PX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PX domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APL5_LEIMU

TriTrypDb:

LmxM.14.0220

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APL5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005543	phospholipid binding	3	12
GO:0008289	lipid binding	2	12
GO:0035091	phosphatidylinositol binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.662
CLV_C14_Caspase3-7	311	315	PF00656	0.418
CLV_C14_Caspase3-7	94	98	PF00656	0.372
CLV_NRD_NRD_1	253	255	PF00675	0.490
CLV_NRD_NRD_1	325	327	PF00675	0.514
CLV_NRD_NRD_1	42	44	PF00675	0.545
CLV_NRD_NRD_1	56	58	PF00675	0.313
CLV_NRD_NRD_1	81	83	PF00675	0.437
CLV_PCSK_KEX2_1	164	166	PF00082	0.499
CLV_PCSK_KEX2_1	253	255	PF00082	0.490
CLV_PCSK_KEX2_1	400	402	PF00082	0.501
CLV_PCSK_KEX2_1	42	44	PF00082	0.507
CLV_PCSK_KEX2_1	56	58	PF00082	0.313
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.499
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.501
CLV_PCSK_PC7_1	160	166	PF00082	0.439
CLV_PCSK_SKI1_1	146	150	PF00082	0.371
CLV_PCSK_SKI1_1	153	157	PF00082	0.419
CLV_PCSK_SKI1_1	167	171	PF00082	0.561
CLV_PCSK_SKI1_1	3	7	PF00082	0.466
CLV_PCSK_SKI1_1	384	388	PF00082	0.457
CLV_PCSK_SKI1_1	65	69	PF00082	0.264
CLV_Separin_Metazoa	429	433	PF03568	0.433
DEG_APCC_DBOX_1	145	153	PF00400	0.486
DEG_COP1_1	19	27	PF00400	0.443
DEG_MDM2_SWIB_1	226	233	PF02201	0.433
DEG_SPOP_SBC_1	179	183	PF00917	0.638
DEG_SPOP_SBC_1	219	223	PF00917	0.734
DOC_CYCLIN_RxL_1	381	389	PF00134	0.450
DOC_CYCLIN_yClb5_NLxxxL_5	103	110	PF00134	0.402
DOC_MAPK_gen_1	326	333	PF00069	0.394
DOC_MAPK_gen_1	56	64	PF00069	0.256
DOC_MAPK_MEF2A_6	326	335	PF00069	0.484
DOC_PP1_RVXF_1	332	338	PF00149	0.327
DOC_PP4_FxxP_1	130	133	PF00568	0.316
DOC_PP4_FxxP_1	22	25	PF00568	0.544
DOC_USP7_MATH_1	178	182	PF00917	0.596
DOC_USP7_MATH_1	220	224	PF00917	0.649
DOC_USP7_MATH_1	444	448	PF00917	0.592
DOC_USP7_MATH_1	81	85	PF00917	0.398
DOC_USP7_UBL2_3	176	180	PF12436	0.633
DOC_WW_Pin1_4	293	298	PF00397	0.472
DOC_WW_Pin1_4	358	363	PF00397	0.378
DOC_WW_Pin1_4	445	450	PF00397	0.612
DOC_WW_Pin1_4	75	80	PF00397	0.427
LIG_14-3-3_CanoR_1	153	158	PF00244	0.576
LIG_14-3-3_CanoR_1	165	170	PF00244	0.512
LIG_14-3-3_CanoR_1	3	8	PF00244	0.447
LIG_14-3-3_CanoR_1	56	64	PF00244	0.278
LIG_14-3-3_CanoR_1	82	87	PF00244	0.402
LIG_Actin_WH2_2	138	155	PF00022	0.489
LIG_Actin_WH2_2	244	261	PF00022	0.396
LIG_Actin_WH2_2	265	283	PF00022	0.525
LIG_Actin_WH2_2	417	434	PF00022	0.442
LIG_BIR_III_4	300	304	PF00653	0.545
LIG_BRCT_BRCA1_1	222	226	PF00533	0.533
LIG_BRCT_BRCA1_1	95	99	PF00533	0.402
LIG_CaM_IQ_9	418	434	PF13499	0.386
LIG_deltaCOP1_diTrp_1	124	130	PF00928	0.402
LIG_eIF4E_1	70	76	PF01652	0.307
LIG_FHA_1	137	143	PF00498	0.512
LIG_FHA_1	377	383	PF00498	0.342
LIG_FHA_1	9	15	PF00498	0.439
LIG_FHA_2	198	204	PF00498	0.561
LIG_FHA_2	21	27	PF00498	0.491
LIG_FHA_2	315	321	PF00498	0.541
LIG_FHA_2	369	375	PF00498	0.528
LIG_LIR_Apic_2	123	128	PF02991	0.401
LIG_LIR_Apic_2	19	25	PF02991	0.439
LIG_LIR_Apic_2	229	235	PF02991	0.494
LIG_LIR_Apic_2	69	73	PF02991	0.307
LIG_LIR_Gen_1	227	237	PF02991	0.507
LIG_LIR_Gen_1	325	335	PF02991	0.354
LIG_LIR_Gen_1	436	446	PF02991	0.536
LIG_LIR_Gen_1	55	64	PF02991	0.256
LIG_LIR_Nem_3	168	172	PF02991	0.595
LIG_LIR_Nem_3	227	233	PF02991	0.520
LIG_LIR_Nem_3	264	268	PF02991	0.498
LIG_LIR_Nem_3	285	289	PF02991	0.479
LIG_LIR_Nem_3	392	397	PF02991	0.564
LIG_LIR_Nem_3	436	442	PF02991	0.573
LIG_LIR_Nem_3	55	61	PF02991	0.256
LIG_LIR_Nem_3	6	10	PF02991	0.367
LIG_LIR_Nem_3	69	75	PF02991	0.263
LIG_NRBOX	63	69	PF00104	0.349
LIG_Pex14_1	125	129	PF04695	0.402
LIG_Pex14_2	121	125	PF04695	0.389
LIG_Pex14_2	226	230	PF04695	0.447
LIG_REV1ctd_RIR_1	190	200	PF16727	0.604
LIG_REV1ctd_RIR_1	394	405	PF16727	0.346
LIG_SH2_CRK	356	360	PF00017	0.425
LIG_SH2_CRK	70	74	PF00017	0.313
LIG_SH2_GRB2like	328	331	PF00017	0.484
LIG_SH2_SRC	232	235	PF00017	0.497
LIG_SH2_STAP1	228	232	PF00017	0.517
LIG_SH2_STAP1	289	293	PF00017	0.394
LIG_SH2_STAP1	378	382	PF00017	0.316
LIG_SH2_STAP1	398	402	PF00017	0.473
LIG_SH2_STAP1	58	62	PF00017	0.256
LIG_SH2_STAT5	172	175	PF00017	0.609
LIG_SH2_STAT5	232	235	PF00017	0.497
LIG_SH2_STAT5	268	271	PF00017	0.406
LIG_SH2_STAT5	323	326	PF00017	0.470
LIG_SH2_STAT5	328	331	PF00017	0.369
LIG_SH2_STAT5	378	381	PF00017	0.322
LIG_SH2_STAT5	7	10	PF00017	0.493
LIG_SH2_STAT5	92	95	PF00017	0.402
LIG_SH3_3	214	220	PF00018	0.716
LIG_SH3_3	22	28	PF00018	0.388
LIG_SH3_3	407	413	PF00018	0.416
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.351
LIG_SUMO_SIM_par_1	59	66	PF11976	0.307
LIG_TRAF2_1	371	374	PF00917	0.434
LIG_TRFH_1	129	133	PF08558	0.401
LIG_TYR_ITIM	5	10	PF00017	0.475
LIG_UBA3_1	76	83	PF00899	0.349
MOD_CDK_SPxxK_3	75	82	PF00069	0.413
MOD_CK1_1	222	228	PF00069	0.579
MOD_CK1_1	236	242	PF00069	0.478
MOD_CK1_1	261	267	PF00069	0.547
