Putative stearic acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stearic acid desaturase, putative

Species:

Leishmania mexicana

UniProt:

E9APP5_LEIMU

TriTrypDb:

LmxM.14.0510

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

E9APP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	16
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	16
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0005488	binding	1	7
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	16
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	16
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005506	iron ion binding	6	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.461
CLV_NRD_NRD_1	141	143	PF00675	0.233
CLV_NRD_NRD_1	178	180	PF00675	0.261
CLV_NRD_NRD_1	323	325	PF00675	0.469
CLV_NRD_NRD_1	356	358	PF00675	0.347
CLV_PCSK_KEX2_1	141	143	PF00082	0.314
CLV_PCSK_KEX2_1	323	325	PF00082	0.281
CLV_PCSK_SKI1_1	216	220	PF00082	0.348
CLV_PCSK_SKI1_1	357	361	PF00082	0.419
CLV_PCSK_SKI1_1	395	399	PF00082	0.247
CLV_PCSK_SKI1_1	404	408	PF00082	0.288
CLV_PCSK_SKI1_1	6	10	PF00082	0.300
DEG_MDM2_SWIB_1	210	217	PF02201	0.308
DEG_MDM2_SWIB_1	35	42	PF02201	0.511
DEG_Nend_Nbox_1	1	3	PF02207	0.701
DOC_CDC14_PxL_1	44	52	PF14671	0.423
DOC_CYCLIN_RxL_1	3	12	PF00134	0.476
DOC_CYCLIN_RxL_1	354	363	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.517
DOC_MAPK_MEF2A_6	170	177	PF00069	0.461
DOC_PP1_RVXF_1	382	388	PF00149	0.613
DOC_PP2B_LxvP_1	336	339	PF13499	0.600
DOC_PP2B_LxvP_1	58	61	PF13499	0.471
DOC_USP7_MATH_1	164	168	PF00917	0.461
DOC_USP7_MATH_1	248	252	PF00917	0.518
DOC_USP7_MATH_1	437	441	PF00917	0.722
DOC_USP7_UBL2_3	354	358	PF12436	0.427
DOC_WW_Pin1_4	17	22	PF00397	0.533
DOC_WW_Pin1_4	244	249	PF00397	0.518
LIG_14-3-3_CanoR_1	59	65	PF00244	0.280
LIG_14-3-3_CanoR_1	6	14	PF00244	0.481
LIG_14-3-3_CanoR_1	88	95	PF00244	0.493
LIG_BRCT_BRCA1_1	250	254	PF00533	0.433
LIG_Clathr_ClatBox_1	359	363	PF01394	0.492
LIG_deltaCOP1_diTrp_1	204	211	PF00928	0.289
LIG_FHA_1	187	193	PF00498	0.308
LIG_FHA_1	75	81	PF00498	0.380
LIG_FHA_1	8	14	PF00498	0.692
LIG_FHA_2	131	137	PF00498	0.475
LIG_FHA_2	199	205	PF00498	0.308
LIG_FHA_2	245	251	PF00498	0.474
LIG_FHA_2	343	349	PF00498	0.491
LIG_LIR_Gen_1	157	166	PF02991	0.491
LIG_LIR_Gen_1	251	259	PF02991	0.471
LIG_LIR_Gen_1	286	296	PF02991	0.582
LIG_LIR_Gen_1	343	353	PF02991	0.558
LIG_LIR_Gen_1	63	72	PF02991	0.241
LIG_LIR_Gen_1	83	94	PF02991	0.286
LIG_LIR_LC3C_4	171	175	PF02991	0.461
LIG_LIR_Nem_3	147	152	PF02991	0.529
LIG_LIR_Nem_3	157	161	PF02991	0.473
LIG_LIR_Nem_3	251	257	PF02991	0.494
LIG_LIR_Nem_3	261	266	PF02991	0.468
LIG_LIR_Nem_3	286	292	PF02991	0.520
LIG_LIR_Nem_3	294	298	PF02991	0.489
LIG_LIR_Nem_3	343	349	PF02991	0.547
LIG_LIR_Nem_3	63	67	PF02991	0.241
LIG_LIR_Nem_3	83	89	PF02991	0.306
LIG_NRBOX	49	55	PF00104	0.308
LIG_Pex14_1	103	107	PF04695	0.489
LIG_Pex14_1	205	209	PF04695	0.275
LIG_Pex14_1	214	218	PF04695	0.328
LIG_Pex14_1	39	43	PF04695	0.308
LIG_Pex14_1	69	73	PF04695	0.308
LIG_Pex14_2	210	214	PF04695	0.436
LIG_Pex14_2	291	295	PF04695	0.502
LIG_Pex14_2	35	39	PF04695	0.520
