Ion_trans_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ion channel, putative

Species:

Leishmania mexicana

UniProt:

E9APP7_LEIMU

TriTrypDb:

LmxM.14.0530

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9APP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0005216	monoatomic ion channel activity	4	13
GO:0005227	calcium activated cation channel activity	6	13
GO:0005261	monoatomic cation channel activity	5	13
GO:0005267	potassium channel activity	6	13
GO:0008324	monoatomic cation transmembrane transporter activity	4	13
GO:0015075	monoatomic ion transmembrane transporter activity	3	13
GO:0015079	potassium ion transmembrane transporter activity	6	13
GO:0015267	channel activity	4	13
GO:0015269	calcium-activated potassium channel activity	7	13
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	13
GO:0016286	small conductance calcium-activated potassium channel activity	8	13
GO:0022803	passive transmembrane transporter activity	3	13
GO:0022836	gated channel activity	5	13
GO:0022839	monoatomic ion gated channel activity	6	13
GO:0022857	transmembrane transporter activity	2	13
GO:0022890	inorganic cation transmembrane transporter activity	4	13
GO:0046873	metal ion transmembrane transporter activity	5	13
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.304
CLV_NRD_NRD_1	339	341	PF00675	0.334
CLV_NRD_NRD_1	398	400	PF00675	0.503
CLV_NRD_NRD_1	472	474	PF00675	0.464
CLV_NRD_NRD_1	485	487	PF00675	0.395
CLV_PCSK_KEX2_1	315	317	PF00082	0.341
CLV_PCSK_KEX2_1	339	341	PF00082	0.306
CLV_PCSK_KEX2_1	398	400	PF00082	0.503
CLV_PCSK_KEX2_1	472	474	PF00082	0.479
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.393
CLV_PCSK_SKI1_1	405	409	PF00082	0.534
DEG_MDM2_SWIB_1	201	208	PF02201	0.388
DEG_Nend_UBRbox_2	1	3	PF02207	0.624
DEG_SCF_FBW7_1	369	376	PF00400	0.734
DEG_SPOP_SBC_1	392	396	PF00917	0.677
DEG_SPOP_SBC_1	435	439	PF00917	0.721
DOC_MAPK_gen_1	312	321	PF00069	0.536
DOC_MAPK_gen_1	41	49	PF00069	0.374
DOC_MAPK_MEF2A_6	315	323	PF00069	0.613
DOC_PP4_MxPP_1	128	131	PF00568	0.500
DOC_USP7_MATH_1	106	110	PF00917	0.640
DOC_USP7_MATH_1	142	146	PF00917	0.282
DOC_USP7_MATH_1	170	174	PF00917	0.627
DOC_USP7_MATH_1	435	439	PF00917	0.732
DOC_USP7_MATH_1	461	465	PF00917	0.706
DOC_WW_Pin1_4	109	114	PF00397	0.494
DOC_WW_Pin1_4	14	19	PF00397	0.619
DOC_WW_Pin1_4	272	277	PF00397	0.547
DOC_WW_Pin1_4	369	374	PF00397	0.688
DOC_WW_Pin1_4	376	381	PF00397	0.680
DOC_WW_Pin1_4	408	413	PF00397	0.666
LIG_14-3-3_CanoR_1	160	167	PF00244	0.554
LIG_14-3-3_CanoR_1	169	175	PF00244	0.496
LIG_14-3-3_CanoR_1	178	183	PF00244	0.451
LIG_14-3-3_CanoR_1	186	190	PF00244	0.465
LIG_14-3-3_CanoR_1	247	254	PF00244	0.296
LIG_14-3-3_CanoR_1	279	285	PF00244	0.597
LIG_14-3-3_CanoR_1	29	34	PF00244	0.626
