Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APL1_LEIMU

TriTrypDb:

LmxM.14.0170

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	530	534	PF00656	0.530
CLV_NRD_NRD_1	290	292	PF00675	0.643
CLV_NRD_NRD_1	297	299	PF00675	0.624
CLV_NRD_NRD_1	511	513	PF00675	0.308
CLV_NRD_NRD_1	634	636	PF00675	0.597
CLV_NRD_NRD_1	663	665	PF00675	0.702
CLV_NRD_NRD_1	75	77	PF00675	0.471
CLV_PCSK_KEX2_1	290	292	PF00082	0.647
CLV_PCSK_KEX2_1	296	298	PF00082	0.659
CLV_PCSK_KEX2_1	511	513	PF00082	0.326
CLV_PCSK_KEX2_1	634	636	PF00082	0.597
CLV_PCSK_KEX2_1	662	664	PF00082	0.702
CLV_PCSK_KEX2_1	75	77	PF00082	0.471
CLV_PCSK_SKI1_1	157	161	PF00082	0.487
CLV_PCSK_SKI1_1	305	309	PF00082	0.530
CLV_PCSK_SKI1_1	319	323	PF00082	0.487
CLV_PCSK_SKI1_1	326	330	PF00082	0.532
CLV_PCSK_SKI1_1	368	372	PF00082	0.465
CLV_PCSK_SKI1_1	42	46	PF00082	0.575
DEG_APCC_DBOX_1	304	312	PF00400	0.507
DEG_APCC_DBOX_1	413	421	PF00400	0.467
DEG_SCF_FBW7_1	144	151	PF00400	0.472
DEG_SIAH_1	594	602	PF03145	0.625
DEG_SPOP_SBC_1	235	239	PF00917	0.555
DEG_SPOP_SBC_1	558	562	PF00917	0.570
DOC_CKS1_1	145	150	PF01111	0.469
DOC_CKS1_1	192	197	PF01111	0.573
DOC_CKS1_1	262	267	PF01111	0.609
DOC_MAPK_gen_1	425	434	PF00069	0.442
DOC_MAPK_gen_1	63	71	PF00069	0.462
DOC_MAPK_MEF2A_6	414	421	PF00069	0.465
DOC_MAPK_MEF2A_6	63	71	PF00069	0.519
DOC_MAPK_NFAT4_5	414	422	PF00069	0.462
DOC_PP1_RVXF_1	40	47	PF00149	0.500
DOC_PP1_RVXF_1	522	528	PF00149	0.471
DOC_PP2B_LxvP_1	115	118	PF13499	0.524
DOC_USP7_MATH_1	12	16	PF00917	0.644
DOC_USP7_MATH_1	222	226	PF00917	0.723
DOC_USP7_MATH_1	229	233	PF00917	0.632
DOC_USP7_MATH_1	235	239	PF00917	0.558
DOC_USP7_MATH_1	558	562	PF00917	0.509
DOC_USP7_MATH_1	67	71	PF00917	0.489
DOC_USP7_MATH_1	679	683	PF00917	0.682
DOC_USP7_MATH_1	91	95	PF00917	0.506
DOC_WW_Pin1_4	144	149	PF00397	0.478
DOC_WW_Pin1_4	191	196	PF00397	0.576
DOC_WW_Pin1_4	258	263	PF00397	0.696
DOC_WW_Pin1_4	326	331	PF00397	0.524
DOC_WW_Pin1_4	35	40	PF00397	0.607
DOC_WW_Pin1_4	445	450	PF00397	0.502
DOC_WW_Pin1_4	657	662	PF00397	0.608
DOC_WW_Pin1_4	675	680	PF00397	0.578
LIG_14-3-3_CanoR_1	224	229	PF00244	0.596
LIG_14-3-3_CanoR_1	247	252	PF00244	0.641
LIG_14-3-3_CanoR_1	425	430	PF00244	0.462
LIG_14-3-3_CanoR_1	556	564	PF00244	0.695
LIG_14-3-3_CanoR_1	625	630	PF00244	0.501
LIG_14-3-3_CanoR_1	634	640	PF00244	0.527
LIG_14-3-3_CanoR_1	646	651	PF00244	0.507
LIG_14-3-3_CanoR_1	662	667	PF00244	0.555
LIG_14-3-3_CanoR_1	83	88	PF00244	0.478
LIG_BRCT_BRCA1_1	251	255	PF00533	0.482
LIG_BRCT_BRCA1_1	560	564	PF00533	0.534
LIG_CSL_BTD_1	142	145	PF09270	0.512
LIG_DLG_GKlike_1	425	432	PF00625	0.404
LIG_FHA_1	112	118	PF00498	0.466
LIG_FHA_1	145	151	PF00498	0.472
LIG_FHA_1	171	177	PF00498	0.466
