VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

von Willebrand factor type A domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APL9_LEIMU

TriTrypDb:

LmxM.14.0260

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	549	553	PF00656	0.571
CLV_C14_Caspase3-7	670	674	PF00656	0.610
CLV_MEL_PAP_1	582	588	PF00089	0.492
CLV_NRD_NRD_1	706	708	PF00675	0.545
CLV_PCSK_FUR_1	704	708	PF00082	0.588
CLV_PCSK_KEX2_1	660	662	PF00082	0.580
CLV_PCSK_KEX2_1	706	708	PF00082	0.547
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.506
CLV_PCSK_SKI1_1	15	19	PF00082	0.510
CLV_PCSK_SKI1_1	413	417	PF00082	0.480
CLV_PCSK_SKI1_1	546	550	PF00082	0.637
CLV_PCSK_SKI1_1	661	665	PF00082	0.519
CLV_PCSK_SKI1_1	82	86	PF00082	0.431
CLV_Separin_Metazoa	267	271	PF03568	0.453
DEG_APCC_DBOX_1	179	187	PF00400	0.651
DEG_Nend_UBRbox_2	1	3	PF02207	0.729
DEG_SPOP_SBC_1	387	391	PF00917	0.402
DOC_CYCLIN_RxL_1	21	32	PF00134	0.561
DOC_MAPK_gen_1	454	463	PF00069	0.419
DOC_MAPK_MEF2A_6	248	256	PF00069	0.600
DOC_PP2B_LxvP_1	201	204	PF13499	0.567
DOC_PP4_FxxP_1	153	156	PF00568	0.504
DOC_USP7_MATH_1	118	122	PF00917	0.587
DOC_USP7_MATH_1	128	132	PF00917	0.495
DOC_USP7_MATH_1	263	267	PF00917	0.556
DOC_USP7_MATH_1	328	332	PF00917	0.451
DOC_USP7_MATH_1	335	339	PF00917	0.454
DOC_USP7_MATH_1	364	368	PF00917	0.426
DOC_USP7_MATH_1	374	378	PF00917	0.378
DOC_USP7_MATH_1	486	490	PF00917	0.649
DOC_USP7_MATH_1	494	498	PF00917	0.655
DOC_USP7_MATH_1	505	509	PF00917	0.470
DOC_USP7_MATH_1	531	535	PF00917	0.640
DOC_USP7_MATH_1	6	10	PF00917	0.624
DOC_USP7_MATH_1	94	98	PF00917	0.645
DOC_WW_Pin1_4	124	129	PF00397	0.522
DOC_WW_Pin1_4	184	189	PF00397	0.563
DOC_WW_Pin1_4	274	279	PF00397	0.546
DOC_WW_Pin1_4	396	401	PF00397	0.474
DOC_WW_Pin1_4	540	545	PF00397	0.689
DOC_WW_Pin1_4	599	604	PF00397	0.643
DOC_WW_Pin1_4	663	668	PF00397	0.448
LIG_14-3-3_CanoR_1	206	212	PF00244	0.570
LIG_14-3-3_CanoR_1	237	243	PF00244	0.377
LIG_14-3-3_CanoR_1	270	275	PF00244	0.584
LIG_14-3-3_CanoR_1	413	423	PF00244	0.454
LIG_14-3-3_CanoR_1	457	462	PF00244	0.383
LIG_14-3-3_CanoR_1	546	556	PF00244	0.600
LIG_14-3-3_CanoR_1	74	78	PF00244	0.460
LIG_Actin_WH2_2	190	208	PF00022	0.488
LIG_BRCT_BRCA1_1	3	7	PF00533	0.725
LIG_EVH1_1	64	68	PF00568	0.510
LIG_FHA_1	117	123	PF00498	0.547
LIG_FHA_1	146	152	PF00498	0.539
LIG_FHA_1	287	293	PF00498	0.576
LIG_FHA_1	340	346	PF00498	0.419
LIG_FHA_1	414	420	PF00498	0.424
LIG_FHA_1	43	49	PF00498	0.524
LIG_FHA_1	458	464	PF00498	0.188
LIG_FHA_1	561	567	PF00498	0.576
LIG_FHA_1	639	645	PF00498	0.586
LIG_FHA_2	239	245	PF00498	0.494
LIG_FHA_2	518	524	PF00498	0.501
LIG_FHA_2	547	553	PF00498	0.546
LIG_FHA_2	644	650	PF00498	0.565
LIG_FHA_2	668	674	PF00498	0.604
LIG_LIR_Apic_2	150	156	PF02991	0.500
LIG_LIR_Apic_2	659	665	PF02991	0.439
LIG_LIR_Gen_1	249	258	PF02991	0.573
LIG_LIR_Gen_1	666	673	PF02991	0.477
LIG_LIR_Nem_3	22	26	PF02991	0.292
LIG_LIR_Nem_3	249	254	PF02991	0.556
LIG_LIR_Nem_3	4	10	PF02991	0.696
LIG_LIR_Nem_3	666	671	PF02991	0.585
LIG_NRBOX	566	572	PF00104	0.552
LIG_SH2_CRK	138	142	PF00017	0.396
LIG_SH2_CRK	23	27	PF00017	0.527
LIG_SH2_CRK	251	255	PF00017	0.535
LIG_SH2_CRK	568	572	PF00017	0.509
LIG_SH2_CRK	662	666	PF00017	0.501
LIG_SH2_CRK	668	672	PF00017	0.536
LIG_SH2_GRB2like	50	53	PF00017	0.400
LIG_SH2_STAT3	70	73	PF00017	0.565
LIG_SH2_STAT5	173	176	PF00017	0.562
LIG_SH2_STAT5	232	235	PF00017	0.473
LIG_SH2_STAT5	423	426	PF00017	0.355
LIG_SH2_STAT5	50	53	PF00017	0.432
LIG_SH2_STAT5	593	596	PF00017	0.498
LIG_SH2_STAT5	639	642	PF00017	0.473
LIG_SH2_STAT5	668	671	PF00017	0.514
LIG_SH2_STAT5	89	92	PF00017	0.560
LIG_SH3_3	160	166	PF00018	0.366
LIG_SH3_3	220	226	PF00018	0.462
LIG_SH3_3	255	261	PF00018	0.512
LIG_SH3_3	397	403	PF00018	0.438
LIG_SH3_3	62	68	PF00018	0.503
LIG_SH3_3	685	691	PF00018	0.614
LIG_SUMO_SIM_par_1	315	321	PF11976	0.392
LIG_SUMO_SIM_par_1	426	432	PF11976	0.378
LIG_SUMO_SIM_par_1	44	49	PF11976	0.525
LIG_SUMO_SIM_par_1	514	520	PF11976	0.526
LIG_SxIP_EBH_1	153	165	PF03271	0.565
LIG_SxIP_EBH_1	412	425	PF03271	0.480
LIG_TRAF2_1	11	14	PF00917	0.614
LIG_TRAF2_1	187	190	PF00917	0.425
LIG_TYR_ITIM	566	571	PF00017	0.513
LIG_TYR_ITSM	247	254	PF00017	0.528
LIG_UBA3_1	378	383	PF00899	0.434
LIG_WW_1	67	70	PF00397	0.498
MOD_CDC14_SPxK_1	543	546	PF00782	0.642
MOD_CDK_SPxK_1	540	546	PF00069	0.676
MOD_CK1_1	282	288	PF00069	0.767
MOD_CK1_1	331	337	PF00069	0.389
MOD_CK1_1	367	373	PF00069	0.402
MOD_CK1_1	489	495	PF00069	0.678
MOD_CK1_1	573	579	PF00069	0.484
MOD_CK1_1	602	608	PF00069	0.615
MOD_CK1_1	666	672	PF00069	0.477
MOD_CK1_1	9	15	PF00069	0.623
MOD_CK2_1	124	130	PF00069	0.491
MOD_CK2_1	184	190	PF00069	0.627
MOD_CK2_1	643	649	PF00069	0.539
MOD_GlcNHglycan	101	104	PF01048	0.697
MOD_GlcNHglycan	114	117	PF01048	0.506
MOD_GlcNHglycan	142	145	PF01048	0.520
MOD_GlcNHglycan	2	6	PF01048	0.671
MOD_GlcNHglycan	281	284	PF01048	0.787
MOD_GlcNHglycan	320	323	PF01048	0.469
MOD_GlcNHglycan	333	336	PF01048	0.405
MOD_GlcNHglycan	37	40	PF01048	0.506
MOD_GlcNHglycan	370	373	PF01048	0.496
MOD_GlcNHglycan	484	487	PF01048	0.589
MOD_GlcNHglycan	488	491	PF01048	0.647
