mRNA_triPase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA capping enzyme, beta chain, putative

Species:

Leishmania mexicana

UniProt:

E9APN8_LEIMU

TriTrypDb:

LmxM.14.0430

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APN8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004651	polynucleotide 5'-phosphatase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.536
CLV_C14_Caspase3-7	260	264	PF00656	0.666
CLV_NRD_NRD_1	296	298	PF00675	0.379
CLV_PCSK_KEX2_1	180	182	PF00082	0.585
CLV_PCSK_KEX2_1	296	298	PF00082	0.379
CLV_PCSK_KEX2_1	376	378	PF00082	0.498
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.585
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.498
CLV_PCSK_SKI1_1	248	252	PF00082	0.532
CLV_PCSK_SKI1_1	78	82	PF00082	0.473
DEG_APCC_DBOX_1	77	85	PF00400	0.468
DEG_SCF_FBW7_1	201	207	PF00400	0.534
DEG_SPOP_SBC_1	14	18	PF00917	0.460
DEG_SPOP_SBC_1	35	39	PF00917	0.447
DEG_SPOP_SBC_1	90	94	PF00917	0.346
DOC_CKS1_1	201	206	PF01111	0.537
DOC_CKS1_1	336	341	PF01111	0.678
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.693
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.601
DOC_MAPK_FxFP_2	11	14	PF00069	0.467
DOC_MAPK_gen_1	110	118	PF00069	0.695
DOC_MAPK_gen_1	229	238	PF00069	0.285
DOC_MAPK_gen_1	273	282	PF00069	0.502
DOC_MAPK_MEF2A_6	110	118	PF00069	0.447
DOC_MAPK_MEF2A_6	169	176	PF00069	0.621
DOC_MAPK_MEF2A_6	25	32	PF00069	0.453
DOC_MAPK_MEF2A_6	253	261	PF00069	0.633
DOC_MAPK_MEF2A_6	95	102	PF00069	0.573
DOC_PP1_RVXF_1	295	302	PF00149	0.591
DOC_PP2B_LxvP_1	114	117	PF13499	0.691
DOC_PP2B_LxvP_1	409	412	PF13499	0.614
DOC_PP4_FxxP_1	11	14	PF00568	0.467
DOC_USP7_MATH_1	14	18	PF00917	0.460
DOC_USP7_MATH_1	204	208	PF00917	0.597
DOC_USP7_MATH_1	269	273	PF00917	0.639
DOC_USP7_MATH_1	276	280	PF00917	0.482
DOC_USP7_MATH_1	306	310	PF00917	0.608
DOC_USP7_MATH_1	315	319	PF00917	0.661
DOC_USP7_MATH_1	35	39	PF00917	0.663
DOC_USP7_MATH_1	382	386	PF00917	0.513
DOC_USP7_MATH_1	52	56	PF00917	0.538
DOC_WW_Pin1_4	119	124	PF00397	0.664
DOC_WW_Pin1_4	138	143	PF00397	0.441
DOC_WW_Pin1_4	190	195	PF00397	0.671
DOC_WW_Pin1_4	200	205	PF00397	0.523
DOC_WW_Pin1_4	317	322	PF00397	0.703
DOC_WW_Pin1_4	335	340	PF00397	0.440
DOC_WW_Pin1_4	45	50	PF00397	0.526
LIG_14-3-3_CanoR_1	275	281	PF00244	0.527
LIG_14-3-3_CanoR_1	284	289	PF00244	0.389
LIG_14-3-3_CanoR_1	350	360	PF00244	0.626
LIG_BRCT_BRCA1_1	47	51	PF00533	0.456
LIG_CtBP_PxDLS_1	258	262	PF00389	0.668
LIG_DCNL_PONY_1	1	4	PF03556	0.476
LIG_eIF4E_2	302	308	PF01652	0.612
LIG_FHA_1	217	223	PF00498	0.662
LIG_FHA_1	289	295	PF00498	0.480
LIG_FHA_1	336	342	PF00498	0.643
LIG_FHA_1	357	363	PF00498	0.509
LIG_FHA_1	388	394	PF00498	0.637
LIG_FHA_2	157	163	PF00498	0.548
LIG_FHA_2	194	200	PF00498	0.560
LIG_FHA_2	356	362	PF00498	0.532
LIG_FHA_2	415	421	PF00498	0.813
LIG_FHA_2	92	98	PF00498	0.611
LIG_GBD_Chelix_1	76	84	PF00786	0.466
LIG_LIR_Apic_2	298	304	PF02991	0.583
