Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 3, putative

Species:

Leishmania mexicana

UniProt:

E9APM1_LEIMU

TriTrypDb:

LmxM.14.0280

Length:

966

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9APM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APM1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	673	677	PF00656	0.479
CLV_C14_Caspase3-7	87	91	PF00656	0.489
CLV_C14_Caspase3-7	925	929	PF00656	0.672
CLV_C14_Caspase3-7	930	934	PF00656	0.631
CLV_NRD_NRD_1	165	167	PF00675	0.506
CLV_NRD_NRD_1	168	170	PF00675	0.502
CLV_NRD_NRD_1	222	224	PF00675	0.461
CLV_NRD_NRD_1	438	440	PF00675	0.499
CLV_NRD_NRD_1	459	461	PF00675	0.538
CLV_NRD_NRD_1	467	469	PF00675	0.481
CLV_NRD_NRD_1	540	542	PF00675	0.677
CLV_NRD_NRD_1	562	564	PF00675	0.542
CLV_NRD_NRD_1	599	601	PF00675	0.484
CLV_NRD_NRD_1	614	616	PF00675	0.319
CLV_NRD_NRD_1	634	636	PF00675	0.278
CLV_NRD_NRD_1	662	664	PF00675	0.450
CLV_NRD_NRD_1	772	774	PF00675	0.411
CLV_NRD_NRD_1	918	920	PF00675	0.813
CLV_PCSK_FUR_1	166	170	PF00082	0.244
CLV_PCSK_FUR_1	220	224	PF00082	0.416
CLV_PCSK_FUR_1	465	469	PF00082	0.532
CLV_PCSK_FUR_1	919	923	PF00082	0.652
CLV_PCSK_KEX2_1	165	167	PF00082	0.543
CLV_PCSK_KEX2_1	168	170	PF00082	0.524
CLV_PCSK_KEX2_1	191	193	PF00082	0.474
CLV_PCSK_KEX2_1	222	224	PF00082	0.460
CLV_PCSK_KEX2_1	288	290	PF00082	0.433
CLV_PCSK_KEX2_1	438	440	PF00082	0.499
CLV_PCSK_KEX2_1	458	460	PF00082	0.370
CLV_PCSK_KEX2_1	467	469	PF00082	0.466
CLV_PCSK_KEX2_1	540	542	PF00082	0.677
CLV_PCSK_KEX2_1	562	564	PF00082	0.542
CLV_PCSK_KEX2_1	614	616	PF00082	0.589
CLV_PCSK_KEX2_1	634	636	PF00082	0.278
CLV_PCSK_KEX2_1	662	664	PF00082	0.564
CLV_PCSK_KEX2_1	772	774	PF00082	0.417
CLV_PCSK_KEX2_1	921	923	PF00082	0.622
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.493
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.433
CLV_PCSK_PC1ET2_1	921	923	PF00082	0.622
CLV_PCSK_PC7_1	630	636	PF00082	0.564
CLV_PCSK_PC7_1	658	664	PF00082	0.544
CLV_PCSK_SKI1_1	168	172	PF00082	0.332
CLV_PCSK_SKI1_1	276	280	PF00082	0.505
CLV_PCSK_SKI1_1	397	401	PF00082	0.414
CLV_PCSK_SKI1_1	412	416	PF00082	0.494
CLV_PCSK_SKI1_1	431	435	PF00082	0.486
CLV_PCSK_SKI1_1	562	566	PF00082	0.402
CLV_PCSK_SKI1_1	594	598	PF00082	0.473
CLV_PCSK_SKI1_1	710	714	PF00082	0.424
CLV_PCSK_SKI1_1	823	827	PF00082	0.514
CLV_Separin_Metazoa	233	237	PF03568	0.498
DEG_APCC_DBOX_1	214	222	PF00400	0.390
DEG_APCC_DBOX_1	466	474	PF00400	0.512
