ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APP4_LEIMU

TriTrypDb:

LmxM.14.0500

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.493
CLV_C14_Caspase3-7	250	254	PF00656	0.658
CLV_C14_Caspase3-7	377	381	PF00656	0.545
CLV_C14_Caspase3-7	422	426	PF00656	0.437
CLV_C14_Caspase3-7	464	468	PF00656	0.524
CLV_NRD_NRD_1	116	118	PF00675	0.411
CLV_NRD_NRD_1	152	154	PF00675	0.682
CLV_NRD_NRD_1	206	208	PF00675	0.535
CLV_NRD_NRD_1	263	265	PF00675	0.614
CLV_NRD_NRD_1	306	308	PF00675	0.450
CLV_NRD_NRD_1	455	457	PF00675	0.375
CLV_NRD_NRD_1	505	507	PF00675	0.451
CLV_NRD_NRD_1	641	643	PF00675	0.423
CLV_NRD_NRD_1	66	68	PF00675	0.528
CLV_PCSK_KEX2_1	116	118	PF00082	0.411
CLV_PCSK_KEX2_1	152	154	PF00082	0.682
CLV_PCSK_KEX2_1	206	208	PF00082	0.538
CLV_PCSK_KEX2_1	262	264	PF00082	0.648
CLV_PCSK_KEX2_1	306	308	PF00082	0.450
CLV_PCSK_KEX2_1	505	507	PF00082	0.422
CLV_PCSK_KEX2_1	66	68	PF00082	0.469
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.422
CLV_PCSK_SKI1_1	264	268	PF00082	0.479
CLV_PCSK_SKI1_1	431	435	PF00082	0.480
CLV_PCSK_SKI1_1	594	598	PF00082	0.440
DEG_APCC_DBOX_1	272	280	PF00400	0.501
DEG_APCC_DBOX_1	7	15	PF00400	0.489
DEG_SCF_FBW7_1	582	588	PF00400	0.528
DEG_SPOP_SBC_1	523	527	PF00917	0.550
DEG_SPOP_SBC_1	534	538	PF00917	0.501
DOC_CKS1_1	397	402	PF01111	0.495
DOC_CKS1_1	582	587	PF01111	0.535
DOC_MAPK_gen_1	503	510	PF00069	0.430
DOC_MAPK_MEF2A_6	469	477	PF00069	0.555
DOC_PP2B_LxvP_1	145	148	PF13499	0.533
DOC_PP4_FxxP_1	477	480	PF00568	0.553
DOC_USP7_MATH_1	224	228	PF00917	0.538
DOC_USP7_MATH_1	251	255	PF00917	0.739
DOC_USP7_MATH_1	310	314	PF00917	0.587
DOC_USP7_MATH_1	363	367	PF00917	0.651
DOC_USP7_MATH_1	374	378	PF00917	0.747
DOC_USP7_MATH_1	389	393	PF00917	0.733
DOC_USP7_MATH_1	524	528	PF00917	0.625
DOC_USP7_MATH_1	534	538	PF00917	0.564
DOC_USP7_MATH_1	585	589	PF00917	0.510
DOC_USP7_MATH_1	657	661	PF00917	0.533
DOC_USP7_UBL2_3	255	259	PF12436	0.439
DOC_USP7_UBL2_3	503	507	PF12436	0.445
DOC_WW_Pin1_4	175	180	PF00397	0.692
DOC_WW_Pin1_4	24	29	PF00397	0.666
DOC_WW_Pin1_4	320	325	PF00397	0.685
DOC_WW_Pin1_4	396	401	PF00397	0.530
DOC_WW_Pin1_4	559	564	PF00397	0.606
DOC_WW_Pin1_4	581	586	PF00397	0.536
LIG_14-3-3_CanoR_1	206	212	PF00244	0.563
LIG_14-3-3_CanoR_1	33	41	PF00244	0.536
LIG_14-3-3_CanoR_1	456	462	PF00244	0.627
LIG_14-3-3_CanoR_1	469	473	PF00244	0.541
LIG_14-3-3_CanoR_1	572	576	PF00244	0.560
