Putative threonine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

threonine synthase, putative

Species:

Leishmania mexicana

UniProt:

E9APM8_LEIMU

TriTrypDb:

LmxM.14.0350

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006566	threonine metabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009066	aspartate family amino acid metabolic process	5	2
GO:0009067	aspartate family amino acid biosynthetic process	6	2
GO:0009088	threonine biosynthetic process	7	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004795	threonine synthase activity	5	9
GO:0016829	lyase activity	2	9
GO:0016835	carbon-oxygen lyase activity	3	9
GO:0016838	carbon-oxygen lyase activity, acting on phosphates	4	9
GO:0005488	binding	1	2
GO:0019842	vitamin binding	3	2
GO:0030170	pyridoxal phosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0070279	vitamin B6 binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.678
CLV_C14_Caspase3-7	503	507	PF00656	0.370
CLV_NRD_NRD_1	429	431	PF00675	0.385
CLV_PCSK_KEX2_1	531	533	PF00082	0.234
CLV_PCSK_KEX2_1	97	99	PF00082	0.627
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.234
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.680
CLV_PCSK_SKI1_1	12	16	PF00082	0.460
CLV_PCSK_SKI1_1	19	23	PF00082	0.401
CLV_PCSK_SKI1_1	340	344	PF00082	0.314
CLV_PCSK_SKI1_1	531	535	PF00082	0.382
CLV_PCSK_SKI1_1	565	569	PF00082	0.604
CLV_PCSK_SKI1_1	631	635	PF00082	0.273
CLV_PCSK_SKI1_1	82	86	PF00082	0.430
DEG_APCC_DBOX_1	81	89	PF00400	0.462
DEG_Nend_Nbox_1	1	3	PF02207	0.451
DEG_SCF_FBW7_2	204	211	PF00400	0.440
DEG_SPOP_SBC_1	459	463	PF00917	0.447
DOC_CKS1_1	196	201	PF01111	0.383
DOC_CYCLIN_RxL_1	340	347	PF00134	0.335
DOC_CYCLIN_RxL_1	470	482	PF00134	0.316
DOC_CYCLIN_RxL_1	79	87	PF00134	0.490
DOC_MAPK_gen_1	9	18	PF00069	0.234
DOC_MAPK_HePTP_8	6	18	PF00069	0.231
DOC_MAPK_MEF2A_6	9	18	PF00069	0.288
DOC_PP2B_PxIxI_1	463	469	PF00149	0.300
DOC_PP4_FxxP_1	226	229	PF00568	0.592
DOC_PP4_FxxP_1	242	245	PF00568	0.385
DOC_PP4_FxxP_1	400	403	PF00568	0.341
DOC_PP4_FxxP_1	502	505	PF00568	0.421
DOC_PP4_FxxP_1	593	596	PF00568	0.405
DOC_USP7_MATH_1	222	226	PF00917	0.626
DOC_USP7_MATH_1	234	238	PF00917	0.429
DOC_USP7_MATH_1	277	281	PF00917	0.355
DOC_USP7_MATH_1	330	334	PF00917	0.405
DOC_USP7_MATH_1	459	463	PF00917	0.314
DOC_USP7_MATH_1	49	53	PF00917	0.549
DOC_USP7_MATH_1	570	574	PF00917	0.659
DOC_USP7_MATH_1	611	615	PF00917	0.565
DOC_USP7_MATH_1	70	74	PF00917	0.321
DOC_USP7_UBL2_3	631	635	PF12436	0.547