DEG_APCC_DBOX_1	641	649	PF00400	0.460
DEG_APCC_DBOX_1	764	772	PF00400	0.380
DEG_COP1_1	205	214	PF00400	0.537
DEG_MDM2_SWIB_1	170	177	PF02201	0.245
DEG_Nend_Nbox_1	1	3	PF02207	0.526
DEG_ODPH_VHL_1	507	519	PF01847	0.542
DEG_SCF_FBW7_1	850	855	PF00400	0.613
DEG_SPOP_SBC_1	860	864	PF00917	0.670
DOC_ANK_TNKS_1	923	930	PF00023	0.636
DOC_CYCLIN_RxL_1	428	437	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.397
DOC_MAPK_DCC_7	642	650	PF00069	0.526
DOC_MAPK_gen_1	165	173	PF00069	0.459
DOC_MAPK_gen_1	597	606	PF00069	0.438
DOC_MAPK_gen_1	736	745	PF00069	0.402
DOC_MAPK_gen_1	772	778	PF00069	0.388
DOC_MAPK_gen_1	798	806	PF00069	0.405
DOC_MAPK_MEF2A_6	13	22	PF00069	0.208
DOC_MAPK_MEF2A_6	223	232	PF00069	0.445
DOC_MAPK_MEF2A_6	600	608	PF00069	0.434
DOC_MAPK_MEF2A_6	736	745	PF00069	0.377
DOC_MAPK_NFAT4_5	601	609	PF00069	0.431
DOC_MAPK_RevD_3	602	615	PF00069	0.499
DOC_PP1_RVXF_1	50	57	PF00149	0.309
DOC_PP2B_LxvP_1	18	21	PF13499	0.354
DOC_PP2B_LxvP_1	208	211	PF13499	0.390
DOC_PP2B_LxvP_1	358	361	PF13499	0.558
DOC_PP4_FxxP_1	199	202	PF00568	0.600
DOC_PP4_FxxP_1	415	418	PF00568	0.531
DOC_USP7_MATH_1	226	230	PF00917	0.355
DOC_USP7_MATH_1	475	479	PF00917	0.577
DOC_USP7_MATH_1	669	673	PF00917	0.282
DOC_USP7_MATH_1	860	864	PF00917	0.740
DOC_USP7_UBL2_3	187	191	PF12436	0.442
DOC_USP7_UBL2_3	597	601	PF12436	0.459
DOC_WW_Pin1_4	148	153	PF00397	0.571
DOC_WW_Pin1_4	311	316	PF00397	0.593
DOC_WW_Pin1_4	421	426	PF00397	0.526
DOC_WW_Pin1_4	831	836	PF00397	0.557
DOC_WW_Pin1_4	846	851	PF00397	0.651
LIG_14-3-3_CanoR_1	115	121	PF00244	0.303
LIG_14-3-3_CanoR_1	168	174	PF00244	0.466
LIG_14-3-3_CanoR_1	220	226	PF00244	0.534
LIG_14-3-3_CanoR_1	227	233	PF00244	0.468
LIG_14-3-3_CanoR_1	402	407	PF00244	0.540
LIG_14-3-3_CanoR_1	658	662	PF00244	0.398
LIG_14-3-3_CanoR_1	663	670	PF00244	0.432
LIG_14-3-3_CanoR_1	710	719	PF00244	0.341
LIG_14-3-3_CanoR_1	773	779	PF00244	0.474
LIG_14-3-3_CanoR_1	97	101	PF00244	0.477
LIG_Actin_WH2_2	645	660	PF00022	0.360
LIG_APCC_ABBA_1	743	748	PF00400	0.336
LIG_BIR_III_4	890	894	PF00653	0.569
LIG_BRCT_BRCA1_1	436	440	PF00533	0.624
LIG_BRCT_BRCA1_1	477	481	PF00533	0.472
LIG_BRCT_BRCA1_1	92	96	PF00533	0.507
LIG_DLG_GKlike_1	402	409	PF00625	0.556
LIG_FHA_1	229	235	PF00498	0.321
LIG_FHA_1	366	372	PF00498	0.426
LIG_FHA_1	525	531	PF00498	0.654
LIG_FHA_1	547	553	PF00498	0.606
LIG_FHA_1	711	717	PF00498	0.348
LIG_FHA_1	724	730	PF00498	0.391