LIG_Actin_WH2_2	441	458	PF00022	0.492
LIG_APCC_ABBA_1	132	137	PF00400	0.517
LIG_BIR_III_2	380	384	PF00653	0.654
LIG_BIR_III_4	358	362	PF00653	0.599
LIG_CaM_IQ_9	198	214	PF13499	0.444
LIG_Dynein_DLC8_1	172	178	PF01221	0.680
LIG_FHA_1	278	284	PF00498	0.458
LIG_FHA_1	306	312	PF00498	0.468
LIG_FHA_1	397	403	PF00498	0.590
LIG_FHA_1	410	416	PF00498	0.367
LIG_FHA_2	226	232	PF00498	0.639
LIG_FHA_2	248	254	PF00498	0.634
LIG_FHA_2	347	353	PF00498	0.466
LIG_FHA_2	396	402	PF00498	0.518
LIG_FHA_2	485	491	PF00498	0.470
LIG_GBD_Chelix_1	624	632	PF00786	0.501
LIG_Integrin_isoDGR_2	570	572	PF01839	0.520
LIG_LIR_Apic_2	476	480	PF02991	0.563
LIG_LIR_Gen_1	185	191	PF02991	0.511
LIG_LIR_Nem_3	50	56	PF02991	0.458
LIG_LIR_Nem_3	619	624	PF02991	0.637
LIG_NRBOX	461	467	PF00104	0.548
LIG_PDZ_Class_1	657	662	PF00595	0.543
LIG_SH2_CRK	621	625	PF00017	0.486
LIG_SH2_STAT3	427	430	PF00017	0.445
LIG_SH2_STAT5	53	56	PF00017	0.419
LIG_SH2_STAT5	617	620	PF00017	0.573
LIG_SH2_STAT5	645	648	PF00017	0.475
LIG_SH3_3	357	363	PF00018	0.639
LIG_SH3_3	380	386	PF00018	0.653
LIG_SH3_3	394	400	PF00018	0.536
LIG_SH3_3	579	585	PF00018	0.561
LIG_SUMO_SIM_anti_2	529	534	PF11976	0.504
LIG_TRAF2_1	210	213	PF00917	0.712
LIG_TRAF2_1	449	452	PF00917	0.445
LIG_TRAF2_1	487	490	PF00917	0.474
LIG_TRAF2_1	613	616	PF00917	0.411
MOD_CDK_SPK_2	177	182	PF00069	0.544
MOD_CDK_SPxK_1	559	565	PF00069	0.607
MOD_CDK_SPxxK_3	175	182	PF00069	0.566
MOD_CDK_SPxxK_3	396	403	PF00069	0.493
MOD_CK1_1	180	186	PF00069	0.666
MOD_CK1_1	254	260	PF00069	0.476
MOD_CK1_1	26	32	PF00069	0.510
MOD_CK1_1	313	319	PF00069	0.603
MOD_CK1_1	320	326	PF00069	0.593
MOD_CK1_1	366	372	PF00069	0.633
MOD_CK1_1	426	432	PF00069	0.647
MOD_CK1_1	515	521	PF00069	0.616
MOD_CK1_1	537	543	PF00069	0.799
MOD_CK1_1	552	558	PF00069	0.563
MOD_CK1_1	580	586	PF00069	0.538
MOD_CK2_1	154	160	PF00069	0.534
MOD_CK2_1	207	213	PF00069	0.535
MOD_CK2_1	225	231	PF00069	0.529
MOD_CK2_1	32	38	PF00069	0.656
MOD_CK2_1	484	490	PF00069	0.480
MOD_CK2_1	585	591	PF00069	0.514
MOD_Cter_Amidation	204	207	PF01082	0.550
MOD_Cter_Amidation	304	307	PF01082	0.425
MOD_GlcNHglycan	123	126	PF01048	0.485
MOD_GlcNHglycan	182	185	PF01048	0.649
MOD_GlcNHglycan	222	225	PF01048	0.605
MOD_GlcNHglycan	313	316	PF01048	0.538
MOD_GlcNHglycan	318	322	PF01048	0.535
MOD_GlcNHglycan	34	37	PF01048	0.729
MOD_GlcNHglycan	354	358	PF01048	0.602
MOD_GlcNHglycan	494	497	PF01048	0.404
