Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APK2_LEIMU

TriTrypDb:

LmxM.14.0080

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.404
CLV_NRD_NRD_1	100	102	PF00675	0.368
CLV_NRD_NRD_1	106	108	PF00675	0.363
CLV_NRD_NRD_1	267	269	PF00675	0.489
CLV_NRD_NRD_1	95	97	PF00675	0.372
CLV_PCSK_KEX2_1	106	108	PF00082	0.384
CLV_PCSK_KEX2_1	51	53	PF00082	0.505
CLV_PCSK_KEX2_1	95	97	PF00082	0.362
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.524
CLV_PCSK_SKI1_1	101	105	PF00082	0.394
CLV_PCSK_SKI1_1	116	120	PF00082	0.397
CLV_PCSK_SKI1_1	148	152	PF00082	0.425
CLV_PCSK_SKI1_1	167	171	PF00082	0.360
CLV_PCSK_SKI1_1	91	95	PF00082	0.395
CLV_PCSK_SKI1_1	96	100	PF00082	0.381
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_PP2B_PxIxI_1	242	248	PF00149	0.401
DOC_PP4_FxxP_1	5	8	PF00568	0.583
DOC_USP7_MATH_1	162	166	PF00917	0.557
DOC_WW_Pin1_4	127	132	PF00397	0.542
DOC_WW_Pin1_4	77	82	PF00397	0.387
LIG_14-3-3_CanoR_1	10	19	PF00244	0.598
LIG_14-3-3_CanoR_1	67	72	PF00244	0.434
LIG_14-3-3_CanoR_1	83	88	PF00244	0.517
LIG_14-3-3_CanoR_1	95	101	PF00244	0.370
LIG_BRCT_BRCA1_1	20	24	PF00533	0.427
LIG_deltaCOP1_diTrp_1	60	68	PF00928	0.456
LIG_FHA_2	140	146	PF00498	0.344
LIG_FHA_2	219	225	PF00498	0.487
LIG_FHA_2	37	43	PF00498	0.509
LIG_FHA_2	51	57	PF00498	0.463
LIG_LIR_Gen_1	117	125	PF02991	0.508
LIG_LIR_Gen_1	183	192	PF02991	0.336
LIG_LIR_Gen_1	198	205	PF02991	0.285
LIG_LIR_Gen_1	216	227	PF02991	0.358
LIG_LIR_Gen_1	241	250	PF02991	0.358
LIG_LIR_Nem_3	109	113	PF02991	0.509
LIG_LIR_Nem_3	117	122	PF02991	0.491
LIG_LIR_Nem_3	132	137	PF02991	0.492
LIG_LIR_Nem_3	165	169	PF02991	0.535
LIG_LIR_Nem_3	183	188	PF02991	0.344
LIG_LIR_Nem_3	198	203	PF02991	0.288
LIG_LIR_Nem_3	224	228	PF02991	0.302
LIG_LIR_Nem_3	241	247	PF02991	0.435
LIG_SH2_CRK	84	88	PF00017	0.379
LIG_SH2_NCK_1	84	88	PF00017	0.393
LIG_SH2_STAP1	178	182	PF00017	0.437
LIG_SH2_STAP1	84	88	PF00017	0.398
LIG_SH2_STAT3	191	194	PF00017	0.336
LIG_SH2_STAT5	84	87	PF00017	0.415
LIG_SH3_3	233	239	PF00018	0.513
LIG_TYR_ITIM	82	87	PF00017	0.373
LIG_UBA3_1	149	154	PF00899	0.511
LIG_WRC_WIRS_1	182	187	PF05994	0.349
MOD_CDK_SPxK_1	77	83	PF00069	0.392
MOD_CK1_1	165	171	PF00069	0.553
MOD_CK1_1	36	42	PF00069	0.496
MOD_CK2_1	139	145	PF00069	0.357
MOD_CK2_1	173	179	PF00069	0.570
MOD_CK2_1	218	224	PF00069	0.397
MOD_CK2_1	36	42	PF00069	0.552
MOD_GSK3_1	123	130	PF00069	0.391
MOD_GSK3_1	42	49	PF00069	0.544
MOD_N-GLC_1	33	38	PF02516	0.489
MOD_NEK2_1	201	206	PF00069	0.322
MOD_NEK2_1	271	276	PF00069	0.435
MOD_NEK2_1	33	38	PF00069	0.596
MOD_PIKK_1	10	16	PF00454	0.676
MOD_PIKK_1	193	199	PF00454	0.461
MOD_PIKK_1	258	264	PF00454	0.445
MOD_PIKK_1	42	48	PF00454	0.603
MOD_PK_1	83	89	PF00069	0.400
MOD_PKA_1	101	107	PF00069	0.345
MOD_PKA_2	138	144	PF00069	0.366
MOD_PKA_2	82	88	PF00069	0.427
MOD_PKA_2	9	15	PF00069	0.671
MOD_Plk_1	33	39	PF00069	0.502
MOD_Plk_2-3	181	187	PF00069	0.466
MOD_Plk_2-3	218	224	PF00069	0.415
MOD_Plk_4	19	25	PF00069	0.478
MOD_Plk_4	218	224	PF00069	0.421
MOD_ProDKin_1	127	133	PF00069	0.538
MOD_ProDKin_1	77	83	PF00069	0.392
TRG_ENDOCYTIC_2	225	228	PF00928	0.330
TRG_ENDOCYTIC_2	84	87	PF00928	0.400
TRG_ER_diArg_1	106	108	PF00400	0.359
TRG_ER_diArg_1	209	212	PF00400	0.382
TRG_ER_diArg_1	94	96	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I365	Leptomonas seymouri	80%	100%
A0A0S4IUM2	Bodo saltans	60%	82%
A0A1X0NNS4	Trypanosomatidae	75%	100%
A0A3S5H6Q6	Leishmania donovani	97%	100%
A0A3S5IS70	Trypanosoma rangeli	67%	100%
A4H7G9	Leishmania braziliensis	90%	100%
A4HVV0	Leishmania infantum	97%	100%
C9ZT77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
Q4QFX7	Leishmania major	96%	100%
V5AXQ5	Trypanosoma cruzi	71%	100%