Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APK4_LEIMU

TriTrypDb:

LmxM.14.0100

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	585	589	PF00656	0.626
CLV_NRD_NRD_1	178	180	PF00675	0.534
CLV_NRD_NRD_1	22	24	PF00675	0.727
CLV_NRD_NRD_1	222	224	PF00675	0.573
CLV_NRD_NRD_1	355	357	PF00675	0.630
CLV_NRD_NRD_1	46	48	PF00675	0.773
CLV_NRD_NRD_1	507	509	PF00675	0.517
CLV_NRD_NRD_1	548	550	PF00675	0.489
CLV_NRD_NRD_1	909	911	PF00675	0.642
CLV_NRD_NRD_1	932	934	PF00675	0.491
CLV_NRD_NRD_1	977	979	PF00675	0.389
CLV_PCSK_FUR_1	505	509	PF00082	0.503
CLV_PCSK_KEX2_1	178	180	PF00082	0.660
CLV_PCSK_KEX2_1	202	204	PF00082	0.641
CLV_PCSK_KEX2_1	222	224	PF00082	0.306
CLV_PCSK_KEX2_1	46	48	PF00082	0.773
CLV_PCSK_KEX2_1	507	509	PF00082	0.476
CLV_PCSK_KEX2_1	80	82	PF00082	0.584
CLV_PCSK_KEX2_1	909	911	PF00082	0.675
CLV_PCSK_KEX2_1	977	979	PF00082	0.491
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.641
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.562
CLV_PCSK_SKI1_1	203	207	PF00082	0.536
CLV_PCSK_SKI1_1	327	331	PF00082	0.612
CLV_PCSK_SKI1_1	367	371	PF00082	0.630
CLV_PCSK_SKI1_1	384	388	PF00082	0.391
CLV_PCSK_SKI1_1	400	404	PF00082	0.448
CLV_PCSK_SKI1_1	47	51	PF00082	0.635
CLV_PCSK_SKI1_1	659	663	PF00082	0.493
CLV_PCSK_SKI1_1	707	711	PF00082	0.406
CLV_PCSK_SKI1_1	788	792	PF00082	0.388
CLV_PCSK_SKI1_1	901	905	PF00082	0.460
CLV_PCSK_SKI1_1	922	926	PF00082	0.535
CLV_Separin_Metazoa	269	273	PF03568	0.361
DEG_APCC_DBOX_1	855	863	PF00400	0.476
DEG_Kelch_Keap1_1	472	477	PF01344	0.473
DEG_SCF_FBW7_1	10	17	PF00400	0.517
DEG_SPOP_SBC_1	38	42	PF00917	0.791
DEG_SPOP_SBC_1	702	706	PF00917	0.473
DOC_CKS1_1	11	16	PF01111	0.646
DOC_CKS1_1	647	652	PF01111	0.572
DOC_CKS1_1	753	758	PF01111	0.546
DOC_CYCLIN_RxL_1	381	389	PF00134	0.491
DOC_CYCLIN_RxL_1	397	404	PF00134	0.467
DOC_MAPK_DCC_7	165	175	PF00069	0.498
DOC_MAPK_gen_1	165	175	PF00069	0.450
DOC_MAPK_gen_1	232	240	PF00069	0.551
DOC_MAPK_gen_1	46	53	PF00069	0.614
DOC_MAPK_MEF2A_6	168	177	PF00069	0.439
DOC_MAPK_MEF2A_6	234	242	PF00069	0.621
DOC_MAPK_MEF2A_6	46	53	PF00069	0.518
DOC_MAPK_MEF2A_6	883	892	PF00069	0.424
DOC_PP1_RVXF_1	1011	1018	PF00149	0.588
DOC_PP1_RVXF_1	705	711	PF00149	0.388
DOC_PP1_RVXF_1	920	927	PF00149	0.495
DOC_USP7_MATH_1	1021	1025	PF00917	0.754
DOC_USP7_MATH_1	119	123	PF00917	0.546
DOC_USP7_MATH_1	141	145	PF00917	0.459
DOC_USP7_MATH_1	28	32	PF00917	0.680
