Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APK6_LEIMU

TriTrypDb:

LmxM.14.0120

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.534
CLV_NRD_NRD_1	271	273	PF00675	0.665
CLV_NRD_NRD_1	287	289	PF00675	0.490
CLV_NRD_NRD_1	295	297	PF00675	0.648
CLV_NRD_NRD_1	327	329	PF00675	0.736
CLV_PCSK_FUR_1	303	307	PF00082	0.790
CLV_PCSK_KEX2_1	221	223	PF00082	0.535
CLV_PCSK_KEX2_1	287	289	PF00082	0.662
CLV_PCSK_KEX2_1	295	297	PF00082	0.678
CLV_PCSK_KEX2_1	305	307	PF00082	0.662
CLV_PCSK_KEX2_1	327	329	PF00082	0.653
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.755
DEG_SPOP_SBC_1	41	45	PF00917	0.542
DOC_CYCLIN_yCln2_LP_2	56	59	PF00134	0.679
DOC_PP2B_LxvP_1	56	59	PF13499	0.638
DOC_USP7_MATH_1	16	20	PF00917	0.705
DOC_USP7_MATH_1	42	46	PF00917	0.579
DOC_USP7_MATH_1	75	79	PF00917	0.715
DOC_WW_Pin1_4	260	265	PF00397	0.787
DOC_WW_Pin1_4	288	293	PF00397	0.758
DOC_WW_Pin1_4	296	301	PF00397	0.819
DOC_WW_Pin1_4	37	42	PF00397	0.566
LIG_14-3-3_CanoR_1	149	154	PF00244	0.354
LIG_14-3-3_CanoR_1	272	280	PF00244	0.567
LIG_14-3-3_CanoR_1	337	345	PF00244	0.657
LIG_EH1_1	169	177	PF00400	0.518
LIG_eIF4E_1	170	176	PF01652	0.581
LIG_eIF4E_1	320	326	PF01652	0.705
LIG_EVH1_1	67	71	PF00568	0.688
LIG_FHA_1	100	106	PF00498	0.805
LIG_FHA_1	146	152	PF00498	0.664
LIG_FHA_1	172	178	PF00498	0.593
LIG_FHA_1	87	93	PF00498	0.667
LIG_FHA_2	214	220	PF00498	0.715
LIG_LIR_Gen_1	148	157	PF02991	0.512
LIG_LIR_Gen_1	240	251	PF02991	0.681
LIG_LIR_Gen_1	274	284	PF02991	0.525
LIG_LIR_Nem_3	129	134	PF02991	0.682
LIG_LIR_Nem_3	148	153	PF02991	0.529
LIG_LIR_Nem_3	240	246	PF02991	0.667
LIG_LIR_Nem_3	274	279	PF02991	0.524
LIG_LIR_Nem_3	340	345	PF02991	0.577
LIG_RPA_C_Fungi	217	229	PF08784	0.670
LIG_SH2_CRK	345	349	PF00017	0.697
LIG_SH2_NCK_1	223	227	PF00017	0.361
LIG_SH2_STAP1	276	280	PF00017	0.570
LIG_SH2_STAT3	333	336	PF00017	0.619
LIG_SH2_STAT5	150	153	PF00017	0.569
LIG_SH2_STAT5	324	327	PF00017	0.576
LIG_SH3_2	256	261	PF14604	0.699
LIG_SH3_3	102	108	PF00018	0.773
LIG_SH3_3	114	120	PF00018	0.591
LIG_SH3_3	21	27	PF00018	0.660
LIG_SH3_3	253	259	PF00018	0.706
LIG_SH3_3	29	35	PF00018	0.748
LIG_SH3_3	311	317	PF00018	0.608
LIG_SH3_3	4	10	PF00018	0.739
LIG_SH3_3	45	51	PF00018	0.708
LIG_SH3_3	52	58	PF00018	0.641
LIG_SH3_3	65	71	PF00018	0.472
LIG_SH3_3	78	84	PF00018	0.732
LIG_SH3_3	88	94	PF00018	0.708
LIG_SH3_3	95	101	PF00018	0.728
LIG_SUMO_SIM_par_1	124	129	PF11976	0.707
LIG_TRAF2_1	152	155	PF00917	0.630
LIG_TRAF2_1	299	302	PF00917	0.635
LIG_TYR_ITSM	146	153	PF00017	0.661
MOD_CDK_SPxxK_3	288	295	PF00069	0.769
MOD_CDK_SPxxK_3	296	303	PF00069	0.807
MOD_CK1_1	19	25	PF00069	0.591
MOD_CK1_1	3	9	PF00069	0.601
MOD_CK2_1	149	155	PF00069	0.526
MOD_CK2_1	213	219	PF00069	0.723
MOD_CK2_1	234	240	PF00069	0.602
MOD_CK2_1	271	277	PF00069	0.547
MOD_CK2_1	296	302	PF00069	0.745
MOD_GlcNHglycan	102	105	PF01048	0.506
MOD_GlcNHglycan	11	14	PF01048	0.546
MOD_GlcNHglycan	135	138	PF01048	0.520
MOD_GlcNHglycan	19	22	PF01048	0.596
MOD_GlcNHglycan	206	209	PF01048	0.428
MOD_GlcNHglycan	273	276	PF01048	0.658
MOD_GlcNHglycan	44	47	PF01048	0.675
MOD_GlcNHglycan	52	55	PF01048	0.717
MOD_GlcNHglycan	77	80	PF01048	0.714
MOD_GlcNHglycan	84	87	PF01048	0.794
MOD_GSK3_1	145	152	PF00069	0.496
MOD_GSK3_1	200	207	PF00069	0.537
MOD_GSK3_1	316	323	PF00069	0.676
MOD_GSK3_1	36	43	PF00069	0.571
MOD_GSK3_1	82	89	PF00069	0.511
MOD_N-GLC_1	197	202	PF02516	0.594
MOD_N-GLC_1	320	325	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	145	150	PF00069	0.690
MOD_NEK2_1	202	207	PF00069	0.673
MOD_NEK2_1	271	276	PF00069	0.677
MOD_PIKK_1	202	208	PF00454	0.685
MOD_PK_1	149	155	PF00069	0.346
MOD_PKA_2	271	277	PF00069	0.630
MOD_Plk_1	145	151	PF00069	0.459
MOD_Plk_1	197	203	PF00069	0.544
MOD_Plk_4	171	177	PF00069	0.452
MOD_Plk_4	213	219	PF00069	0.720
MOD_Plk_4	320	326	PF00069	0.608
MOD_Plk_4	60	66	PF00069	0.703
MOD_ProDKin_1	260	266	PF00069	0.784
MOD_ProDKin_1	288	294	PF00069	0.763
MOD_ProDKin_1	296	302	PF00069	0.820
MOD_ProDKin_1	37	43	PF00069	0.567
TRG_ENDOCYTIC_2	150	153	PF00928	0.569
TRG_ENDOCYTIC_2	276	279	PF00928	0.513
TRG_ER_diArg_1	221	223	PF00400	0.392
TRG_ER_diArg_1	287	290	PF00400	0.667
TRG_ER_diArg_1	295	297	PF00400	0.804
TRG_ER_diArg_1	326	328	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NPB8	Trypanosomatidae	38%	73%
A0A3Q8I9R2	Leishmania donovani	90%	98%
A4H7H3	Leishmania braziliensis	73%	100%
A4HVV4	Leishmania infantum	90%	98%
C9ZT73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	70%
Q4QFX3	Leishmania major	87%	100%