Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9APK1_LEIMU

TriTrypDb:

LmxM.14.0070

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9APK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.291
CLV_NRD_NRD_1	176	178	PF00675	0.270
CLV_NRD_NRD_1	274	276	PF00675	0.364
CLV_PCSK_KEX2_1	151	153	PF00082	0.245
CLV_PCSK_KEX2_1	176	178	PF00082	0.279
CLV_PCSK_SKI1_1	177	181	PF00082	0.245
DEG_APCC_DBOX_1	176	184	PF00400	0.445
DEG_MDM2_SWIB_1	62	69	PF02201	0.275
DOC_CYCLIN_yClb5_NLxxxL_5	112	121	PF00134	0.529
DOC_MAPK_DCC_7	80	90	PF00069	0.245
DOC_MAPK_gen_1	151	159	PF00069	0.460
DOC_MAPK_gen_1	176	183	PF00069	0.445
DOC_MAPK_MEF2A_6	207	216	PF00069	0.260
DOC_MAPK_NFAT4_5	207	215	PF00069	0.260
DOC_PP1_RVXF_1	36	42	PF00149	0.531
DOC_PP2B_PxIxI_1	85	91	PF00149	0.344
DOC_USP7_MATH_1	144	148	PF00917	0.561
DOC_USP7_MATH_1	187	191	PF00917	0.301
DOC_USP7_MATH_1	43	47	PF00917	0.506
DOC_USP7_MATH_1	94	98	PF00917	0.301
DOC_WW_Pin1_4	39	44	PF00397	0.511
DOC_WW_Pin1_4	70	75	PF00397	0.343
LIG_14-3-3_CanoR_1	70	74	PF00244	0.322
LIG_Actin_WH2_2	223	241	PF00022	0.301
LIG_Actin_WH2_2	57	72	PF00022	0.342
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	193	197	PF00533	0.180
LIG_CSL_BTD_1	40	43	PF09270	0.512
LIG_CtBP_PxDLS_1	118	122	PF00389	0.599
LIG_EH1_1	46	54	PF00400	0.280
LIG_eIF4E_1	178	184	PF01652	0.280
LIG_FHA_1	136	142	PF00498	0.491
LIG_FHA_1	215	221	PF00498	0.486
LIG_FHA_1	225	231	PF00498	0.258
LIG_FHA_1	97	103	PF00498	0.305
LIG_GBD_Chelix_1	230	238	PF00786	0.301
LIG_LIR_Apic_2	68	74	PF02991	0.308
LIG_LIR_Gen_1	2	11	PF02991	0.633
LIG_LIR_Gen_1	46	56	PF02991	0.369
LIG_LIR_Gen_1	59	69	PF02991	0.213
LIG_LIR_Nem_3	194	200	PF02991	0.282
LIG_LIR_Nem_3	2	7	PF02991	0.637
LIG_LIR_Nem_3	46	51	PF02991	0.384
LIG_LIR_Nem_3	59	65	PF02991	0.283
LIG_NRBOX	60	66	PF00104	0.333
LIG_Pex14_2	62	66	PF04695	0.280
LIG_SH2_CRK	71	75	PF00017	0.346
LIG_SH2_GRB2like	250	253	PF00017	0.460
LIG_SH2_NCK_1	71	75	PF00017	0.346
LIG_SH2_STAT5	129	132	PF00017	0.552
LIG_SH2_STAT5	135	138	PF00017	0.445
LIG_SH2_STAT5	178	181	PF00017	0.280
LIG_SH2_STAT5	199	202	PF00017	0.245
LIG_SH2_STAT5	213	216	PF00017	0.262
LIG_SH2_STAT5	233	236	PF00017	0.320
LIG_SH2_STAT5	71	74	PF00017	0.391
LIG_SH3_3	200	206	PF00018	0.307
LIG_SH3_3	268	274	PF00018	0.536
LIG_SUMO_SIM_par_1	222	227	PF11976	0.479
LIG_SUMO_SIM_par_1	48	54	PF11976	0.266
LIG_SUMO_SIM_par_1	91	97	PF11976	0.308
LIG_SUMO_SIM_par_1	98	105	PF11976	0.269
MOD_CK1_1	120	126	PF00069	0.571
MOD_CK2_1	6	12	PF00069	0.632
MOD_GlcNHglycan	123	126	PF01048	0.376
MOD_GlcNHglycan	146	149	PF01048	0.260
MOD_GlcNHglycan	189	192	PF01048	0.344
MOD_GlcNHglycan	193	196	PF01048	0.307
MOD_GlcNHglycan	21	24	PF01048	0.419
MOD_GlcNHglycan	96	99	PF01048	0.301
MOD_GSK3_1	117	124	PF00069	0.595
MOD_GSK3_1	15	22	PF00069	0.682
MOD_GSK3_1	183	190	PF00069	0.328
MOD_GSK3_1	220	227	PF00069	0.372
MOD_GSK3_1	251	258	PF00069	0.485
MOD_GSK3_1	39	46	PF00069	0.508
MOD_GSK3_1	56	63	PF00069	0.280
MOD_GSK3_1	65	72	PF00069	0.324
MOD_N-GLC_1	251	256	PF02516	0.287
MOD_N-GLC_2	154	156	PF02516	0.245
MOD_NEK2_1	101	106	PF00069	0.280
MOD_NEK2_1	121	126	PF00069	0.584
MOD_NEK2_1	182	187	PF00069	0.330
MOD_NEK2_1	220	225	PF00069	0.347
MOD_NEK2_1	251	256	PF00069	0.470
MOD_NEK2_1	60	65	PF00069	0.324
MOD_NEK2_1	69	74	PF00069	0.319
MOD_NEK2_2	135	140	PF00069	0.491
MOD_PIKK_1	142	148	PF00454	0.500
MOD_PKA_2	142	148	PF00069	0.445
MOD_PKA_2	69	75	PF00069	0.319
MOD_Plk_1	43	49	PF00069	0.491
MOD_Plk_4	220	226	PF00069	0.476
MOD_Plk_4	56	62	PF00069	0.356
MOD_Plk_4	96	102	PF00069	0.341
MOD_ProDKin_1	39	45	PF00069	0.508
MOD_ProDKin_1	70	76	PF00069	0.340
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.491
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.445
TRG_ENDOCYTIC_2	178	181	PF00928	0.286
TRG_ENDOCYTIC_2	199	202	PF00928	0.291
TRG_ENDOCYTIC_2	213	216	PF00928	0.230
TRG_ENDOCYTIC_2	28	31	PF00928	0.600
TRG_ER_diArg_1	176	178	PF00400	0.430
TRG_ER_diArg_1	256	259	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B1	Leptomonas seymouri	58%	100%
A0A0N1I542	Leptomonas seymouri	32%	94%
A0A0S4IR23	Bodo saltans	32%	80%
A0A3S7WSS8	Leishmania donovani	95%	100%
A0A3S7WZD9	Leishmania donovani	27%	85%
A4H7G8	Leishmania braziliensis	80%	100%
A4HVU9	Leishmania infantum	95%	100%
A4I1S8	Leishmania infantum	27%	85%
B3DN87	Arabidopsis thaliana	29%	83%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
E9AXW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
F1QAM1	Danio rerio	33%	81%
F1QHM7	Danio rerio	27%	69%
F1R013	Danio rerio	28%	72%
F1RE57	Danio rerio	24%	88%
O14345	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	85%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	80%
O80685	Arabidopsis thaliana	28%	68%
P59268	Mus musculus	28%	77%
Q2TGI8	Rattus norvegicus	31%	100%
Q2TGK3	Rattus norvegicus	26%	93%
Q4Q9K8	Leishmania major	26%	85%
Q4QFX8	Leishmania major	95%	100%
Q500Z2	Arabidopsis thaliana	30%	100%
Q58DA8	Bos taurus	28%	77%
Q58DT3	Bos taurus	28%	81%
Q5FVR1	Rattus norvegicus	31%	81%
Q5PNZ1	Arabidopsis thaliana	29%	68%
Q5R5J8	Pongo abelii	29%	77%
Q5Y5T2	Mus musculus	30%	73%
Q8R173	Mus musculus	26%	93%
Q8VYS8	Arabidopsis thaliana	27%	69%
Q9NYG2	Homo sapiens	26%	93%
Q9Y397	Homo sapiens	28%	77%