Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APJ7_LEIMU

TriTrypDb:

LmxM.14.0030

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9APJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.717
CLV_NRD_NRD_1	141	143	PF00675	0.712
CLV_NRD_NRD_1	81	83	PF00675	0.528
CLV_NRD_NRD_1	9	11	PF00675	0.446
CLV_PCSK_KEX2_1	120	122	PF00082	0.684
CLV_PCSK_KEX2_1	143	145	PF00082	0.792
CLV_PCSK_KEX2_1	80	82	PF00082	0.503
CLV_PCSK_KEX2_1	9	11	PF00082	0.446
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.673
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.781
CLV_PCSK_SKI1_1	224	228	PF00082	0.720
CLV_PCSK_SKI1_1	258	262	PF00082	0.754
CLV_PCSK_SKI1_1	9	13	PF00082	0.422
DEG_SCF_FBW7_1	175	181	PF00400	0.592
DEG_SCF_FBW7_1	226	233	PF00400	0.504
DOC_CKS1_1	175	180	PF01111	0.579
DOC_CKS1_1	227	232	PF01111	0.503
DOC_MAPK_gen_1	89	97	PF00069	0.536
DOC_PP4_FxxP_1	227	230	PF00568	0.508
DOC_USP7_MATH_1	178	182	PF00917	0.615
DOC_USP7_MATH_1	192	196	PF00917	0.539
DOC_USP7_MATH_1	215	219	PF00917	0.512
DOC_USP7_MATH_1	230	234	PF00917	0.541
DOC_USP7_MATH_1	41	45	PF00917	0.677
DOC_WW_Pin1_4	109	114	PF00397	0.620
DOC_WW_Pin1_4	171	176	PF00397	0.560
DOC_WW_Pin1_4	226	231	PF00397	0.510
LIG_14-3-3_CanoR_1	191	197	PF00244	0.553
LIG_BRCT_BRCA1_1	199	203	PF00533	0.526
LIG_FHA_1	238	244	PF00498	0.535
LIG_FHA_1	251	257	PF00498	0.512
LIG_FHA_1	260	266	PF00498	0.498
LIG_LIR_Apic_2	225	230	PF02991	0.512
LIG_LIR_Gen_1	218	227	PF02991	0.541
LIG_LIR_Gen_1	44	52	PF02991	0.661
LIG_LIR_Nem_3	44	49	PF02991	0.657
LIG_PCNA_yPIPBox_3	8	17	PF02747	0.665
LIG_Pex14_2	238	242	PF04695	0.454
LIG_SH2_STAT5	125	128	PF00017	0.510
LIG_SH2_STAT5	14	17	PF00017	0.649
LIG_SH3_3	169	175	PF00018	0.536
LIG_SH3_3	30	36	PF00018	0.634
LIG_TRAF2_1	148	151	PF00917	0.596
LIG_TRAF2_1	70	73	PF00917	0.700
LIG_WRC_WIRS_1	94	99	PF05994	0.401
MOD_CK1_1	171	177	PF00069	0.400
MOD_CK1_1	190	196	PF00069	0.605
MOD_CK1_1	264	270	PF00069	0.546
MOD_CK1_1	44	50	PF00069	0.671
MOD_CK2_1	128	134	PF00069	0.523
MOD_CK2_1	178	184	PF00069	0.624
MOD_CK2_1	215	221	PF00069	0.549
MOD_CK2_1	251	257	PF00069	0.488
MOD_CK2_1	44	50	PF00069	0.620
MOD_CK2_1	67	73	PF00069	0.709
MOD_GlcNHglycan	150	155	PF01048	0.617
MOD_GlcNHglycan	231	235	PF01048	0.749
MOD_GlcNHglycan	43	46	PF01048	0.487
MOD_GlcNHglycan	62	65	PF01048	0.382
MOD_GSK3_1	124	131	PF00069	0.504
MOD_GSK3_1	174	181	PF00069	0.571
MOD_GSK3_1	192	199	PF00069	0.404
MOD_GSK3_1	226	233	PF00069	0.532
MOD_GSK3_1	247	254	PF00069	0.532
MOD_GSK3_1	259	266	PF00069	0.464
MOD_GSK3_1	67	74	PF00069	0.734
MOD_N-GLC_1	160	165	PF02516	0.748
MOD_NEK2_1	115	120	PF00069	0.461
MOD_NEK2_1	168	173	PF00069	0.407
MOD_NEK2_1	203	208	PF00069	0.537
MOD_NEK2_1	238	243	PF00069	0.464
MOD_NEK2_1	261	266	PF00069	0.503
MOD_NEK2_2	160	165	PF00069	0.606
MOD_PIKK_1	190	196	PF00454	0.569
MOD_PKA_2	190	196	PF00069	0.524
MOD_Plk_1	160	166	PF00069	0.437
MOD_Plk_1	203	209	PF00069	0.591
MOD_Plk_1	238	244	PF00069	0.504
MOD_Plk_1	247	253	PF00069	0.515
MOD_Plk_1	71	77	PF00069	0.680
MOD_Plk_4	198	204	PF00069	0.539
MOD_Plk_4	238	244	PF00069	0.528
MOD_Plk_4	93	99	PF00069	0.432
MOD_ProDKin_1	109	115	PF00069	0.622
MOD_ProDKin_1	171	177	PF00069	0.559
MOD_ProDKin_1	226	232	PF00069	0.504
MOD_SUMO_for_1	155	158	PF00179	0.516
TRG_ENDOCYTIC_2	46	49	PF00928	0.688
TRG_ER_diArg_1	141	144	PF00400	0.555
TRG_ER_diArg_1	79	82	PF00400	0.732
TRG_ER_diArg_1	9	11	PF00400	0.646
TRG_NLS_MonoCore_2	141	146	PF00514	0.566
TRG_NLS_MonoExtC_3	141	147	PF00514	0.586
TRG_NLS_MonoExtN_4	140	146	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV2	Leptomonas seymouri	50%	100%
A0A0S4IQN6	Bodo saltans	23%	97%
A0A1X0NNV6	Trypanosomatidae	24%	100%
A0A3S5H6Q5	Leishmania donovani	91%	100%
A0A422NXF3	Trypanosoma rangeli	24%	100%
A4H7G4	Leishmania braziliensis	74%	96%
A4HVU5	Leishmania infantum	91%	100%
Q4QFY2	Leishmania major	89%	100%