DOC_WW_Pin1_4	168	173	PF00397	0.387
DOC_WW_Pin1_4	195	200	PF00397	0.378
DOC_WW_Pin1_4	204	209	PF00397	0.595
DOC_WW_Pin1_4	307	312	PF00397	0.372
DOC_WW_Pin1_4	460	465	PF00397	0.300
LIG_14-3-3_CanoR_1	107	116	PF00244	0.457
LIG_14-3-3_CanoR_1	187	194	PF00244	0.480
LIG_14-3-3_CanoR_1	364	373	PF00244	0.275
LIG_14-3-3_CanoR_1	65	74	PF00244	0.434
LIG_BRCT_BRCA1_1	222	226	PF00533	0.598
LIG_Clathr_ClatBox_1	201	205	PF01394	0.345
LIG_DCNL_PONY_1	1	4	PF03556	0.414
LIG_FAT_LD_1	489	497	PF03623	0.450
LIG_FHA_1	1	7	PF00498	0.427
LIG_FHA_1	18	24	PF00498	0.232
LIG_FHA_1	196	202	PF00498	0.415
LIG_FHA_1	261	267	PF00498	0.388
LIG_FHA_1	313	319	PF00498	0.371
LIG_FHA_1	484	490	PF00498	0.357
LIG_FHA_1	496	502	PF00498	0.357
LIG_FHA_2	277	283	PF00498	0.300
LIG_FHA_2	339	345	PF00498	0.447
LIG_FHA_2	501	507	PF00498	0.402
LIG_FHA_2	573	579	PF00498	0.580
LIG_GBD_Chelix_1	488	496	PF00786	0.421
LIG_LIR_Apic_2	223	229	PF02991	0.600
LIG_LIR_Apic_2	240	245	PF02991	0.327
LIG_LIR_Gen_1	113	123	PF02991	0.320
LIG_LIR_Gen_1	440	451	PF02991	0.335
LIG_LIR_Gen_1	475	481	PF02991	0.357
LIG_LIR_Gen_1	587	598	PF02991	0.331
LIG_LIR_Nem_3	113	118	PF02991	0.320
LIG_LIR_Nem_3	173	179	PF02991	0.431
LIG_LIR_Nem_3	246	252	PF02991	0.300
LIG_LIR_Nem_3	370	376	PF02991	0.295
LIG_LIR_Nem_3	440	446	PF02991	0.335
LIG_LIR_Nem_3	475	480	PF02991	0.357
LIG_LIR_Nem_3	56	62	PF02991	0.511
LIG_LIR_Nem_3	587	593	PF02991	0.327
LIG_LYPXL_S_1	175	179	PF13949	0.421
LIG_LYPXL_yS_3	176	179	PF13949	0.421
LIG_PCNA_PIPBox_1	339	348	PF02747	0.293
LIG_PCNA_yPIPBox_3	231	242	PF02747	0.466
LIG_PCNA_yPIPBox_3	339	352	PF02747	0.329
LIG_PCNA_yPIPBox_3	439	447	PF02747	0.421
LIG_PCNA_yPIPBox_3	65	78	PF02747	0.496
LIG_Pex14_2	257	261	PF04695	0.300
LIG_SH2_CRK	271	275	PF00017	0.222
LIG_SH2_CRK	443	447	PF00017	0.447
LIG_SH2_PTP2	273	276	PF00017	0.335
LIG_SH2_SRC	154	157	PF00017	0.335
LIG_SH2_SRC	183	186	PF00017	0.414
LIG_SH2_SRC	626	629	PF00017	0.466
LIG_SH2_STAT5	130	133	PF00017	0.392
LIG_SH2_STAT5	145	148	PF00017	0.193
LIG_SH2_STAT5	154	157	PF00017	0.279
LIG_SH2_STAT5	260	263	PF00017	0.271
LIG_SH2_STAT5	273	276	PF00017	0.335
LIG_SH2_STAT5	383	386	PF00017	0.300
LIG_SH2_STAT5	420	423	PF00017	0.385
LIG_SH2_STAT5	479	482	PF00017	0.344
LIG_SH3_1	133	139	PF00018	0.421
LIG_SH3_3	133	139	PF00018	0.374
LIG_SH3_3	193	199	PF00018	0.385
LIG_SH3_3	299	305	PF00018	0.300
LIG_SH3_3	354	360	PF00018	0.462
LIG_SH3_3	388	394	PF00018	0.407
LIG_SH3_3	403	409	PF00018	0.151
LIG_SH3_3	51	57	PF00018	0.511
