LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania mexicana
UniProt:
E9APN1_LEIMU
TriTrypDb:
LmxM.14.0380
Length:
606

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 15
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

E9APN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APN1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 15
GO:0022857 transmembrane transporter activity 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 442 446 PF00656 0.501
CLV_NRD_NRD_1 316 318 PF00675 0.249
CLV_NRD_NRD_1 594 596 PF00675 0.397
CLV_PCSK_KEX2_1 316 318 PF00082 0.249
CLV_PCSK_KEX2_1 594 596 PF00082 0.397
CLV_PCSK_SKI1_1 319 323 PF00082 0.250
DEG_SPOP_SBC_1 230 234 PF00917 0.346
DEG_SPOP_SBC_1 302 306 PF00917 0.413
DEG_SPOP_SBC_1 38 42 PF00917 0.548
DEG_SPOP_SBC_1 412 416 PF00917 0.316
DEG_SPOP_SBC_1 440 444 PF00917 0.422
DOC_CKS1_1 91 96 PF01111 0.616
DOC_CYCLIN_RxL_1 316 325 PF00134 0.492
DOC_MAPK_gen_1 316 326 PF00069 0.449
DOC_PP1_RVXF_1 220 227 PF00149 0.260
DOC_PP2B_PxIxI_1 362 368 PF00149 0.241
DOC_PP4_FxxP_1 196 199 PF00568 0.324
DOC_PP4_FxxP_1 551 554 PF00568 0.404
DOC_PP4_FxxP_1 91 94 PF00568 0.622
DOC_SPAK_OSR1_1 434 438 PF12202 0.435
DOC_USP7_MATH_1 167 171 PF00917 0.533
DOC_USP7_MATH_1 208 212 PF00917 0.482
DOC_USP7_MATH_1 258 262 PF00917 0.272
DOC_USP7_MATH_1 310 314 PF00917 0.584
DOC_USP7_MATH_1 329 333 PF00917 0.220
DOC_USP7_MATH_1 554 558 PF00917 0.312
DOC_WW_Pin1_4 206 211 PF00397 0.407
DOC_WW_Pin1_4 286 291 PF00397 0.241
DOC_WW_Pin1_4 39 44 PF00397 0.578
DOC_WW_Pin1_4 90 95 PF00397 0.655
LIG_14-3-3_CanoR_1 17 27 PF00244 0.624
LIG_14-3-3_CanoR_1 300 308 PF00244 0.474
LIG_14-3-3_CanoR_1 316 322 PF00244 0.535
LIG_14-3-3_CanoR_1 411 420 PF00244 0.261
LIG_14-3-3_CanoR_1 441 450 PF00244 0.438
LIG_14-3-3_CanoR_1 48 56 PF00244 0.630
LIG_14-3-3_CanoR_1 88 92 PF00244 0.605
LIG_Actin_WH2_2 168 185 PF00022 0.333
LIG_BIR_II_1 1 5 PF00653 0.638
LIG_BRCT_BRCA1_1 331 335 PF00533 0.272
LIG_BRCT_BRCA1_1 499 503 PF00533 0.470
LIG_BRCT_BRCA1_1 547 551 PF00533 0.395
LIG_deltaCOP1_diTrp_1 102 106 PF00928 0.643
LIG_deltaCOP1_diTrp_1 113 120 PF00928 0.455
LIG_EH1_1 540 548 PF00400 0.305
LIG_eIF4E_1 239 245 PF01652 0.317
LIG_FHA_1 119 125 PF00498 0.179
LIG_FHA_1 230 236 PF00498 0.382
LIG_FHA_1 277 283 PF00498 0.232
LIG_FHA_1 287 293 PF00498 0.249
LIG_FHA_1 303 309 PF00498 0.501
LIG_FHA_1 39 45 PF00498 0.705
LIG_FHA_1 488 494 PF00498 0.454
LIG_FHA_1 506 512 PF00498 0.306
LIG_FHA_1 525 531 PF00498 0.236
LIG_FHA_1 559 565 PF00498 0.474
LIG_FHA_1 62 68 PF00498 0.567
LIG_FHA_1 71 77 PF00498 0.543
LIG_FHA_2 139 145 PF00498 0.297
LIG_FHA_2 21 27 PF00498 0.615
LIG_GBD_Chelix_1 535 543 PF00786 0.201
LIG_LIR_Apic_2 194 199 PF02991 0.308
LIG_LIR_Apic_2 548 554 PF02991 0.475
LIG_LIR_Apic_2 90 94 PF02991 0.616
