Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APN5_LEIMU

TriTrypDb:

LmxM.14.0405

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.700
CLV_NRD_NRD_1	161	163	PF00675	0.467
CLV_PCSK_KEX2_1	109	111	PF00082	0.714
CLV_PCSK_KEX2_1	161	163	PF00082	0.467
CLV_PCSK_SKI1_1	161	165	PF00082	0.533
CLV_PCSK_SKI1_1	176	180	PF00082	0.573
CLV_Separin_Metazoa	89	93	PF03568	0.471
DEG_SPOP_SBC_1	72	76	PF00917	0.655
DOC_PP2B_LxvP_1	136	139	PF13499	0.644
DOC_USP7_MATH_1	117	121	PF00917	0.730
DOC_USP7_MATH_1	63	67	PF00917	0.678
DOC_USP7_MATH_1	72	76	PF00917	0.626
DOC_WW_Pin1_4	121	126	PF00397	0.601
LIG_14-3-3_CanoR_1	176	184	PF00244	0.363
LIG_14-3-3_CanoR_1	47	52	PF00244	0.443
LIG_14-3-3_CanoR_1	92	100	PF00244	0.602
LIG_Actin_WH2_2	12	30	PF00022	0.598
LIG_BIR_II_1	1	5	PF00653	0.478
LIG_BIR_III_1	1	5	PF00653	0.478
LIG_BIR_III_2	52	56	PF00653	0.587
LIG_BIR_III_3	1	5	PF00653	0.478
LIG_BRCT_BRCA1_1	133	137	PF00533	0.576
LIG_FHA_1	177	183	PF00498	0.522
LIG_FHA_1	74	80	PF00498	0.725
LIG_FHA_2	80	86	PF00498	0.510
LIG_LIR_Nem_3	158	163	PF02991	0.525
LIG_SH2_CRK	160	164	PF00017	0.531
LIG_SH2_STAT5	144	147	PF00017	0.600
LIG_SH3_3	135	141	PF00018	0.710
LIG_SUMO_SIM_par_1	101	106	PF11976	0.603
LIG_SUMO_SIM_par_1	62	68	PF11976	0.609
MOD_CK1_1	131	137	PF00069	0.713
MOD_CK1_1	33	39	PF00069	0.439
MOD_CK1_1	71	77	PF00069	0.736
MOD_CK1_1	84	90	PF00069	0.568
MOD_CK2_1	74	80	PF00069	0.684
MOD_GlcNHglycan	105	108	PF01048	0.598
MOD_GlcNHglycan	150	153	PF01048	0.487
MOD_GlcNHglycan	24	27	PF01048	0.605
MOD_GlcNHglycan	70	73	PF01048	0.655
MOD_GlcNHglycan	76	79	PF01048	0.696
MOD_GlcNHglycan	95	98	PF01048	0.478
MOD_GSK3_1	117	124	PF00069	0.528
MOD_GSK3_1	143	150	PF00069	0.579
MOD_GSK3_1	53	60	PF00069	0.702
MOD_GSK3_1	63	70	PF00069	0.473
MOD_NEK2_1	32	37	PF00069	0.542
MOD_NEK2_1	67	72	PF00069	0.550
MOD_PIKK_1	117	123	PF00454	0.816
MOD_PIKK_1	170	176	PF00454	0.318
MOD_PIKK_1	65	71	PF00454	0.559
MOD_PKB_1	45	53	PF00069	0.433
MOD_Plk_2-3	81	87	PF00069	0.504
MOD_ProDKin_1	121	127	PF00069	0.600
TRG_ENDOCYTIC_2	160	163	PF00928	0.527
TRG_ER_diArg_1	109	111	PF00400	0.539
TRG_ER_diArg_1	160	162	PF00400	0.485
TRG_ER_diArg_1	45	48	PF00400	0.415
TRG_ER_FFAT_2	29	40	PF00635	0.431
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD9	Leptomonas seymouri	46%	100%
A0A1X0NP94	Trypanosomatidae	28%	85%
A0A3Q8I9Q7	Leishmania donovani	81%	100%
A4H7K0	Leishmania braziliensis	71%	100%
A4HVY3	Leishmania infantum	81%	100%
Q4QFU4	Leishmania major	83%	99%