Putative amino acid permease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyamine transporter 1, putative

Species:

Leishmania mexicana

UniProt:

E9APM5_LEIMU

TriTrypDb:

LmxM.14.0320

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9APM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM5

Function

Biological processes
Term	Name	Level	Count
GO:0000296	spermine transport	6	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0009987	cellular process	1	1
GO:0015695	organic cation transport	5	1
GO:0015846	polyamine transport	5	1
GO:0015847	putrescine transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:1902047	polyamine transmembrane transport	3	1
GO:1903710	spermine transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0015203	polyamine transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0015489	putrescine transmembrane transporter activity	4	1
GO:0015606	spermidine transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	304	306	PF00675	0.348
CLV_NRD_NRD_1	61	63	PF00675	0.553
CLV_NRD_NRD_1	612	614	PF00675	0.504
CLV_NRD_NRD_1	73	75	PF00675	0.479
CLV_NRD_NRD_1	779	781	PF00675	0.518
CLV_NRD_NRD_1	793	795	PF00675	0.625
CLV_NRD_NRD_1	80	82	PF00675	0.515
CLV_NRD_NRD_1	86	88	PF00675	0.504
CLV_PCSK_FUR_1	59	63	PF00082	0.538
CLV_PCSK_KEX2_1	304	306	PF00082	0.363
CLV_PCSK_KEX2_1	61	63	PF00082	0.538
CLV_PCSK_KEX2_1	612	614	PF00082	0.504
CLV_PCSK_KEX2_1	73	75	PF00082	0.479
CLV_PCSK_KEX2_1	779	781	PF00082	0.470
CLV_PCSK_KEX2_1	80	82	PF00082	0.515
CLV_PCSK_KEX2_1	86	88	PF00082	0.504
CLV_PCSK_SKI1_1	264	268	PF00082	0.419
CLV_PCSK_SKI1_1	304	308	PF00082	0.346
CLV_PCSK_SKI1_1	360	364	PF00082	0.411
CLV_PCSK_SKI1_1	447	451	PF00082	0.411
CLV_PCSK_SKI1_1	48	52	PF00082	0.500
CLV_PCSK_SKI1_1	613	617	PF00082	0.436
DEG_APCC_DBOX_1	94	102	PF00400	0.546
DEG_Nend_UBRbox_1	1	4	PF02207	0.783
DOC_CKS1_1	410	415	PF01111	0.411
DOC_CKS1_1	592	597	PF01111	0.676
DOC_CYCLIN_RxL_1	444	454	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.411
DOC_MAPK_DCC_7	409	419	PF00069	0.411
DOC_MAPK_gen_1	27	34	PF00069	0.616
DOC_MAPK_JIP1_4	467	473	PF00069	0.619
DOC_MAPK_MEF2A_6	264	271	PF00069	0.619
DOC_MAPK_MEF2A_6	309	316	PF00069	0.546
DOC_MAPK_NFAT4_5	309	317	PF00069	0.530
DOC_PP1_RVXF_1	271	277	PF00149	0.547
DOC_PP2B_LxvP_1	583	586	PF13499	0.815
DOC_PP2B_LxvP_1	759	762	PF13499	0.754
DOC_PP2B_PxIxI_1	414	420	PF00149	0.411
DOC_USP7_MATH_1	155	159	PF00917	0.546
DOC_USP7_MATH_1	16	20	PF00917	0.718
DOC_USP7_MATH_1	172	176	PF00917	0.546
DOC_USP7_MATH_1	328	332	PF00917	0.411
DOC_USP7_MATH_1	497	501	PF00917	0.411
DOC_USP7_MATH_1	599	603	PF00917	0.726
DOC_USP7_MATH_1	620	624	PF00917	0.774
DOC_USP7_MATH_1	708	712	PF00917	0.768
DOC_USP7_MATH_1	724	728	PF00917	0.656