LIG_14-3-3_CanoR_1	351	357	PF00244	0.612
LIG_14-3-3_CanoR_1	365	370	PF00244	0.659
LIG_14-3-3_CanoR_1	398	404	PF00244	0.697
LIG_14-3-3_CanoR_1	494	502	PF00244	0.728
LIG_Actin_WH2_2	356	372	PF00022	0.633
LIG_APCC_ABBA_1	401	406	PF00400	0.697
LIG_BRCT_BRCA1_1	319	323	PF00533	0.539
LIG_CaM_IQ_9	299	314	PF13499	0.516
LIG_Clathr_ClatBox_1	30	34	PF01394	0.634
LIG_FHA_1	161	167	PF00498	0.609
LIG_FHA_1	247	253	PF00498	0.284
LIG_FHA_1	25	31	PF00498	0.560
LIG_FHA_1	285	291	PF00498	0.625
LIG_FHA_1	370	376	PF00498	0.788
LIG_FHA_1	469	475	PF00498	0.610
LIG_FHA_1	478	484	PF00498	0.604
LIG_FHA_2	211	217	PF00498	0.292
LIG_FHA_2	273	279	PF00498	0.555
LIG_FHA_2	353	359	PF00498	0.620
LIG_GBD_Chelix_1	202	210	PF00786	0.400
LIG_GBD_Chelix_1	70	78	PF00786	0.376
LIG_LIR_Gen_1	112	122	PF02991	0.353
LIG_LIR_Gen_1	144	154	PF02991	0.368
LIG_LIR_Gen_1	320	328	PF02991	0.527
LIG_LIR_Gen_1	400	409	PF02991	0.704
LIG_LIR_Nem_3	112	117	PF02991	0.371
LIG_LIR_Nem_3	144	149	PF02991	0.316
LIG_LIR_Nem_3	151	157	PF02991	0.251
LIG_LIR_Nem_3	230	236	PF02991	0.262
LIG_LIR_Nem_3	320	326	PF02991	0.646
LIG_LIR_Nem_3	334	338	PF02991	0.503
LIG_LIR_Nem_3	400	404	PF02991	0.703
LIG_MYND_3	442	446	PF01753	0.691
LIG_Pex14_1	244	248	PF04695	0.304
LIG_Pex14_2	185	189	PF04695	0.622
LIG_Pex14_2	201	205	PF04695	0.448
LIG_SH2_NCK_1	236	240	PF00017	0.157
LIG_SH2_PTP2	152	155	PF00017	0.310
LIG_SH2_SRC	152	155	PF00017	0.342
LIG_SH2_SRC	220	223	PF00017	0.361
LIG_SH2_STAP1	220	224	PF00017	0.344
LIG_SH2_STAP1	236	240	PF00017	0.327
LIG_SH2_STAT5	114	117	PF00017	0.388
LIG_SH2_STAT5	152	155	PF00017	0.284
LIG_SH2_STAT5	157	160	PF00017	0.359
LIG_SH2_STAT5	212	215	PF00017	0.273
LIG_SH2_STAT5	225	228	PF00017	0.253
LIG_SH2_STAT5	309	312	PF00017	0.555
LIG_SH2_STAT5	354	357	PF00017	0.630
LIG_SH3_1	413	419	PF00018	0.578
LIG_SH3_3	15	21	PF00018	0.610
LIG_SH3_3	374	380	PF00018	0.706
LIG_SH3_3	406	412	PF00018	0.746
LIG_SH3_3	413	419	PF00018	0.755
LIG_SUMO_SIM_anti_2	478	485	PF11976	0.644
LIG_SUMO_SIM_par_1	29	34	PF11976	0.618
LIG_SUMO_SIM_par_1	74	79	PF11976	0.294
LIG_TRAF2_1	421	424	PF00917	0.626
LIG_TYR_ITIM	234	239	PF00017	0.261
LIG_WRC_WIRS_1	143	148	PF05994	0.327
MOD_CDK_SPK_2	373	378	PF00069	0.707
MOD_CDK_SPK_2	408	413	PF00069	0.660
MOD_CDK_SPxxK_3	272	279	PF00069	0.516
MOD_CK1_1	109	115	PF00069	0.523
MOD_CK1_1	162	168	PF00069	0.613
MOD_CK1_1	334	340	PF00069	0.574
MOD_CK1_1	352	358	PF00069	0.502
MOD_CK1_1	364	370	PF00069	0.670
MOD_CK1_1	376	382	PF00069	0.673
MOD_CK1_1	394	400	PF00069	0.693
MOD_CK1_1	437	443	PF00069	0.723
MOD_CK1_1	464	470	PF00069	0.655
MOD_CK2_1	210	216	PF00069	0.251
MOD_CK2_1	272	278	PF00069	0.571
MOD_CK2_1	495	501	PF00069	0.707
MOD_GlcNHglycan	385	388	PF01048	0.558
MOD_GlcNHglycan	459	462	PF01048	0.524
MOD_GlcNHglycan	463	466	PF01048	0.477
