Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 18 protein

Species:

Leishmania mexicana

UniProt:

E9APL3_LEIMU

TriTrypDb:

LmxM.14.0200

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0034464	BBSome	2	7
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APL3

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0030030	cell projection organization	4	7
GO:0030031	cell projection assembly	5	7
GO:0044782	cilium organization	5	7
GO:0060271	cilium assembly	6	7
GO:0070925	organelle assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0120031	plasma membrane bounded cell projection assembly	6	7
GO:0120036	plasma membrane bounded cell projection organization	5	7
GO:0008104	protein localization	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1
GO:0097499	protein localization to non-motile cilium	7	1
GO:0097500	receptor localization to non-motile cilium	6	1
GO:1903441	protein localization to ciliary membrane	5	1
GO:1990778	protein localization to cell periphery	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.284
CLV_NRD_NRD_1	137	139	PF00675	0.480
CLV_PCSK_KEX2_1	137	139	PF00082	0.480
CLV_PCSK_KEX2_1	66	68	PF00082	0.333
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.333
DEG_Nend_UBRbox_2	1	3	PF02207	0.576
DEG_SPOP_SBC_1	177	181	PF00917	0.620
DOC_MAPK_JIP1_4	38	44	PF00069	0.304
DOC_USP7_MATH_1	130	134	PF00917	0.741
DOC_USP7_MATH_1	165	169	PF00917	0.633
DOC_USP7_MATH_1	184	188	PF00917	0.509
DOC_USP7_MATH_1	43	47	PF00917	0.304
DOC_USP7_UBL2_3	54	58	PF12436	0.346
DOC_WW_Pin1_4	111	116	PF00397	0.542
DOC_WW_Pin1_4	119	124	PF00397	0.577
DOC_WW_Pin1_4	180	185	PF00397	0.593
DOC_WW_Pin1_4	79	84	PF00397	0.463
LIG_14-3-3_CanoR_1	137	147	PF00244	0.653
LIG_14-3-3_CanoR_1	170	177	PF00244	0.587
LIG_BRCT_BRCA1_1	81	85	PF00533	0.396
LIG_FHA_1	13	19	PF00498	0.369
LIG_FHA_2	79	85	PF00498	0.493
LIG_MYND_1	39	43	PF01753	0.304
LIG_SH3_3	94	100	PF00018	0.558
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.205
LIG_TRAF2_1	140	143	PF00917	0.624
LIG_UBA3_1	41	45	PF00899	0.245
MOD_CDK_SPxK_1	111	117	PF00069	0.588
MOD_CK1_1	133	139	PF00069	0.634
MOD_CK1_1	141	147	PF00069	0.482
MOD_CK1_1	169	175	PF00069	0.577
MOD_CK1_1	178	184	PF00069	0.589
MOD_CK2_1	160	166	PF00069	0.584
MOD_CK2_1	170	176	PF00069	0.585
MOD_GlcNHglycan	124	127	PF01048	0.623
MOD_GlcNHglycan	132	135	PF01048	0.605
MOD_GlcNHglycan	162	165	PF01048	0.690
MOD_GlcNHglycan	184	187	PF01048	0.672
MOD_GSK3_1	141	148	PF00069	0.623
MOD_GSK3_1	165	172	PF00069	0.614
MOD_GSK3_1	175	182	PF00069	0.527
MOD_GSK3_1	79	86	PF00069	0.557
MOD_LATS_1	108	114	PF00433	0.482
MOD_N-GLC_2	118	120	PF02516	0.505
MOD_NEK2_1	145	150	PF00069	0.500
MOD_NEK2_1	78	83	PF00069	0.530
MOD_PIKK_1	138	144	PF00454	0.650
MOD_PKA_2	166	172	PF00069	0.553
MOD_Plk_1	12	18	PF00069	0.390
MOD_ProDKin_1	111	117	PF00069	0.543
MOD_ProDKin_1	119	125	PF00069	0.580
MOD_ProDKin_1	180	186	PF00069	0.594
MOD_ProDKin_1	79	85	PF00069	0.469
MOD_SUMO_rev_2	50	60	PF00179	0.317
TRG_ER_FFAT_2	141	153	PF00635	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP5	Leptomonas seymouri	46%	100%
A0A3Q8II74	Leishmania donovani	77%	100%
A4H7I0	Leishmania braziliensis	71%	100%
A4HVW2	Leishmania infantum	77%	100%
Q4QFW5	Leishmania major	79%	100%