J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APK3_LEIMU

TriTrypDb:

LmxM.14.0090

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.704
CLV_NRD_NRD_1	142	144	PF00675	0.501
CLV_NRD_NRD_1	163	165	PF00675	0.818
CLV_NRD_NRD_1	197	199	PF00675	0.685
CLV_NRD_NRD_1	207	209	PF00675	0.602
CLV_NRD_NRD_1	255	257	PF00675	0.716
CLV_NRD_NRD_1	260	262	PF00675	0.692
CLV_NRD_NRD_1	347	349	PF00675	0.587
CLV_PCSK_FUR_1	253	257	PF00082	0.645
CLV_PCSK_KEX2_1	162	164	PF00082	0.741
CLV_PCSK_KEX2_1	197	199	PF00082	0.685
CLV_PCSK_KEX2_1	207	209	PF00082	0.602
CLV_PCSK_KEX2_1	255	257	PF00082	0.712
CLV_PCSK_KEX2_1	259	261	PF00082	0.701
CLV_PCSK_KEX2_1	347	349	PF00082	0.684
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.643
CLV_PCSK_PC7_1	255	261	PF00082	0.653
CLV_PCSK_SKI1_1	270	274	PF00082	0.608
CLV_PCSK_SKI1_1	40	44	PF00082	0.609
DEG_Nend_UBRbox_2	1	3	PF02207	0.529
DEG_SPOP_SBC_1	188	192	PF00917	0.437
DOC_CYCLIN_yCln2_LP_2	61	67	PF00134	0.520
DOC_MAPK_gen_1	162	172	PF00069	0.739
DOC_MAPK_gen_1	197	203	PF00069	0.677
DOC_MAPK_gen_1	34	43	PF00069	0.531
DOC_MAPK_MEF2A_6	163	172	PF00069	0.738
DOC_MAPK_MEF2A_6	368	375	PF00069	0.577
DOC_MAPK_NFAT4_5	368	376	PF00069	0.580
DOC_PP2B_LxvP_1	65	68	PF13499	0.527
DOC_USP7_MATH_1	137	141	PF00917	0.825
DOC_USP7_MATH_1	15	19	PF00917	0.542
DOC_USP7_MATH_1	178	182	PF00917	0.725
DOC_USP7_MATH_1	187	191	PF00917	0.574
DOC_USP7_MATH_1	226	230	PF00917	0.705
DOC_USP7_MATH_1	246	250	PF00917	0.725
DOC_USP7_MATH_1	275	279	PF00917	0.712
DOC_USP7_MATH_1	295	299	PF00917	0.645
DOC_USP7_MATH_1	312	316	PF00917	0.817
DOC_USP7_MATH_1	340	344	PF00917	0.617
DOC_USP7_MATH_1	96	100	PF00917	0.647
DOC_USP7_UBL2_3	144	148	PF12436	0.808
DOC_WW_Pin1_4	130	135	PF00397	0.601
DOC_WW_Pin1_4	276	281	PF00397	0.707
DOC_WW_Pin1_4	300	305	PF00397	0.793
DOC_WW_Pin1_4	328	333	PF00397	0.796
DOC_WW_Pin1_4	94	99	PF00397	0.458
LIG_14-3-3_CanoR_1	106	110	PF00244	0.611
LIG_14-3-3_CanoR_1	198	204	PF00244	0.658
LIG_14-3-3_CanoR_1	259	267	PF00244	0.837
LIG_14-3-3_CanoR_1	276	280	PF00244	0.538
LIG_14-3-3_CanoR_1	361	371	PF00244	0.652
LIG_Actin_WH2_2	182	199	PF00022	0.451
LIG_BIR_III_2	292	296	PF00653	0.620
LIG_FHA_1	222	228	PF00498	0.702
LIG_FHA_1	242	248	PF00498	0.699
LIG_FHA_1	269	275	PF00498	0.742
LIG_FHA_1	311	317	PF00498	0.780
LIG_FHA_1	364	370	PF00498	0.662
LIG_FHA_2	88	94	PF00498	0.436
LIG_Integrin_isoDGR_2	141	143	PF01839	0.738
LIG_LIR_Gen_1	102	110	PF02991	0.522
LIG_LIR_Gen_1	18	29	PF02991	0.495
LIG_LIR_Gen_1	213	220	PF02991	0.616
LIG_LIR_Gen_1	289	296	PF02991	0.685
LIG_LIR_Gen_1	30	38	PF02991	0.479
LIG_LIR_Gen_1	82	88	PF02991	0.549
LIG_LIR_Nem_3	102	107	PF02991	0.526
LIG_LIR_Nem_3	18	24	PF02991	0.482
LIG_LIR_Nem_3	213	218	PF02991	0.638
LIG_LIR_Nem_3	372	378	PF02991	0.595
LIG_LIR_Nem_3	82	86	PF02991	0.544
LIG_SH2_STAP1	32	36	PF00017	0.522
LIG_SH3_1	151	157	PF00018	0.683
LIG_SH3_1	162	168	PF00018	0.744
LIG_SH3_3	151	157	PF00018	0.752
LIG_SH3_3	162	168	PF00018	0.605
LIG_SH3_3	298	304	PF00018	0.647
