Chromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APL0_LEIMU

TriTrypDb:

LmxM.14.0160

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.485
CLV_NRD_NRD_1	165	167	PF00675	0.716
CLV_NRD_NRD_1	168	170	PF00675	0.718
CLV_PCSK_FUR_1	166	170	PF00082	0.678
CLV_PCSK_KEX2_1	12	14	PF00082	0.485
CLV_PCSK_KEX2_1	168	170	PF00082	0.634
CLV_PCSK_KEX2_1	190	192	PF00082	0.699
CLV_PCSK_KEX2_1	38	40	PF00082	0.602
CLV_PCSK_KEX2_1	78	80	PF00082	0.629
CLV_PCSK_KEX2_1	95	97	PF00082	0.579
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.667
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.683
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.602
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.650
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.579
CLV_PCSK_SKI1_1	170	174	PF00082	0.671
CLV_PCSK_SKI1_1	341	345	PF00082	0.526
CLV_PCSK_SKI1_1	7	11	PF00082	0.308
CLV_PCSK_SKI1_1	75	79	PF00082	0.728
DEG_SCF_FBW7_2	318	324	PF00400	0.624
DEG_SPOP_SBC_1	87	91	PF00917	0.592
DOC_CDC14_PxL_1	180	188	PF14671	0.682
DOC_CDC14_PxL_1	243	251	PF14671	0.608
DOC_CKS1_1	318	323	PF01111	0.624
DOC_MAPK_MEF2A_6	331	339	PF00069	0.457
DOC_MAPK_MEF2A_6	341	349	PF00069	0.373
DOC_PP1_RVXF_1	339	345	PF00149	0.536
DOC_PP2B_LxvP_1	119	122	PF13499	0.707
DOC_PP4_FxxP_1	257	260	PF00568	0.685
DOC_USP7_MATH_1	172	176	PF00917	0.703
DOC_USP7_MATH_1	234	238	PF00917	0.426
DOC_WW_Pin1_4	208	213	PF00397	0.563
DOC_WW_Pin1_4	280	285	PF00397	0.596
DOC_WW_Pin1_4	308	313	PF00397	0.630
DOC_WW_Pin1_4	317	322	PF00397	0.633
DOC_WW_Pin1_4	98	103	PF00397	0.779
LIG_14-3-3_CanoR_1	169	179	PF00244	0.665
LIG_14-3-3_CanoR_1	236	243	PF00244	0.504
LIG_14-3-3_CanoR_1	276	280	PF00244	0.609
LIG_14-3-3_CanoR_1	331	336	PF00244	0.479
LIG_14-3-3_CanoR_1	96	101	PF00244	0.769
LIG_APCC_ABBA_1	294	299	PF00400	0.680
LIG_BIR_III_4	130	134	PF00653	0.574
LIG_BRCT_BRCA1_1	282	286	PF00533	0.686
LIG_deltaCOP1_diTrp_1	66	73	PF00928	0.680
LIG_FHA_1	174	180	PF00498	0.689
LIG_FHA_1	320	326	PF00498	0.681
LIG_FHA_1	352	358	PF00498	0.535
LIG_FHA_2	3	9	PF00498	0.615
LIG_FHA_2	59	65	PF00498	0.581
LIG_FHA_2	87	93	PF00498	0.748
LIG_LIR_Nem_3	338	343	PF02991	0.479
LIG_NRBOX	113	119	PF00104	0.639
LIG_Pex14_2	213	217	PF04695	0.707
LIG_Pex14_2	340	344	PF04695	0.533
LIG_SH2_PTP2	305	308	PF00017	0.566
LIG_SH2_STAP1	23	27	PF00017	0.439
LIG_SH2_STAT3	107	110	PF00017	0.449
LIG_SH2_STAT5	107	110	PF00017	0.449
LIG_SH2_STAT5	305	308	PF00017	0.440