DOC_USP7_MATH_1	763	767	PF00917	0.790
DOC_WW_Pin1_4	409	414	PF00397	0.411
DOC_WW_Pin1_4	586	591	PF00397	0.644
DOC_WW_Pin1_4	602	607	PF00397	0.812
DOC_WW_Pin1_4	632	637	PF00397	0.632
DOC_WW_Pin1_4	661	666	PF00397	0.761
DOC_WW_Pin1_4	719	724	PF00397	0.790
DOC_WW_Pin1_4	750	755	PF00397	0.739
DOC_WW_Pin1_4	769	774	PF00397	0.749
DOC_WW_Pin1_4	778	783	PF00397	0.703
LIG_14-3-3_CanoR_1	612	621	PF00244	0.771
LIG_14-3-3_CanoR_1	95	104	PF00244	0.619
LIG_Actin_WH2_2	60	75	PF00022	0.719
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.619
LIG_BRCT_BRCA1_1	258	262	PF00533	0.619
LIG_BRCT_BRCA1_1	429	433	PF00533	0.389
LIG_BRCT_BRCA1_2	258	264	PF00533	0.466
LIG_Clathr_ClatBox_1	629	633	PF01394	0.645
LIG_deltaCOP1_diTrp_1	357	364	PF00928	0.346
LIG_eIF4E_1	444	450	PF01652	0.411
LIG_FHA_1	128	134	PF00498	0.411
LIG_FHA_1	180	186	PF00498	0.546
LIG_FHA_1	26	32	PF00498	0.616
LIG_FHA_1	380	386	PF00498	0.411
LIG_FHA_1	432	438	PF00498	0.419
LIG_FHA_1	476	482	PF00498	0.502
LIG_FHA_1	669	675	PF00498	0.835
LIG_FHA_1	73	79	PF00498	0.707
LIG_FHA_1	783	789	PF00498	0.796
LIG_FHA_1	98	104	PF00498	0.411
LIG_FHA_2	572	578	PF00498	0.786
LIG_FHA_2	614	620	PF00498	0.844
LIG_FHA_2	633	639	PF00498	0.617
LIG_FHA_2	720	726	PF00498	0.834
LIG_LIR_Gen_1	175	184	PF02991	0.546
LIG_LIR_Gen_1	278	288	PF02991	0.562
LIG_LIR_Gen_1	430	439	PF02991	0.345
LIG_LIR_Gen_1	518	526	PF02991	0.595
LIG_LIR_LC3C_4	130	133	PF02991	0.299
LIG_LIR_Nem_3	175	179	PF02991	0.546
LIG_LIR_Nem_3	182	187	PF02991	0.546
LIG_LIR_Nem_3	192	196	PF02991	0.546
LIG_LIR_Nem_3	278	283	PF02991	0.552
LIG_LIR_Nem_3	284	290	PF02991	0.555
LIG_LIR_Nem_3	317	322	PF02991	0.411
LIG_LIR_Nem_3	357	361	PF02991	0.346
LIG_LIR_Nem_3	430	436	PF02991	0.345
LIG_LIR_Nem_3	461	465	PF02991	0.546
LIG_LIR_Nem_3	518	524	PF02991	0.591
LIG_LIR_Nem_3	666	672	PF02991	0.742
LIG_LYPXL_yS_3	193	196	PF13949	0.546
LIG_LYPXL_yS_3	462	465	PF13949	0.546
LIG_NRBOX	445	451	PF00104	0.513
LIG_PDZ_Class_1	798	803	PF00595	0.789
LIG_Pex14_1	139	143	PF04695	0.411
LIG_Pex14_1	276	280	PF04695	0.546
LIG_Pex14_2	104	108	PF04695	0.411
LIG_Pex14_2	258	262	PF04695	0.546
LIG_PTB_Apo_2	187	194	PF02174	0.546
LIG_PTB_Phospho_1	187	193	PF10480	0.546
LIG_SH2_CRK	452	456	PF00017	0.411
LIG_SH2_CRK	469	473	PF00017	0.546
LIG_SH2_CRK	521	525	PF00017	0.607
LIG_SH2_GRB2like	287	290	PF00017	0.546
LIG_SH2_NCK_1	287	291	PF00017	0.546
LIG_SH2_NCK_1	469	473	PF00017	0.619
LIG_SH2_PTP2	268	271	PF00017	0.530
LIG_SH2_PTP2	322	325	PF00017	0.411
LIG_SH2_SRC	268	271	PF00017	0.531
LIG_SH2_SRC	287	290	PF00017	0.611
LIG_SH2_STAP1	200	204	PF00017	0.546
LIG_SH2_STAP1	452	456	PF00017	0.411
LIG_SH2_STAT3	200	203	PF00017	0.546
LIG_SH2_STAT3	634	637	PF00017	0.833
LIG_SH2_STAT5	268	271	PF00017	0.530