MOD_GlcNHglycan	496	499	PF01048	0.349
MOD_GlcNHglycan	507	510	PF01048	0.423
MOD_GlcNHglycan	525	528	PF01048	0.372
MOD_GlcNHglycan	549	552	PF01048	0.405
MOD_GlcNHglycan	596	599	PF01048	0.628
MOD_GlcNHglycan	618	623	PF01048	0.720
MOD_GlcNHglycan	675	678	PF01048	0.706
MOD_GSK3_1	112	119	PF00069	0.577
MOD_GSK3_1	124	131	PF00069	0.520
MOD_GSK3_1	151	158	PF00069	0.525
MOD_GSK3_1	270	277	PF00069	0.595
MOD_GSK3_1	278	285	PF00069	0.666
MOD_GSK3_1	331	338	PF00069	0.458
MOD_GSK3_1	364	371	PF00069	0.480
MOD_GSK3_1	482	489	PF00069	0.596
MOD_GSK3_1	663	670	PF00069	0.518
MOD_GSK3_1	85	92	PF00069	0.591
MOD_NEK2_1	109	114	PF00069	0.637
MOD_NEK2_1	19	24	PF00069	0.571
MOD_NEK2_1	221	226	PF00069	0.695
MOD_NEK2_1	238	243	PF00069	0.323
MOD_NEK2_1	296	301	PF00069	0.443
MOD_NEK2_1	339	344	PF00069	0.474
MOD_NEK2_1	591	596	PF00069	0.567
MOD_NEK2_1	627	632	PF00069	0.474
MOD_PIKK_1	116	122	PF00454	0.487
MOD_PIKK_1	178	184	PF00454	0.649
MOD_PIKK_1	517	523	PF00454	0.486
MOD_PIKK_1	560	566	PF00454	0.457
MOD_PIKK_1	573	579	PF00454	0.503
MOD_PIKK_1	9	15	PF00454	0.610
MOD_PKA_2	35	41	PF00069	0.488
MOD_PKA_2	73	79	PF00069	0.283
MOD_Plk_1	110	116	PF00069	0.396
MOD_Plk_1	573	579	PF00069	0.313
MOD_Plk_4	128	134	PF00069	0.438
MOD_Plk_4	155	161	PF00069	0.503
MOD_Plk_4	328	334	PF00069	0.459
MOD_Plk_4	341	347	PF00069	0.249
MOD_Plk_4	358	364	PF00069	0.453
MOD_Plk_4	374	380	PF00069	0.335
MOD_ProDKin_1	124	130	PF00069	0.523
MOD_ProDKin_1	184	190	PF00069	0.563
MOD_ProDKin_1	274	280	PF00069	0.560
MOD_ProDKin_1	396	402	PF00069	0.474
MOD_ProDKin_1	540	546	PF00069	0.680
MOD_ProDKin_1	599	605	PF00069	0.647
MOD_ProDKin_1	663	669	PF00069	0.449
MOD_SUMO_for_1	382	385	PF00179	0.480
MOD_SUMO_for_1	589	592	PF00179	0.300
MOD_SUMO_rev_2	676	684	PF00179	0.733
TRG_DiLeu_BaEn_1	14	19	PF01217	0.551
TRG_DiLeu_BaEn_1	53	58	PF01217	0.519
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.556
TRG_ENDOCYTIC_2	173	176	PF00928	0.534
TRG_ENDOCYTIC_2	23	26	PF00928	0.535
TRG_ENDOCYTIC_2	251	254	PF00928	0.617
TRG_ENDOCYTIC_2	568	571	PF00928	0.514
TRG_ENDOCYTIC_2	668	671	PF00928	0.518
TRG_ER_diArg_1	703	706	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B7	Leptomonas seymouri	44%	97%
A0A1X0NPD4	Trypanosomatidae	29%	86%
A0A3S5H6R0	Leishmania donovani	91%	100%
A0A422NXB2	Trypanosoma rangeli	30%	87%
A4H7I6	Leishmania braziliensis	77%	100%
A4HVW8	Leishmania infantum	92%	100%
C9ZT55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	86%
Q4QFV9	Leishmania major	91%	100%
V5AXR7	Trypanosoma cruzi	29%	86%