C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iguana/Dzip1-like DAZ-interacting protein N-terminal, putative

Species:

Leishmania mexicana

UniProt:

E9APN7_LEIMU

TriTrypDb:

LmxM.14.0420

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005814	centriole	5	5
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9APN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APN7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.643
CLV_NRD_NRD_1	179	181	PF00675	0.562
CLV_NRD_NRD_1	359	361	PF00675	0.552
CLV_NRD_NRD_1	813	815	PF00675	0.800
CLV_PCSK_KEX2_1	126	128	PF00082	0.643
CLV_PCSK_KEX2_1	181	183	PF00082	0.708
CLV_PCSK_KEX2_1	359	361	PF00082	0.552
CLV_PCSK_KEX2_1	813	815	PF00082	0.800
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.708
CLV_PCSK_SKI1_1	120	124	PF00082	0.342
CLV_PCSK_SKI1_1	127	131	PF00082	0.444
CLV_PCSK_SKI1_1	142	146	PF00082	0.572
CLV_PCSK_SKI1_1	27	31	PF00082	0.432
DEG_APCC_DBOX_1	250	258	PF00400	0.709
DEG_APCC_DBOX_1	358	366	PF00400	0.693
DEG_ODPH_VHL_1	678	689	PF01847	0.819
DEG_SCF_FBW7_1	278	285	PF00400	0.572
DEG_SCF_FBW7_1	592	599	PF00400	0.707
DEG_SIAH_1	418	426	PF03145	0.506
DEG_SPOP_SBC_1	282	286	PF00917	0.842
DEG_SPOP_SBC_1	399	403	PF00917	0.564
DEG_SPOP_SBC_1	515	519	PF00917	0.586
DEG_SPOP_SBC_1	578	582	PF00917	0.605
DEG_SPOP_SBC_1	616	620	PF00917	0.832
DEG_SPOP_SBC_1	670	674	PF00917	0.664
DOC_CDC14_PxL_1	741	749	PF14671	0.815
DOC_CKS1_1	277	282	PF01111	0.571
DOC_CKS1_1	460	465	PF01111	0.720
DOC_CKS1_1	56	61	PF01111	0.632
DOC_CKS1_1	570	575	PF01111	0.716
DOC_CKS1_1	593	598	PF01111	0.579
DOC_CKS1_1	780	785	PF01111	0.824
DOC_CYCLIN_RxL_1	123	133	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	457	463	PF00134	0.831
DOC_CYCLIN_yCln2_LP_2	501	504	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.843
DOC_CYCLIN_yCln2_LP_2	747	753	PF00134	0.830
DOC_MAPK_gen_1	248	256	PF00069	0.575
DOC_MAPK_gen_1	359	365	PF00069	0.538
DOC_MAPK_MEF2A_6	14	23	PF00069	0.632
DOC_MAPK_MEF2A_6	251	258	PF00069	0.596
DOC_MAPK_NFAT4_5	251	259	PF00069	0.708
DOC_PP1_RVXF_1	12	18	PF00149	0.632
DOC_PP2B_LxvP_1	457	460	PF13499	0.834
DOC_PP2B_LxvP_1	461	464	PF13499	0.757
DOC_PP2B_LxvP_1	468	471	PF13499	0.632
DOC_PP2B_LxvP_1	501	504	PF13499	0.799
DOC_PP2B_LxvP_1	526	529	PF13499	0.650
DOC_PP2B_LxvP_1	723	726	PF13499	0.815
DOC_PP2B_LxvP_1	747	750	PF13499	0.822
DOC_USP7_MATH_1	188	192	PF00917	0.814
DOC_USP7_MATH_1	223	227	PF00917	0.779
DOC_USP7_MATH_1	261	265	PF00917	0.770
DOC_USP7_MATH_1	283	287	PF00917	0.739
DOC_USP7_MATH_1	306	310	PF00917	0.766
DOC_USP7_MATH_1	391	395	PF00917	0.823
DOC_USP7_MATH_1	398	402	PF00917	0.728
DOC_USP7_MATH_1	544	548	PF00917	0.658
DOC_USP7_MATH_1	563	567	PF00917	0.513
DOC_USP7_MATH_1	596	600	PF00917	0.823
DOC_USP7_MATH_1	643	647	PF00917	0.821
DOC_USP7_MATH_1	660	664	PF00917	0.545