LIG_LIR_Gen_1 113 123 PF02991 0.449
LIG_LIR_Gen_1 332 341 PF02991 0.351
LIG_LIR_Gen_1 431 440 PF02991 0.272
LIG_LIR_Gen_1 447 458 PF02991 0.361
LIG_LIR_Gen_1 489 499 PF02991 0.475
LIG_LIR_Gen_1 500 511 PF02991 0.475
LIG_LIR_Gen_1 531 540 PF02991 0.263
LIG_LIR_Gen_1 561 571 PF02991 0.465
LIG_LIR_Gen_1 579 589 PF02991 0.425
LIG_LIR_Nem_3 113 118 PF02991 0.454
LIG_LIR_Nem_3 332 336 PF02991 0.333
LIG_LIR_Nem_3 359 365 PF02991 0.295
LIG_LIR_Nem_3 414 420 PF02991 0.297
LIG_LIR_Nem_3 431 435 PF02991 0.262
LIG_LIR_Nem_3 447 453 PF02991 0.518
LIG_LIR_Nem_3 489 494 PF02991 0.508
LIG_LIR_Nem_3 500 506 PF02991 0.529
LIG_LIR_Nem_3 531 535 PF02991 0.243
LIG_LIR_Nem_3 549 555 PF02991 0.343
LIG_LIR_Nem_3 561 566 PF02991 0.409
LIG_LIR_Nem_3 576 580 PF02991 0.504
LIG_LYPXL_yS_3 362 365 PF13949 0.272
LIG_NRBOX 521 527 PF00104 0.241
LIG_Pex14_1 115 119 PF04695 0.368
LIG_Pex14_2 368 372 PF04695 0.344
LIG_Pex14_2 499 503 PF04695 0.449
LIG_SH2_CRK 239 243 PF00017 0.351
LIG_SH2_CRK 471 475 PF00017 0.449
LIG_SH2_CRK 552 556 PF00017 0.351
LIG_SH2_CRK 581 585 PF00017 0.506
LIG_SH2_GRB2like 467 470 PF00017 0.449
LIG_SH2_NCK_1 552 556 PF00017 0.329
LIG_SH2_SRC 483 486 PF00017 0.467
LIG_SH2_STAP1 581 585 PF00017 0.502
LIG_SH2_STAT3 248 251 PF00017 0.484
LIG_SH2_STAT3 295 298 PF00017 0.372
LIG_SH2_STAT3 467 470 PF00017 0.402
LIG_SH2_STAT5 28 31 PF00017 0.636
LIG_SH2_STAT5 295 298 PF00017 0.237
LIG_SH2_STAT5 39 42 PF00017 0.578
LIG_SH2_STAT5 393 396 PF00017 0.316
LIG_SH2_STAT5 467 470 PF00017 0.449
LIG_SH2_STAT5 483 486 PF00017 0.449
LIG_SH2_STAT5 591 594 PF00017 0.608
LIG_SH3_3 204 210 PF00018 0.340
LIG_SH3_3 31 37 PF00018 0.593
LIG_SH3_3 398 404 PF00018 0.249
LIG_SUMO_SIM_anti_2 144 149 PF11976 0.347
LIG_SUMO_SIM_anti_2 240 246 PF11976 0.306
LIG_SUMO_SIM_anti_2 311 316 PF11976 0.425
LIG_SUMO_SIM_par_1 322 328 PF11976 0.226
LIG_SUMO_SIM_par_1 521 527 PF11976 0.353
LIG_TYR_ITIM 237 242 PF00017 0.340
LIG_TYR_ITIM 360 365 PF00017 0.241
LIG_TYR_ITIM 550 555 PF00017 0.329
LIG_UBA3_1 147 155 PF00899 0.260
LIG_Vh1_VBS_1 366 384 PF01044 0.234
LIG_WRC_WIRS_1 429 434 PF05994 0.272
LIG_WRC_WIRS_1 514 519 PF05994 0.226
MOD_CDC14_SPxK_1 42 45 PF00782 0.576
MOD_CDK_SPxK_1 39 45 PF00069 0.561
MOD_CK1_1 2 8 PF00069 0.636
MOD_CK1_1 209 215 PF00069 0.479
MOD_CK1_1 261 267 PF00069 0.365
MOD_CK1_1 325 331 PF00069 0.351
MOD_CK1_1 416 422 PF00069 0.319
MOD_CK1_1 428 434 PF00069 0.273
MOD_CK1_1 50 56 PF00069 0.658
MOD_CK2_1 573 579 PF00069 0.497
MOD_CK2_1 96 102 PF00069 0.671
MOD_GlcNHglycan 239 242 PF01048 0.464
MOD_GlcNHglycan 256 259 PF01048 0.343
MOD_GlcNHglycan 263 266 PF01048 0.348
MOD_GlcNHglycan 327 330 PF01048 0.331
MOD_GlcNHglycan 356 359 PF01048 0.457
MOD_GlcNHglycan 377 380 PF01048 0.317
MOD_GlcNHglycan 499 502 PF01048 0.249
MOD_GlcNHglycan 518 521 PF01048 0.271
MOD_GlcNHglycan 52 55 PF01048 0.566
MOD_GSK3_1 226 233 PF00069 0.444
MOD_GSK3_1 254 261 PF00069 0.351
MOD_GSK3_1 325 332 PF00069 0.358
MOD_GSK3_1 412 419 PF00069 0.291
MOD_GSK3_1 421 428 PF00069 0.291
MOD_GSK3_1 436 443 PF00069 0.455
MOD_GSK3_1 46 53 PF00069 0.797
MOD_GSK3_1 524 531 PF00069 0.299
MOD_GSK3_1 541 548 PF00069 0.263
MOD_GSK3_1 554 561 PF00069 0.278
MOD_GSK3_1 596 603 PF00069 0.533
MOD_N-GLC_1 18 23 PF02516 0.462
MOD_NEK2_1 1 6 PF00069 0.587
MOD_NEK2_1 118 123 PF00069 0.270
MOD_NEK2_1 20 25 PF00069 0.719
MOD_NEK2_1 216 221 PF00069 0.406
MOD_NEK2_1 254 259 PF00069 0.388
MOD_NEK2_1 303 308 PF00069 0.503
MOD_NEK2_1 322 327 PF00069 0.262
MOD_NEK2_1 425 430 PF00069 0.376
MOD_NEK2_1 436 441 PF00069 0.490
MOD_NEK2_1 541 546 PF00069 0.337
MOD_NEK2_1 573 578 PF00069 0.498
MOD_NEK2_2 167 172 PF00069 0.390
MOD_NEK2_2 558 563 PF00069 0.462
MOD_NEK2_2 596 601 PF00069 0.510
MOD_PIKK_1 589 595 PF00454 0.524
MOD_PKA_2 410 416 PF00069 0.332
MOD_PKA_2 440 446 PF00069 0.435
MOD_PKA_2 47 53 PF00069 0.668
MOD_PKA_2 87 93 PF00069 0.646
MOD_Plk_1 596 602 PF00069 0.530
MOD_Plk_4 216 222 PF00069 0.308
MOD_Plk_4 231 237 PF00069 0.351
MOD_Plk_4 258 264 PF00069 0.400
MOD_Plk_4 303 309 PF00069 0.514
MOD_Plk_4 310 316 PF00069 0.454
MOD_Plk_4 343 349 PF00069 0.269
MOD_Plk_4 388 394 PF00069 0.291
MOD_Plk_4 421 427 PF00069 0.291
MOD_Plk_4 487 493 PF00069 0.525
MOD_Plk_4 513 519 PF00069 0.362
MOD_Plk_4 541 547 PF00069 0.317
MOD_Plk_4 558 564 PF00069 0.429
MOD_Plk_4 596 602 PF00069 0.574
MOD_Plk_4 87 93 PF00069 0.648
MOD_ProDKin_1 206 212 PF00069 0.403
MOD_ProDKin_1 286 292 PF00069 0.241
MOD_ProDKin_1 39 45 PF00069 0.581
MOD_ProDKin_1 90 96 PF00069 0.652
TRG_DiLeu_BaEn_1 489 494 PF01217 0.492
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.272
TRG_ENDOCYTIC_2 213 216 PF00928 0.452
TRG_ENDOCYTIC_2 239 242 PF00928 0.356
TRG_ENDOCYTIC_2 362 365 PF00928 0.351
TRG_ENDOCYTIC_2 471 474 PF00928 0.447
TRG_ENDOCYTIC_2 552 555 PF00928 0.329
TRG_ENDOCYTIC_2 581 584 PF00928 0.479
TRG_ER_diArg_1 106 109 PF00400 0.635
TRG_ER_diArg_1 315 317 PF00400 0.561
TRG_NES_CRM1_1 359 374 PF08389 0.196
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.329

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9D8 Leptomonas seymouri 33% 100%
A0A0N1PA24 Leptomonas seymouri 56% 100%
A0A1X0P8J3 Trypanosomatidae 36% 100%
A0A3Q8I9V7 Leishmania donovani 88% 100%
A0A3S7XAV8 Leishmania donovani 37% 100%
A4H7J7 Leishmania braziliensis 77% 100%
A4HP90 Leishmania braziliensis 38% 100%
A4HVY0 Leishmania infantum 88% 100%
A4IDJ5 Leishmania infantum 37% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
Q4I8E9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 29% 100%
Q4Q1K0 Leishmania major 36% 100%
Q4QFU7 Leishmania major 87% 100%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS