Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APN4_LEIMU

TriTrypDb:

LmxM.14.0400

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.458
CLV_C14_Caspase3-7	96	100	PF00656	0.466
CLV_NRD_NRD_1	20	22	PF00675	0.452
CLV_NRD_NRD_1	206	208	PF00675	0.405
CLV_NRD_NRD_1	285	287	PF00675	0.714
CLV_PCSK_KEX2_1	20	22	PF00082	0.426
CLV_PCSK_SKI1_1	116	120	PF00082	0.474
CLV_PCSK_SKI1_1	20	24	PF00082	0.425
DEG_APCC_DBOX_1	19	27	PF00400	0.475
DOC_MAPK_gen_1	48	57	PF00069	0.394
DOC_MAPK_MEF2A_6	48	57	PF00069	0.375
DOC_MAPK_NFAT4_5	50	58	PF00069	0.302
DOC_PP1_RVXF_1	258	264	PF00149	0.491
DOC_PP1_RVXF_1	292	299	PF00149	0.476
DOC_PP1_RVXF_1	46	52	PF00149	0.526
DOC_USP7_MATH_1	162	166	PF00917	0.391
DOC_USP7_UBL2_3	154	158	PF12436	0.300
DOC_WW_Pin1_4	158	163	PF00397	0.405
LIG_14-3-3_CanoR_1	260	264	PF00244	0.469
LIG_14-3-3_CanoR_1	90	98	PF00244	0.432
LIG_BIR_III_4	16	20	PF00653	0.417
LIG_BRCT_BRCA1_1	164	168	PF00533	0.375
LIG_FHA_1	122	128	PF00498	0.438
LIG_FHA_1	133	139	PF00498	0.451
LIG_FHA_1	197	203	PF00498	0.524
LIG_FHA_1	237	243	PF00498	0.416
LIG_FHA_1	265	271	PF00498	0.559
LIG_FHA_1	54	60	PF00498	0.273
LIG_FHA_2	273	279	PF00498	0.559
LIG_LIR_Apic_2	147	153	PF02991	0.398
LIG_LIR_Gen_1	123	131	PF02991	0.353
LIG_LIR_Gen_1	199	205	PF02991	0.433
LIG_LIR_Gen_1	44	53	PF02991	0.471
LIG_LIR_Nem_3	123	129	PF02991	0.353
LIG_LIR_Nem_3	185	190	PF02991	0.487
LIG_LIR_Nem_3	199	203	PF02991	0.370
LIG_LIR_Nem_3	27	32	PF02991	0.452
LIG_LIR_Nem_3	44	49	PF02991	0.417
LIG_SH2_CRK	187	191	PF00017	0.387
LIG_SH2_CRK	69	73	PF00017	0.457
LIG_SH2_STAP1	32	36	PF00017	0.290
LIG_SH2_STAP1	77	81	PF00017	0.367
LIG_SH2_STAT5	187	190	PF00017	0.519
LIG_SH2_STAT5	200	203	PF00017	0.454
LIG_SH2_STAT5	66	69	PF00017	0.369
LIG_SH2_STAT5	80	83	PF00017	0.351
LIG_SH3_1	69	75	PF00018	0.471
LIG_SH3_3	69	75	PF00018	0.452
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.435
LIG_UBA3_1	175	184	PF00899	0.388
MOD_CK1_1	144	150	PF00069	0.491
MOD_CK1_1	161	167	PF00069	0.256
MOD_CK1_1	236	242	PF00069	0.591
MOD_CK2_1	286	292	PF00069	0.680
MOD_CK2_1	303	309	PF00069	0.586
MOD_CK2_1	81	87	PF00069	0.481
MOD_Cter_Amidation	18	21	PF01082	0.472
MOD_Cter_Amidation	284	287	PF01082	0.505
MOD_GlcNHglycan	16	20	PF01048	0.538
MOD_GlcNHglycan	220	224	PF01048	0.503
MOD_GlcNHglycan	252	255	PF01048	0.516
MOD_GlcNHglycan	280	283	PF01048	0.580
MOD_GlcNHglycan	288	291	PF01048	0.592
MOD_GSK3_1	144	151	PF00069	0.435
MOD_GSK3_1	158	165	PF00069	0.350
MOD_GSK3_1	274	281	PF00069	0.745
MOD_GSK3_1	299	306	PF00069	0.685
MOD_GSK3_1	37	44	PF00069	0.392
MOD_GSK3_1	75	82	PF00069	0.445
MOD_GSK3_1	8	15	PF00069	0.543
MOD_GSK3_1	86	93	PF00069	0.460
MOD_N-GLC_1	144	149	PF02516	0.461
MOD_N-GLC_1	158	163	PF02516	0.378
MOD_N-GLC_1	41	46	PF02516	0.453
MOD_N-GLC_2	108	110	PF02516	0.404
MOD_NEK2_1	141	146	PF00069	0.496
MOD_NEK2_1	218	223	PF00069	0.514
MOD_NEK2_1	264	269	PF00069	0.617
MOD_NEK2_1	272	277	PF00069	0.644
MOD_NEK2_1	53	58	PF00069	0.391
MOD_NEK2_1	81	86	PF00069	0.451
MOD_PIKK_1	27	33	PF00454	0.570
MOD_PKA_1	286	292	PF00069	0.710
MOD_PKA_2	148	154	PF00069	0.396
MOD_PKA_2	259	265	PF00069	0.308
MOD_Plk_1	121	127	PF00069	0.458
MOD_Plk_1	132	138	PF00069	0.371
MOD_Plk_1	144	150	PF00069	0.343
MOD_Plk_1	233	239	PF00069	0.617
MOD_Plk_1	292	298	PF00069	0.693
MOD_Plk_1	34	40	PF00069	0.437
MOD_Plk_1	41	47	PF00069	0.456
MOD_Plk_2-3	292	298	PF00069	0.702
MOD_Plk_2-3	303	309	PF00069	0.730
MOD_Plk_4	121	127	PF00069	0.435
MOD_Plk_4	132	138	PF00069	0.414
MOD_Plk_4	196	202	PF00069	0.488
MOD_Plk_4	75	81	PF00069	0.385
MOD_ProDKin_1	158	164	PF00069	0.401
MOD_SUMO_for_1	153	156	PF00179	0.434
MOD_SUMO_rev_2	111	118	PF00179	0.484
MOD_SUMO_rev_2	151	160	PF00179	0.290
MOD_SUMO_rev_2	293	302	PF00179	0.538
TRG_ENDOCYTIC_2	187	190	PF00928	0.620
TRG_ENDOCYTIC_2	200	203	PF00928	0.474
TRG_ENDOCYTIC_2	226	229	PF00928	0.564
TRG_ER_diArg_1	20	22	PF00400	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0V1	Leptomonas seymouri	49%	100%
A0A0S4KDQ4	Bodo saltans	44%	100%
A0A1X0NQ77	Trypanosomatidae	44%	99%
A0A381MFS8	Leishmania infantum	79%	100%
A0A3Q8I9T1	Leishmania donovani	72%	100%
A0A3R7N2S2	Trypanosoma rangeli	44%	97%
A0A3S7WSX7	Leishmania donovani	78%	100%
A4H7J8	Leishmania braziliensis	51%	100%
C9ZT43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9AGK8	Leishmania infantum	73%	100%
E9APN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9APN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFU5	Leishmania major	71%	100%
Q4QFU6	Leishmania major	76%	100%
V5BD72	Trypanosoma cruzi	44%	97%