Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9APK8_LEIMU

TriTrypDb:

LmxM.14.0140

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK8

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004402	histone acetyltransferase activity	4	12
GO:0008080	N-acetyltransferase activity	6	12
GO:0016407	acetyltransferase activity	5	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0034212	peptide N-acetyltransferase activity	7	12
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.556
CLV_NRD_NRD_1	290	292	PF00675	0.365
CLV_NRD_NRD_1	387	389	PF00675	0.252
CLV_NRD_NRD_1	89	91	PF00675	0.751
CLV_PCSK_FUR_1	136	140	PF00082	0.697
CLV_PCSK_KEX2_1	138	140	PF00082	0.643
CLV_PCSK_KEX2_1	290	292	PF00082	0.365
CLV_PCSK_KEX2_1	387	389	PF00082	0.252
CLV_PCSK_KEX2_1	473	475	PF00082	0.402
CLV_PCSK_KEX2_1	89	91	PF00082	0.751
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.460
CLV_PCSK_PC7_1	286	292	PF00082	0.356
CLV_PCSK_PC7_1	469	475	PF00082	0.420
CLV_PCSK_SKI1_1	259	263	PF00082	0.477
CLV_PCSK_SKI1_1	314	318	PF00082	0.270
CLV_PCSK_SKI1_1	474	478	PF00082	0.548
CLV_PCSK_SKI1_1	479	483	PF00082	0.559
CLV_PCSK_SKI1_1	99	103	PF00082	0.591
DEG_SCF_TRCP1_1	220	225	PF00400	0.490
DEG_SPOP_SBC_1	195	199	PF00917	0.656
DOC_CKS1_1	392	397	PF01111	0.556
DOC_CKS1_1	80	85	PF01111	0.632
DOC_MAPK_gen_1	290	297	PF00069	0.562
DOC_MAPK_MEF2A_6	290	297	PF00069	0.471
DOC_PP2B_LxvP_1	364	367	PF13499	0.452
DOC_SPAK_OSR1_1	376	380	PF12202	0.452
DOC_USP7_MATH_1	110	114	PF00917	0.510
DOC_USP7_MATH_1	228	232	PF00917	0.677
DOC_USP7_MATH_1	245	249	PF00917	0.430
DOC_USP7_UBL2_3	473	477	PF12436	0.534
DOC_WW_Pin1_4	163	168	PF00397	0.414
DOC_WW_Pin1_4	324	329	PF00397	0.452
DOC_WW_Pin1_4	351	356	PF00397	0.452
DOC_WW_Pin1_4	391	396	PF00397	0.452
DOC_WW_Pin1_4	79	84	PF00397	0.745
LIG_14-3-3_CanoR_1	247	252	PF00244	0.452
LIG_APCC_ABBA_1	258	263	PF00400	0.469
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	140	144	PF00533	0.513
LIG_BRCT_BRCA1_1	312	316	PF00533	0.452
LIG_BRCT_BRCA1_1	482	486	PF00533	0.503
LIG_Clathr_ClatBox_1	292	296	PF01394	0.464
LIG_deltaCOP1_diTrp_1	161	165	PF00928	0.405
LIG_FHA_1	100	106	PF00498	0.801
LIG_FHA_1	145	151	PF00498	0.559
LIG_FHA_1	202	208	PF00498	0.788
LIG_FHA_1	325	331	PF00498	0.463
LIG_FHA_1	337	343	PF00498	0.463
LIG_FHA_1	414	420	PF00498	0.556
LIG_FHA_1	436	442	PF00498	0.498
LIG_FHA_1	470	476	PF00498	0.533
LIG_FHA_1	486	492	PF00498	0.523
LIG_FHA_2	302	308	PF00498	0.537
LIG_FHA_2	459	465	PF00498	0.479
LIG_GBD_Chelix_1	293	301	PF00786	0.356
LIG_LIR_Apic_2	161	167	PF02991	0.399
LIG_LIR_Apic_2	283	288	PF02991	0.452
LIG_LIR_Gen_1	485	495	PF02991	0.493
LIG_LIR_Nem_3	162	168	PF02991	0.435
LIG_LIR_Nem_3	327	332	PF02991	0.459
LIG_LIR_Nem_3	37	43	PF02991	0.478
LIG_LIR_Nem_3	404	410	PF02991	0.470
LIG_LIR_Nem_3	482	487	PF02991	0.502
LIG_LIR_Nem_3	499	504	PF02991	0.631
LIG_MLH1_MIPbox_1	140	144	PF16413	0.513
LIG_Pex14_1	493	497	PF04695	0.509
LIG_Pex14_2	497	501	PF04695	0.588
LIG_PTB_Apo_2	17	24	PF02174	0.556
LIG_REV1ctd_RIR_1	141	150	PF16727	0.461
LIG_SH2_CRK	16	20	PF00017	0.463
LIG_SH2_STAP1	151	155	PF00017	0.423
LIG_SH2_STAP1	471	475	PF00017	0.437
LIG_SH2_STAP1	487	491	PF00017	0.381
LIG_SH2_STAT3	433	436	PF00017	0.463
LIG_SH2_STAT3	46	49	PF00017	0.463
LIG_SH2_STAT5	164	167	PF00017	0.380
LIG_SH2_STAT5	256	259	PF00017	0.481
LIG_SH2_STAT5	332	335	PF00017	0.476
LIG_SH2_STAT5	347	350	PF00017	0.536
LIG_SH2_STAT5	407	410	PF00017	0.454
LIG_SH2_STAT5	43	46	PF00017	0.457
LIG_SH2_STAT5	433	436	PF00017	0.460
LIG_SH2_STAT5	471	474	PF00017	0.455
LIG_SH2_STAT5	484	487	PF00017	0.297