DOC_USP7_MATH_1	668	672	PF00917	0.678
DOC_USP7_MATH_1	680	684	PF00917	0.491
DOC_USP7_MATH_1	771	775	PF00917	0.817
DOC_USP7_MATH_1	781	785	PF00917	0.657
DOC_USP7_UBL2_3	119	123	PF12436	0.574
DOC_WW_Pin1_4	186	191	PF00397	0.647
DOC_WW_Pin1_4	197	202	PF00397	0.668
DOC_WW_Pin1_4	265	270	PF00397	0.830
DOC_WW_Pin1_4	276	281	PF00397	0.574
DOC_WW_Pin1_4	289	294	PF00397	0.759
DOC_WW_Pin1_4	302	307	PF00397	0.591
DOC_WW_Pin1_4	389	394	PF00397	0.812
DOC_WW_Pin1_4	459	464	PF00397	0.719
DOC_WW_Pin1_4	474	479	PF00397	0.766
DOC_WW_Pin1_4	538	543	PF00397	0.781
DOC_WW_Pin1_4	55	60	PF00397	0.632
DOC_WW_Pin1_4	554	559	PF00397	0.598
DOC_WW_Pin1_4	561	566	PF00397	0.749
DOC_WW_Pin1_4	569	574	PF00397	0.682
DOC_WW_Pin1_4	592	597	PF00397	0.613
DOC_WW_Pin1_4	641	646	PF00397	0.780
DOC_WW_Pin1_4	650	655	PF00397	0.744
DOC_WW_Pin1_4	671	676	PF00397	0.684
DOC_WW_Pin1_4	681	686	PF00397	0.791
DOC_WW_Pin1_4	726	731	PF00397	0.588
DOC_WW_Pin1_4	736	741	PF00397	0.797
DOC_WW_Pin1_4	764	769	PF00397	0.739
DOC_WW_Pin1_4	779	784	PF00397	0.669
LIG_14-3-3_CanoR_1	110	118	PF00244	0.632
LIG_14-3-3_CanoR_1	126	130	PF00244	0.380
LIG_14-3-3_CanoR_1	182	192	PF00244	0.780
LIG_14-3-3_CanoR_1	263	269	PF00244	0.814
LIG_14-3-3_CanoR_1	27	37	PF00244	0.632
LIG_14-3-3_CanoR_1	696	700	PF00244	0.687
LIG_14-3-3_CanoR_1	808	817	PF00244	0.534
LIG_Actin_WH2_2	358	375	PF00022	0.686
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_1	1	5	PF00653	0.692
LIG_BIR_III_3	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	2	6	PF00533	0.673
LIG_Clathr_ClatBox_1	20	24	PF01394	0.632
LIG_Clathr_ClatBox_1	362	366	PF01394	0.685
LIG_CSL_BTD_1	765	768	PF09270	0.558
LIG_CtBP_PxDLS_1	454	458	PF00389	0.841
LIG_EVH1_1	468	472	PF00568	0.691
LIG_EVH1_1	602	606	PF00568	0.716
LIG_FHA_1	113	119	PF00498	0.560
LIG_FHA_1	156	162	PF00498	0.645
LIG_FHA_1	562	568	PF00498	0.839
LIG_FHA_1	570	576	PF00498	0.551
LIG_FHA_1	595	601	PF00498	0.848
LIG_FHA_1	625	631	PF00498	0.846
LIG_FHA_1	642	648	PF00498	0.558
LIG_FHA_1	664	670	PF00498	0.820
LIG_FHA_1	758	764	PF00498	0.718
LIG_FHA_1	773	779	PF00498	0.516
LIG_FHA_2	30	36	PF00498	0.632
LIG_FHA_2	315	321	PF00498	0.680
LIG_FHA_2	48	54	PF00498	0.423
LIG_FHA_2	717	723	PF00498	0.823
LIG_FHA_2	98	104	PF00498	0.525
LIG_GSK3_LRP6_1	389	394	PF00069	0.812
LIG_LIR_Apic_2	158	163	PF02991	0.627
LIG_LIR_Apic_2	765	769	PF02991	0.830
LIG_LIR_Gen_1	3	13	PF02991	0.524
LIG_LIR_Nem_3	16	20	PF02991	0.526
LIG_LIR_Nem_3	3	9	PF02991	0.524
LIG_LIR_Nem_3	792	796	PF02991	0.832
LIG_MYND_1	455	459	PF01753	0.839
LIG_MYND_1	499	503	PF01753	0.804
LIG_MYND_1	535	539	PF01753	0.561
LIG_MYND_1	645	649	PF01753	0.547
LIG_PROFILIN_1	293	299	PF00235	0.518
LIG_PROFILIN_1	463	469	PF00235	0.688
LIG_PTAP_UEV_1	405	410	PF05743	0.541
LIG_PTB_Apo_2	40	47	PF02174	0.632
LIG_SH2_PTP2	160	163	PF00017	0.615