MOD_GlcNHglycan	526	529	PF01048	0.641
MOD_GlcNHglycan	540	543	PF01048	0.515
MOD_GlcNHglycan	550	554	PF01048	0.521
MOD_GlcNHglycan	579	582	PF01048	0.567
MOD_GSK3_1	173	180	PF00069	0.662
MOD_GSK3_1	19	26	PF00069	0.434
MOD_GSK3_1	220	227	PF00069	0.596
MOD_GSK3_1	245	252	PF00069	0.636
MOD_GSK3_1	27	34	PF00069	0.539
MOD_GSK3_1	310	317	PF00069	0.614
MOD_GSK3_1	451	458	PF00069	0.501
MOD_GSK3_1	512	519	PF00069	0.630
MOD_GSK3_1	524	531	PF00069	0.682
MOD_GSK3_1	533	540	PF00069	0.564
MOD_GSK3_1	555	562	PF00069	0.635
MOD_GSK3_1	577	584	PF00069	0.629
MOD_N-GLC_1	534	539	PF02516	0.596
MOD_NEK2_1	409	414	PF00069	0.348
MOD_NEK2_1	494	499	PF00069	0.430
MOD_NEK2_1	52	57	PF00069	0.473
MOD_NEK2_1	533	538	PF00069	0.787
MOD_NEK2_1	554	559	PF00069	0.584
MOD_PIKK_1	173	179	PF00454	0.675
MOD_PIKK_1	426	432	PF00454	0.492
MOD_PIKK_1	512	518	PF00454	0.473
MOD_PIKK_1	90	96	PF00454	0.515
MOD_PKA_1	206	212	PF00069	0.572
MOD_PKA_2	173	179	PF00069	0.675
MOD_PKA_2	206	212	PF00069	0.572
MOD_PKA_2	305	311	PF00069	0.639
MOD_PKA_2	32	38	PF00069	0.539
MOD_PKA_2	389	395	PF00069	0.591
MOD_PKA_2	436	442	PF00069	0.424
MOD_PKA_2	455	461	PF00069	0.467
MOD_PKA_2	468	474	PF00069	0.541
MOD_PKA_2	564	570	PF00069	0.653
MOD_PKA_2	571	577	PF00069	0.599
MOD_Plk_1	451	457	PF00069	0.506
MOD_Plk_1	489	495	PF00069	0.367
MOD_Plk_1	528	534	PF00069	0.625
MOD_Plk_2-3	420	426	PF00069	0.439
MOD_Plk_4	110	116	PF00069	0.410
MOD_Plk_4	528	534	PF00069	0.759
MOD_ProDKin_1	175	181	PF00069	0.691
MOD_ProDKin_1	24	30	PF00069	0.669
MOD_ProDKin_1	320	326	PF00069	0.681
MOD_ProDKin_1	396	402	PF00069	0.527
MOD_ProDKin_1	559	565	PF00069	0.607
MOD_ProDKin_1	581	587	PF00069	0.527
MOD_SUMO_for_1	266	269	PF00179	0.508
MOD_SUMO_rev_2	249	257	PF00179	0.478
MOD_SUMO_rev_2	395	405	PF00179	0.485
TRG_DiLeu_BaEn_1	261	266	PF01217	0.479
TRG_DiLeu_BaEn_1	411	416	PF01217	0.487
TRG_DiLeu_BaEn_4	489	495	PF01217	0.457
TRG_DiLeu_LyEn_5	411	416	PF01217	0.487
TRG_ENDOCYTIC_2	53	56	PF00928	0.419
TRG_ENDOCYTIC_2	621	624	PF00928	0.618
TRG_ER_diArg_1	115	117	PF00400	0.394
TRG_ER_diArg_1	262	264	PF00400	0.618
TRG_ER_diArg_1	61	64	PF00400	0.382
TRG_ER_diArg_1	65	67	PF00400	0.442
TRG_NLS_MonoExtN_4	503	509	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9D0	Leptomonas seymouri	35%	98%
A0A3S7WSW7	Leishmania donovani	80%	100%
A4H6I2	Leishmania braziliensis	62%	98%
A4HVZ2	Leishmania infantum	80%	100%
Q4QFT5	Leishmania major	78%	100%