LIG_FHA_1	778	784	PF00498	0.441
LIG_FHA_1	80	86	PF00498	0.473
LIG_FHA_2	183	189	PF00498	0.529
LIG_FHA_2	261	267	PF00498	0.449
LIG_FHA_2	275	281	PF00498	0.402
LIG_FHA_2	948	954	PF00498	0.777
LIG_LIR_Apic_2	196	202	PF02991	0.598
LIG_LIR_Apic_2	257	261	PF02991	0.425
LIG_LIR_Apic_2	413	418	PF02991	0.512
LIG_LIR_Gen_1	181	190	PF02991	0.395
LIG_LIR_Gen_1	277	285	PF02991	0.494
LIG_LIR_Gen_1	296	306	PF02991	0.342
LIG_LIR_Gen_1	374	384	PF02991	0.376
LIG_LIR_Gen_1	405	414	PF02991	0.486
LIG_LIR_Gen_1	442	450	PF02991	0.460
LIG_LIR_Gen_1	478	489	PF02991	0.465
LIG_LIR_Gen_1	496	504	PF02991	0.458
LIG_LIR_Gen_1	777	787	PF02991	0.373
LIG_LIR_Gen_1	842	850	PF02991	0.602
LIG_LIR_LC3C_4	205	210	PF02991	0.466
LIG_LIR_Nem_3	172	177	PF02991	0.389
LIG_LIR_Nem_3	181	186	PF02991	0.419
LIG_LIR_Nem_3	277	282	PF02991	0.494
LIG_LIR_Nem_3	374	380	PF02991	0.430
LIG_LIR_Nem_3	405	409	PF02991	0.510
LIG_LIR_Nem_3	442	446	PF02991	0.465
LIG_LIR_Nem_3	478	484	PF02991	0.450
LIG_LIR_Nem_3	496	500	PF02991	0.420
LIG_LIR_Nem_3	569	575	PF02991	0.560
LIG_LIR_Nem_3	718	722	PF02991	0.459
LIG_LIR_Nem_3	777	782	PF02991	0.360
LIG_LIR_Nem_3	786	791	PF02991	0.524
LIG_LIR_Nem_3	842	846	PF02991	0.591
LIG_MLH1_MIPbox_1	477	481	PF16413	0.472
LIG_PCNA_PIPBox_1	427	436	PF02747	0.617
LIG_Pex14_2	170	174	PF04695	0.232
LIG_REV1ctd_RIR_1	35	44	PF16727	0.234
LIG_REV1ctd_RIR_1	822	830	PF16727	0.572
LIG_RPA_C_Fungi	454	466	PF08784	0.600
LIG_SH2_CRK	138	142	PF00017	0.527
LIG_SH2_CRK	183	187	PF00017	0.446
LIG_SH2_CRK	406	410	PF00017	0.470
LIG_SH2_CRK	497	501	PF00017	0.475
LIG_SH2_CRK	637	641	PF00017	0.517
LIG_SH2_CRK	788	792	PF00017	0.518
LIG_SH2_CRK	843	847	PF00017	0.666
LIG_SH2_NCK_1	497	501	PF00017	0.459
LIG_SH2_NCK_1	843	847	PF00017	0.623
LIG_SH2_PTP2	258	261	PF00017	0.465
LIG_SH2_STAP1	138	142	PF00017	0.552
LIG_SH2_STAP1	350	354	PF00017	0.429
LIG_SH2_STAP1	377	381	PF00017	0.373
LIG_SH2_STAP1	788	792	PF00017	0.410
LIG_SH2_STAT5	258	261	PF00017	0.505
LIG_SH2_STAT5	342	345	PF00017	0.391
LIG_SH2_STAT5	767	770	PF00017	0.476
LIG_SH2_STAT5	781	784	PF00017	0.268
LIG_SH3_3	174	180	PF00018	0.497
LIG_SH3_3	250	256	PF00018	0.601
LIG_SH3_3	388	394	PF00018	0.464
LIG_SH3_3	523	529	PF00018	0.639
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.489
LIG_SUMO_SIM_anti_2	231	236	PF11976	0.322
LIG_SUMO_SIM_anti_2	448	454	PF11976	0.502
LIG_SUMO_SIM_anti_2	801	808	PF11976	0.514
LIG_SUMO_SIM_par_1	205	212	PF11976	0.539