LIG_SH2_STAP1	132	136	PF00017	0.643
LIG_SH2_STAP1	78	82	PF00017	0.632
LIG_SH2_STAT3	134	137	PF00017	0.646
LIG_SH2_STAT3	548	551	PF00017	0.872
LIG_SH2_STAT5	160	163	PF00017	0.615
LIG_SH2_STAT5	164	167	PF00017	0.568
LIG_SH2_STAT5	492	495	PF00017	0.714
LIG_SH2_STAT5	692	695	PF00017	0.820
LIG_SH2_STAT5	75	78	PF00017	0.632
LIG_SH3_1	385	391	PF00018	0.530
LIG_SH3_3	187	193	PF00018	0.651
LIG_SH3_3	198	204	PF00018	0.637
LIG_SH3_3	268	274	PF00018	0.841
LIG_SH3_3	287	293	PF00018	0.793
LIG_SH3_3	294	300	PF00018	0.637
LIG_SH3_3	331	337	PF00018	0.755
LIG_SH3_3	385	391	PF00018	0.805
LIG_SH3_3	403	409	PF00018	0.523
LIG_SH3_3	419	425	PF00018	0.465
LIG_SH3_3	457	463	PF00018	0.831
LIG_SH3_3	464	470	PF00018	0.700
LIG_SH3_3	477	483	PF00018	0.504
LIG_SH3_3	533	539	PF00018	0.559
LIG_SH3_3	555	561	PF00018	0.840
LIG_SH3_3	562	568	PF00018	0.723
LIG_SH3_3	590	596	PF00018	0.555
LIG_SH3_3	597	603	PF00018	0.783
LIG_SH3_3	679	685	PF00018	0.664
LIG_SH3_3	701	707	PF00018	0.701
LIG_SH3_3	709	715	PF00018	0.803
LIG_SH3_3	742	748	PF00018	0.663
LIG_SH3_3	765	771	PF00018	0.824
LIG_SH3_3	775	781	PF00018	0.671
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.708
LIG_SUMO_SIM_par_1	19	24	PF11976	0.632
LIG_SUMO_SIM_par_1	361	366	PF11976	0.535
LIG_TRAF2_1	100	103	PF00917	0.513
LIG_UBA3_1	82	89	PF00899	0.632
LIG_WRC_WIRS_1	790	795	PF05994	0.677
MOD_CK1_1	112	118	PF00069	0.632
MOD_CK1_1	174	180	PF00069	0.671
MOD_CK1_1	186	192	PF00069	0.613
MOD_CK1_1	264	270	PF00069	0.823
MOD_CK1_1	309	315	PF00069	0.753
MOD_CK1_1	448	454	PF00069	0.834
MOD_CK1_1	47	53	PF00069	0.632
MOD_CK1_1	505	511	PF00069	0.807
MOD_CK1_1	527	533	PF00069	0.574
MOD_CK1_1	579	585	PF00069	0.837
MOD_CK1_1	619	625	PF00069	0.839
MOD_CK1_1	626	632	PF00069	0.726
MOD_CK1_1	650	656	PF00069	0.672
MOD_CK1_1	663	669	PF00069	0.643
MOD_CK1_1	671	677	PF00069	0.694
MOD_CK1_1	681	687	PF00069	0.525
MOD_CK1_1	691	697	PF00069	0.494
MOD_CK1_1	762	768	PF00069	0.837
MOD_CK1_1	792	798	PF00069	0.691
MOD_CK1_1	799	805	PF00069	0.754
MOD_CK2_1	47	53	PF00069	0.632
MOD_CK2_1	716	722	PF00069	0.818
MOD_CK2_1	97	103	PF00069	0.519
MOD_DYRK1A_RPxSP_1	538	542	PF00069	0.691
MOD_GlcNHglycan	146	149	PF01048	0.745
MOD_GlcNHglycan	185	188	PF01048	0.511
MOD_GlcNHglycan	285	288	PF01048	0.684
MOD_GlcNHglycan	311	314	PF01048	0.688
MOD_GlcNHglycan	338	342	PF01048	0.694
MOD_GlcNHglycan	393	396	PF01048	0.833
MOD_GlcNHglycan	402	405	PF01048	0.674
MOD_GlcNHglycan	406	409	PF01048	0.605
MOD_GlcNHglycan	450	453	PF01048	0.840
MOD_GlcNHglycan	650	653	PF01048	0.841
MOD_GlcNHglycan	662	665	PF01048	0.641
MOD_GlcNHglycan	697	700	PF01048	0.681
MOD_GlcNHglycan	783	786	PF01048	0.725
MOD_GlcNHglycan	804	807	PF01048	0.679
MOD_GSK3_1	121	128	PF00069	0.659
MOD_GSK3_1	182	189	PF00069	0.666
MOD_GSK3_1	219	226	PF00069	0.711
MOD_GSK3_1	259	266	PF00069	0.762