LIG_SH3_3	329	335	PF00018	0.793
LIG_SH3_3	45	51	PF00018	0.624
LIG_SH3_3	61	67	PF00018	0.363
LIG_SH3_4	146	153	PF00018	0.742
LIG_TRAF2_1	266	269	PF00917	0.747
MOD_CDC14_SPxK_1	133	136	PF00782	0.511
MOD_CDK_SPxK_1	130	136	PF00069	0.507
MOD_CK1_1	191	197	PF00069	0.613
MOD_CK1_1	229	235	PF00069	0.711
MOD_CK1_1	262	268	PF00069	0.709
MOD_CK1_1	305	311	PF00069	0.804
MOD_CK1_1	315	321	PF00069	0.625
MOD_CK1_1	333	339	PF00069	0.543
MOD_CK1_1	7	13	PF00069	0.514
MOD_CK2_1	231	237	PF00069	0.662
MOD_CK2_1	246	252	PF00069	0.767
MOD_CK2_1	96	102	PF00069	0.654
MOD_Cter_Amidation	141	144	PF01082	0.737
MOD_DYRK1A_RPxSP_1	276	280	PF00069	0.733
MOD_GlcNHglycan	218	221	PF01048	0.635
MOD_GlcNHglycan	264	267	PF01048	0.764
MOD_GlcNHglycan	286	289	PF01048	0.567
MOD_GlcNHglycan	318	321	PF01048	0.770
MOD_GlcNHglycan	325	329	PF01048	0.676
MOD_GlcNHglycan	74	77	PF01048	0.569
MOD_GlcNHglycan	98	101	PF01048	0.650
MOD_GSK3_1	142	149	PF00069	0.600
MOD_GSK3_1	16	23	PF00069	0.429
MOD_GSK3_1	174	181	PF00069	0.714
MOD_GSK3_1	187	194	PF00069	0.688
MOD_GSK3_1	276	283	PF00069	0.699
MOD_GSK3_1	312	319	PF00069	0.837
MOD_GSK3_1	324	331	PF00069	0.625
MOD_N-GLC_1	15	20	PF02516	0.463
MOD_N-GLC_1	280	285	PF02516	0.495
MOD_NEK2_1	105	110	PF00069	0.619
MOD_NEK2_1	196	201	PF00069	0.596
MOD_NEK2_1	218	223	PF00069	0.657
MOD_NEK2_1	241	246	PF00069	0.697
MOD_NEK2_1	286	291	PF00069	0.774
MOD_NEK2_1	362	367	PF00069	0.683
MOD_NEK2_1	4	9	PF00069	0.497
MOD_NEK2_2	312	317	PF00069	0.816
MOD_PIKK_1	146	152	PF00454	0.526
MOD_PIKK_1	191	197	PF00454	0.606
MOD_PIKK_1	218	224	PF00454	0.662
MOD_PIKK_1	259	265	PF00454	0.791
MOD_PKA_1	259	265	PF00069	0.636
MOD_PKA_2	105	111	PF00069	0.616
MOD_PKA_2	142	148	PF00069	0.549
MOD_PKA_2	196	202	PF00069	0.649
MOD_PKA_2	259	265	PF00069	0.663
MOD_PKA_2	275	281	PF00069	0.590
MOD_PKA_2	30	36	PF00069	0.540
MOD_PKB_1	259	267	PF00069	0.725
MOD_Plk_1	15	21	PF00069	0.460
MOD_Plk_1	229	235	PF00069	0.618
MOD_Plk_1	324	330	PF00069	0.798
MOD_Plk_1	371	377	PF00069	0.600
MOD_Plk_4	105	111	PF00069	0.616
MOD_Plk_4	16	22	PF00069	0.388
MOD_Plk_4	286	292	PF00069	0.793
MOD_Plk_4	4	10	PF00069	0.562
MOD_ProDKin_1	130	136	PF00069	0.604
MOD_ProDKin_1	276	282	PF00069	0.704
MOD_ProDKin_1	300	306	PF00069	0.792
MOD_ProDKin_1	328	334	PF00069	0.793
MOD_ProDKin_1	94	100	PF00069	0.451
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.710
TRG_ENDOCYTIC_2	21	24	PF00928	0.483
TRG_ENDOCYTIC_2	291	294	PF00928	0.799
TRG_ENDOCYTIC_2	32	35	PF00928	0.468
TRG_ER_diArg_1	162	164	PF00400	0.831
TRG_ER_diArg_1	196	198	PF00400	0.670
TRG_ER_diArg_1	253	256	PF00400	0.732
TRG_ER_diArg_1	259	261	PF00400	0.722
TRG_ER_diArg_1	346	348	PF00400	0.686
TRG_ER_diArg_1	355	358	PF00400	0.536
TRG_NLS_MonoExtC_3	142	147	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB18	Leptomonas seymouri	48%	97%
A0A3S7WSS6	Leishmania donovani	90%	100%
A4H7H0	Leishmania braziliensis	71%	99%
A4HVV1	Leishmania infantum	90%	100%
Q4QFX6	Leishmania major	91%	100%