DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania mexicana

UniProt:

E9APL4_LEIMU

TriTrypDb:

LmxM.14.0210

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9APL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APL4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.598
CLV_C14_Caspase3-7	274	278	PF00656	0.705
CLV_C14_Caspase3-7	419	423	PF00656	0.509
CLV_NRD_NRD_1	107	109	PF00675	0.439
CLV_NRD_NRD_1	131	133	PF00675	0.509
CLV_NRD_NRD_1	24	26	PF00675	0.387
CLV_NRD_NRD_1	253	255	PF00675	0.523
CLV_NRD_NRD_1	32	34	PF00675	0.455
CLV_NRD_NRD_1	369	371	PF00675	0.272
CLV_NRD_NRD_1	398	400	PF00675	0.248
CLV_NRD_NRD_1	9	11	PF00675	0.588
CLV_NRD_NRD_1	94	96	PF00675	0.540
CLV_PCSK_FUR_1	251	255	PF00082	0.568
CLV_PCSK_KEX2_1	107	109	PF00082	0.443
CLV_PCSK_KEX2_1	130	132	PF00082	0.606
CLV_PCSK_KEX2_1	24	26	PF00082	0.382
CLV_PCSK_KEX2_1	253	255	PF00082	0.576
CLV_PCSK_KEX2_1	32	34	PF00082	0.484
CLV_PCSK_KEX2_1	367	369	PF00082	0.248
CLV_PCSK_KEX2_1	398	400	PF00082	0.272
CLV_PCSK_KEX2_1	8	10	PF00082	0.571
CLV_PCSK_KEX2_1	93	95	PF00082	0.574
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.464
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.248
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.308
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.617
CLV_PCSK_SKI1_1	102	106	PF00082	0.485
CLV_PCSK_SKI1_1	108	112	PF00082	0.478
CLV_PCSK_SKI1_1	254	258	PF00082	0.554
CLV_PCSK_SKI1_1	390	394	PF00082	0.261
CLV_PCSK_SKI1_1	418	422	PF00082	0.272
DEG_APCC_DBOX_1	245	253	PF00400	0.393
DEG_APCC_DBOX_1	331	339	PF00400	0.534
DEG_APCC_DBOX_1	406	414	PF00400	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DEG_SCF_FBW7_2	141	147	PF00400	0.615
DEG_SPOP_SBC_1	261	265	PF00917	0.613
DOC_CKS1_1	141	146	PF01111	0.623
DOC_CKS1_1	87	92	PF01111	0.640
DOC_CYCLIN_RxL_1	106	113	PF00134	0.545
DOC_MAPK_gen_1	318	327	PF00069	0.448
DOC_MAPK_gen_1	379	386	PF00069	0.534
DOC_USP7_MATH_1	165	169	PF00917	0.522
DOC_USP7_MATH_1	17	21	PF00917	0.520
DOC_USP7_MATH_1	215	219	PF00917	0.447
DOC_USP7_MATH_1	261	265	PF00917	0.692
DOC_USP7_MATH_1	60	64	PF00917	0.663
DOC_USP7_MATH_1	74	78	PF00917	0.700
DOC_USP7_UBL2_3	316	320	PF12436	0.459
DOC_WW_Pin1_4	140	145	PF00397	0.553
DOC_WW_Pin1_4	86	91	PF00397	0.582
LIG_BIR_III_2	70	74	PF00653	0.445
LIG_BRCT_BRCA1_1	205	209	PF00533	0.583
LIG_BRCT_BRCA1_1	53	57	PF00533	0.590
LIG_BRCT_BRCA1_1	76	80	PF00533	0.659
LIG_CaM_IQ_9	19	35	PF13499	0.456
LIG_CaM_IQ_9	240	256	PF13499	0.544
LIG_Clathr_ClatBox_1	290	294	PF01394	0.448
LIG_FHA_1	268	274	PF00498	0.441
LIG_FHA_1	320	326	PF00498	0.448
LIG_FHA_1	406	412	PF00498	0.534
LIG_FHA_1	419	425	PF00498	0.518
LIG_FHA_2	140	146	PF00498	0.606
LIG_FHA_2	188	194	PF00498	0.359
LIG_FHA_2	272	278	PF00498	0.742
LIG_FHA_2	350	356	PF00498	0.456
LIG_FHA_2	87	93	PF00498	0.529
LIG_LIR_Gen_1	222	230	PF02991	0.495
LIG_LIR_Gen_1	292	298	PF02991	0.448
LIG_LIR_Gen_1	77	87	PF02991	0.651
LIG_LIR_Nem_3	147	153	PF02991	0.567
LIG_LIR_Nem_3	193	199	PF02991	0.392
LIG_LIR_Nem_3	222	227	PF02991	0.503
LIG_LIR_Nem_3	292	296	PF02991	0.448
LIG_LIR_Nem_3	77	83	PF02991	0.660
LIG_LIR_Nem_3	99	104	PF02991	0.439
LIG_PCNA_PIPBox_1	119	128	PF02747	0.471
LIG_Pex14_2	289	293	PF04695	0.534
