Putative 60S ribosomal protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein, putative

Species:

Leishmania mexicana

UniProt:

E9APK9_LEIMU

TriTrypDb:

LmxM.14.0150

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

E9APK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK9

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.317
CLV_NRD_NRD_1	2	4	PF00675	0.543
CLV_PCSK_KEX2_1	2	4	PF00082	0.543
CLV_PCSK_SKI1_1	126	130	PF00082	0.290
CLV_PCSK_SKI1_1	13	17	PF00082	0.558
CLV_PCSK_SKI1_1	132	136	PF00082	0.290
CLV_PCSK_SKI1_1	2	6	PF00082	0.568
CLV_PCSK_SKI1_1	52	56	PF00082	0.444
CLV_PCSK_SKI1_1	67	71	PF00082	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.545
DEG_SIAH_1	83	91	PF03145	0.404
DOC_MAPK_gen_1	104	116	PF00069	0.510
DOC_MAPK_gen_1	129	139	PF00069	0.290
DOC_MAPK_RevD_3	42	57	PF00069	0.452
DOC_PP1_RVXF_1	50	56	PF00149	0.450
DOC_PP2B_PxIxI_1	120	126	PF00149	0.301
DOC_USP7_UBL2_3	101	105	PF12436	0.579
DOC_USP7_UBL2_3	144	148	PF12436	0.422
DOC_USP7_UBL2_3	171	175	PF12436	0.422
LIG_FHA_1	109	115	PF00498	0.314
LIG_FHA_2	41	47	PF00498	0.425
LIG_LIR_Gen_1	37	47	PF02991	0.435
LIG_LIR_Nem_3	37	42	PF02991	0.453
LIG_PDZ_Class_3	174	179	PF00595	0.301
LIG_RPA_C_Plants	132	143	PF08784	0.284
LIG_SH2_CRK	39	43	PF00017	0.428
LIG_SH2_STAP1	112	116	PF00017	0.347
LIG_SH2_STAP1	65	69	PF00017	0.478
LIG_SH2_STAT5	20	23	PF00017	0.618
LIG_WRC_WIRS_1	116	121	PF05994	0.148
MOD_CK1_1	40	46	PF00069	0.452
MOD_CK2_1	40	46	PF00069	0.444
MOD_GlcNHglycan	7	10	PF01048	0.614
MOD_GSK3_1	5	12	PF00069	0.605
MOD_N-GLC_1	135	140	PF02516	0.393
MOD_N-GLC_1	155	160	PF02516	0.368
MOD_NEK2_1	152	157	PF00069	0.290
MOD_NEK2_1	5	10	PF00069	0.634
MOD_PIKK_1	37	43	PF00454	0.439
MOD_Plk_1	135	141	PF00069	0.393
MOD_Plk_2-3	108	114	PF00069	0.509
MOD_SUMO_for_1	100	103	PF00179	0.624
MOD_SUMO_for_1	114	117	PF00179	0.347
MOD_SUMO_for_1	174	177	PF00179	0.422
MOD_SUMO_rev_2	108	116	PF00179	0.330
MOD_SUMO_rev_2	117	125	PF00179	0.314
MOD_SUMO_rev_2	138	145	PF00179	0.334
MOD_SUMO_rev_2	98	107	PF00179	0.591
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.557
TRG_ENDOCYTIC_2	169	172	PF00928	0.422
TRG_ENDOCYTIC_2	39	42	PF00928	0.416
TRG_ER_diArg_1	1	3	PF00400	0.551
TRG_NES_CRM1_1	130	141	PF08389	0.278
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q4	Leptomonas seymouri	82%	99%
A0A0S4IRA5	Bodo saltans	61%	78%
A0A0S4JKH3	Bodo saltans	45%	75%
A0A1X0NNT1	Trypanosomatidae	69%	97%
A0A3S5H6Q7	Leishmania donovani	91%	99%
A0A422NF54	Trypanosoma rangeli	37%	90%
A0A422NX95	Trypanosoma rangeli	62%	91%
A4H7H6	Leishmania braziliensis	80%	100%
A4HVV7	Leishmania infantum	90%	99%
A6LKB9	Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)	29%	100%
B3EER1	Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)	35%	100%
C9ZMG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	84%
C9ZT69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	98%
P36247	Liberibacter asiaticus	30%	100%
P52815	Homo sapiens	32%	90%
P52827	Cricetus cricetus	35%	88%
Q089R2	Shewanella frigidimarina (strain NCIMB 400)	30%	100%
Q160X6	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	37%	100%
Q4QFX0	Leishmania major	90%	100%
Q7YR75	Bos taurus	33%	90%
Q9DB15	Mus musculus	34%	89%
Q9ZE21	Rickettsia prowazekii (strain Madrid E)	29%	100%
V5BHT7	Trypanosoma cruzi	66%	97%