LeishMANIAdb
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Cystathionine beta-lyase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cystathionine beta-lyase-like protein
Gene product:
cystathionine beta-lyase-like protein
Species:
Leishmania mexicana
UniProt:
E9APP1_LEIMU
TriTrypDb:
LmxM.14.0460
Length:
459

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9APP1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP1

Function

Biological processes
Term Name Level Count
GO:0000096 sulfur amino acid metabolic process 4 8
GO:0000097 sulfur amino acid biosynthetic process 5 8
GO:0006082 organic acid metabolic process 3 8
GO:0006520 amino acid metabolic process 3 8
GO:0006534 cysteine metabolic process 5 8
GO:0006555 methionine metabolic process 5 8
GO:0006790 sulfur compound metabolic process 3 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0008652 amino acid biosynthetic process 4 8
GO:0009058 biosynthetic process 2 8
GO:0009066 aspartate family amino acid metabolic process 5 8
GO:0009067 aspartate family amino acid biosynthetic process 6 8
GO:0009069 serine family amino acid metabolic process 5 8
GO:0009086 methionine biosynthetic process 6 8
GO:0009092 homoserine metabolic process 6 8
GO:0009987 cellular process 1 8
GO:0016053 organic acid biosynthetic process 4 8
GO:0019346 transsulfuration 6 8
GO:0019752 carboxylic acid metabolic process 5 8
GO:0043436 oxoacid metabolic process 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044272 sulfur compound biosynthetic process 4 8
GO:0044281 small molecule metabolic process 2 8
GO:0044283 small molecule biosynthetic process 3 8
GO:0046394 carboxylic acid biosynthetic process 5 8
GO:0050667 homocysteine metabolic process 5 8
GO:0071265 L-methionine biosynthetic process 7 8
GO:0071266 'de novo' L-methionine biosynthetic process 8 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
GO:1901605 alpha-amino acid metabolic process 4 8
GO:1901607 alpha-amino acid biosynthetic process 5 8
GO:0009070 serine family amino acid biosynthetic process 6 1
GO:0019343 cysteine biosynthetic process via cystathionine 7 1
GO:0019344 cysteine biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004121 cystathionine beta-lyase activity 4 8
GO:0005488 binding 1 8
GO:0016829 lyase activity 2 8
GO:0016846 carbon-sulfur lyase activity 3 8
GO:0019842 vitamin binding 3 8
GO:0030170 pyridoxal phosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0070279 vitamin B6 binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8
GO:0004123 cystathionine gamma-lyase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 187 189 PF00675 0.321
CLV_PCSK_KEX2_1 279 281 PF00082 0.328
CLV_PCSK_KEX2_1 378 380 PF00082 0.351
CLV_PCSK_KEX2_1 52 54 PF00082 0.629
CLV_PCSK_PC1ET2_1 279 281 PF00082 0.328
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.351
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.629
CLV_PCSK_SKI1_1 14 18 PF00082 0.600
CLV_PCSK_SKI1_1 163 167 PF00082 0.351
CLV_PCSK_SKI1_1 188 192 PF00082 0.399
CLV_PCSK_SKI1_1 280 284 PF00082 0.328
CLV_PCSK_SKI1_1 388 392 PF00082 0.357