LIG_SUMO_SIM_par_1	801	808	PF11976	0.514
LIG_TRAF2_1	122	125	PF00917	0.638
LIG_TRAF2_1	376	379	PF00917	0.449
LIG_TRAF2_1	913	916	PF00917	0.777
LIG_TRAF2_1	940	943	PF00917	0.636
LIG_TRAF2_1	950	953	PF00917	0.507
LIG_TRFH_1	406	410	PF08558	0.425
LIG_TYR_ITIM	136	141	PF00017	0.643
LIG_WRC_WIRS_1	716	721	PF05994	0.492
MOD_CDK_SPK_2	148	153	PF00069	0.406
MOD_CDK_SPK_2	848	853	PF00069	0.476
MOD_CDK_SPxxK_3	846	853	PF00069	0.467
MOD_CK1_1	119	125	PF00069	0.538
MOD_CK1_1	543	549	PF00069	0.678
MOD_CK1_1	641	647	PF00069	0.550
MOD_CK1_1	723	729	PF00069	0.493
MOD_CK1_1	79	85	PF00069	0.434
MOD_CK1_1	905	911	PF00069	0.702
MOD_CK2_1	119	125	PF00069	0.622
MOD_CK2_1	127	133	PF00069	0.648
MOD_CK2_1	260	266	PF00069	0.404
MOD_CK2_1	274	280	PF00069	0.374
MOD_CK2_1	66	72	PF00069	0.587
MOD_CK2_1	842	848	PF00069	0.575
MOD_CK2_1	882	888	PF00069	0.797
MOD_CK2_1	910	916	PF00069	0.727
MOD_CK2_1	947	953	PF00069	0.699
MOD_GlcNHglycan	130	133	PF01048	0.556
MOD_GlcNHglycan	3	6	PF01048	0.614
MOD_GlcNHglycan	344	347	PF01048	0.515
MOD_GlcNHglycan	546	549	PF01048	0.709
MOD_GlcNHglycan	60	63	PF01048	0.527
MOD_GlcNHglycan	884	887	PF01048	0.719
MOD_GlcNHglycan	904	907	PF01048	0.689
MOD_GSK3_1	115	122	PF00069	0.475
MOD_GSK3_1	154	161	PF00069	0.487
MOD_GSK3_1	169	176	PF00069	0.456
MOD_GSK3_1	338	345	PF00069	0.581
MOD_GSK3_1	484	491	PF00069	0.570
MOD_GSK3_1	540	547	PF00069	0.717
MOD_GSK3_1	58	65	PF00069	0.542
MOD_GSK3_1	751	758	PF00069	0.481
MOD_GSK3_1	842	849	PF00069	0.577
MOD_GSK3_1	860	867	PF00069	0.701
MOD_LATS_1	539	545	PF00433	0.703
MOD_N-GLC_1	249	254	PF02516	0.606
MOD_N-GLC_1	622	627	PF02516	0.586
MOD_N-GLC_1	723	728	PF02516	0.522
MOD_N-GLC_2	513	515	PF02516	0.629
MOD_N-GLC_2	568	570	PF02516	0.460
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	221	226	PF00069	0.493
MOD_NEK2_1	274	279	PF00069	0.522
MOD_NEK2_1	327	332	PF00069	0.602
MOD_NEK2_1	349	354	PF00069	0.440
MOD_NEK2_1	433	438	PF00069	0.579
MOD_NEK2_1	488	493	PF00069	0.624
MOD_NEK2_1	657	662	PF00069	0.283
MOD_NEK2_1	66	71	PF00069	0.601
MOD_NEK2_1	720	725	PF00069	0.517
MOD_NEK2_1	746	751	PF00069	0.350
MOD_NEK2_1	771	776	PF00069	0.496
MOD_NEK2_1	839	844	PF00069	0.619
MOD_NEK2_1	96	101	PF00069	0.383
MOD_NEK2_2	116	121	PF00069	0.551
MOD_NEK2_2	281	286	PF00069	0.376
MOD_NEK2_2	383	388	PF00069	0.391
MOD_NEK2_2	410	415	PF00069	0.460
MOD_NEK2_2	475	480	PF00069	0.582
MOD_PKA_1	540	546	PF00069	0.691
MOD_PKA_2	214	220	PF00069	0.402