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.317
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.357
LIG_SUMO_SIM_anti_2	465	470	PF11976	0.300
LIG_SUMO_SIM_par_1	19	25	PF11976	0.329
LIG_SUMO_SIM_par_1	2	7	PF11976	0.519
LIG_SUMO_SIM_par_1	580	587	PF11976	0.377
LIG_TRAF2_1	618	621	PF00917	0.526
LIG_TRAF2_1	665	668	PF00917	0.228
LIG_TYR_ITIM	441	446	PF00017	0.385
LIG_TYR_ITSM	172	179	PF00017	0.447
LIG_UBA3_1	424	431	PF00899	0.383
LIG_WRC_WIRS_1	317	322	PF05994	0.421
MOD_CDK_SPxK_1	204	210	PF00069	0.651
MOD_CDK_SPxxK_3	307	314	PF00069	0.251
MOD_CK1_1	102	108	PF00069	0.389
MOD_CK1_1	110	116	PF00069	0.365
MOD_CK1_1	186	192	PF00069	0.460
MOD_CK1_1	280	286	PF00069	0.313
MOD_CK1_1	367	373	PF00069	0.300
MOD_CK1_1	462	468	PF00069	0.438
MOD_CK1_1	514	520	PF00069	0.156
MOD_CK1_1	537	543	PF00069	0.447
MOD_CK1_1	572	578	PF00069	0.662
MOD_CK1_1	69	75	PF00069	0.496
MOD_CK1_1	87	93	PF00069	0.430
MOD_CK2_1	234	240	PF00069	0.392
MOD_CK2_1	32	38	PF00069	0.570
MOD_CK2_1	338	344	PF00069	0.447
MOD_CK2_1	469	475	PF00069	0.300
MOD_CK2_1	70	76	PF00069	0.400
MOD_GlcNHglycan	222	225	PF01048	0.620
MOD_GlcNHglycan	279	282	PF01048	0.299
MOD_GlcNHglycan	288	291	PF01048	0.300
MOD_GlcNHglycan	29	32	PF01048	0.558
MOD_GlcNHglycan	36	41	PF01048	0.612
MOD_GlcNHglycan	366	369	PF01048	0.300
MOD_GlcNHglycan	417	420	PF01048	0.379
MOD_GlcNHglycan	50	54	PF01048	0.547
MOD_GlcNHglycan	537	540	PF01048	0.430
MOD_GlcNHglycan	68	71	PF01048	0.218
MOD_GlcNHglycan	78	81	PF01048	0.433
MOD_GlcNHglycan	89	92	PF01048	0.430
MOD_GSK3_1	134	141	PF00069	0.360
MOD_GSK3_1	166	173	PF00069	0.447
MOD_GSK3_1	260	267	PF00069	0.336
MOD_GSK3_1	276	283	PF00069	0.300
MOD_GSK3_1	312	319	PF00069	0.421
MOD_GSK3_1	32	39	PF00069	0.626
MOD_GSK3_1	363	370	PF00069	0.300
MOD_GSK3_1	4	11	PF00069	0.395
MOD_GSK3_1	458	465	PF00069	0.291
MOD_GSK3_1	479	486	PF00069	0.356
MOD_GSK3_1	565	572	PF00069	0.608
MOD_GSK3_1	66	73	PF00069	0.377
MOD_GSK3_1	99	106	PF00069	0.474
MOD_N-GLC_1	234	239	PF02516	0.414
MOD_N-GLC_1	321	326	PF02516	0.215
MOD_NEK2_1	103	108	PF00069	0.209
MOD_NEK2_1	276	281	PF00069	0.302
MOD_NEK2_1	29	34	PF00069	0.432
MOD_NEK2_1	4	9	PF00069	0.405
MOD_NEK2_1	445	450	PF00069	0.316
MOD_NEK2_1	458	463	PF00069	0.300
MOD_NEK2_1	469	474	PF00069	0.259
MOD_NEK2_1	534	539	PF00069	0.411
MOD_NEK2_1	66	71	PF00069	0.439
MOD_NEK2_1	84	89	PF00069	0.325
MOD_NEK2_2	338	343	PF00069	0.300
MOD_NEK2_2	526	531	PF00069	0.335
MOD_PIKK_1	138	144	PF00454	0.289
MOD_PIKK_1	264	270	PF00454	0.388
MOD_PIKK_1	295	301	PF00454	0.421