LIG_LIR_Apic_2	8	14	PF02991	0.467
LIG_LIR_Gen_1	309	317	PF02991	0.660
LIG_LIR_Nem_3	374	378	PF02991	0.502
LIG_Pex14_1	375	379	PF04695	0.486
LIG_SH2_CRK	186	190	PF00017	0.724
LIG_SH2_CRK	213	217	PF00017	0.683
LIG_SH2_STAT5	310	313	PF00017	0.732
LIG_SH2_STAT5	387	390	PF00017	0.510
LIG_SH2_STAT5	436	439	PF00017	0.585
LIG_SH3_3	117	123	PF00018	0.682
LIG_SH3_3	198	204	PF00018	0.723
LIG_SH3_3	209	215	PF00018	0.687
LIG_SH3_3	235	241	PF00018	0.264
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.440
LIG_SUMO_SIM_anti_2	221	226	PF11976	0.571
LIG_SUMO_SIM_anti_2	37	45	PF11976	0.454
LIG_SUMO_SIM_par_1	115	122	PF11976	0.593
LIG_SUMO_SIM_par_1	257	263	PF11976	0.638
LIG_SUMO_SIM_par_1	354	363	PF11976	0.458
LIG_WW_3	410	414	PF00397	0.543
MOD_CDK_SPxxK_3	190	197	PF00069	0.510
MOD_CK1_1	17	23	PF00069	0.456
MOD_CK1_1	252	258	PF00069	0.494
MOD_CK2_1	203	209	PF00069	0.739
MOD_CK2_1	306	312	PF00069	0.639
MOD_CK2_1	351	357	PF00069	0.719
MOD_CK2_1	91	97	PF00069	0.575
MOD_GlcNHglycan	225	228	PF01048	0.588
MOD_GlcNHglycan	384	387	PF01048	0.477
MOD_GlcNHglycan	390	393	PF01048	0.494
MOD_GSK3_1	13	20	PF00069	0.445
MOD_GSK3_1	200	207	PF00069	0.595
MOD_GSK3_1	216	223	PF00069	0.665
MOD_GSK3_1	284	291	PF00069	0.475
MOD_GSK3_1	331	338	PF00069	0.584
MOD_GSK3_1	35	42	PF00069	0.617
MOD_GSK3_1	351	358	PF00069	0.403
MOD_GSK3_1	382	389	PF00069	0.505
MOD_GSK3_1	394	401	PF00069	0.590
MOD_GSK3_1	5	12	PF00069	0.470
MOD_NEK2_1	106	111	PF00069	0.562
MOD_NEK2_1	126	131	PF00069	0.294
MOD_NEK2_1	15	20	PF00069	0.460
MOD_NEK2_1	216	221	PF00069	0.693
MOD_NEK2_1	290	295	PF00069	0.465
MOD_NEK2_1	388	393	PF00069	0.574
MOD_NEK2_2	405	410	PF00069	0.717
MOD_PIKK_1	216	222	PF00454	0.604
MOD_PIKK_1	288	294	PF00454	0.578
MOD_PK_1	101	107	PF00069	0.575
MOD_PK_1	284	290	PF00069	0.500
MOD_PKA_2	276	282	PF00069	0.522
MOD_PKA_2	412	418	PF00069	0.735
MOD_PKA_2	5	11	PF00069	0.472
MOD_PKB_1	273	281	PF00069	0.533
MOD_Plk_1	356	362	PF00069	0.484
MOD_Plk_1	405	411	PF00069	0.718
MOD_Plk_4	101	107	PF00069	0.575
MOD_Plk_4	325	331	PF00069	0.653
MOD_Plk_4	39	45	PF00069	0.522
MOD_Plk_4	424	430	PF00069	0.750
MOD_ProDKin_1	119	125	PF00069	0.655
MOD_ProDKin_1	138	144	PF00069	0.437
MOD_ProDKin_1	190	196	PF00069	0.676
MOD_ProDKin_1	200	206	PF00069	0.522
MOD_ProDKin_1	317	323	PF00069	0.700
MOD_ProDKin_1	335	341	PF00069	0.445
MOD_ProDKin_1	45	51	PF00069	0.527
MOD_SUMO_rev_2	226	231	PF00179	0.474
TRG_DiLeu_BaEn_1	433	438	PF01217	0.497
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.592
TRG_ENDOCYTIC_2	186	189	PF00928	0.715
TRG_ENDOCYTIC_2	213	216	PF00928	0.688
TRG_ENDOCYTIC_2	310	313	PF00928	0.655
TRG_NES_CRM1_1	164	179	PF08389	0.348
TRG_NES_CRM1_1	70	85	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D6	Leptomonas seymouri	38%	100%
A0A3Q8ID33	Leishmania donovani	88%	100%
A4H7K3	Leishmania braziliensis	78%	100%
A4HVY6	Leishmania infantum	88%	100%
Q4QFU1	Leishmania major	87%	100%