LIG_SH2_CRK	158	162	PF00017	0.499
LIG_SH2_CRK	86	90	PF00017	0.489
LIG_SH2_GRB2like	263	266	PF00017	0.475
LIG_SH2_PTP2	289	292	PF00017	0.418
LIG_SH2_SRC	43	46	PF00017	0.483
LIG_SH2_STAT3	266	269	PF00017	0.433
LIG_SH2_STAT5	130	133	PF00017	0.475
LIG_SH2_STAT5	181	184	PF00017	0.549
LIG_SH2_STAT5	289	292	PF00017	0.494
LIG_SH2_STAT5	344	347	PF00017	0.473
LIG_SH2_STAT5	365	368	PF00017	0.493
LIG_SH2_STAT5	401	404	PF00017	0.464
LIG_SH2_STAT5	424	427	PF00017	0.537
LIG_SH2_STAT5	43	46	PF00017	0.417
LIG_SH3_1	371	377	PF00018	0.536
LIG_SH3_3	371	377	PF00018	0.552
LIG_SUMO_SIM_par_1	365	370	PF11976	0.553
LIG_TRAF2_1	21	24	PF00917	0.657
LIG_TRAF2_1	442	445	PF00917	0.598
LIG_WRC_WIRS_1	292	297	PF05994	0.508
MOD_CDK_SPK_2	17	22	PF00069	0.533
MOD_CK1_1	439	445	PF00069	0.654
MOD_CK2_1	17	23	PF00069	0.690
MOD_CK2_1	198	204	PF00069	0.308
MOD_CK2_1	439	445	PF00069	0.712
MOD_CMANNOS	211	214	PF00535	0.357
MOD_Cter_Amidation	355	358	PF01082	0.370
MOD_GlcNHglycan	439	442	PF01048	0.568
MOD_GlcNHglycan	444	449	PF01048	0.542
MOD_GSK3_1	226	233	PF00069	0.328
MOD_GSK3_1	244	251	PF00069	0.479
MOD_GSK3_1	379	386	PF00069	0.473
MOD_GSK3_1	9	16	PF00069	0.688
MOD_N-GLC_1	310	315	PF02516	0.223
MOD_NEK2_1	113	118	PF00069	0.477
MOD_NEK2_1	144	149	PF00069	0.475
MOD_NEK2_1	169	174	PF00069	0.433
MOD_NEK2_1	226	231	PF00069	0.332
MOD_NEK2_1	236	241	PF00069	0.451
MOD_NEK2_1	291	296	PF00069	0.505
MOD_NEK2_1	62	67	PF00069	0.293
MOD_NEK2_1	9	14	PF00069	0.684
MOD_PIKK_1	318	324	PF00454	0.431
MOD_Plk_1	342	348	PF00069	0.556
MOD_Plk_4	169	175	PF00069	0.568
MOD_Plk_4	248	254	PF00069	0.480
MOD_Plk_4	291	297	PF00069	0.619
MOD_Plk_4	9	15	PF00069	0.673
MOD_ProDKin_1	17	23	PF00069	0.533
MOD_ProDKin_1	244	250	PF00069	0.518
MOD_SUMO_for_1	21	24	PF00179	0.638
MOD_SUMO_rev_2	163	172	PF00179	0.433
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.378
TRG_ENDOCYTIC_2	158	161	PF00928	0.511
TRG_ENDOCYTIC_2	181	184	PF00928	0.455
TRG_ENDOCYTIC_2	289	292	PF00928	0.494
TRG_ENDOCYTIC_2	37	40	PF00928	0.615
TRG_ENDOCYTIC_2	86	89	PF00928	0.475
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5Q309	Tachysurus fulvidraco	32%	100%
A0A0N1PCI5	Leptomonas seymouri	46%	100%
A0A0S4KNP4	Bodo saltans	42%	100%
A0A1X0NW01	Trypanosomatidae	47%	100%
A0A3Q8I9W7	Leishmania donovani	92%	97%
A0A3Q8IBJ0	Leishmania donovani	47%	100%
A0A3R7MEL0	Trypanosoma rangeli	48%	100%
A4H6I1	Leishmania braziliensis	82%	100%
A4HDT6	Leishmania braziliensis	47%	100%
A4HVZ3	Leishmania infantum	92%	97%
A4I134	Leishmania infantum	47%	100%
B7SB92	Tribolium castaneum	29%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
G5ED44	Caenorhabditis elegans	29%	100%
O44390	Trichoplusia ni	31%	100%
O65797	Arabidopsis thaliana	24%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	95%
P0DOW2	Anemone leveillei	27%	100%
P0DOW3	Anemone leveillei	28%	100%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	89%
Q12618	Ajellomyces capsulatus	38%	95%
Q4QAA5	Leishmania major	46%	100%
Q4QFT4	Leishmania major	92%	100%
Q6US81	Spodoptera littoralis	31%	100%
Q9FV68	Limnanthes douglasii	28%	100%