LIG_SH2_STAT5	319	322	PF00017	0.409
LIG_SH2_STAT5	444	447	PF00017	0.411
LIG_SH2_STAT5	521	524	PF00017	0.559
LIG_SH2_STAT5	634	637	PF00017	0.715
LIG_SH3_1	794	800	PF00018	0.786
LIG_SH3_3	19	25	PF00018	0.708
LIG_SH3_3	297	303	PF00018	0.546
LIG_SH3_3	460	466	PF00018	0.539
LIG_SH3_3	478	484	PF00018	0.305
LIG_SH3_3	589	595	PF00018	0.624
LIG_SH3_3	793	799	PF00018	0.731
LIG_SH3_CIN85_PxpxPR_1	595	600	PF14604	0.673
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.411
LIG_SUMO_SIM_anti_2	421	428	PF11976	0.513
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.502
LIG_SUMO_SIM_par_1	312	318	PF11976	0.513
LIG_SxIP_EBH_1	409	420	PF03271	0.411
LIG_TRAF2_1	565	568	PF00917	0.758
LIG_TRAF2_1	625	628	PF00917	0.847
LIG_TRAF2_1	711	714	PF00917	0.785
LIG_TRAF2_1	715	718	PF00917	0.784
LIG_TYR_ITIM	266	271	PF00017	0.530
LIG_TYR_ITIM	450	455	PF00017	0.411
LIG_TYR_ITIM	460	465	PF00017	0.546
LIG_WRC_WIRS_1	173	178	PF05994	0.546
LIG_WRC_WIRS_1	184	189	PF05994	0.546
MOD_CK1_1	250	256	PF00069	0.246
MOD_CK1_1	281	287	PF00069	0.546
MOD_CK1_1	421	427	PF00069	0.411
MOD_CK1_1	435	441	PF00069	0.411
MOD_CK1_1	493	499	PF00069	0.361
MOD_CK1_1	515	521	PF00069	0.471
MOD_CK1_1	556	562	PF00069	0.758
MOD_CK1_1	57	63	PF00069	0.675
MOD_CK1_1	571	577	PF00069	0.627
MOD_CK1_1	602	608	PF00069	0.807
MOD_CK1_1	664	670	PF00069	0.757
MOD_CK1_1	766	772	PF00069	0.794
MOD_CK1_1	97	103	PF00069	0.389
MOD_CK2_1	41	47	PF00069	0.736
MOD_CK2_1	613	619	PF00069	0.810
MOD_CK2_1	708	714	PF00069	0.746
MOD_CK2_1	719	725	PF00069	0.759
MOD_Cter_Amidation	777	780	PF01082	0.447
MOD_DYRK1A_RPxSP_1	771	775	PF00069	0.794
MOD_GlcNHglycan	123	126	PF01048	0.513
MOD_GlcNHglycan	159	162	PF01048	0.346
MOD_GlcNHglycan	208	211	PF01048	0.230
MOD_GlcNHglycan	330	333	PF01048	0.411
MOD_GlcNHglycan	369	372	PF01048	0.433
MOD_GlcNHglycan	495	498	PF01048	0.595
MOD_GlcNHglycan	51	54	PF01048	0.491
MOD_GlcNHglycan	514	517	PF01048	0.257
MOD_GlcNHglycan	540	543	PF01048	0.493
MOD_GlcNHglycan	555	558	PF01048	0.539
MOD_GlcNHglycan	56	59	PF01048	0.452
MOD_GlcNHglycan	570	573	PF01048	0.407
MOD_GlcNHglycan	649	652	PF01048	0.504
MOD_GlcNHglycan	658	661	PF01048	0.445
MOD_GlcNHglycan	666	669	PF01048	0.418
MOD_GlcNHglycan	710	713	PF01048	0.521
MOD_GlcNHglycan	714	717	PF01048	0.513
MOD_GlcNHglycan	725	729	PF01048	0.563
MOD_GlcNHglycan	733	736	PF01048	0.569
MOD_GlcNHglycan	776	779	PF01048	0.597
MOD_GSK3_1	151	158	PF00069	0.546
MOD_GSK3_1	179	186	PF00069	0.546
MOD_GSK3_1	375	382	PF00069	0.411
MOD_GSK3_1	421	428	PF00069	0.411
MOD_GSK3_1	431	438	PF00069	0.346
MOD_GSK3_1	471	478	PF00069	0.484
MOD_GSK3_1	486	493	PF00069	0.339
MOD_GSK3_1	664	671	PF00069	0.711
MOD_GSK3_1	697	704	PF00069	0.762
MOD_GSK3_1	708	715	PF00069	0.738