MOD_PIKK_1	312	318	PF00454	0.421
MOD_PIKK_1	321	327	PF00454	0.403
MOD_PKA_2	186	192	PF00069	0.439
MOD_PKA_2	363	369	PF00069	0.267
MOD_PKA_2	519	525	PF00069	0.323
MOD_PKA_2	8	14	PF00069	0.494
MOD_Plk_1	166	172	PF00069	0.313
MOD_Plk_1	234	240	PF00069	0.382
MOD_Plk_1	49	55	PF00069	0.507
MOD_Plk_4	171	177	PF00069	0.427
MOD_Plk_4	234	240	PF00069	0.367
MOD_Plk_4	38	44	PF00069	0.512
MOD_Plk_4	511	517	PF00069	0.218
MOD_Plk_4	99	105	PF00069	0.500
MOD_ProDKin_1	168	174	PF00069	0.387
MOD_ProDKin_1	195	201	PF00069	0.380
MOD_ProDKin_1	204	210	PF00069	0.598
MOD_ProDKin_1	307	313	PF00069	0.372
MOD_ProDKin_1	460	466	PF00069	0.300
MOD_SUMO_rev_2	11	16	PF00179	0.510
TRG_DiLeu_BaEn_2	110	116	PF01217	0.374
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.370
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.425
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.316
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.339
TRG_ENDOCYTIC_2	176	179	PF00928	0.421
TRG_ENDOCYTIC_2	271	274	PF00928	0.301
TRG_ENDOCYTIC_2	443	446	PF00928	0.385
TRG_ENDOCYTIC_2	626	629	PF00928	0.359
TRG_ENDOCYTIC_2	64	67	PF00928	0.384
TRG_ER_diArg_1	453	456	PF00400	0.335
TRG_NES_CRM1_1	13	25	PF08389	0.441
TRG_NES_CRM1_1	495	506	PF08389	0.156
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ2	Leptomonas seymouri	71%	99%
A0A0S4ITY7	Bodo saltans	46%	100%
A0A1X0NNP4	Trypanosomatidae	48%	100%
A0A3Q8II85	Leishmania donovani	93%	100%
A0A422NX69	Trypanosoma rangeli	53%	100%
A4H7J4	Leishmania braziliensis	85%	100%
A4HVX7	Leishmania infantum	93%	100%
C9ZT46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
O24924	Helicobacter pylori (strain ATCC 700392 / 26695)	30%	100%
P16120	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P23669	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	32%	100%
P29363	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	35%	100%
P37145	Methylobacillus glycogenes	32%	100%
Q00063	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	100%
Q2YDP8	Danio rerio	28%	100%
Q42598	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4QFV0	Leishmania major	92%	100%
Q5M7T9	Rattus norvegicus	28%	100%
Q5R5P3	Pongo abelii	38%	91%
Q5RFE6	Pongo abelii	28%	100%
Q5XH07	Xenopus laevis	28%	100%
Q80W22	Mus musculus	28%	100%
Q86YJ6	Homo sapiens	28%	100%
Q8BH55	Mus musculus	38%	91%
Q8IYQ7	Homo sapiens	38%	91%
Q9BH05	Macaca fascicularis	37%	91%
Q9ZMX5	Helicobacter pylori (strain J99 / ATCC 700824)	31%	100%
V5BD69	Trypanosoma cruzi	53%	100%