MOD_GlcNHglycan	62	65	PF01048	0.643
MOD_GSK3_1	109	116	PF00069	0.398
MOD_GSK3_1	131	138	PF00069	0.345
MOD_GSK3_1	156	163	PF00069	0.512
MOD_GSK3_1	20	27	PF00069	0.647
MOD_GSK3_1	280	287	PF00069	0.577
MOD_GSK3_1	361	368	PF00069	0.650
MOD_GSK3_1	369	376	PF00069	0.683
MOD_GSK3_1	379	386	PF00069	0.608
MOD_GSK3_1	393	400	PF00069	0.710
MOD_GSK3_1	408	415	PF00069	0.695
MOD_GSK3_1	434	441	PF00069	0.706
MOD_GSK3_1	457	464	PF00069	0.742
MOD_GSK3_1	497	504	PF00069	0.662
MOD_GSK3_1	97	104	PF00069	0.593
MOD_NEK2_1	133	138	PF00069	0.277
MOD_NEK2_1	156	161	PF00069	0.441
MOD_NEK2_1	185	190	PF00069	0.518
MOD_NEK2_1	210	215	PF00069	0.271
MOD_NEK2_1	226	231	PF00069	0.187
MOD_NEK2_1	284	289	PF00069	0.546
MOD_NEK2_1	326	331	PF00069	0.507
MOD_NEK2_1	349	354	PF00069	0.549
MOD_NEK2_1	456	461	PF00069	0.765
MOD_NEK2_1	495	500	PF00069	0.606
MOD_NEK2_1	60	65	PF00069	0.379
MOD_NEK2_1	76	81	PF00069	0.279
MOD_NEK2_2	106	111	PF00069	0.620
MOD_NEK2_2	55	60	PF00069	0.340
MOD_PIKK_1	160	166	PF00454	0.577
MOD_PIKK_1	24	30	PF00454	0.704
MOD_PKA_2	159	165	PF00069	0.608
MOD_PKA_2	185	191	PF00069	0.545
MOD_PKA_2	246	252	PF00069	0.319
MOD_PKA_2	350	356	PF00069	0.612
MOD_PKA_2	364	370	PF00069	0.654
MOD_PKA_2	397	403	PF00069	0.749
MOD_Plk_1	134	140	PF00069	0.348
MOD_Plk_1	216	222	PF00069	0.338
MOD_Plk_1	477	483	PF00069	0.621
MOD_Plk_2-3	216	222	PF00069	0.261
MOD_Plk_4	113	119	PF00069	0.326
MOD_Plk_4	142	148	PF00069	0.322
MOD_Plk_4	162	168	PF00069	0.543
MOD_Plk_4	178	184	PF00069	0.467
MOD_Plk_4	185	191	PF00069	0.519
MOD_Plk_4	240	246	PF00069	0.289
MOD_Plk_4	263	269	PF00069	0.344
MOD_Plk_4	280	286	PF00069	0.517
MOD_Plk_4	479	485	PF00069	0.648
MOD_Plk_4	55	61	PF00069	0.271
MOD_ProDKin_1	109	115	PF00069	0.418
MOD_ProDKin_1	14	20	PF00069	0.616
MOD_ProDKin_1	272	278	PF00069	0.547
MOD_ProDKin_1	369	375	PF00069	0.689
MOD_ProDKin_1	376	382	PF00069	0.680
MOD_ProDKin_1	408	414	PF00069	0.668
MOD_SUMO_for_1	311	314	PF00179	0.529
MOD_SUMO_for_1	343	346	PF00179	0.418
MOD_SUMO_rev_2	400	409	PF00179	0.669
TRG_DiLeu_BaEn_1	446	451	PF01217	0.656
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.503
TRG_ENDOCYTIC_2	114	117	PF00928	0.361
TRG_ENDOCYTIC_2	152	155	PF00928	0.271
TRG_ENDOCYTIC_2	236	239	PF00928	0.264
TRG_ER_diArg_1	338	340	PF00400	0.492
TRG_ER_diArg_1	472	474	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W7	Leptomonas seymouri	62%	98%
A0A0S4IWT9	Bodo saltans	31%	95%
A0A0S4IZM8	Bodo saltans	35%	100%
A0A1X0NNP7	Trypanosomatidae	28%	94%
A0A1X0NP80	Trypanosomatidae	40%	100%
A0A3Q8I9U0	Leishmania donovani	90%	100%
A0A422NNJ1	Trypanosoma rangeli	41%	100%
A0A422NNK5	Trypanosoma rangeli	31%	98%
A4H7L1	Leishmania braziliensis	74%	100%
A4HVZ5	Leishmania infantum	90%	100%
Q4QFT2	Leishmania major	90%	100%