DOC_USP7_MATH_1	39	43	PF00917	0.733
DOC_USP7_MATH_1	465	469	PF00917	0.499
DOC_USP7_MATH_1	803	807	PF00917	0.545
DOC_USP7_MATH_1	938	942	PF00917	0.476
DOC_USP7_UBL2_3	135	139	PF12436	0.526
DOC_WW_Pin1_4	10	15	PF00397	0.699
DOC_WW_Pin1_4	30	35	PF00397	0.700
DOC_WW_Pin1_4	433	438	PF00397	0.600
DOC_WW_Pin1_4	578	583	PF00397	0.572
DOC_WW_Pin1_4	646	651	PF00397	0.582
DOC_WW_Pin1_4	752	757	PF00397	0.420
DOC_WW_Pin1_4	788	793	PF00397	0.498
DOC_WW_Pin1_4	829	834	PF00397	0.561
LIG_14-3-3_CanoR_1	274	279	PF00244	0.522
LIG_14-3-3_CanoR_1	367	376	PF00244	0.506
LIG_14-3-3_CanoR_1	600	610	PF00244	0.510
LIG_14-3-3_CanoR_1	767	774	PF00244	0.600
LIG_14-3-3_CanoR_1	869	876	PF00244	0.552
LIG_14-3-3_CanoR_1	883	892	PF00244	0.344
LIG_14-3-3_CanoR_1	909	918	PF00244	0.683
LIG_14-3-3_CanoR_1	933	942	PF00244	0.560
LIG_14-3-3_CanoR_1	993	1001	PF00244	0.475
LIG_Actin_WH2_2	438	456	PF00022	0.276
LIG_Actin_WH2_2	493	509	PF00022	0.500
LIG_Actin_WH2_2	552	568	PF00022	0.567
LIG_Actin_WH2_2	658	676	PF00022	0.526
LIG_APCC_ABBA_1	953	958	PF00400	0.359
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_BRCT_BRCA1_1	613	617	PF00533	0.568
LIG_BRCT_BRCA1_1	705	709	PF00533	0.467
LIG_BRCT_BRCA1_1	922	926	PF00533	0.478
LIG_CaM_IQ_9	195	211	PF13499	0.600
LIG_Clathr_ClatBox_1	50	54	PF01394	0.609
LIG_eIF4E_1	280	286	PF01652	0.570
LIG_eIF4E_1	317	323	PF01652	0.646
LIG_eIF4E_1	85	91	PF01652	0.476
LIG_FHA_1	1004	1010	PF00498	0.503
LIG_FHA_1	129	135	PF00498	0.443
LIG_FHA_1	293	299	PF00498	0.504
LIG_FHA_1	30	36	PF00498	0.661
LIG_FHA_1	368	374	PF00498	0.585
LIG_FHA_1	581	587	PF00498	0.741
LIG_FHA_1	589	595	PF00498	0.567
LIG_FHA_1	689	695	PF00498	0.441
LIG_FHA_1	703	709	PF00498	0.362
LIG_FHA_1	753	759	PF00498	0.547
LIG_FHA_1	815	821	PF00498	0.501
LIG_FHA_1	889	895	PF00498	0.431
LIG_FHA_1	919	925	PF00498	0.571
LIG_FHA_1	957	963	PF00498	0.446
LIG_FHA_1	996	1002	PF00498	0.481
LIG_FHA_2	146	152	PF00498	0.479
LIG_FHA_2	323	329	PF00498	0.665
LIG_FHA_2	38	44	PF00498	0.717
LIG_FHA_2	426	432	PF00498	0.562
LIG_FHA_2	691	697	PF00498	0.516
LIG_FHA_2	893	899	PF00498	0.462
LIG_IBAR_NPY_1	186	188	PF08397	0.455
LIG_LIR_Apic_2	393	398	PF02991	0.560
LIG_LIR_Apic_2	431	437	PF02991	0.613
LIG_LIR_Gen_1	17	27	PF02991	0.727
LIG_LIR_Gen_1	377	387	PF02991	0.624
LIG_LIR_Gen_1	477	487	PF02991	0.388
LIG_LIR_Gen_1	683	694	PF02991	0.509
LIG_LIR_Gen_1	952	961	PF02991	0.390
LIG_LIR_Nem_3	17	22	PF02991	0.683