MOD_GSK3_1	278	285	PF00069	0.677
MOD_GSK3_1	29	36	PF00069	0.632
MOD_GSK3_1	302	309	PF00069	0.783
MOD_GSK3_1	312	319	PF00069	0.716
MOD_GSK3_1	400	407	PF00069	0.666
MOD_GSK3_1	474	481	PF00069	0.598
MOD_GSK3_1	490	497	PF00069	0.720
MOD_GSK3_1	503	510	PF00069	0.698
MOD_GSK3_1	559	566	PF00069	0.847
MOD_GSK3_1	578	585	PF00069	0.830
MOD_GSK3_1	592	599	PF00069	0.617
MOD_GSK3_1	615	622	PF00069	0.837
MOD_GSK3_1	643	650	PF00069	0.802
MOD_GSK3_1	655	662	PF00069	0.612
MOD_GSK3_1	688	695	PF00069	0.816
MOD_GSK3_1	735	742	PF00069	0.615
MOD_GSK3_1	753	760	PF00069	0.718
MOD_GSK3_1	792	799	PF00069	0.803
MOD_N-GLC_1	183	188	PF02516	0.763
MOD_N-GLC_1	345	350	PF02516	0.691
MOD_N-GLC_1	620	625	PF02516	0.840
MOD_NEK2_1	144	149	PF00069	0.704
MOD_NEK2_1	259	264	PF00069	0.744
MOD_NEK2_1	28	33	PF00069	0.632
MOD_NEK2_1	372	377	PF00069	0.693
MOD_NEK2_1	411	416	PF00069	0.846
MOD_NEK2_1	624	629	PF00069	0.849
MOD_NEK2_1	734	739	PF00069	0.823
MOD_NEK2_1	796	801	PF00069	0.707
MOD_PIKK_1	121	127	PF00454	0.718
MOD_PIKK_1	261	267	PF00454	0.661
MOD_PIKK_1	505	511	PF00454	0.848
MOD_PIKK_1	76	82	PF00454	0.632
MOD_PKA_2	109	115	PF00069	0.632
MOD_PKA_2	125	131	PF00069	0.377
MOD_PKA_2	372	378	PF00069	0.697
MOD_PKA_2	47	53	PF00069	0.632
MOD_PKA_2	537	543	PF00069	0.692
MOD_PKA_2	695	701	PF00069	0.687
MOD_PKB_1	180	188	PF00069	0.748
MOD_Plk_1	337	343	PF00069	0.698
MOD_Plk_1	620	626	PF00069	0.841
MOD_Plk_1	721	727	PF00069	0.696
MOD_Plk_4	155	161	PF00069	0.660
MOD_Plk_4	497	503	PF00069	0.662
MOD_Plk_4	688	694	PF00069	0.817
MOD_Plk_4	708	714	PF00069	0.500
MOD_ProDKin_1	186	192	PF00069	0.651
MOD_ProDKin_1	197	203	PF00069	0.663
MOD_ProDKin_1	265	271	PF00069	0.831
MOD_ProDKin_1	276	282	PF00069	0.571
MOD_ProDKin_1	289	295	PF00069	0.756
MOD_ProDKin_1	302	308	PF00069	0.592
MOD_ProDKin_1	389	395	PF00069	0.815
MOD_ProDKin_1	459	465	PF00069	0.720
MOD_ProDKin_1	474	480	PF00069	0.601
MOD_ProDKin_1	538	544	PF00069	0.782
MOD_ProDKin_1	55	61	PF00069	0.632
MOD_ProDKin_1	554	560	PF00069	0.599
MOD_ProDKin_1	561	567	PF00069	0.749
MOD_ProDKin_1	569	575	PF00069	0.683
MOD_ProDKin_1	592	598	PF00069	0.613
MOD_ProDKin_1	641	647	PF00069	0.783
MOD_ProDKin_1	650	656	PF00069	0.746
MOD_ProDKin_1	671	677	PF00069	0.686
MOD_ProDKin_1	681	687	PF00069	0.792
MOD_ProDKin_1	726	732	PF00069	0.585
MOD_ProDKin_1	736	742	PF00069	0.793
MOD_ProDKin_1	764	770	PF00069	0.738
MOD_ProDKin_1	779	785	PF00069	0.671
TRG_DiLeu_BaEn_1	103	108	PF01217	0.632
TRG_DiLeu_BaEn_1	252	257	PF01217	0.707
TRG_ENDOCYTIC_2	613	616	PF00928	0.848
TRG_ER_diArg_1	179	182	PF00400	0.705
TRG_ER_diArg_1	232	235	PF00400	0.727
TRG_ER_diArg_1	358	360	PF00400	0.709
TRG_ER_diArg_1	813	815	PF00400	0.800
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSW0	Leishmania donovani	83%	100%
A4HVY5	Leishmania infantum	82%	100%
Q4QFU2	Leishmania major	82%	98%