Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APM3_LEIMU

TriTrypDb:

LmxM.14.0300

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.465
CLV_NRD_NRD_1	15	17	PF00675	0.614
CLV_NRD_NRD_1	195	197	PF00675	0.576
CLV_NRD_NRD_1	82	84	PF00675	0.765
CLV_PCSK_KEX2_1	195	197	PF00082	0.576
CLV_PCSK_KEX2_1	82	84	PF00082	0.676
DOC_MAPK_gen_1	195	203	PF00069	0.488
DOC_MAPK_gen_1	227	233	PF00069	0.587
DOC_USP7_MATH_1	128	132	PF00917	0.531
DOC_USP7_MATH_1	149	153	PF00917	0.621
DOC_USP7_MATH_1	46	50	PF00917	0.626
DOC_USP7_UBL2_3	17	21	PF12436	0.610
DOC_USP7_UBL2_3	228	232	PF12436	0.589
DOC_WW_Pin1_4	144	149	PF00397	0.688
DOC_WW_Pin1_4	42	47	PF00397	0.630
LIG_14-3-3_CanoR_1	195	200	PF00244	0.552
LIG_14-3-3_CanoR_1	96	102	PF00244	0.554
LIG_Actin_WH2_2	174	191	PF00022	0.610
LIG_APCC_ABBA_1	99	104	PF00400	0.529
LIG_FHA_1	112	118	PF00498	0.739
LIG_FHA_1	13	19	PF00498	0.554
LIG_FHA_1	176	182	PF00498	0.602
LIG_FHA_1	196	202	PF00498	0.325
LIG_FHA_2	149	155	PF00498	0.475
LIG_FHA_2	42	48	PF00498	0.626
LIG_FHA_2	58	64	PF00498	0.573
LIG_LIR_Gen_1	209	216	PF02991	0.527
LIG_LIR_Gen_1	49	59	PF02991	0.644
LIG_LIR_Nem_3	157	163	PF02991	0.397
LIG_LIR_Nem_3	209	213	PF02991	0.498
LIG_LIR_Nem_3	214	220	PF02991	0.483
LIG_LIR_Nem_3	49	55	PF02991	0.638
LIG_LIR_Nem_3	97	102	PF02991	0.526
LIG_NRBOX	71	77	PF00104	0.625
LIG_Pex14_1	4	8	PF04695	0.630
LIG_Pex14_2	206	210	PF04695	0.550
LIG_SH2_CRK	52	56	PF00017	0.652
LIG_SH2_SRC	102	105	PF00017	0.519
LIG_SH2_STAP1	8	12	PF00017	0.585
LIG_SH2_STAT3	161	164	PF00017	0.519
LIG_SH2_STAT5	161	164	PF00017	0.561
LIG_SH2_STAT5	19	22	PF00017	0.555
LIG_SH2_STAT5	52	55	PF00017	0.649
LIG_SH3_3	106	112	PF00018	0.746
LIG_TYR_ITIM	50	55	PF00017	0.641
MOD_CK1_1	27	33	PF00069	0.625
MOD_CK1_1	3	9	PF00069	0.589
MOD_CK1_1	87	93	PF00069	0.680
MOD_CK2_1	129	135	PF00069	0.755
MOD_CK2_1	206	212	PF00069	0.549
MOD_CK2_1	3	9	PF00069	0.561
MOD_CK2_1	97	103	PF00069	0.613
MOD_GlcNHglycan	26	29	PF01048	0.542
MOD_GlcNHglycan	5	8	PF01048	0.616
MOD_GlcNHglycan	86	89	PF01048	0.701
MOD_GSK3_1	140	147	PF00069	0.752
MOD_GSK3_1	177	184	PF00069	0.621
MOD_GSK3_1	42	49	PF00069	0.620
MOD_N-GLC_1	97	102	PF02516	0.515
MOD_NEK2_1	177	182	PF00069	0.595
MOD_NEK2_1	50	55	PF00069	0.660
MOD_NEK2_2	129	134	PF00069	0.533
MOD_NMyristoyl	1	7	PF02799	0.569
MOD_PKA_1	195	201	PF00069	0.559
MOD_PKA_2	195	201	PF00069	0.559
MOD_Plk_1	211	217	PF00069	0.522
MOD_Plk_1	97	103	PF00069	0.541
MOD_Plk_2-3	187	193	PF00069	0.534
MOD_Plk_4	177	183	PF00069	0.615
MOD_Plk_4	212	218	PF00069	0.553
MOD_Plk_4	46	52	PF00069	0.653
MOD_ProDKin_1	144	150	PF00069	0.680
MOD_ProDKin_1	42	48	PF00069	0.626
MOD_SUMO_for_1	226	229	PF00179	0.577
TRG_DiLeu_BaEn_1	221	226	PF01217	0.563
TRG_DiLeu_BaEn_2	167	173	PF01217	0.517
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.620
TRG_ENDOCYTIC_2	160	163	PF00928	0.521
TRG_ENDOCYTIC_2	174	177	PF00928	0.507
TRG_ENDOCYTIC_2	52	55	PF00928	0.649
TRG_ER_diArg_1	81	83	PF00400	0.745
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F1	Leptomonas seymouri	55%	67%
A0A3Q8IBX5	Leishmania donovani	93%	100%
A4H7I9	Leishmania braziliensis	83%	100%
A4HVX2	Leishmania infantum	93%	100%
C9ZT50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QFV5	Leishmania major	92%	100%
V5AXT5	Trypanosoma cruzi	32%	100%