LIG_FHA_1	262	268	PF00498	0.684
LIG_FHA_1	28	34	PF00498	0.536
LIG_FHA_1	337	343	PF00498	0.457
LIG_FHA_1	348	354	PF00498	0.437
LIG_FHA_1	449	455	PF00498	0.437
LIG_FHA_1	493	499	PF00498	0.438
LIG_FHA_1	56	62	PF00498	0.595
LIG_FHA_1	66	72	PF00498	0.482
LIG_FHA_2	105	111	PF00498	0.416
LIG_FHA_2	160	166	PF00498	0.422
LIG_FHA_2	301	307	PF00498	0.597
LIG_FHA_2	329	335	PF00498	0.542
LIG_FHA_2	349	355	PF00498	0.354
LIG_FHA_2	528	534	PF00498	0.511
LIG_FHA_2	663	669	PF00498	0.602
LIG_FXI_DFP_1	409	413	PF00024	0.519
LIG_Integrin_RGD_1	531	533	PF01839	0.521
LIG_LIR_Apic_2	191	195	PF02991	0.574
LIG_LIR_Apic_2	652	657	PF02991	0.608
LIG_LIR_Gen_1	107	116	PF02991	0.475
LIG_LIR_Gen_1	415	424	PF02991	0.398
LIG_LIR_Gen_1	565	574	PF02991	0.473
LIG_LIR_Nem_3	107	111	PF02991	0.458
LIG_LIR_Nem_3	140	146	PF02991	0.475
LIG_LIR_Nem_3	165	171	PF02991	0.417
LIG_LIR_Nem_3	415	419	PF02991	0.400
LIG_LIR_Nem_3	552	557	PF02991	0.669
LIG_LIR_Nem_3	561	567	PF02991	0.422
LIG_MYND_1	265	269	PF01753	0.659
LIG_NRBOX	416	422	PF00104	0.427
LIG_PCNA_yPIPBox_3	109	122	PF02747	0.392
LIG_Pex14_2	412	416	PF04695	0.415
LIG_SH2_CRK	567	571	PF00017	0.528
LIG_SH2_STAP1	567	571	PF00017	0.528
LIG_SH2_STAT5	158	161	PF00017	0.431
LIG_SH2_STAT5	504	507	PF00017	0.447
LIG_SH2_STAT5	608	611	PF00017	0.611
LIG_SH3_1	655	661	PF00018	0.616
LIG_SH3_2	207	212	PF14604	0.623
LIG_SH3_2	658	663	PF14604	0.609
LIG_SH3_3	117	123	PF00018	0.562
LIG_SH3_3	142	148	PF00018	0.474
LIG_SH3_3	204	210	PF00018	0.633
LIG_SH3_3	259	265	PF00018	0.606
LIG_SH3_3	655	661	PF00018	0.599
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.403
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.460
LIG_SUMO_SIM_par_1	494	500	PF11976	0.293
LIG_SUMO_SIM_par_1	67	73	PF11976	0.467
MOD_CDC14_SPxK_1	660	663	PF00782	0.611
MOD_CDK_SPK_2	657	662	PF00069	0.535
MOD_CDK_SPxK_1	657	663	PF00069	0.605
MOD_CDK_SPxxK_3	261	268	PF00069	0.532
MOD_CDK_SPxxK_3	35	42	PF00069	0.591
MOD_CDK_SPxxK_3	657	664	PF00069	0.608
MOD_CK1_1	149	155	PF00069	0.514
MOD_CK1_1	199	205	PF00069	0.585
MOD_CK1_1	220	226	PF00069	0.693
MOD_CK1_1	394	400	PF00069	0.477
MOD_CK1_1	448	454	PF00069	0.453
MOD_CK1_1	506	512	PF00069	0.463
MOD_CK1_1	562	568	PF00069	0.532
MOD_CK1_1	70	76	PF00069	0.447
MOD_CK2_1	149	155	PF00069	0.478
MOD_CK2_1	159	165	PF00069	0.419
MOD_CK2_1	300	306	PF00069	0.545
MOD_CK2_1	340	346	PF00069	0.441
MOD_CK2_1	469	475	PF00069	0.411
MOD_CK2_1	494	500	PF00069	0.389
MOD_CK2_1	56	62	PF00069	0.630
MOD_CK2_1	662	668	PF00069	0.630
MOD_Cter_Amidation	288	291	PF01082	0.541
MOD_DYRK1A_RPxSP_1	326	330	PF00069	0.437
MOD_GlcNHglycan	139	142	PF01048	0.488
MOD_GlcNHglycan	14	17	PF01048	0.650
MOD_GlcNHglycan	199	202	PF01048	0.657