MOD_PKA_2	221	227	PF00069	0.401
MOD_PKA_2	434	440	PF00069	0.554
MOD_PKA_2	540	546	PF00069	0.675
MOD_PKA_2	641	647	PF00069	0.459
MOD_PKA_2	657	663	PF00069	0.434
MOD_PKA_2	771	777	PF00069	0.512
MOD_PKA_2	96	102	PF00069	0.499
MOD_PKB_1	458	466	PF00069	0.603
MOD_Plk_1	249	255	PF00069	0.608
MOD_Plk_1	62	68	PF00069	0.609
MOD_Plk_4	103	109	PF00069	0.507
MOD_Plk_4	142	148	PF00069	0.526
MOD_Plk_4	169	175	PF00069	0.494
MOD_Plk_4	214	220	PF00069	0.535
MOD_Plk_4	240	246	PF00069	0.502
MOD_Plk_4	254	260	PF00069	0.598
MOD_Plk_4	338	344	PF00069	0.481
MOD_Plk_4	410	416	PF00069	0.537
MOD_Plk_4	475	481	PF00069	0.451
MOD_Plk_4	715	721	PF00069	0.490
MOD_Plk_4	774	780	PF00069	0.371
MOD_Plk_4	799	805	PF00069	0.377
MOD_ProDKin_1	148	154	PF00069	0.571
MOD_ProDKin_1	311	317	PF00069	0.594
MOD_ProDKin_1	421	427	PF00069	0.520
MOD_ProDKin_1	831	837	PF00069	0.556
MOD_ProDKin_1	846	852	PF00069	0.653
MOD_SUMO_for_1	261	264	PF00179	0.468
TRG_DiLeu_BaEn_1	442	447	PF01217	0.498
TRG_DiLeu_BaEn_4	502	508	PF01217	0.462
TRG_ENDOCYTIC_2	138	141	PF00928	0.527
TRG_ENDOCYTIC_2	167	170	PF00928	0.349
TRG_ENDOCYTIC_2	183	186	PF00928	0.348
TRG_ENDOCYTIC_2	377	380	PF00928	0.364
TRG_ENDOCYTIC_2	406	409	PF00928	0.434
TRG_ENDOCYTIC_2	497	500	PF00928	0.471
TRG_ENDOCYTIC_2	637	640	PF00928	0.515
TRG_ENDOCYTIC_2	788	791	PF00928	0.519
TRG_ENDOCYTIC_2	843	846	PF00928	0.690
TRG_ER_diArg_1	165	167	PF00400	0.467
TRG_ER_diArg_1	168	170	PF00400	0.458
TRG_ER_diArg_1	219	222	PF00400	0.425
TRG_ER_diArg_1	438	440	PF00400	0.499
TRG_ER_diArg_1	457	460	PF00400	0.406
TRG_ER_diArg_1	465	468	PF00400	0.478
TRG_ER_diArg_1	562	564	PF00400	0.545
TRG_ER_diArg_1	614	616	PF00400	0.608
TRG_ER_diArg_1	661	663	PF00400	0.553
TRG_ER_diArg_1	771	773	PF00400	0.410
TRG_ER_diArg_1	821	824	PF00400	0.418
TRG_NLS_MonoCore_2	918	923	PF00514	0.669
TRG_NLS_MonoExtC_3	918	923	PF00514	0.750
TRG_NLS_MonoExtN_4	918	925	PF00514	0.745
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	638	643	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK9	Leptomonas seymouri	78%	100%
A0A0S4IYU3	Bodo saltans	27%	83%
A0A1X0NQD8	Trypanosomatidae	46%	91%
A0A3S7WST9	Leishmania donovani	94%	100%
A0A422NXF4	Trypanosoma rangeli	47%	95%
A4H7I7	Leishmania braziliensis	87%	99%
A4HVX0	Leishmania infantum	94%	100%
C9ZT54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
Q4QFV7	Leishmania major	95%	100%
V5BHS0	Trypanosoma cruzi	47%	96%