Aa_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane amino acid transporter protein, putative

Species:

Leishmania mexicana

UniProt:

E9APM6_LEIMU

TriTrypDb:

LmxM.14.0330

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9APM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM6

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.650
CLV_NRD_NRD_1	645	647	PF00675	0.294
CLV_NRD_NRD_1	651	653	PF00675	0.284
CLV_PCSK_KEX2_1	645	647	PF00082	0.290
CLV_PCSK_SKI1_1	300	304	PF00082	0.387
CLV_PCSK_SKI1_1	311	315	PF00082	0.355
CLV_PCSK_SKI1_1	363	367	PF00082	0.358
CLV_PCSK_SKI1_1	508	512	PF00082	0.336
CLV_PCSK_SKI1_1	581	585	PF00082	0.276
CLV_PCSK_SKI1_1	648	652	PF00082	0.350
DEG_Nend_UBRbox_1	1	4	PF02207	0.762
DEG_SCF_FBW7_1	24	31	PF00400	0.756
DEG_SPOP_SBC_1	396	400	PF00917	0.484
DOC_CDC14_PxL_1	279	287	PF14671	0.725
DOC_CKS1_1	110	115	PF01111	0.819
DOC_CKS1_1	25	30	PF01111	0.793
DOC_CKS1_1	33	38	PF01111	0.751
DOC_CYCLIN_RxL_1	502	516	PF00134	0.574
DOC_CYCLIN_RxL_1	652	661	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	319	325	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	635	641	PF00134	0.378
DOC_MAPK_gen_1	435	445	PF00069	0.515
DOC_MAPK_gen_1	508	517	PF00069	0.503
DOC_MAPK_gen_1	652	659	PF00069	0.536
DOC_MAPK_JIP1_4	56	62	PF00069	0.607
DOC_MAPK_JIP1_4	596	602	PF00069	0.531
DOC_MAPK_MEF2A_6	377	384	PF00069	0.550
DOC_MAPK_MEF2A_6	508	517	PF00069	0.481
DOC_PP1_RVXF_1	653	660	PF00149	0.550
DOC_PP2B_LxvP_1	319	322	PF13499	0.272
DOC_PP2B_LxvP_1	421	424	PF13499	0.377
DOC_PP2B_LxvP_1	635	638	PF13499	0.378
DOC_PP4_FxxP_1	22	25	PF00568	0.817
DOC_PP4_FxxP_1	613	616	PF00568	0.428
DOC_USP7_MATH_1	143	147	PF00917	0.787
DOC_USP7_MATH_1	155	159	PF00917	0.750
DOC_USP7_MATH_1	215	219	PF00917	0.728
DOC_USP7_MATH_1	256	260	PF00917	0.638
DOC_USP7_MATH_1	341	345	PF00917	0.443
DOC_USP7_MATH_1	396	400	PF00917	0.441
DOC_USP7_MATH_1	444	448	PF00917	0.432
DOC_USP7_MATH_1	534	538	PF00917	0.257
DOC_USP7_MATH_1	554	558	PF00917	0.321
DOC_USP7_MATH_1	79	83	PF00917	0.719
DOC_WW_Pin1_4	109	114	PF00397	0.770
DOC_WW_Pin1_4	15	20	PF00397	0.808
DOC_WW_Pin1_4	24	29	PF00397	0.785
DOC_WW_Pin1_4	32	37	PF00397	0.782
DOC_WW_Pin1_4	473	478	PF00397	0.363
DOC_WW_Pin1_4	692	697	PF00397	0.393
LIG_14-3-3_CanoR_1	107	113	PF00244	0.686
LIG_14-3-3_CanoR_1	514	518	PF00244	0.400
LIG_14-3-3_CanoR_1	52	56	PF00244	0.620