DEG_APCC_DBOX_1 13 21 PF00400 0.599
DOC_AGCK_PIF_2 99 104 PF00069 0.351
DOC_MAPK_gen_1 302 311 PF00069 0.351
DOC_MAPK_gen_1 385 394 PF00069 0.367
DOC_MAPK_HePTP_8 299 311 PF00069 0.351
DOC_MAPK_MEF2A_6 302 311 PF00069 0.351
DOC_MAPK_MEF2A_6 388 396 PF00069 0.351
DOC_PP1_RVXF_1 277 284 PF00149 0.351
DOC_PP4_FxxP_1 91 94 PF00568 0.351
DOC_USP7_MATH_1 130 134 PF00917 0.351
DOC_USP7_MATH_1 8 12 PF00917 0.473
DOC_WW_Pin1_4 201 206 PF00397 0.351
DOC_WW_Pin1_4 234 239 PF00397 0.351
DOC_WW_Pin1_4 342 347 PF00397 0.399
LIG_14-3-3_CanoR_1 163 172 PF00244 0.351
LIG_14-3-3_CanoR_1 302 308 PF00244 0.351
LIG_14-3-3_CanoR_1 327 335 PF00244 0.385
LIG_14-3-3_CanoR_1 360 369 PF00244 0.405
LIG_14-3-3_CanoR_1 427 431 PF00244 0.405
LIG_Actin_WH2_2 224 242 PF00022 0.476
LIG_BRCT_BRCA1_1 379 383 PF00533 0.351
LIG_Clathr_ClatBox_1 199 203 PF01394 0.351
LIG_FHA_1 167 173 PF00498 0.362
LIG_FHA_1 182 188 PF00498 0.355
LIG_FHA_1 204 210 PF00498 0.351
LIG_FHA_1 254 260 PF00498 0.351
LIG_FHA_1 304 310 PF00498 0.351
LIG_FHA_1 327 333 PF00498 0.196
LIG_FHA_1 372 378 PF00498 0.405
LIG_FHA_1 441 447 PF00498 0.405
LIG_FHA_1 63 69 PF00498 0.459
LIG_FHA_2 111 117 PF00498 0.325
LIG_FHA_2 16 22 PF00498 0.594
LIG_LIR_Apic_2 35 39 PF02991 0.724
LIG_LIR_Apic_2 88 94 PF02991 0.351
LIG_LIR_Gen_1 296 304 PF02991 0.351
LIG_LIR_Gen_1 43 51 PF02991 0.603
LIG_LIR_Nem_3 296 301 PF02991 0.351
LIG_LIR_Nem_3 43 47 PF02991 0.608
LIG_LIR_Nem_3 97 102 PF02991 0.317
LIG_Pex14_2 178 182 PF04695 0.351
LIG_SH2_CRK 337 341 PF00017 0.405
LIG_SH2_CRK 36 40 PF00017 0.656
LIG_SH2_SRC 102 105 PF00017 0.405
LIG_SH2_STAT3 26 29 PF00017 0.614
LIG_SH2_STAT5 26 29 PF00017 0.607
LIG_SH2_STAT5 357 360 PF00017 0.399
LIG_SH3_2 48 53 PF14604 0.626
LIG_SH3_3 174 180 PF00018 0.385
LIG_SH3_3 189 195 PF00018 0.463
LIG_SH3_3 202 208 PF00018 0.276
LIG_SH3_3 340 346 PF00018 0.185
LIG_SH3_3 400 406 PF00018 0.328
LIG_SH3_3 45 51 PF00018 0.611
LIG_SH3_3 71 77 PF00018 0.467
LIG_SUMO_SIM_par_1 368 374 PF11976 0.385
LIG_TRAF2_1 19 22 PF00917 0.583
LIG_TYR_ITIM 335 340 PF00017 0.351
MOD_CDC14_SPxK_1 237 240 PF00782 0.351
MOD_CDK_SPxK_1 234 240 PF00069 0.351
MOD_CK1_1 251 257 PF00069 0.405
MOD_CK1_1 326 332 PF00069 0.385
MOD_CK1_1 349 355 PF00069 0.351
MOD_CK1_1 361 367 PF00069 0.351
MOD_CK1_1 368 374 PF00069 0.351
MOD_CK1_1 395 401 PF00069 0.389
MOD_CK1_1 410 416 PF00069 0.272
MOD_CK2_1 110 116 PF00069 0.325
MOD_CK2_1 15 21 PF00069 0.511
MOD_CK2_1 347 353 PF00069 0.365
MOD_CK2_1 398 404 PF00069 0.351
MOD_GlcNHglycan 106 109 PF01048 0.351
MOD_GlcNHglycan 132 135 PF01048 0.365
MOD_GlcNHglycan 253 256 PF01048 0.351
MOD_GlcNHglycan 363 366 PF01048 0.351
MOD_GlcNHglycan 5 8 PF01048 0.562
MOD_GSK3_1 104 111 PF00069 0.351
MOD_GSK3_1 137 144 PF00069 0.351
MOD_GSK3_1 147 154 PF00069 0.351
MOD_GSK3_1 163 170 PF00069 0.291
MOD_GSK3_1 227 234 PF00069 0.351
MOD_GSK3_1 3 10 PF00069 0.635
MOD_GSK3_1 326 333 PF00069 0.385
MOD_GSK3_1 342 349 PF00069 0.374
MOD_GSK3_1 361 368 PF00069 0.244
MOD_GSK3_1 373 380 PF00069 0.351
MOD_GSK3_1 42 49 PF00069 0.643
MOD_N-GLC_1 12 17 PF02516 0.632
MOD_NEK2_1 129 134 PF00069 0.351
