P-loop containing nucleoside triphosphate hydrolase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APK0_LEIMU

TriTrypDb:

LmxM.14.0060

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.721
CLV_PCSK_SKI1_1	116	120	PF00082	0.675
CLV_PCSK_SKI1_1	150	154	PF00082	0.690
CLV_PCSK_SKI1_1	82	86	PF00082	0.597
DOC_MAPK_gen_1	57	64	PF00069	0.689
DOC_MAPK_MEF2A_6	57	64	PF00069	0.655
DOC_USP7_MATH_1	109	113	PF00917	0.563
DOC_WW_Pin1_4	36	41	PF00397	0.708
DOC_WW_Pin1_4	50	55	PF00397	0.548
LIG_14-3-3_CanoR_1	116	125	PF00244	0.648
LIG_BRCT_BRCA1_1	111	115	PF00533	0.594
LIG_eIF4E_1	25	31	PF01652	0.645
LIG_FHA_1	15	21	PF00498	0.542
LIG_FHA_1	25	31	PF00498	0.578
LIG_FHA_1	59	65	PF00498	0.600
LIG_FHA_1	90	96	PF00498	0.699
LIG_FHA_2	143	149	PF00498	0.559
LIG_FHA_2	40	46	PF00498	0.677
LIG_LIR_Gen_1	74	79	PF02991	0.635
LIG_LIR_Gen_1	91	100	PF02991	0.694
LIG_LIR_Nem_3	112	118	PF02991	0.600
LIG_LIR_Nem_3	169	174	PF02991	0.598
LIG_LIR_Nem_3	184	190	PF02991	0.552
LIG_LIR_Nem_3	74	78	PF02991	0.629
LIG_LIR_Nem_3	91	97	PF02991	0.613
LIG_SH2_STAT3	117	120	PF00017	0.699
LIG_SH2_STAT3	25	28	PF00017	0.618
LIG_SH2_STAT5	117	120	PF00017	0.497
LIG_SH2_STAT5	25	28	PF00017	0.683
LIG_SH2_STAT5	7	10	PF00017	0.565
LIG_SH2_STAT5	98	101	PF00017	0.653
LIG_SUMO_SIM_par_1	164	170	PF11976	0.664
LIG_SUMO_SIM_par_1	60	66	PF11976	0.632
LIG_TRAF2_1	145	148	PF00917	0.601
LIG_TRAF2_1	42	45	PF00917	0.685
LIG_WRC_WIRS_1	149	154	PF05994	0.634
MOD_CDK_SPxxK_3	50	57	PF00069	0.698
MOD_CK1_1	50	56	PF00069	0.757
MOD_CK1_1	89	95	PF00069	0.692
MOD_CK2_1	142	148	PF00069	0.558
MOD_CK2_1	39	45	PF00069	0.768
MOD_CK2_1	74	80	PF00069	0.634
MOD_GlcNHglycan	86	91	PF01048	0.690
MOD_GSK3_1	10	17	PF00069	0.563
MOD_GSK3_1	67	74	PF00069	0.640
MOD_NEK2_1	110	115	PF00069	0.645
MOD_NEK2_1	30	35	PF00069	0.628
MOD_NEK2_1	67	72	PF00069	0.647
MOD_NEK2_1	78	83	PF00069	0.553
MOD_PIKK_1	116	122	PF00454	0.713
MOD_PIKK_1	24	30	PF00454	0.658
MOD_PK_1	137	143	PF00069	0.679
MOD_Plk_1	47	53	PF00069	0.712
MOD_Plk_4	110	116	PF00069	0.575
MOD_Plk_4	128	134	PF00069	0.637
MOD_Plk_4	67	73	PF00069	0.620
MOD_Plk_4	74	80	PF00069	0.587
MOD_ProDKin_1	36	42	PF00069	0.710
MOD_ProDKin_1	50	56	PF00069	0.545
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE8	Leptomonas seymouri	61%	78%
A0A1X0NNU1	Trypanosomatidae	36%	100%
A0A3R7LA27	Trypanosoma rangeli	42%	100%
A0A3S7WSS1	Leishmania donovani	96%	100%
A4H7G7	Leishmania braziliensis	87%	100%
A4HVU8	Leishmania infantum	97%	100%
C9ZT78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QFX9	Leishmania major	93%	100%
V5DE15	Trypanosoma cruzi	41%	100%