LIG_14-3-3_CanoR_1	553	562	PF00244	0.352
LIG_14-3-3_CanoR_1	588	595	PF00244	0.538
LIG_14-3-3_CanoR_1	601	605	PF00244	0.326
LIG_14-3-3_CanoR_1	652	658	PF00244	0.542
LIG_Actin_WH2_2	538	555	PF00022	0.360
LIG_Actin_WH2_2	637	654	PF00022	0.402
LIG_APCC_ABBA_1	364	369	PF00400	0.472
LIG_APCC_ABBAyCdc20_2	363	369	PF00400	0.490
LIG_BIR_III_2	288	292	PF00653	0.522
LIG_BRCT_BRCA1_1	217	221	PF00533	0.730
LIG_BRCT_BRCA1_1	306	310	PF00533	0.443
LIG_BRCT_BRCA1_1	319	323	PF00533	0.361
LIG_BRCT_BRCA1_1	477	481	PF00533	0.390
LIG_BRCT_BRCA1_1	609	613	PF00533	0.320
LIG_Clathr_ClatBox_1	457	461	PF01394	0.443
LIG_EH1_1	385	393	PF00400	0.400
LIG_eIF4E_1	367	373	PF01652	0.572
LIG_eIF4E_1	379	385	PF01652	0.303
LIG_eIF4E_1	386	392	PF01652	0.250
LIG_FHA_1	265	271	PF00498	0.756
LIG_FHA_1	314	320	PF00498	0.339
LIG_FHA_1	447	453	PF00498	0.391
LIG_FHA_1	495	501	PF00498	0.400
LIG_FHA_1	537	543	PF00498	0.301
LIG_FHA_1	570	576	PF00498	0.428
LIG_FHA_1	88	94	PF00498	0.812
LIG_FHA_2	180	186	PF00498	0.710
LIG_GBD_Chelix_1	620	628	PF00786	0.554
LIG_HP1_1	430	434	PF01393	0.443
LIG_IRF3_LxIS_1	597	603	PF10401	0.473
LIG_IRF3_LxIS_1	620	625	PF10401	0.331
LIG_LIR_Apic_2	610	616	PF02991	0.412
LIG_LIR_Gen_1	478	489	PF02991	0.325
LIG_LIR_Gen_1	520	529	PF02991	0.400
LIG_LIR_Gen_1	603	612	PF02991	0.439
LIG_LIR_Gen_1	661	670	PF02991	0.492
LIG_LIR_LC3C_4	284	287	PF02991	0.664
LIG_LIR_Nem_3	307	313	PF02991	0.367
LIG_LIR_Nem_3	478	484	PF02991	0.332
LIG_LIR_Nem_3	520	524	PF02991	0.400
LIG_LIR_Nem_3	530	535	PF02991	0.324
LIG_LIR_Nem_3	590	595	PF02991	0.537
LIG_LIR_Nem_3	603	607	PF02991	0.377
LIG_LIR_Nem_3	614	620	PF02991	0.400
LIG_LIR_Nem_3	656	662	PF02991	0.483
LIG_LYPXL_yS_3	379	382	PF13949	0.369
LIG_MAD2	363	371	PF02301	0.530
LIG_MLH1_MIPbox_1	477	481	PF16413	0.390
LIG_MYND_1	24	28	PF01753	0.750
LIG_PDZ_Class_3	694	699	PF00595	0.486
LIG_Pex14_1	375	379	PF04695	0.493
LIG_Pex14_1	49	53	PF04695	0.620
LIG_Pex14_2	306	310	PF04695	0.443
LIG_Pex14_2	666	670	PF04695	0.420
LIG_PTB_Apo_2	380	387	PF02174	0.443
LIG_PTB_Phospho_1	380	386	PF10480	0.443
LIG_SH2_CRK	386	390	PF00017	0.362
LIG_SH2_CRK	618	622	PF00017	0.271
LIG_SH2_CRK	671	675	PF00017	0.398
LIG_SH2_PTP2	662	665	PF00017	0.400
LIG_SH2_STAP1	346	350	PF00017	0.403
LIG_SH2_STAT3	464	467	PF00017	0.331
LIG_SH2_STAT5	351	354	PF00017	0.517
LIG_SH2_STAT5	509	512	PF00017	0.490
LIG_SH2_STAT5	604	607	PF00017	0.378