MOD_GSK3_1	729	736	PF00069	0.820
MOD_GSK3_1	763	770	PF00069	0.757
MOD_GSK3_1	774	781	PF00069	0.764
MOD_N-GLC_1	189	194	PF02516	0.346
MOD_N-GLC_1	235	240	PF02516	0.466
MOD_N-GLC_1	553	558	PF02516	0.474
MOD_N-GLC_1	647	652	PF02516	0.567
MOD_N-GLC_1	701	706	PF02516	0.469
MOD_N-GLC_1	788	793	PF02516	0.598
MOD_NEK2_1	314	319	PF00069	0.411
MOD_NEK2_1	374	379	PF00069	0.472
MOD_NEK2_1	418	423	PF00069	0.411
MOD_NEK2_1	425	430	PF00069	0.411
MOD_NEK2_1	431	436	PF00069	0.346
MOD_NEK2_1	439	444	PF00069	0.411
MOD_NEK2_1	49	54	PF00069	0.713
MOD_NEK2_1	490	495	PF00069	0.443
MOD_NEK2_1	656	661	PF00069	0.783
MOD_NEK2_1	731	736	PF00069	0.804
MOD_NEK2_1	790	795	PF00069	0.803
MOD_NEK2_2	678	683	PF00069	0.792
MOD_PIKK_1	604	610	PF00454	0.789
MOD_PIKK_1	620	626	PF00454	0.641
MOD_PKA_1	397	403	PF00069	0.546
MOD_PKA_2	568	574	PF00069	0.680
MOD_PKA_2	599	605	PF00069	0.773
MOD_PKA_2	72	78	PF00069	0.696
MOD_PKA_2	94	100	PF00069	0.576
MOD_PKB_1	685	693	PF00069	0.780
MOD_Plk_1	189	195	PF00069	0.546
MOD_Plk_1	235	241	PF00069	0.266
MOD_Plk_1	431	437	PF00069	0.346
MOD_Plk_1	553	559	PF00069	0.674
MOD_Plk_1	678	684	PF00069	0.846
MOD_Plk_4	172	178	PF00069	0.569
MOD_Plk_4	179	185	PF00069	0.521
MOD_Plk_4	235	241	PF00069	0.346
MOD_Plk_4	250	256	PF00069	0.411
MOD_Plk_4	315	321	PF00069	0.389
MOD_Plk_4	418	424	PF00069	0.409
MOD_Plk_4	432	438	PF00069	0.352
MOD_Plk_4	439	445	PF00069	0.394
MOD_Plk_4	451	457	PF00069	0.411
MOD_Plk_4	490	496	PF00069	0.569
MOD_Plk_4	515	521	PF00069	0.469
MOD_ProDKin_1	409	415	PF00069	0.411
MOD_ProDKin_1	586	592	PF00069	0.645
MOD_ProDKin_1	602	608	PF00069	0.812
MOD_ProDKin_1	632	638	PF00069	0.631
MOD_ProDKin_1	661	667	PF00069	0.762
MOD_ProDKin_1	719	725	PF00069	0.789
MOD_ProDKin_1	750	756	PF00069	0.738
MOD_ProDKin_1	769	775	PF00069	0.749
MOD_ProDKin_1	778	784	PF00069	0.703
MOD_SUMO_rev_2	44	50	PF00179	0.740
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.411
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.546
TRG_ENDOCYTIC_2	193	196	PF00928	0.546
TRG_ENDOCYTIC_2	268	271	PF00928	0.531
TRG_ENDOCYTIC_2	287	290	PF00928	0.611
TRG_ENDOCYTIC_2	361	364	PF00928	0.411
TRG_ENDOCYTIC_2	452	455	PF00928	0.411
TRG_ENDOCYTIC_2	462	465	PF00928	0.546
TRG_ENDOCYTIC_2	521	524	PF00928	0.601
TRG_ER_diArg_1	303	305	PF00400	0.563
TRG_ER_diArg_1	59	62	PF00400	0.739
TRG_ER_diArg_1	611	613	PF00400	0.659
TRG_ER_diArg_1	682	685	PF00400	0.742
TRG_ER_diArg_1	72	74	PF00400	0.687
TRG_ER_diArg_1	79	81	PF00400	0.697
TRG_ER_diArg_1	85	87	PF00400	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U3	Leptomonas seymouri	64%	99%
A0A3S7WSV4	Leishmania donovani	91%	100%
A4H7J1	Leishmania braziliensis	77%	99%
A4HVX4	Leishmania infantum	91%	100%
Q5C8V6	Leishmania major	90%	100%