J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APK5_LEIMU

TriTrypDb:

LmxM.14.0110

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9APK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.504
CLV_NRD_NRD_1	13	15	PF00675	0.495
CLV_NRD_NRD_1	223	225	PF00675	0.342
CLV_NRD_NRD_1	227	229	PF00675	0.357
CLV_NRD_NRD_1	238	240	PF00675	0.344
CLV_NRD_NRD_1	303	305	PF00675	0.474
CLV_NRD_NRD_1	33	35	PF00675	0.399
CLV_NRD_NRD_1	398	400	PF00675	0.348
CLV_NRD_NRD_1	433	435	PF00675	0.454
CLV_PCSK_FUR_1	11	15	PF00082	0.380
CLV_PCSK_FUR_1	303	307	PF00082	0.463
CLV_PCSK_KEX2_1	13	15	PF00082	0.495
CLV_PCSK_KEX2_1	223	225	PF00082	0.334
CLV_PCSK_KEX2_1	227	229	PF00082	0.340
CLV_PCSK_KEX2_1	303	305	PF00082	0.415
CLV_PCSK_KEX2_1	33	35	PF00082	0.399
CLV_PCSK_KEX2_1	398	400	PF00082	0.356
CLV_PCSK_KEX2_1	432	434	PF00082	0.468
CLV_PCSK_KEX2_1	488	490	PF00082	0.373
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.397
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.383
CLV_PCSK_PC7_1	223	229	PF00082	0.435
CLV_PCSK_PC7_1	394	400	PF00082	0.356
CLV_PCSK_SKI1_1	177	181	PF00082	0.411
CLV_PCSK_SKI1_1	263	267	PF00082	0.286
CLV_PCSK_SKI1_1	404	408	PF00082	0.436
CLV_PCSK_SKI1_1	461	465	PF00082	0.291
DEG_APCC_DBOX_1	168	176	PF00400	0.599
DEG_APCC_DBOX_1	433	441	PF00400	0.623
DEG_Kelch_Keap1_1	509	514	PF01344	0.655
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DEG_SCF_TRCP1_1	511	516	PF00400	0.689
DOC_MAPK_FxFP_2	151	154	PF00069	0.510
DOC_MAPK_gen_1	303	309	PF00069	0.579
DOC_MAPK_gen_1	74	81	PF00069	0.516
DOC_MAPK_JIP1_4	263	269	PF00069	0.469
DOC_MAPK_MEF2A_6	293	301	PF00069	0.543
DOC_PP4_FxxP_1	108	111	PF00568	0.509
DOC_PP4_FxxP_1	151	154	PF00568	0.510
DOC_USP7_UBL2_3	461	465	PF12436	0.544
DOC_WW_Pin1_4	27	32	PF00397	0.694
DOC_WW_Pin1_4	278	283	PF00397	0.556
DOC_WW_Pin1_4	379	384	PF00397	0.569
DOC_WW_Pin1_4	500	505	PF00397	0.358
LIG_14-3-3_CanoR_1	13	22	PF00244	0.632
LIG_14-3-3_CanoR_1	132	138	PF00244	0.635
LIG_14-3-3_CanoR_1	33	39	PF00244	0.642
LIG_14-3-3_CanoR_1	432	440	PF00244	0.661
LIG_Actin_WH2_2	351	367	PF00022	0.440
LIG_BRCT_BRCA1_1	339	343	PF00533	0.443
LIG_BRCT_BRCA1_1	35	39	PF00533	0.706
LIG_FHA_1	289	295	PF00498	0.515
LIG_FHA_1	4	10	PF00498	0.730
LIG_FHA_2	380	386	PF00498	0.606
LIG_FHA_2	423	429	PF00498	0.673
LIG_FHA_2	457	463	PF00498	0.446
LIG_LIR_Apic_2	106	111	PF02991	0.500
LIG_LIR_Apic_2	16	22	PF02991	0.531
LIG_LIR_Apic_2	165	171	PF02991	0.572
LIG_LIR_Gen_1	190	198	PF02991	0.526
LIG_LIR_Nem_3	190	195	PF02991	0.526
LIG_LIR_Nem_3	496	501	PF02991	0.474
LIG_MYND_1	476	480	PF01753	0.358
LIG_Pex14_2	108	112	PF04695	0.509
LIG_Pex14_2	151	155	PF04695	0.540
LIG_Pex14_2	241	245	PF04695	0.553
LIG_Pex14_2	266	270	PF04695	0.519
LIG_Pex14_2	35	39	PF04695	0.706
LIG_SH2_CRK	446	450	PF00017	0.432
LIG_SH2_CRK	498	502	PF00017	0.451
LIG_SH2_SRC	7	10	PF00017	0.562
LIG_SH2_STAT5	140	143	PF00017	0.592
LIG_SH2_STAT5	7	10	PF00017	0.502
LIG_SH3_3	291	297	PF00018	0.501
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.558
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.531
LIG_SUMO_SIM_par_1	170	176	PF11976	0.516
LIG_SxIP_EBH_1	204	214	PF03271	0.493
LIG_TRAF2_1	382	385	PF00917	0.595
LIG_UBA3_1	448	454	PF00899	0.488
MOD_CDC14_SPxK_1	30	33	PF00782	0.619
MOD_CDK_SPK_2	500	505	PF00069	0.358
MOD_CDK_SPxK_1	27	33	PF00069	0.721
MOD_CDK_SPxxK_3	27	34	PF00069	0.619