LIG_SH2_STAT5	643	646	PF00017	0.488
LIG_SH2_STAT5	662	665	PF00017	0.181
LIG_SH2_STAT5	87	90	PF00017	0.780
LIG_SH3_1	471	477	PF00018	0.273
LIG_SH3_2	466	471	PF14604	0.350
LIG_SH3_3	112	118	PF00018	0.693
LIG_SH3_3	22	28	PF00018	0.810
LIG_SH3_3	30	36	PF00018	0.772
LIG_SH3_3	463	469	PF00018	0.364
LIG_SH3_3	471	477	PF00018	0.273
LIG_SH3_3	500	506	PF00018	0.561
LIG_Sin3_3	556	563	PF02671	0.484
LIG_SUMO_SIM_anti_2	454	459	PF11976	0.462
LIG_SUMO_SIM_anti_2	564	569	PF11976	0.369
LIG_SUMO_SIM_par_1	441	447	PF11976	0.523
LIG_SUMO_SIM_par_1	448	454	PF11976	0.369
LIG_SUMO_SIM_par_1	496	501	PF11976	0.484
LIG_SUMO_SIM_par_1	620	625	PF11976	0.350
LIG_TRAF2_1	182	185	PF00917	0.735
LIG_TRAF2_1	45	48	PF00917	0.776
LIG_TRFH_1	53	57	PF08558	0.761
LIG_TYR_ITIM	365	370	PF00017	0.463
LIG_TYR_ITIM	384	389	PF00017	0.200
LIG_TYR_ITIM	602	607	PF00017	0.405
LIG_TYR_ITIM	615	620	PF00017	0.204
LIG_TYR_ITSM	588	595	PF00017	0.531
LIG_UBA3_1	405	412	PF00899	0.390
LIG_ULM_U2AF65_1	645	650	PF00076	0.531
LIG_WRC_WIRS_1	310	315	PF05994	0.379
MOD_CDK_SPxxK_3	109	116	PF00069	0.794
MOD_CK1_1	246	252	PF00069	0.686
MOD_CK1_1	259	265	PF00069	0.709
MOD_CK1_1	496	502	PF00069	0.484
MOD_CK1_1	541	547	PF00069	0.340
MOD_CK2_1	114	120	PF00069	0.782
MOD_CK2_1	179	185	PF00069	0.699
MOD_CK2_1	473	479	PF00069	0.330
MOD_CK2_1	89	95	PF00069	0.761
MOD_CMANNOS	375	378	PF00535	0.330
MOD_GlcNHglycan	140	143	PF01048	0.574
MOD_GlcNHglycan	145	148	PF01048	0.514
MOD_GlcNHglycan	157	160	PF01048	0.598
MOD_GlcNHglycan	165	170	PF01048	0.558
MOD_GlcNHglycan	258	261	PF01048	0.520
MOD_GlcNHglycan	414	417	PF01048	0.400
MOD_GlcNHglycan	529	532	PF01048	0.443
MOD_GlcNHglycan	556	559	PF01048	0.319
MOD_GlcNHglycan	6	9	PF01048	0.616
MOD_GlcNHglycan	607	610	PF01048	0.400
MOD_GlcNHglycan	624	627	PF01048	0.380
MOD_GlcNHglycan	681	684	PF01048	0.422
MOD_GlcNHglycan	81	84	PF01048	0.580
MOD_GSK3_1	105	112	PF00069	0.716
MOD_GSK3_1	123	130	PF00069	0.654
MOD_GSK3_1	165	172	PF00069	0.742
MOD_GSK3_1	20	27	PF00069	0.763
MOD_GSK3_1	225	232	PF00069	0.673
MOD_GSK3_1	243	250	PF00069	0.639
MOD_GSK3_1	256	263	PF00069	0.718
MOD_GSK3_1	28	35	PF00069	0.621
MOD_GSK3_1	309	316	PF00069	0.349
MOD_GSK3_1	336	343	PF00069	0.365
MOD_GSK3_1	489	496	PF00069	0.328
MOD_GSK3_1	51	58	PF00069	0.765
MOD_GSK3_1	513	520	PF00069	0.558
MOD_GSK3_1	534	541	PF00069	0.250
MOD_GSK3_1	607	614	PF00069	0.447