MOD_GlcNHglycan	217	220	PF01048	0.571
MOD_GlcNHglycan	224	227	PF01048	0.625
MOD_GlcNHglycan	231	234	PF01048	0.590
MOD_GlcNHglycan	238	241	PF01048	0.614
MOD_GlcNHglycan	251	254	PF01048	0.500
MOD_GlcNHglycan	278	281	PF01048	0.489
MOD_GlcNHglycan	35	38	PF01048	0.497
MOD_GlcNHglycan	396	399	PF01048	0.480
MOD_GlcNHglycan	561	564	PF01048	0.527
MOD_GlcNHglycan	576	579	PF01048	0.560
MOD_GlcNHglycan	58	61	PF01048	0.514
MOD_GlcNHglycan	615	618	PF01048	0.435
MOD_GSK3_1	144	151	PF00069	0.472
MOD_GSK3_1	220	227	PF00069	0.691
MOD_GSK3_1	336	343	PF00069	0.466
MOD_GSK3_1	439	446	PF00069	0.397
MOD_GSK3_1	503	510	PF00069	0.421
MOD_GSK3_1	558	565	PF00069	0.588
MOD_GSK3_1	645	652	PF00069	0.604
MOD_GSK3_1	662	669	PF00069	0.554
MOD_GSK3_1	675	682	PF00069	0.801
MOD_GSK3_1	79	86	PF00069	0.445
MOD_N-GLC_1	507	512	PF02516	0.425
MOD_NEK2_1	196	201	PF00069	0.691
MOD_NEK2_1	33	38	PF00069	0.559
MOD_NEK2_1	373	378	PF00069	0.484
MOD_NEK2_1	420	425	PF00069	0.387
MOD_NEK2_1	45	50	PF00069	0.478
MOD_NEK2_1	487	492	PF00069	0.444
MOD_NEK2_1	527	532	PF00069	0.607
MOD_NEK2_1	559	564	PF00069	0.649
MOD_NEK2_1	606	611	PF00069	0.665
MOD_NEK2_1	613	618	PF00069	0.602
MOD_NEK2_1	633	638	PF00069	0.624
MOD_NEK2_2	67	72	PF00069	0.447
MOD_NEK2_2	91	96	PF00069	0.513
MOD_PIKK_1	224	230	PF00454	0.708
MOD_PIKK_1	443	449	PF00454	0.420
MOD_PKA_1	662	668	PF00069	0.549
MOD_PKA_2	229	235	PF00069	0.611
MOD_PKA_2	574	580	PF00069	0.520
MOD_PKA_2	633	639	PF00069	0.558
MOD_PKA_2	645	651	PF00069	0.504
MOD_PKA_2	662	668	PF00069	0.548
MOD_Plk_4	111	117	PF00069	0.498
MOD_Plk_4	171	177	PF00069	0.466
MOD_Plk_4	340	346	PF00069	0.441
MOD_Plk_4	348	354	PF00069	0.437
MOD_Plk_4	391	397	PF00069	0.503
MOD_Plk_4	487	493	PF00069	0.547
MOD_Plk_4	625	631	PF00069	0.583
MOD_Plk_4	67	73	PF00069	0.472
MOD_ProDKin_1	144	150	PF00069	0.470
MOD_ProDKin_1	191	197	PF00069	0.582
MOD_ProDKin_1	258	264	PF00069	0.698
MOD_ProDKin_1	326	332	PF00069	0.524
MOD_ProDKin_1	35	41	PF00069	0.596
MOD_ProDKin_1	445	451	PF00069	0.495
MOD_ProDKin_1	657	663	PF00069	0.610
MOD_ProDKin_1	675	681	PF00069	0.575
TRG_DiLeu_BaEn_1	566	571	PF01217	0.478
TRG_DiLeu_BaEn_2	154	160	PF01217	0.444
TRG_ENDOCYTIC_2	54	57	PF00928	0.422
TRG_ENDOCYTIC_2	567	570	PF00928	0.464
TRG_ER_diArg_1	295	298	PF00400	0.690
TRG_ER_diArg_1	375	378	PF00400	0.454
TRG_ER_diArg_1	424	427	PF00400	0.392
TRG_ER_diArg_1	524	527	PF00400	0.412
TRG_ER_diArg_1	633	635	PF00400	0.595
TRG_ER_diArg_1	661	664	PF00400	0.644
TRG_ER_diArg_1	74	76	PF00400	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B4	Leptomonas seymouri	44%	100%
A0A3Q8I8P4	Leishmania donovani	91%	100%
A4H7H8	Leishmania braziliensis	77%	100%
A4HVV9	Leishmania infantum	91%	100%
Q4QFW8	Leishmania major	90%	100%