LIG_LIR_Nem_3	377	382	PF02991	0.550
LIG_LIR_Nem_3	460	466	PF02991	0.553
LIG_LIR_Nem_3	477	482	PF02991	0.239
LIG_LIR_Nem_3	683	689	PF02991	0.522
LIG_LIR_Nem_3	706	712	PF02991	0.378
LIG_LIR_Nem_3	722	728	PF02991	0.342
LIG_LIR_Nem_3	852	858	PF02991	0.405
LIG_LIR_Nem_3	952	956	PF02991	0.367
LIG_MLH1_MIPbox_1	922	926	PF16413	0.305
LIG_PCNA_yPIPBox_3	246	258	PF02747	0.438
LIG_PCNA_yPIPBox_3	848	858	PF02747	0.436
LIG_PDZ_Class_1	1024	1029	PF00595	0.712
LIG_Pex14_2	469	473	PF04695	0.370
LIG_Pex14_2	483	487	PF04695	0.351
LIG_PTB_Apo_2	183	190	PF02174	0.398
LIG_SH2_CRK	379	383	PF00017	0.544
LIG_SH2_CRK	520	524	PF00017	0.529
LIG_SH2_CRK	87	91	PF00017	0.400
LIG_SH2_SRC	479	482	PF00017	0.389
LIG_SH2_SRC	750	753	PF00017	0.480
LIG_SH2_STAP1	379	383	PF00017	0.544
LIG_SH2_STAP1	606	610	PF00017	0.614
LIG_SH2_STAP1	750	754	PF00017	0.486
LIG_SH2_STAP1	87	91	PF00017	0.404
LIG_SH2_STAT3	481	484	PF00017	0.459
LIG_SH2_STAT5	158	161	PF00017	0.502
LIG_SH2_STAT5	188	191	PF00017	0.431
LIG_SH2_STAT5	293	296	PF00017	0.510
LIG_SH2_STAT5	395	398	PF00017	0.558
LIG_SH2_STAT5	479	482	PF00017	0.369
LIG_SH2_STAT5	512	515	PF00017	0.526
LIG_SH2_STAT5	858	861	PF00017	0.388
LIG_SH3_1	395	401	PF00018	0.596
LIG_SH3_1	459	465	PF00018	0.576
LIG_SH3_2	462	467	PF14604	0.562
LIG_SH3_3	174	180	PF00018	0.629
LIG_SH3_3	395	401	PF00018	0.596
LIG_SH3_3	459	465	PF00018	0.599
LIG_SH3_3	576	582	PF00018	0.399
LIG_SH3_3	750	756	PF00018	0.424
LIG_SH3_3	8	14	PF00018	0.648
LIG_SH3_3	968	974	PF00018	0.426
LIG_SUMO_SIM_anti_2	958	964	PF11976	0.512
LIG_SUMO_SIM_par_1	558	563	PF11976	0.308
LIG_SUMO_SIM_par_1	997	1003	PF11976	0.533
LIG_TRAF2_1	329	332	PF00917	0.635
LIG_TRAF2_1	635	638	PF00917	0.536
LIG_TRAF2_1	680	683	PF00917	0.452
LIG_TRAF2_1	781	784	PF00917	0.477
LIG_TRFH_1	520	524	PF08558	0.516
LIG_TYR_ITIM	518	523	PF00017	0.495
LIG_UBA3_1	820	829	PF00899	0.373
LIG_WRC_WIRS_1	466	471	PF05994	0.454
LIG_WRC_WIRS_1	50	55	PF05994	0.602
MOD_CDK_SPK_2	10	15	PF00069	0.514
MOD_CDK_SPxxK_3	829	836	PF00069	0.602
MOD_CK1_1	128	134	PF00069	0.435
MOD_CK1_1	433	439	PF00069	0.578
MOD_CK1_1	457	463	PF00069	0.657
MOD_CK1_1	580	586	PF00069	0.659
MOD_CK1_1	770	776	PF00069	0.533
MOD_CK1_1	868	874	PF00069	0.640
MOD_CK1_1	875	881	PF00069	0.554
MOD_CK1_1	886	892	PF00069	0.280
MOD_CK1_1	917	923	PF00069	0.478
MOD_CK2_1	145	151	PF00069	0.482
MOD_CK2_1	322	328	PF00069	0.614
