_SH2_STAT5	222	225	PF00017	0.389
LIG_SH2_STAT5	228	231	PF00017	0.546
LIG_SH2_STAT5	324	327	PF00017	0.400
LIG_SH2_STAT5	392	395	PF00017	0.650
LIG_SH2_STAT5	440	443	PF00017	0.599
LIG_SH2_STAT5	80	83	PF00017	0.644
LIG_SH3_1	379	385	PF00018	0.668
LIG_SH3_3	193	199	PF00018	0.443
LIG_SH3_3	379	385	PF00018	0.668
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.700
LIG_SUMO_SIM_anti_2	98	104	PF11976	0.560
LIG_SUMO_SIM_par_1	115	120	PF11976	0.487
LIG_SUMO_SIM_par_1	122	128	PF11976	0.434
LIG_SUMO_SIM_par_1	392	397	PF11976	0.621
LIG_TYR_ITIM	300	305	PF00017	0.336
LIG_UBA3_1	123	131	PF00899	0.186
LIG_UBA3_1	148	153	PF00899	0.378
LIG_WRC_WIRS_1	230	235	PF05994	0.420
MOD_CK1_1	125	131	PF00069	0.447
MOD_CK1_1	2	8	PF00069	0.569
MOD_CK1_1	238	244	PF00069	0.537
MOD_CK1_1	293	299	PF00069	0.397
MOD_CK1_1	308	314	PF00069	0.326
MOD_CK1_1	341	347	PF00069	0.524
MOD_CK1_1	417	423	PF00069	0.422
MOD_CK1_1	472	478	PF00069	0.584
MOD_CK1_1	504	510	PF00069	0.594
MOD_CK2_1	20	26	PF00069	0.782
MOD_CK2_1	417	423	PF00069	0.592
MOD_CK2_1	507	513	PF00069	0.655
MOD_CK2_1	95	101	PF00069	0.354
MOD_Cter_Amidation	67	70	PF01082	0.619
MOD_DYRK1A_RPxSP_1	28	32	PF00069	0.563
MOD_GlcNHglycan	131	134	PF01048	0.532
MOD_GlcNHglycan	161	164	PF01048	0.504
MOD_GlcNHglycan	237	240	PF01048	0.512
MOD_GlcNHglycan	310	313	PF01048	0.408
MOD_GlcNHglycan	363	366	PF01048	0.434
MOD_GlcNHglycan	432	435	PF01048	0.539
MOD_GlcNHglycan	50	53	PF01048	0.612
MOD_GlcNHglycan	504	507	PF01048	0.645
MOD_GlcNHglycan	538	541	PF01048	0.662
MOD_GSK3_1	125	132	PF00069	0.487
MOD_GSK3_1	278	285	PF00069	0.481
MOD_GSK3_1	390	397	PF00069	0.474
MOD_GSK3_1	500	507	PF00069	0.679
MOD_GSK3_1	541	548	PF00069	0.634
MOD_N-GLC_1	136	141	PF02516	0.408
MOD_N-GLC_1	282	287	PF02516	0.407
MOD_N-GLC_1	414	419	PF02516	0.567
MOD_NEK2_1	1	6	PF00069	0.489
MOD_NEK2_1	117	122	PF00069	0.323
MOD_NEK2_1	13	18	PF00069	0.500
MOD_NEK2_1	141	146	PF00069	0.329
MOD_NEK2_1	245	250	PF00069	0.411
MOD_NEK2_1	278	283	PF00069	0.388
MOD_NEK2_1	290	295	PF00069	0.348
MOD_NEK2_1	330	335	PF00069	0.394
MOD_NEK2_1	356	361	PF00069	0.493
MOD_NEK2_1	394	399	PF00069	0.426
MOD_NEK2_1	414	419	PF00069	0.279
MOD_NEK2_1	470	475	PF00069	0.655
MOD_NEK2_1	501	506	PF00069	0.702
MOD_NEK2_1	549	554	PF00069	0.750
MOD_NEK2_1	56	61	PF00069	0.635
MOD_PIKK_1	141	147	PF00454	0.435
MOD_PIKK_1	278	284	PF00454	0.407
MOD_PK_1	215	221	PF00069	0.447
MOD_PKA_1	48	54	PF00069	0.564
MOD_PKA_2	27	33	PF00069	0.741
MOD_PKA_2	407	413	PF00069	0.507
MOD_PKA_2	48	54	PF00069	0.575
MOD_PKA_2	529	535	PF00069	0.512
MOD_Plk_1	13	19	PF00069	0.537
MOD_Plk_1	136	142	PF00069	0.342
MOD_Plk_1	282	288	PF00069	0.435
MOD_Plk_1	422	428	PF00069	0.441
MOD_Plk_1	95	101	PF00069	0.545
MOD_Plk_4	101	107	PF00069	0.477
MOD_Plk_4	122	128	PF00069	0.339
MOD_Plk_4	136	142	PF00069	0.280
MOD_Plk_4	215	221	PF00069	0.390
MOD_Plk_4	245	251	PF00069	0.489
MOD_Plk_4	262	268	PF00069	0.247
MOD_Plk_4	320	326	PF00069	0.403
MOD_Plk_4	333	339	PF00069	0.424
MOD_Plk_4	346	352	PF00069	0.418
MOD_Plk_4	39	45	PF00069	0.579
MOD_Plk_4	478	484	PF00069	0.598
MOD_ProDKin_1	174	180	PF00069	0.320
MOD_ProDKin_1	191	197	PF00069	0.409
MOD_ProDKin_1	28	34	PF00069	0.690
MOD_ProDKin_1	303	309	PF00069	0.336
MOD_SUMO_rev_2	519	529	PF00179	0.635
TRG_DiLeu_BaEn_1	480	485	PF01217	0.369
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.579
TRG_ENDOCYTIC_2	204	207	PF00928	0.458
TRG_ENDOCYTIC_2	210	213	PF00928	0.320
TRG_ENDOCYTIC_2	217	220	PF00928	0.311
TRG_ENDOCYTIC_2	230	233	PF00928	0.401
TRG_ENDOCYTIC_2	302	305	PF00928	0.346
TRG_ENDOCYTIC_2	324	327	PF00928	0.355
TRG_ENDOCYTIC_2	335	338	PF00928	0.391
TRG_ENDOCYTIC_2	440	443	PF00928	0.612
TRG_ENDOCYTIC_2	80	83	PF00928	0.547
TRG_ER_diArg_1	360	363	PF00400	0.521
TRG_ER_diArg_1	408	411	PF00400	0.447
TRG_ER_diArg_1	464	467	PF00400	0.523
TRG_ER_diArg_1	48	50	PF00400	0.595
TRG_ER_diArg_1	69	71	PF00400	0.629
TRG_NLS_MonoCore_2	46	51	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A8	Leptomonas seymouri	65%	100%
A0A0S4IWT9	Bodo saltans	34%	100%
A0A1X0NNP7	Trypanosomatidae	41%	100%
A0A3S7WSZ6	Leishmania donovani	92%	100%
A0A422NNK5	Trypanosoma rangeli	40%	100%
A4H7L2	Leishmania braziliensis	77%	100%
A4HVZ6	Leishmania infantum	92%	100%
Q4QFT1	Leishmania major	93%	100%
V5BNC5	Trypanosoma cruzi	41%	100%