MOD_CK1_1	44	50	PF00069	0.326
MOD_CK1_1	84	90	PF00069	0.383
MOD_CK2_1	165	171	PF00069	0.634
MOD_CK2_1	314	320	PF00069	0.589
MOD_CK2_1	368	374	PF00069	0.631
MOD_CK2_1	84	90	PF00069	0.351
MOD_GlcNHglycan	235	238	PF01048	0.505
MOD_GlcNHglycan	260	263	PF01048	0.469
MOD_GlcNHglycan	34	37	PF01048	0.606
MOD_GlcNHglycan	50	53	PF01048	0.293
MOD_GlcNHglycan	93	96	PF01048	0.402
MOD_GSK3_1	180	187	PF00069	0.523
MOD_GSK3_1	218	225	PF00069	0.605
MOD_GSK3_1	289	296	PF00069	0.485
MOD_GSK3_1	364	371	PF00069	0.527
MOD_GSK3_1	376	383	PF00069	0.291
MOD_GSK3_1	44	51	PF00069	0.353
MOD_GSK3_1	71	78	PF00069	0.368
MOD_GSK3_1	84	91	PF00069	0.336
MOD_N-GLC_2	330	332	PF02516	0.466
MOD_NEK2_1	184	189	PF00069	0.479
MOD_NEK2_1	191	196	PF00069	0.421
MOD_NEK2_1	258	263	PF00069	0.443
MOD_NEK2_1	308	313	PF00069	0.543
MOD_NEK2_1	376	381	PF00069	0.414
MOD_NEK2_2	289	294	PF00069	0.470
MOD_PIKK_1	314	320	PF00454	0.520
MOD_PIKK_1	376	382	PF00454	0.428
MOD_PK_1	82	88	PF00069	0.402
MOD_PKA_1	56	62	PF00069	0.256
MOD_PKA_1	82	88	PF00069	0.402
MOD_PKA_2	133	139	PF00069	0.388
MOD_PKA_2	41	47	PF00069	0.443
MOD_PKA_2	56	62	PF00069	0.289
MOD_PKA_2	81	87	PF00069	0.383
MOD_PKB_1	165	173	PF00069	0.493
MOD_Plk_1	18	24	PF00069	0.478
MOD_Plk_1	228	234	PF00069	0.504
MOD_Plk_1	289	295	PF00069	0.493
MOD_Plk_4	138	144	PF00069	0.487
MOD_Plk_4	180	186	PF00069	0.520
MOD_Plk_4	308	314	PF00069	0.404
MOD_Plk_4	71	77	PF00069	0.288
MOD_Plk_4	88	94	PF00069	0.256
MOD_ProDKin_1	293	299	PF00069	0.472
MOD_ProDKin_1	358	364	PF00069	0.384
MOD_ProDKin_1	445	451	PF00069	0.617
MOD_ProDKin_1	75	81	PF00069	0.427
MOD_SUMO_rev_2	320	329	PF00179	0.537
TRG_DiLeu_BaEn_1	138	143	PF01217	0.488
TRG_ENDOCYTIC_2	328	331	PF00928	0.348
TRG_ENDOCYTIC_2	356	359	PF00928	0.451
TRG_ENDOCYTIC_2	394	397	PF00928	0.544
TRG_ENDOCYTIC_2	58	61	PF00928	0.256
TRG_ENDOCYTIC_2	7	10	PF00928	0.449
TRG_ER_diArg_1	143	146	PF00400	0.487
TRG_ER_diArg_1	41	43	PF00400	0.543
TRG_ER_diArg_1	56	58	PF00400	0.313
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW83	Leptomonas seymouri	74%	78%
A0A0S4IZJ1	Bodo saltans	26%	81%
A0A1X0NNT5	Trypanosomatidae	30%	80%
A0A3R7LA20	Trypanosoma rangeli	29%	92%
A0A3S7WSS9	Leishmania donovani	98%	100%
A4H7I2	Leishmania braziliensis	93%	100%
A4HVW4	Leishmania infantum	98%	100%
C9ZT62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
Q4QFW3	Leishmania major	97%	100%
V5BMA1	Trypanosoma cruzi	30%	91%