Aa_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane amino acid transporter protein, putative

Species:

Leishmania mexicana

UniProt:

E9APM6_LEIMU

TriTrypDb:

LmxM.14.0330

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

E9APM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM6

Function

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Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.650
CLV_NRD_NRD_1	645	647	PF00675	0.294
CLV_NRD_NRD_1	651	653	PF00675	0.284
CLV_PCSK_KEX2_1	645	647	PF00082	0.290
CLV_PCSK_SKI1_1	300	304	PF00082	0.387
CLV_PCSK_SKI1_1	311	315	PF00082	0.355
CLV_PCSK_SKI1_1	363	367	PF00082	0.358
CLV_PCSK_SKI1_1	508	512	PF00082	0.336
CLV_PCSK_SKI1_1	581	585	PF00082	0.276
CLV_PCSK_SKI1_1	648	652	PF00082	0.350

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C5	Leptomonas seymouri	68%	95%
A0A0N1PBG3	Leptomonas seymouri	36%	83%
A0A0S4ISI1	Bodo saltans	44%	100%
A0A1X0NNS0	Trypanosomatidae	47%	100%
A0A3S7WST2	Leishmania donovani	87%	98%
A4H7J2	Leishmania braziliensis	72%	100%
A4HVX5	Leishmania infantum	88%	98%
Q4QFV2	Leishmania major	80%	100%

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