MOD_CK2_1	38	44	PF00069	0.649
MOD_CK2_1	414	420	PF00069	0.741
MOD_CK2_1	425	431	PF00069	0.460
MOD_CK2_1	471	477	PF00069	0.428
MOD_CK2_1	535	541	PF00069	0.413
MOD_CK2_1	555	561	PF00069	0.505
MOD_CK2_1	578	584	PF00069	0.583
MOD_CK2_1	677	683	PF00069	0.518
MOD_CK2_1	690	696	PF00069	0.567
MOD_CK2_1	716	722	PF00069	0.501
MOD_CK2_1	892	898	PF00069	0.462
MOD_Cter_Amidation	907	910	PF01082	0.590
MOD_DYRK1A_RPxSP_1	788	792	PF00069	0.424
MOD_GlcNHglycan	117	120	PF01048	0.529
MOD_GlcNHglycan	127	130	PF01048	0.497
MOD_GlcNHglycan	143	146	PF01048	0.423
MOD_GlcNHglycan	203	206	PF01048	0.576
MOD_GlcNHglycan	290	293	PF01048	0.456
MOD_GlcNHglycan	403	406	PF01048	0.677
MOD_GlcNHglycan	408	411	PF01048	0.772
MOD_GlcNHglycan	439	442	PF01048	0.499
MOD_GlcNHglycan	456	459	PF01048	0.399
MOD_GlcNHglycan	631	634	PF01048	0.368
MOD_GlcNHglycan	730	734	PF01048	0.491
MOD_GlcNHglycan	788	791	PF01048	0.427
MOD_GlcNHglycan	905	909	PF01048	0.664
MOD_GlcNHglycan	936	939	PF01048	0.456
MOD_GlcNHglycan	947	950	PF01048	0.467
MOD_GlcNHglycan	990	993	PF01048	0.484
MOD_GSK3_1	1	8	PF00069	0.687
MOD_GSK3_1	10	17	PF00069	0.721
MOD_GSK3_1	115	122	PF00069	0.579
MOD_GSK3_1	141	148	PF00069	0.576
MOD_GSK3_1	288	295	PF00069	0.541
MOD_GSK3_1	433	440	PF00069	0.626
MOD_GSK3_1	611	618	PF00069	0.397
MOD_GSK3_1	70	77	PF00069	0.693
MOD_GSK3_1	864	871	PF00069	0.616
MOD_GSK3_1	888	895	PF00069	0.498
MOD_GSK3_1	910	917	PF00069	0.652
MOD_GSK3_1	934	941	PF00069	0.565
MOD_GSK3_1	945	952	PF00069	0.585
MOD_GSK3_1	96	103	PF00069	0.618
MOD_N-GLC_1	1024	1029	PF02516	0.473
MOD_N-GLC_1	115	120	PF02516	0.598
MOD_N-GLC_1	367	372	PF02516	0.516
MOD_N-GLC_1	767	772	PF02516	0.605
MOD_N-GLC_1	910	915	PF02516	0.655
MOD_N-GLC_1	995	1000	PF02516	0.559
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	100	105	PF00069	0.580
MOD_NEK2_1	1000	1005	PF00069	0.514
MOD_NEK2_1	107	112	PF00069	0.404
MOD_NEK2_1	189	194	PF00069	0.464
MOD_NEK2_1	322	327	PF00069	0.651
MOD_NEK2_1	386	391	PF00069	0.556
MOD_NEK2_1	535	540	PF00069	0.453
MOD_NEK2_1	575	580	PF00069	0.690
MOD_NEK2_1	617	622	PF00069	0.624
MOD_NEK2_1	688	693	PF00069	0.443
MOD_NEK2_1	888	893	PF00069	0.429
MOD_NEK2_1	904	909	PF00069	0.584
MOD_NEK2_1	956	961	PF00069	0.368
MOD_NEK2_1	983	988	PF00069	0.443
MOD_PIKK_1	367	373	PF00454	0.647
MOD_PIKK_1	688	694	PF00454	0.529
MOD_PIKK_1	868	874	PF00454	0.557
MOD_PIKK_1	875	881	PF00454	0.516
MOD_PIKK_1	883	889	PF00454	0.308
