HYPK_UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APP6_LEIMU

TriTrypDb:

LmxM.14.0520

Length:

109

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP6

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	1
GO:0031647	regulation of protein stability	3	1
GO:0042981	regulation of apoptotic process	6	1
GO:0043066	negative regulation of apoptotic process	7	1
GO:0043067	regulation of programmed cell death	5	1
GO:0043069	negative regulation of programmed cell death	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050821	protein stabilization	4	1
GO:0060548	negative regulation of cell death	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.708
CLV_PCSK_SKI1_1	12	16	PF00082	0.718
CLV_PCSK_SKI1_1	84	88	PF00082	0.450
DOC_MAPK_gen_1	55	64	PF00069	0.524
DOC_USP7_UBL2_3	9	13	PF12436	0.755
DOC_WW_Pin1_4	76	81	PF00397	0.547
LIG_BIR_III_4	100	104	PF00653	0.509
LIG_FHA_1	21	27	PF00498	0.635
LIG_FHA_1	93	99	PF00498	0.522
LIG_PCNA_yPIPBox_3	84	98	PF02747	0.461
LIG_PDZ_Class_1	104	109	PF00595	0.400
LIG_SH3_3	99	105	PF00018	0.522
LIG_TRAF2_1	33	36	PF00917	0.563
MOD_GSK3_1	21	28	PF00069	0.591
MOD_PIKK_1	43	49	PF00454	0.522
MOD_PKA_1	12	18	PF00069	0.559
MOD_Plk_1	92	98	PF00069	0.528
MOD_ProDKin_1	76	82	PF00069	0.548
MOD_SUMO_rev_2	6	11	PF00179	0.696
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I281	Leptomonas seymouri	60%	100%
A0A0S4KIP0	Bodo saltans	39%	95%
A0A1X0NQ53	Trypanosomatidae	38%	96%
A0A3R7M108	Trypanosoma rangeli	39%	97%
A0A3S7WSY1	Leishmania donovani	97%	100%
A4H7L0	Leishmania braziliensis	90%	100%
A4HVZ4	Leishmania infantum	97%	100%
C9ZT24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
Q4QFT3	Leishmania major	95%	100%