LIG_SH2_STAT5	81	84	PF00017	0.633
LIG_SH3_1	502	508	PF00018	0.645
LIG_SH3_3	389	395	PF00018	0.458
LIG_SH3_3	502	508	PF00018	0.563
LIG_SH3_3	513	519	PF00018	0.566
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.463
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.463
LIG_SUMO_SIM_par_1	27	34	PF11976	0.556
LIG_SUMO_SIM_par_1	291	296	PF11976	0.464
LIG_SUMO_SIM_par_1	377	382	PF11976	0.462
LIG_TRAF2_1	422	425	PF00917	0.463
LIG_TRFH_1	256	260	PF08558	0.336
LIG_UBA3_1	311	320	PF00899	0.462
MOD_CDK_SPxK_1	391	397	PF00069	0.452
MOD_CK1_1	197	203	PF00069	0.673
MOD_CK1_1	205	211	PF00069	0.696
MOD_CK1_1	235	241	PF00069	0.683
MOD_CK1_1	336	342	PF00069	0.526
MOD_CK1_1	92	98	PF00069	0.682
MOD_CK2_1	301	307	PF00069	0.537
MOD_CK2_1	383	389	PF00069	0.465
MOD_CK2_1	458	464	PF00069	0.566
MOD_GlcNHglycan	115	119	PF01048	0.660
MOD_GlcNHglycan	140	143	PF01048	0.656
MOD_GlcNHglycan	200	203	PF01048	0.684
MOD_GlcNHglycan	204	207	PF01048	0.709
MOD_GlcNHglycan	208	211	PF01048	0.674
MOD_GlcNHglycan	220	223	PF01048	0.485
MOD_GlcNHglycan	230	233	PF01048	0.595
MOD_GlcNHglycan	234	237	PF01048	0.570
MOD_GlcNHglycan	3	6	PF01048	0.658
MOD_GlcNHglycan	83	86	PF01048	0.649
MOD_GSK3_1	110	117	PF00069	0.598
MOD_GSK3_1	138	145	PF00069	0.556
MOD_GSK3_1	159	166	PF00069	0.429
MOD_GSK3_1	180	187	PF00069	0.710
MOD_GSK3_1	194	201	PF00069	0.630
MOD_GSK3_1	202	209	PF00069	0.613
MOD_GSK3_1	218	225	PF00069	0.741
MOD_GSK3_1	228	235	PF00069	0.706
MOD_GSK3_1	243	250	PF00069	0.507
MOD_GSK3_1	297	304	PF00069	0.556
MOD_GSK3_1	379	386	PF00069	0.454
MOD_GSK3_1	485	492	PF00069	0.430
MOD_GSK3_1	81	88	PF00069	0.628
MOD_GSK3_1	99	106	PF00069	0.666
MOD_N-GLC_1	19	24	PF02516	0.356
MOD_N-GLC_1	358	363	PF02516	0.252
MOD_N-GLC_1	73	78	PF02516	0.689
MOD_N-GLC_1	92	97	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	144	149	PF00069	0.525
MOD_NEK2_1	19	24	PF00069	0.380
MOD_NEK2_1	194	199	PF00069	0.766
MOD_NEK2_1	406	411	PF00069	0.469
MOD_PIKK_1	180	186	PF00454	0.675
MOD_PKA_1	138	144	PF00069	0.519
MOD_PKA_1	89	95	PF00069	0.749
MOD_PKA_2	138	144	PF00069	0.665
MOD_PKA_2	232	238	PF00069	0.640
MOD_PKA_2	89	95	PF00069	0.749
MOD_PKB_1	136	144	PF00069	0.526
MOD_Plk_1	358	364	PF00069	0.452
MOD_Plk_1	379	385	PF00069	0.452
MOD_Plk_1	479	485	PF00069	0.538
MOD_Plk_4	159	165	PF00069	0.427
MOD_Plk_4	406	412	PF00069	0.515
MOD_Plk_4	482	488	PF00069	0.477
MOD_Plk_4	506	512	PF00069	0.621
MOD_ProDKin_1	163	169	PF00069	0.428
MOD_ProDKin_1	324	330	PF00069	0.452
MOD_ProDKin_1	351	357	PF00069	0.452
MOD_ProDKin_1	391	397	PF00069	0.452
MOD_ProDKin_1	79	85	PF00069	0.744
MOD_SUMO_rev_2	313	322	PF00179	0.461
MOD_SUMO_rev_2	384	392	PF00179	0.463
TRG_DiLeu_BaEn_1	307	312	PF01217	0.463
TRG_ENDOCYTIC_2	16	19	PF00928	0.463
TRG_ENDOCYTIC_2	487	490	PF00928	0.374
TRG_ENDOCYTIC_2	498	501	PF00928	0.483
TRG_ER_diArg_1	136	139	PF00400	0.706
TRG_ER_diArg_1	289	291	PF00400	0.556
TRG_NES_CRM1_1	307	318	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	447	452	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B0	Leptomonas seymouri	81%	100%
A0A0S4IZ19	Bodo saltans	39%	100%
A0A1X0NNT9	Trypanosomatidae	59%	100%
A0A3R7M6T2	Trypanosoma rangeli	58%	100%
A4H7H5	Leishmania braziliensis	88%	100%
A4HVV6	Leishmania infantum	96%	100%
C9ZT70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D7RTH9	Leishmania donovani	96%	100%
E9B048	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
O94446	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q4QFX1	Leishmania major	96%	100%
Q5A7Q2	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	97%
V5BHR3	Trypanosoma cruzi	58%	100%