MOD_PK_1	910	916	PF00069	0.735
MOD_PKA_1	909	915	PF00069	0.674
MOD_PKA_2	1021	1027	PF00069	0.761
MOD_PKA_2	334	340	PF00069	0.657
MOD_PKA_2	70	76	PF00069	0.640
MOD_PKA_2	868	874	PF00069	0.554
MOD_PKA_2	909	915	PF00069	0.672
MOD_PKB_1	272	280	PF00069	0.425
MOD_Plk_1	119	125	PF00069	0.547
MOD_Plk_1	367	373	PF00069	0.582
MOD_Plk_1	430	436	PF00069	0.689
MOD_Plk_1	55	61	PF00069	0.683
MOD_Plk_1	770	776	PF00069	0.533
MOD_Plk_1	872	878	PF00069	0.605
MOD_Plk_1	910	916	PF00069	0.603
MOD_Plk_1	995	1001	PF00069	0.552
MOD_Plk_2-3	414	420	PF00069	0.704
MOD_Plk_2-3	425	431	PF00069	0.508
MOD_Plk_4	107	113	PF00069	0.456
MOD_Plk_4	145	151	PF00069	0.568
MOD_Plk_4	189	195	PF00069	0.522
MOD_Plk_4	274	280	PF00069	0.462
MOD_Plk_4	490	496	PF00069	0.525
MOD_Plk_4	892	898	PF00069	0.383
MOD_Plk_4	995	1001	PF00069	0.491
MOD_ProDKin_1	10	16	PF00069	0.700
MOD_ProDKin_1	30	36	PF00069	0.702
MOD_ProDKin_1	433	439	PF00069	0.588
MOD_ProDKin_1	578	584	PF00069	0.572
MOD_ProDKin_1	646	652	PF00069	0.575
MOD_ProDKin_1	752	758	PF00069	0.419
MOD_ProDKin_1	788	794	PF00069	0.496
MOD_ProDKin_1	829	835	PF00069	0.554
MOD_SUMO_for_1	1007	1010	PF00179	0.307
TRG_DiLeu_BaEn_1	530	535	PF01217	0.384
TRG_DiLeu_BaEn_2	897	903	PF01217	0.476
TRG_DiLeu_BaEn_4	268	274	PF01217	0.507
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.407
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.436
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.643
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.493
TRG_ENDOCYTIC_2	379	382	PF00928	0.548
TRG_ENDOCYTIC_2	479	482	PF00928	0.379
TRG_ENDOCYTIC_2	520	523	PF00928	0.542
TRG_ENDOCYTIC_2	750	753	PF00928	0.487
TRG_ENDOCYTIC_2	782	785	PF00928	0.581
TRG_ENDOCYTIC_2	87	90	PF00928	0.410
TRG_ER_diArg_1	177	179	PF00400	0.522
TRG_ER_diArg_1	271	274	PF00400	0.564
TRG_ER_diArg_1	45	47	PF00400	0.750
TRG_ER_diArg_1	505	508	PF00400	0.429
TRG_ER_diArg_1	976	978	PF00400	0.474
TRG_NES_CRM1_1	363	377	PF08389	0.516
TRG_NES_CRM1_1	852	866	PF08389	0.406
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW77	Leptomonas seymouri	52%	97%
A0A0S4ITT6	Bodo saltans	26%	100%
A0A1X0NQF9	Trypanosomatidae	30%	100%
A0A3Q8I9T9	Leishmania donovani	90%	100%
A4H7H1	Leishmania braziliensis	78%	100%
A4HVV2	Leishmania infantum	90%	100%
C9ZT75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QFX5	Leishmania major	91%	100%
V5BM93	Trypanosoma cruzi	30%	100%