LIG_SH2_STAT5	351	354	PF00017	0.538
LIG_SH2_STAT5	4	7	PF00017	0.579
LIG_SH3_3	209	215	PF00018	0.712
LIG_SH3_3	312	318	PF00018	0.600
LIG_SH3_3	339	345	PF00018	0.568
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.671
LIG_SUMO_SIM_par_1	142	148	PF11976	0.599
LIG_SUMO_SIM_par_1	259	264	PF11976	0.669
LIG_TRAF2_1	289	292	PF00917	0.606
LIG_TRAF2_1	61	64	PF00917	0.590
LIG_WW_3	120	124	PF00397	0.622
MOD_CK2_1	2	8	PF00069	0.609
MOD_CK2_1	58	64	PF00069	0.594
MOD_CK2_1	86	92	PF00069	0.763
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.742
MOD_GlcNHglycan	153	158	PF01048	0.592
MOD_GlcNHglycan	252	255	PF01048	0.544
MOD_GlcNHglycan	287	290	PF01048	0.661
MOD_GSK3_1	168	175	PF00069	0.722
MOD_GSK3_1	196	203	PF00069	0.539
MOD_GSK3_1	331	338	PF00069	0.458
MOD_GSK3_1	94	101	PF00069	0.745
MOD_LATS_1	239	245	PF00433	0.575
MOD_LATS_1	329	335	PF00433	0.582
MOD_N-GLC_1	159	164	PF02516	0.743
MOD_NEK2_1	159	164	PF00069	0.729
MOD_NEK2_1	250	255	PF00069	0.559
MOD_NEK2_1	275	280	PF00069	0.583
MOD_NEK2_1	285	290	PF00069	0.532
MOD_NEK2_1	353	358	PF00069	0.517
MOD_NEK2_1	86	91	PF00069	0.740
MOD_PK_1	241	247	PF00069	0.586
MOD_PK_1	96	102	PF00069	0.767
MOD_PKA_1	168	174	PF00069	0.648
MOD_PKA_2	168	174	PF00069	0.704
MOD_PKA_2	235	241	PF00069	0.555
MOD_PKA_2	275	281	PF00069	0.617
MOD_Plk_1	153	159	PF00069	0.629
MOD_Plk_1	32	38	PF00069	0.511
MOD_Plk_4	139	145	PF00069	0.586
MOD_Plk_4	196	202	PF00069	0.580
MOD_Plk_4	335	341	PF00069	0.427
MOD_Plk_4	353	359	PF00069	0.497
MOD_ProDKin_1	208	214	PF00069	0.564
MOD_ProDKin_1	280	286	PF00069	0.597
MOD_ProDKin_1	308	314	PF00069	0.637
MOD_ProDKin_1	317	323	PF00069	0.635
MOD_ProDKin_1	98	104	PF00069	0.776
MOD_SUMO_for_1	25	28	PF00179	0.486
TRG_DiLeu_BaEn_1	140	145	PF01217	0.615
TRG_DiLeu_BaEn_3	138	144	PF01217	0.713
TRG_DiLeu_BaEn_3	153	159	PF01217	0.459
TRG_ER_diArg_1	12	14	PF00400	0.485
TRG_NLS_Bipartite_1	78	99	PF00514	0.773
TRG_NLS_MonoCore_2	165	170	PF00514	0.607
TRG_NLS_MonoExtC_3	165	170	PF00514	0.721
TRG_NLS_MonoExtN_4	166	172	PF00514	0.644
TRG_NLS_MonoExtN_4	93	99	PF00514	0.770
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I624	Leptomonas seymouri	54%	92%
A0A1X0NPE6	Trypanosomatidae	29%	100%
A0A3Q8ID14	Leishmania donovani	92%	100%
A0A422NX90	Trypanosoma rangeli	31%	100%
A4H7H7	Leishmania braziliensis	82%	100%
A4HVV8	Leishmania infantum	92%	100%
C9ZT68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4QFW9	Leishmania major	89%	98%
V5BM97	Trypanosoma cruzi	30%	100%