MOD_CDK_SPxxK_3	500	507	PF00069	0.358
MOD_CK1_1	213	219	PF00069	0.500
MOD_CK1_1	248	254	PF00069	0.531
MOD_CK1_1	27	33	PF00069	0.692
MOD_CK1_1	275	281	PF00069	0.552
MOD_CK1_1	503	509	PF00069	0.532
MOD_CK1_1	516	522	PF00069	0.762
MOD_CK2_1	164	170	PF00069	0.533
MOD_CK2_1	187	193	PF00069	0.527
MOD_CK2_1	216	222	PF00069	0.596
MOD_CK2_1	34	40	PF00069	0.735
MOD_CK2_1	379	385	PF00069	0.608
MOD_GlcNHglycan	116	120	PF01048	0.332
MOD_GlcNHglycan	15	18	PF01048	0.371
MOD_GlcNHglycan	164	167	PF01048	0.278
MOD_GlcNHglycan	340	343	PF01048	0.435
MOD_GlcNHglycan	375	378	PF01048	0.390
MOD_GlcNHglycan	455	459	PF01048	0.275
MOD_GlcNHglycan	511	514	PF01048	0.428
MOD_GlcNHglycan	515	518	PF01048	0.456
MOD_GSK3_1	115	122	PF00069	0.493
MOD_GSK3_1	13	20	PF00069	0.679
MOD_GSK3_1	179	186	PF00069	0.525
MOD_GSK3_1	23	30	PF00069	0.689
MOD_GSK3_1	241	248	PF00069	0.567
MOD_GSK3_1	273	280	PF00069	0.540
MOD_GSK3_1	428	435	PF00069	0.767
MOD_GSK3_1	509	516	PF00069	0.653
MOD_N-GLC_1	133	138	PF02516	0.486
MOD_N-GLC_1	248	253	PF02516	0.346
MOD_N-GLC_2	91	93	PF02516	0.382
MOD_NEK2_1	114	119	PF00069	0.509
MOD_NEK2_1	133	138	PF00069	0.628
MOD_NEK2_1	179	184	PF00069	0.501
MOD_NEK2_1	187	192	PF00069	0.535
MOD_NEK2_1	210	215	PF00069	0.510
MOD_NEK2_1	241	246	PF00069	0.565
MOD_NEK2_1	257	262	PF00069	0.552
MOD_NEK2_1	270	275	PF00069	0.494
MOD_NEK2_1	456	461	PF00069	0.452
MOD_NEK2_2	119	124	PF00069	0.509
MOD_PIKK_1	133	139	PF00454	0.574
MOD_PIKK_1	516	522	PF00454	0.733
MOD_PKA_1	13	19	PF00069	0.564
MOD_PKA_1	33	39	PF00069	0.593
MOD_PKA_1	432	438	PF00069	0.648
MOD_PKA_2	13	19	PF00069	0.633
MOD_PKA_2	203	209	PF00069	0.512
MOD_PKA_2	33	39	PF00069	0.690
MOD_PKA_2	432	438	PF00069	0.638
MOD_PKB_1	11	19	PF00069	0.614
MOD_Plk_1	248	254	PF00069	0.558
MOD_Plk_2-3	101	107	PF00069	0.493
MOD_Plk_4	183	189	PF00069	0.488
MOD_Plk_4	203	209	PF00069	0.572
MOD_Plk_4	216	222	PF00069	0.524
MOD_Plk_4	241	247	PF00069	0.552
MOD_Plk_4	3	9	PF00069	0.556
MOD_Plk_4	314	320	PF00069	0.322
MOD_Plk_4	34	40	PF00069	0.751
MOD_Plk_4	67	73	PF00069	0.619
MOD_ProDKin_1	27	33	PF00069	0.697
MOD_ProDKin_1	278	284	PF00069	0.553
MOD_ProDKin_1	379	385	PF00069	0.571
MOD_ProDKin_1	500	506	PF00069	0.358
MOD_SUMO_for_1	411	414	PF00179	0.561
TRG_ENDOCYTIC_2	158	161	PF00928	0.528
TRG_ENDOCYTIC_2	445	448	PF00928	0.454
TRG_ENDOCYTIC_2	498	501	PF00928	0.451
TRG_ER_diArg_1	11	14	PF00400	0.649
TRG_ER_diArg_1	223	225	PF00400	0.532
TRG_ER_diArg_1	227	229	PF00400	0.540
TRG_ER_diArg_1	303	306	PF00400	0.665
TRG_ER_diArg_1	33	35	PF00400	0.747
TRG_ER_diArg_1	350	353	PF00400	0.572
TRG_ER_diArg_1	397	399	PF00400	0.532
TRG_ER_diArg_1	432	434	PF00400	0.663
TRG_NES_CRM1_1	363	375	PF08389	0.510
TRG_NES_CRM1_1	462	477	PF08389	0.540
TRG_NLS_MonoExtN_4	303	308	PF00514	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	24%	100%
A0A0N1IK13	Leptomonas seymouri	78%	99%
A0A0S4ITI3	Bodo saltans	44%	100%
A0A1X0NQB1	Trypanosomatidae	56%	100%
A0A1X0NVK2	Trypanosomatidae	24%	100%
A0A3S7WSV3	Leishmania donovani	95%	100%
A0A3S7WYG6	Leishmania donovani	26%	100%
A0A422N8L2	Trypanosoma rangeli	23%	100%
A4H7H2	Leishmania braziliensis	86%	100%
A4HDG4	Leishmania braziliensis	25%	100%
A4HVV3	Leishmania infantum	95%	100%
C9ZT74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAM5	Leishmania major	24%	100%
Q4QFX4	Leishmania major	95%	100%
V5BD52	Trypanosoma cruzi	55%	100%
V5DSF1	Trypanosoma cruzi	22%	100%