LIG_SH2_CRK	101	105	PF00017	0.452
LIG_SH2_CRK	118	122	PF00017	0.418
LIG_SH2_NCK_1	2	6	PF00017	0.641
LIG_SH2_PTP2	224	227	PF00017	0.498
LIG_SH2_SRC	182	185	PF00017	0.551
LIG_SH2_SRC	2	5	PF00017	0.673
LIG_SH2_STAT3	126	129	PF00017	0.567
LIG_SH2_STAT5	199	202	PF00017	0.402
LIG_SH2_STAT5	224	227	PF00017	0.545
LIG_SH2_STAT5	242	245	PF00017	0.353
LIG_SH3_3	84	90	PF00018	0.611
LIG_SUMO_SIM_par_1	48	54	PF11976	0.513
LIG_TRAF2_1	190	193	PF00917	0.486
LIG_TRAF2_1	352	355	PF00917	0.474
LIG_TRAF2_1	89	92	PF00917	0.566
LIG_TYR_ITIM	116	121	PF00017	0.563
LIG_TYR_ITIM	240	245	PF00017	0.466
LIG_UBA3_1	249	257	PF00899	0.593
MOD_CDK_SPxxK_3	86	93	PF00069	0.569
MOD_CK1_1	264	270	PF00069	0.687
MOD_CK2_1	187	193	PF00069	0.359
MOD_CK2_1	299	305	PF00069	0.551
MOD_CK2_1	348	354	PF00069	0.458
MOD_CK2_1	86	92	PF00069	0.539
MOD_GlcNHglycan	167	170	PF01048	0.485
MOD_GlcNHglycan	264	267	PF01048	0.677
MOD_GSK3_1	260	267	PF00069	0.658
MOD_GSK3_1	426	433	PF00069	0.584
MOD_LATS_1	373	379	PF00433	0.534
MOD_N-GLC_1	299	304	PF02516	0.353
MOD_NEK2_1	203	208	PF00069	0.469
MOD_NEK2_1	209	214	PF00069	0.450
MOD_NEK2_1	262	267	PF00069	0.687
MOD_NEK2_1	363	368	PF00069	0.458
MOD_NEK2_1	41	46	PF00069	0.650
MOD_NEK2_1	420	425	PF00069	0.476
MOD_NEK2_1	51	56	PF00069	0.690
MOD_NEK2_1	83	88	PF00069	0.700
MOD_PKA_2	41	47	PF00069	0.554
MOD_PKB_1	25	33	PF00069	0.315
MOD_Plk_1	187	193	PF00069	0.492
MOD_Plk_1	298	304	PF00069	0.553
MOD_Plk_1	426	432	PF00069	0.598
MOD_Plk_1	436	442	PF00069	0.594
MOD_Plk_2-3	187	193	PF00069	0.279
MOD_Plk_2-3	299	305	PF00069	0.537
MOD_Plk_2-3	308	314	PF00069	0.513
MOD_Plk_4	17	23	PF00069	0.558
MOD_Plk_4	427	433	PF00069	0.576
MOD_ProDKin_1	140	146	PF00069	0.543
MOD_ProDKin_1	86	92	PF00069	0.573
MOD_SUMO_for_1	296	299	PF00179	0.448
MOD_SUMO_for_1	424	427	PF00179	0.497
MOD_SUMO_for_1	434	437	PF00179	0.426
TRG_DiLeu_BaEn_1	100	105	PF01217	0.436
TRG_DiLeu_BaEn_4	312	318	PF01217	0.534
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.564
TRG_ENDOCYTIC_2	101	104	PF00928	0.432
TRG_ENDOCYTIC_2	118	121	PF00928	0.439
TRG_ENDOCYTIC_2	150	153	PF00928	0.538
TRG_ENDOCYTIC_2	182	185	PF00928	0.551
TRG_ENDOCYTIC_2	2	5	PF00928	0.518
TRG_ENDOCYTIC_2	224	227	PF00928	0.576
TRG_ENDOCYTIC_2	242	245	PF00928	0.364
TRG_ER_diArg_1	130	132	PF00400	0.630
TRG_ER_diArg_1	161	164	PF00400	0.508
TRG_ER_diArg_1	179	182	PF00400	0.524
TRG_ER_diArg_1	239	242	PF00400	0.512
TRG_ER_diArg_1	24	26	PF00400	0.533
TRG_ER_diArg_1	245	248	PF00400	0.511
TRG_ER_diArg_1	250	253	PF00400	0.543
TRG_ER_diArg_1	368	370	PF00400	0.465
TRG_ER_diArg_1	406	409	PF00400	0.534
TRG_ER_diArg_1	8	10	PF00400	0.645
TRG_NLS_Bipartite_1	93	111	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC16	Leptomonas seymouri	68%	100%
A0A0S4IZV5	Bodo saltans	36%	100%
A0A1X0NPB4	Trypanosomatidae	38%	100%
A0A3S5H6Q9	Leishmania donovani	92%	100%
A0A422NXD4	Trypanosoma rangeli	37%	100%
A4H7I1	Leishmania braziliensis	81%	100%
A4HVW3	Leishmania infantum	93%	100%
C9ZT63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q2M329	Homo sapiens	30%	80%
Q4QFW4	Leishmania major	91%	100%
Q95LS7	Macaca fascicularis	29%	79%
Q9CR92	Mus musculus	28%	76%
V5BHR7	Trypanosoma cruzi	38%	100%