MOD_NEK2_1 141 146 PF00069 0.351
MOD_NEK2_1 323 328 PF00069 0.405
MOD_NEK2_1 358 363 PF00069 0.405
MOD_NEK2_1 390 395 PF00069 0.351
MOD_NEK2_2 248 253 PF00069 0.405
MOD_PIKK_1 163 169 PF00454 0.351
MOD_PIKK_1 358 364 PF00454 0.372
MOD_PIKK_1 440 446 PF00454 0.405
MOD_PIKK_1 62 68 PF00454 0.462
MOD_PK_1 305 311 PF00069 0.351
MOD_PKA_2 326 332 PF00069 0.385
MOD_PKA_2 426 432 PF00069 0.351
MOD_Plk_1 12 18 PF00069 0.685
MOD_Plk_1 231 237 PF00069 0.351
MOD_Plk_1 248 254 PF00069 0.351
MOD_Plk_4 114 120 PF00069 0.405
MOD_Plk_4 137 143 PF00069 0.351
MOD_Plk_4 147 153 PF00069 0.335
MOD_Plk_4 231 237 PF00069 0.351
MOD_Plk_4 365 371 PF00069 0.351
MOD_Plk_4 398 404 PF00069 0.351
MOD_Plk_4 87 93 PF00069 0.351
MOD_ProDKin_1 201 207 PF00069 0.351
MOD_ProDKin_1 234 240 PF00069 0.351
MOD_ProDKin_1 342 348 PF00069 0.399
MOD_SUMO_for_1 272 275 PF00179 0.351
MOD_SUMO_rev_2 274 281 PF00179 0.405
TRG_DiLeu_BaEn_1 404 409 PF01217 0.351
TRG_DiLeu_BaEn_4 22 28 PF01217 0.597
TRG_DiLeu_BaEn_4 353 359 PF01217 0.476
TRG_DiLeu_BaLyEn_6 160 165 PF01217 0.351
TRG_ENDOCYTIC_2 158 161 PF00928 0.316
TRG_ENDOCYTIC_2 337 340 PF00928 0.351
TRG_ENDOCYTIC_2 44 47 PF00928 0.608
TRG_NES_CRM1_1 315 328 PF08389 0.351
TRG_NES_CRM1_1 441 456 PF08389 0.483
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.321
TRG_Pf-PMV_PEXEL_1 419 424 PF00026 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0D2YG02 Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) 29% 100%
A0A0J6G7P5 Pseudomonas deceptionensis 36% 100%
A0A0N0P3U0 Leptomonas seymouri 90% 90%
A0A0N0P8H0 Leptomonas seymouri 27% 100%
A0A0N1HW05 Leptomonas seymouri 33% 100%
A0A0N1PG90 Leptomonas seymouri 29% 100%
A0A0S4IZX4 Bodo saltans 31% 100%
A0A1X0NP01 Trypanosomatidae 72% 94%
A0A1X0P5N4 Trypanosomatidae 32% 100%
A0A3Q8ILD8 Leishmania donovani 28% 100%
A0A3R7R3B5 Trypanosoma rangeli 31% 100%
A0A3S7WSY5 Leishmania donovani 98% 100%
A0A3S7X9N0 Leishmania donovani 31% 100%
A2RM21 Lactococcus lactis subsp. cremoris (strain MG1363) 39% 100%
A4H7K6 Leishmania braziliensis 92% 100%
A4HKQ5 Leishmania braziliensis 28% 100%
A4HMZ0 Leishmania braziliensis 32% 100%
A4HVY9 Leishmania infantum 98% 88%
A4I885 Leishmania infantum 28% 100%
A4IBL4 Leishmania infantum 31% 100%
C9ZZ26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AFE7 Leishmania major 32% 100%
E9B343 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6K2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O05394 Bacillus subtilis (strain 168) 40% 100%
O13326 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
O31631 Bacillus subtilis (strain 168) 34% 100%
O31632 Bacillus subtilis (strain 168) 42% 100%
O42851 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
O94350 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 100%
P00935 Escherichia coli (strain K12) 37% 100%
P06106 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P06721 Escherichia coli (strain K12) 26% 100%
P0A4K2 Lactococcus lactis subsp. lactis (strain IL1403) 39% 100%
P0C2T9 Lactococcus lactis subsp. cremoris 39% 100%
P13254 Pseudomonas putida 38% 100%
P18757 Rattus norvegicus 39% 100%