MOD_GSK3_1	620	627	PF00069	0.270
MOD_GSK3_1	69	76	PF00069	0.795
MOD_GSK3_1	89	96	PF00069	0.716
MOD_N-GLC_1	123	128	PF02516	0.571
MOD_N-GLC_1	39	44	PF02516	0.534
MOD_NEK2_1	105	110	PF00069	0.731
MOD_NEK2_1	238	243	PF00069	0.714
MOD_NEK2_1	306	311	PF00069	0.349
MOD_NEK2_1	313	318	PF00069	0.327
MOD_NEK2_1	336	341	PF00069	0.238
MOD_NEK2_1	397	402	PF00069	0.404
MOD_NEK2_1	446	451	PF00069	0.335
MOD_NEK2_1	484	489	PF00069	0.420
MOD_NEK2_1	513	518	PF00069	0.518
MOD_NEK2_1	527	532	PF00069	0.397
MOD_NEK2_1	543	548	PF00069	0.260
MOD_NEK2_1	561	566	PF00069	0.155
MOD_NEK2_1	584	589	PF00069	0.595
MOD_NEK2_1	600	605	PF00069	0.290
MOD_NEK2_1	607	612	PF00069	0.370
MOD_NEK2_1	620	625	PF00069	0.196
MOD_NEK2_2	169	174	PF00069	0.604
MOD_NEK2_2	51	56	PF00069	0.618
MOD_PIKK_1	232	238	PF00454	0.628
MOD_PIKK_1	436	442	PF00454	0.530
MOD_PKA_2	138	144	PF00069	0.802
MOD_PKA_2	179	185	PF00069	0.787
MOD_PKA_2	51	57	PF00069	0.734
MOD_PKA_2	513	519	PF00069	0.530
MOD_PKA_2	587	593	PF00069	0.531
MOD_PKA_2	600	606	PF00069	0.242
MOD_PKA_2	73	79	PF00069	0.827
MOD_Plk_1	39	45	PF00069	0.673
MOD_Plk_1	460	466	PF00069	0.449
MOD_Plk_4	225	231	PF00069	0.606
MOD_Plk_4	290	296	PF00069	0.593
MOD_Plk_4	422	428	PF00069	0.380
MOD_Plk_4	446	452	PF00069	0.368
MOD_Plk_4	484	490	PF00069	0.484
MOD_Plk_4	538	544	PF00069	0.330
MOD_Plk_4	563	569	PF00069	0.365
MOD_ProDKin_1	109	115	PF00069	0.765
MOD_ProDKin_1	15	21	PF00069	0.808
MOD_ProDKin_1	24	30	PF00069	0.785
MOD_ProDKin_1	32	38	PF00069	0.784
MOD_ProDKin_1	473	479	PF00069	0.363
MOD_ProDKin_1	692	698	PF00069	0.394
MOD_SUMO_rev_2	296	302	PF00179	0.567
TRG_ENDOCYTIC_2	194	197	PF00928	0.686
TRG_ENDOCYTIC_2	367	370	PF00928	0.471
TRG_ENDOCYTIC_2	379	382	PF00928	0.369
TRG_ENDOCYTIC_2	386	389	PF00928	0.432
TRG_ENDOCYTIC_2	509	512	PF00928	0.490
TRG_ENDOCYTIC_2	592	595	PF00928	0.514
TRG_ENDOCYTIC_2	604	607	PF00928	0.372
TRG_ENDOCYTIC_2	617	620	PF00928	0.191
TRG_ENDOCYTIC_2	662	665	PF00928	0.347
TRG_ENDOCYTIC_2	671	674	PF00928	0.350
TRG_ER_diArg_1	644	646	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C5	Leptomonas seymouri	68%	95%
A0A0N1PBG3	Leptomonas seymouri	36%	83%
A0A0S4ISI1	Bodo saltans	44%	100%
A0A1X0NNS0	Trypanosomatidae	47%	100%
A0A3S7WST2	Leishmania donovani	87%	98%
A4H7J2	Leishmania braziliensis	72%	100%
A4HVX5	Leishmania infantum	88%	98%
Q4QFV2	Leishmania major	80%	100%