CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-terminal conserved domain of Nudc./CS domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APP0_LEIMU

TriTrypDb:

LmxM.14.0450

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9APP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APP0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.456
CLV_NRD_NRD_1	107	109	PF00675	0.389
CLV_NRD_NRD_1	304	306	PF00675	0.581
CLV_NRD_NRD_1	32	34	PF00675	0.204
CLV_NRD_NRD_1	45	47	PF00675	0.510
CLV_NRD_NRD_1	63	65	PF00675	0.515
CLV_PCSK_KEX2_1	45	47	PF00082	0.566
CLV_PCSK_SKI1_1	163	167	PF00082	0.307
CLV_PCSK_SKI1_1	246	250	PF00082	0.478
CLV_PCSK_SKI1_1	64	68	PF00082	0.555
CLV_Separin_Metazoa	302	306	PF03568	0.383
DEG_APCC_DBOX_1	175	183	PF00400	0.495
DOC_MAPK_DCC_7	176	184	PF00069	0.421
DOC_MAPK_gen_1	185	193	PF00069	0.405
DOC_MAPK_MEF2A_6	176	184	PF00069	0.435
DOC_MAPK_MEF2A_6	185	193	PF00069	0.415
DOC_MAPK_MEF2A_6	5	13	PF00069	0.404
DOC_PIKK_1	263	270	PF02985	0.467
DOC_PP4_FxxP_1	38	41	PF00568	0.404
DOC_USP7_MATH_1	262	266	PF00917	0.467
DOC_USP7_MATH_1	44	48	PF00917	0.473
DOC_USP7_UBL2_3	288	292	PF12436	0.576
LIG_14-3-3_CanoR_1	275	279	PF00244	0.416
LIG_14-3-3_CanoR_1	33	41	PF00244	0.404
LIG_14-3-3_CanoR_1	45	49	PF00244	0.392
LIG_14-3-3_CanoR_1	79	87	PF00244	0.629
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_deltaCOP1_diTrp_1	243	249	PF00928	0.441
LIG_DLG_GKlike_1	5	13	PF00625	0.471
LIG_FHA_1	229	235	PF00498	0.417
LIG_FHA_2	223	229	PF00498	0.404
LIG_FHA_2	292	298	PF00498	0.409
LIG_FHA_2	37	43	PF00498	0.455
LIG_FHA_2	99	105	PF00498	0.290
LIG_LIR_Apic_2	35	41	PF02991	0.404
LIG_LIR_Gen_1	212	219	PF02991	0.390
LIG_LIR_Gen_1	3	14	PF02991	0.255
LIG_LIR_Nem_3	212	217	PF02991	0.404
LIG_LIR_Nem_3	243	248	PF02991	0.298
LIG_LIR_Nem_3	25	31	PF02991	0.436
LIG_PCNA_PIPBox_1	49	58	PF02747	0.463
LIG_PCNA_yPIPBox_3	299	308	PF02747	0.508
LIG_PCNA_yPIPBox_3	45	56	PF02747	0.524
LIG_Pex14_1	245	249	PF04695	0.434
LIG_SH2_CRK	214	218	PF00017	0.447
LIG_SH2_STAP1	161	165	PF00017	0.240
LIG_SH2_STAT5	164	167	PF00017	0.471
LIG_SH2_STAT5	55	58	PF00017	0.570
LIG_SH3_3	172	178	PF00018	0.434
LIG_SUMO_SIM_anti_2	80	92	PF11976	0.514
LIG_SUMO_SIM_par_1	230	235	PF11976	0.415
LIG_TRAF2_1	169	172	PF00917	0.415
LIG_TRAF2_1	89	92	PF00917	0.462
LIG_WRC_WIRS_1	24	29	PF05994	0.404
MOD_CK1_1	77	83	PF00069	0.563
MOD_CK2_1	166	172	PF00069	0.404
MOD_CK2_1	291	297	PF00069	0.418
MOD_CK2_1	79	85	PF00069	0.499
MOD_CK2_1	86	92	PF00069	0.455
MOD_CK2_1	98	104	PF00069	0.396
MOD_GSK3_1	187	194	PF00069	0.518
MOD_GSK3_1	228	235	PF00069	0.423
MOD_GSK3_1	32	39	PF00069	0.419
MOD_GSK3_1	74	81	PF00069	0.672
MOD_NEK2_1	166	171	PF00069	0.430
MOD_NEK2_1	314	319	PF00069	0.414
MOD_NEK2_2	244	249	PF00069	0.437
MOD_PIKK_1	164	170	PF00454	0.404
MOD_PIKK_1	314	320	PF00454	0.473
MOD_PIKK_1	36	42	PF00454	0.429
MOD_PK_1	187	193	PF00069	0.421
MOD_PKA_2	274	280	PF00069	0.414
MOD_PKA_2	32	38	PF00069	0.404
MOD_PKA_2	44	50	PF00069	0.387
MOD_PKA_2	78	84	PF00069	0.660
MOD_Plk_2-3	134	140	PF00069	0.450
MOD_Plk_4	187	193	PF00069	0.421
MOD_Plk_4	228	234	PF00069	0.419
MOD_Plk_4	23	29	PF00069	0.384
MOD_Plk_4	244	250	PF00069	0.339
MOD_Plk_4	5	11	PF00069	0.447
MOD_SUMO_for_1	124	127	PF00179	0.429
MOD_SUMO_rev_2	118	124	PF00179	0.531
TRG_ENDOCYTIC_2	214	217	PF00928	0.447
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P482	Leptomonas seymouri	76%	97%
A0A0S4KFL2	Bodo saltans	57%	100%
A0A1X0NNN1	Trypanosomatidae	64%	100%
A0A3R7KDG6	Trypanosoma rangeli	63%	100%
A0A3S5H6R4	Leishmania donovani	94%	100%
A4H7K5	Leishmania braziliensis	85%	100%
A4HVY8	Leishmania infantum	94%	100%
C9ZT35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
O35685	Mus musculus	45%	97%
Q17QG2	Bos taurus	45%	97%
Q4QFT9	Leishmania major	92%	100%
Q5RB75	Pongo abelii	29%	89%
Q5ZIN1	Gallus gallus	44%	94%
Q63525	Rattus norvegicus	45%	97%
Q8IVD9	Homo sapiens	31%	89%
Q8R1N4	Mus musculus	30%	89%
Q9VVA6	Drosophila melanogaster	37%	97%
Q9Y266	Homo sapiens	46%	97%
V5BHT5	Trypanosoma cruzi	63%	77%