P18949 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 25% 100%
P24601 Herpetosiphon aurantiacus 40% 100%
P31373 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P32929 Homo sapiens 39% 100%
P38716 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P44502 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 37% 100%
P44527 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 26% 100%
P46807 Mycobacterium leprae (strain TN) 37% 100%
P50125 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 30% 100%
P53101 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 99%
P53780 Arabidopsis thaliana 48% 99%
P55216 Caenorhabditis elegans 37% 100%
P55217 Arabidopsis thaliana 33% 82%
P55218 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 36% 100%
P56069 Helicobacter pylori (strain ATCC 700392 / 26695) 41% 100%
P66876 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 36% 100%
P94890 Leptospira meyeri 32% 100%
P9WGB4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 32% 100%
P9WGB5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 32% 100%
P9WGB6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 36% 100%
P9WGB7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 36% 100%
Q07703 Bordetella avium 32% 100%
Q19QT7 Sus scrofa 38% 100%
Q1K8G0 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 42% 100%
Q1M0P5 Helicobacter pylori 40% 100%
Q4L332 Staphylococcus haemolyticus (strain JCSC1435) 35% 100%
Q4Q511 Leishmania major 28% 100%
Q4QFT8 Leishmania major 98% 100%
Q52811 Rhizobium leguminosarum bv. viciae (strain 3841) 28% 100%
Q55DV9 Dictyostelium discoideum 38% 100%
Q58DW2 Bos taurus 39% 100%
Q59829 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 32% 100%
Q5MNH8 Epichloe uncinata 28% 97%
Q5SJ58 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 29% 100%
Q5SK88 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 30% 100%
Q60HG7 Macaca fascicularis 38% 100%
Q73GL9 Wolbachia pipientis wMel 26% 100%
Q73KL7 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 37% 100%
Q79VI4 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 33% 100%
Q7MX71 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 36% 100%
Q826W3 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 34% 100%
Q83A83 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 38% 100%
Q8J0B2 Epichloe uncinata 29% 97%
Q8L0X4 Fusobacterium nucleatum subsp. polymorphum 34% 100%
Q8RDT4 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 35% 100%
Q8VCN5 Mus musculus 39% 100%
Q92441 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 31% 100%
Q9C876 Arabidopsis thaliana 35% 100%
Q9SGU9 Arabidopsis thaliana 30% 100%
Q9WZY4 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 30% 100%
Q9X0Z7 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 33% 100%
Q9ZMW7 Helicobacter pylori (strain J99 / ATCC 700824) 40% 100%
S0DUX5 Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) 29% 100%
V5DUQ5 Trypanosoma cruzi 31% 100%
W7MS09 Gibberella moniliformis (strain M3125 / FGSC 7600) 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS