CW-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APM9_LEIMU

TriTrypDb:

LmxM.14.0360

Length:

1034

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.740
CLV_C14_Caspase3-7	451	455	PF00656	0.787
CLV_C14_Caspase3-7	808	812	PF00656	0.753
CLV_C14_Caspase3-7	908	912	PF00656	0.766
CLV_C14_Caspase3-7	919	923	PF00656	0.853
CLV_NRD_NRD_1	200	202	PF00675	0.812
CLV_NRD_NRD_1	321	323	PF00675	0.625
CLV_NRD_NRD_1	343	345	PF00675	0.654
CLV_NRD_NRD_1	451	453	PF00675	0.716
CLV_NRD_NRD_1	545	547	PF00675	0.678
CLV_NRD_NRD_1	769	771	PF00675	0.653
CLV_NRD_NRD_1	777	779	PF00675	0.650
CLV_NRD_NRD_1	796	798	PF00675	0.678
CLV_NRD_NRD_1	865	867	PF00675	0.765
CLV_PCSK_KEX2_1	1024	1026	PF00082	0.642
CLV_PCSK_KEX2_1	1028	1030	PF00082	0.698
CLV_PCSK_KEX2_1	200	202	PF00082	0.816
CLV_PCSK_KEX2_1	212	214	PF00082	0.711
CLV_PCSK_KEX2_1	321	323	PF00082	0.625
CLV_PCSK_KEX2_1	342	344	PF00082	0.656
CLV_PCSK_KEX2_1	350	352	PF00082	0.602
CLV_PCSK_KEX2_1	545	547	PF00082	0.653
CLV_PCSK_KEX2_1	777	779	PF00082	0.728
CLV_PCSK_KEX2_1	789	791	PF00082	0.794
CLV_PCSK_KEX2_1	796	798	PF00082	0.656
CLV_PCSK_KEX2_1	863	865	PF00082	0.752
CLV_PCSK_PC1ET2_1	1024	1026	PF00082	0.562
CLV_PCSK_PC1ET2_1	1028	1030	PF00082	0.588
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.566
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.511
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.664
CLV_PCSK_PC1ET2_1	863	865	PF00082	0.752
CLV_PCSK_PC7_1	792	798	PF00082	0.547
CLV_PCSK_SKI1_1	165	169	PF00082	0.792
CLV_PCSK_SKI1_1	545	549	PF00082	0.699
CLV_PCSK_SKI1_1	746	750	PF00082	0.477
CLV_PCSK_SKI1_1	778	782	PF00082	0.717
CLV_PCSK_SKI1_1	860	864	PF00082	0.847
CLV_PCSK_SKI1_1	950	954	PF00082	0.763
CLV_PCSK_SKI1_1	98	102	PF00082	0.818
DEG_APCC_DBOX_1	578	586	PF00400	0.488
DEG_COP1_1	462	472	PF00400	0.711
DEG_Nend_UBRbox_2	1	3	PF02207	0.785
DEG_SCF_FBW7_1	886	892	PF00400	0.833
DEG_SCF_FBW7_2	724	730	PF00400	0.505
DEG_SCF_TRCP1_1	922	927	PF00400	0.843
DEG_SPOP_SBC_1	110	114	PF00917	0.740
DEG_SPOP_SBC_1	157	161	PF00917	0.668
DEG_SPOP_SBC_1	889	893	PF00917	0.767
DEG_SPOP_SBC_1	952	956	PF00917	0.648
DOC_ANK_TNKS_1	798	805	PF00023	0.543
DOC_CDC14_PxL_1	659	667	PF14671	0.672
DOC_CKS1_1	724	729	PF01111	0.704
DOC_CKS1_1	886	891	PF01111	0.844
DOC_CYCLIN_RxL_1	126	136	PF00134	0.728
DOC_CYCLIN_RxL_1	540	549	PF00134	0.625
DOC_CYCLIN_RxL_1	703	712	PF00134	0.834
DOC_MAPK_gen_1	350	358	PF00069	0.494
DOC_MAPK_gen_1	371	381	PF00069	0.546
DOC_MAPK_gen_1	509	517	PF00069	0.505
DOC_MAPK_gen_1	878	886	PF00069	0.825
DOC_MAPK_JIP1_4	264	270	PF00069	0.643
DOC_MAPK_MEF2A_6	264	272	PF00069	0.715
DOC_MAPK_MEF2A_6	371	379	PF00069	0.632
DOC_PP1_RVXF_1	53	59	PF00149	0.727
DOC_PP2B_LxvP_1	101	104	PF13499	0.546
DOC_PP2B_LxvP_1	402	405	PF13499	0.721
DOC_PP2B_LxvP_1	665	668	PF13499	0.707
DOC_PP4_FxxP_1	294	297	PF00568	0.560
DOC_PP4_FxxP_1	495	498	PF00568	0.503
DOC_USP7_MATH_1	109	113	PF00917	0.735
DOC_USP7_MATH_1	157	161	PF00917	0.754
DOC_USP7_MATH_1	173	177	PF00917	0.554
DOC_USP7_MATH_1	196	200	PF00917	0.758
DOC_USP7_MATH_1	242	246	PF00917	0.684
DOC_USP7_MATH_1	263	267	PF00917	0.555
DOC_USP7_MATH_1	718	722	PF00917	0.650
DOC_USP7_MATH_1	87	91	PF00917	0.640
DOC_USP7_MATH_1	887	891	PF00917	0.721
DOC_USP7_MATH_1	9	13	PF00917	0.723
DOC_USP7_MATH_1	952	956	PF00917	0.648
DOC_USP7_UBL2_3	1024	1028	PF12436	0.572
DOC_WW_Pin1_4	143	148	PF00397	0.845
DOC_WW_Pin1_4	238	243	PF00397	0.660
DOC_WW_Pin1_4	244	249	PF00397	0.586
DOC_WW_Pin1_4	407	412	PF00397	0.788
DOC_WW_Pin1_4	440	445	PF00397	0.739
DOC_WW_Pin1_4	47	52	PF00397	0.594
DOC_WW_Pin1_4	720	725	PF00397	0.758
DOC_WW_Pin1_4	73	78	PF00397	0.645
DOC_WW_Pin1_4	82	87	PF00397	0.734
DOC_WW_Pin1_4	865	870	PF00397	0.737
DOC_WW_Pin1_4	885	890	PF00397	0.843
DOC_WW_Pin1_4	943	948	PF00397	0.654
LIG_14-3-3_CanoR_1	134	140	PF00244	0.734
LIG_14-3-3_CanoR_1	163	168	PF00244	0.791
LIG_14-3-3_CanoR_1	232	238	PF00244	0.744
LIG_14-3-3_CanoR_1	264	269	PF00244	0.589
LIG_14-3-3_CanoR_1	344	353	PF00244	0.642
LIG_14-3-3_CanoR_1	474	479	PF00244	0.460
LIG_14-3-3_CanoR_1	496	505	PF00244	0.546
LIG_14-3-3_CanoR_1	581	586	PF00244	0.477
LIG_14-3-3_CanoR_1	777	781	PF00244	0.524
LIG_14-3-3_CanoR_1	864	869	PF00244	0.823
LIG_14-3-3_CanoR_1	98	104	PF00244	0.571
LIG_BIR_III_2	811	815	PF00653	0.742
LIG_BIR_III_4	172	176	PF00653	0.545
LIG_BRCT_BRCA1_1	268	272	PF00533	0.705
LIG_BRCT_BRCA1_1	386	390	PF00533	0.726
LIG_BRCT_BRCA1_1	491	495	PF00533	0.503
LIG_BRCT_BRCA1_1	569	573	PF00533	0.525
LIG_CtBP_PxDLS_1	676	680	PF00389	0.835
LIG_deltaCOP1_diTrp_1	756	762	PF00928	0.554
LIG_eIF4E_1	281	287	PF01652	0.566
LIG_FHA_1	128	134	PF00498	0.724
LIG_FHA_1	176	182	PF00498	0.545
LIG_FHA_1	281	287	PF00498	0.514
LIG_FHA_1	303	309	PF00498	0.367
LIG_FHA_1	34	40	PF00498	0.716
LIG_FHA_1	443	449	PF00498	0.647
LIG_FHA_1	460	466	PF00498	0.576
LIG_FHA_1	471	477	PF00498	0.562
LIG_FHA_1	542	548	PF00498	0.694
LIG_FHA_1	687	693	PF00498	0.672
LIG_FHA_1	92	98	PF00498	0.803
LIG_FHA_1	957	963	PF00498	0.736
LIG_FHA_1	967	973	PF00498	0.711
LIG_FHA_2	164	170	PF00498	0.745
LIG_FHA_2	449	455	PF00498	0.689
LIG_FHA_2	585	591	PF00498	0.343
LIG_FHA_2	747	753	PF00498	0.495
LIG_LIR_Apic_2	492	498	PF02991	0.508
LIG_LIR_Gen_1	1014	1023	PF02991	0.617
LIG_LIR_Gen_1	273	281	PF02991	0.599
LIG_LIR_Gen_1	483	494	PF02991	0.502
LIG_LIR_LC3C_4	326	330	PF02991	0.653
LIG_LIR_Nem_3	1014	1020	PF02991	0.631
LIG_LIR_Nem_3	273	278	PF02991	0.599
LIG_LIR_Nem_3	483	489	PF02991	0.465
LIG_MLH1_MIPbox_1	569	573	PF16413	0.567
LIG_MYND_1	663	667	PF01753	0.696
LIG_PCNA_yPIPBox_3	371	380	PF02747	0.637
LIG_Pex14_1	758	762	PF04695	0.536
LIG_RPA_C_Fungi	252	264	PF08784	0.692
LIG_SH2_CRK	310	314	PF00017	0.328
LIG_SH2_GRB2like	361	364	PF00017	0.487
LIG_SH2_NCK_1	521	525	PF00017	0.499
LIG_SH2_SRC	361	364	PF00017	0.472
LIG_SH2_SRC	521	524	PF00017	0.458
LIG_SH2_STAP1	281	285	PF00017	0.580
LIG_SH2_STAP1	361	365	PF00017	0.523
LIG_SH2_STAP1	521	525	PF00017	0.499
LIG_SH2_STAT5	277	280	PF00017	0.600
LIG_SH3_1	866	872	PF00018	0.647
LIG_SH3_3	137	143	PF00018	0.838
LIG_SH3_3	144	150	PF00018	0.831
LIG_SH3_3	236	242	PF00018	0.644
LIG_SH3_3	294	300	PF00018	0.634
LIG_SH3_3	405	411	PF00018	0.683
LIG_SH3_3	413	419	PF00018	0.729
LIG_SH3_3	427	433	PF00018	0.564
LIG_SH3_3	670	676	PF00018	0.709
LIG_SH3_3	721	727	PF00018	0.693
LIG_SH3_3	866	872	PF00018	0.671
LIG_SH3_3	881	887	PF00018	0.662
LIG_SH3_4	1015	1022	PF00018	0.420
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.590
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.580
LIG_SUMO_SIM_par_1	445	451	PF11976	0.690
LIG_SxIP_EBH_1	486	496	PF03271	0.611
LIG_TRAF2_1	247	250	PF00917	0.737
LIG_TYR_ITIM	308	313	PF00017	0.616
LIG_TYR_ITIM	365	370	PF00017	0.611
LIG_WRC_WIRS_1	568	573	PF05994	0.350
MOD_CDC14_SPxK_1	151	154	PF00782	0.770
MOD_CDK_SPK_2	865	870	PF00069	0.737
MOD_CDK_SPxK_1	148	154	PF00069	0.770
MOD_CDK_SPxxK_3	244	251	PF00069	0.752
MOD_CDK_SPxxK_3	943	950	PF00069	0.548
MOD_CK1_1	113	119	PF00069	0.727
MOD_CK1_1	121	127	PF00069	0.753
MOD_CK1_1	183	189	PF00069	0.782
MOD_CK1_1	211	217	PF00069	0.641
MOD_CK1_1	222	228	PF00069	0.807
MOD_CK1_1	233	239	PF00069	0.676
MOD_CK1_1	266	272	PF00069	0.633
MOD_CK1_1	407	413	PF00069	0.726
MOD_CK1_1	443	449	PF00069	0.681
MOD_CK1_1	597	603	PF00069	0.517
MOD_CK1_1	702	708	PF00069	0.648
MOD_CK1_1	723	729	PF00069	0.735
MOD_CK1_1	85	91	PF00069	0.826
MOD_CK1_1	890	896	PF00069	0.831
MOD_CK1_1	897	903	PF00069	0.779
MOD_CK1_1	904	910	PF00069	0.549
MOD_CK1_1	912	918	PF00069	0.789
MOD_CK1_1	929	935	PF00069	0.763
MOD_CK2_1	114	120	PF00069	0.702
MOD_CK2_1	222	228	PF00069	0.541
MOD_CK2_1	244	250	PF00069	0.594
MOD_CK2_1	497	503	PF00069	0.520
MOD_CK2_1	614	620	PF00069	0.612
MOD_Cter_Amidation	786	789	PF01082	0.640
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.748
MOD_GlcNHglycan	1030	1033	PF01048	0.691
MOD_GlcNHglycan	193	196	PF01048	0.765
MOD_GlcNHglycan	207	211	PF01048	0.703
MOD_GlcNHglycan	221	224	PF01048	0.773
MOD_GlcNHglycan	232	235	PF01048	0.750
MOD_GlcNHglycan	244	247	PF01048	0.732
MOD_GlcNHglycan	381	384	PF01048	0.597
MOD_GlcNHglycan	433	436	PF01048	0.755
MOD_GlcNHglycan	559	562	PF01048	0.622
MOD_GlcNHglycan	603	606	PF01048	0.525
MOD_GlcNHglycan	607	610	PF01048	0.499
MOD_GlcNHglycan	693	696	PF01048	0.824
MOD_GlcNHglycan	793	796	PF01048	0.841
MOD_GlcNHglycan	903	906	PF01048	0.744
MOD_GlcNHglycan	907	910	PF01048	0.741
MOD_GlcNHglycan	922	925	PF01048	0.740
MOD_GlcNHglycan	928	931	PF01048	0.831
MOD_GlcNHglycan	964	967	PF01048	0.676
MOD_GlcNHglycan	975	978	PF01048	0.620
MOD_GSK3_1	105	112	PF00069	0.735
MOD_GSK3_1	114	121	PF00069	0.775
MOD_GSK3_1	123	130	PF00069	0.693
MOD_GSK3_1	159	166	PF00069	0.700
MOD_GSK3_1	173	180	PF00069	0.702
MOD_GSK3_1	222	229	PF00069	0.696
MOD_GSK3_1	233	240	PF00069	0.771
MOD_GSK3_1	436	443	PF00069	0.718
MOD_GSK3_1	459	466	PF00069	0.699
MOD_GSK3_1	470	477	PF00069	0.470
MOD_GSK3_1	484	491	PF00069	0.314
MOD_GSK3_1	567	574	PF00069	0.429
MOD_GSK3_1	580	587	PF00069	0.366
MOD_GSK3_1	597	604	PF00069	0.565
MOD_GSK3_1	640	647	PF00069	0.548
MOD_GSK3_1	851	858	PF00069	0.570
MOD_GSK3_1	87	94	PF00069	0.717
MOD_GSK3_1	885	892	PF00069	0.758
MOD_GSK3_1	893	900	PF00069	0.782
MOD_GSK3_1	901	908	PF00069	0.811
MOD_GSK3_1	909	916	PF00069	0.842
MOD_GSK3_1	920	927	PF00069	0.725
MOD_GSK3_1	952	959	PF00069	0.716
MOD_GSK3_1	962	969	PF00069	0.723
MOD_GSK3_1	971	978	PF00069	0.780
MOD_GSK3_1	989	996	PF00069	0.626
MOD_N-GLC_1	157	162	PF02516	0.649
MOD_N-GLC_1	384	389	PF02516	0.438
MOD_N-GLC_1	541	546	PF02516	0.409
MOD_N-GLC_1	622	627	PF02516	0.499
MOD_N-GLC_1	88	93	PF02516	0.751
MOD_N-GLC_1	909	914	PF02516	0.846
MOD_N-GLC_1	920	925	PF02516	0.663
MOD_NEK2_1	127	132	PF00069	0.710
MOD_NEK2_1	133	138	PF00069	0.672
MOD_NEK2_1	286	291	PF00069	0.544
MOD_NEK2_1	379	384	PF00069	0.583
MOD_NEK2_1	436	441	PF00069	0.819
MOD_NEK2_1	485	490	PF00069	0.526
MOD_NEK2_1	571	576	PF00069	0.409
MOD_NEK2_1	61	66	PF00069	0.734
MOD_NEK2_1	614	619	PF00069	0.495
MOD_NEK2_1	765	770	PF00069	0.586
MOD_NEK2_1	99	104	PF00069	0.751
MOD_NEK2_2	366	371	PF00069	0.530
MOD_PIKK_1	286	292	PF00454	0.552
MOD_PIKK_1	597	603	PF00454	0.468
MOD_PIKK_1	614	620	PF00454	0.470
MOD_PIKK_1	88	94	PF00454	0.582
MOD_PKA_1	1028	1034	PF00069	0.705
MOD_PKA_1	343	349	PF00069	0.647
MOD_PKA_1	781	787	PF00069	0.794
MOD_PKA_1	788	794	PF00069	0.689
MOD_PKA_1	864	870	PF00069	0.772
MOD_PKA_2	1028	1034	PF00069	0.705
MOD_PKA_2	133	139	PF00069	0.747
MOD_PKA_2	196	202	PF00069	0.725
MOD_PKA_2	263	269	PF00069	0.621
MOD_PKA_2	343	349	PF00069	0.677
MOD_PKA_2	508	514	PF00069	0.633
MOD_PKA_2	580	586	PF00069	0.592
MOD_PKA_2	61	67	PF00069	0.732
MOD_PKA_2	614	620	PF00069	0.546
MOD_PKA_2	702	708	PF00069	0.614
MOD_PKA_2	765	771	PF00069	0.406
MOD_PKA_2	776	782	PF00069	0.499
MOD_PKA_2	791	797	PF00069	0.519
MOD_PKA_2	864	870	PF00069	0.772
MOD_PKB_1	163	171	PF00069	0.556
MOD_PKB_1	579	587	PF00069	0.496
MOD_Plk_1	622	628	PF00069	0.545
MOD_Plk_1	88	94	PF00069	0.634
MOD_Plk_4	324	330	PF00069	0.351
MOD_Plk_4	418	424	PF00069	0.728
MOD_Plk_4	443	449	PF00069	0.629
MOD_Plk_4	474	480	PF00069	0.478
MOD_Plk_4	567	573	PF00069	0.383
MOD_Plk_4	661	667	PF00069	0.688
MOD_Plk_4	9	15	PF00069	0.721
MOD_ProDKin_1	143	149	PF00069	0.845
MOD_ProDKin_1	238	244	PF00069	0.658
MOD_ProDKin_1	407	413	PF00069	0.791
MOD_ProDKin_1	440	446	PF00069	0.735
MOD_ProDKin_1	47	53	PF00069	0.595
MOD_ProDKin_1	720	726	PF00069	0.755
MOD_ProDKin_1	73	79	PF00069	0.647
MOD_ProDKin_1	82	88	PF00069	0.733
MOD_ProDKin_1	865	871	PF00069	0.738
MOD_ProDKin_1	885	891	PF00069	0.844
MOD_ProDKin_1	943	949	PF00069	0.649
MOD_SUMO_rev_2	1018	1026	PF00179	0.588
MOD_SUMO_rev_2	116	124	PF00179	0.756
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.615
TRG_ENDOCYTIC_2	310	313	PF00928	0.480
TRG_ENDOCYTIC_2	367	370	PF00928	0.502
TRG_ER_diArg_1	320	322	PF00400	0.599
TRG_ER_diArg_1	342	344	PF00400	0.671
TRG_ER_diArg_1	537	540	PF00400	0.685
TRG_ER_diArg_1	545	547	PF00400	0.577
TRG_ER_diArg_1	578	581	PF00400	0.293
TRG_ER_diArg_1	796	799	PF00400	0.621
TRG_ER_diArg_1	864	866	PF00400	0.731
TRG_NLS_Bipartite_1	770	792	PF00514	0.720
TRG_NLS_Bipartite_1	863	884	PF00514	0.745
TRG_NLS_MonoCore_2	862	867	PF00514	0.730
TRG_NLS_MonoExtC_3	787	792	PF00514	0.585
TRG_NLS_MonoExtN_4	788	793	PF00514	0.567
TRG_NLS_MonoExtN_4	860	867	PF00514	0.756
TRG_NLS_MonoExtN_4	878	884	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	1010	1014	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.846
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	873	877	PF00026	0.775

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH7	Leptomonas seymouri	39%	100%
A0A3S5H6R2	Leishmania donovani	86%	99%
A4H7J5	Leishmania braziliensis	66%	98%
A4HVX8	Leishmania infantum	85%	99%
Q4QFU9	Leishmania major	84%	100%