Putative phosphatidylinositol 3-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 3-kinase, putative

Species:

Leishmania mexicana

UniProt:

E9APJ6_LEIMU

TriTrypDb:

LmxM.14.0020

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0006644	phospholipid metabolic process	4	6
GO:0006650	glycerophospholipid metabolic process	5	6
GO:0006661	phosphatidylinositol biosynthetic process	6	6
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0007165	signal transduction	2	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	6
GO:0008654	phospholipid biosynthetic process	5	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019637	organophosphate metabolic process	3	6
GO:0035556	intracellular signal transduction	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044255	cellular lipid metabolic process	3	6
GO:0045017	glycerolipid biosynthetic process	4	6
GO:0046474	glycerophospholipid biosynthetic process	5	6
GO:0046486	glycerolipid metabolic process	4	6
GO:0046488	phosphatidylinositol metabolic process	6	6
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	6
GO:0048015	phosphatidylinositol-mediated signaling	5	8
GO:0048017	inositol lipid-mediated signaling	4	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0065007	biological regulation	1	8
GO:0071704	organic substance metabolic process	2	6
GO:0090407	organophosphate biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0016303	1-phosphatidylinositol-3-kinase activity	6	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0035004	phosphatidylinositol 3-kinase activity	5	2
GO:0052742	phosphatidylinositol kinase activity	5	2
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	6	1
GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	6	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.473
CLV_C14_Caspase3-7	496	500	PF00656	0.287
CLV_C14_Caspase3-7	702	706	PF00656	0.246
CLV_NRD_NRD_1	395	397	PF00675	0.565
CLV_NRD_NRD_1	402	404	PF00675	0.541
CLV_NRD_NRD_1	484	486	PF00675	0.537
CLV_NRD_NRD_1	550	552	PF00675	0.464
CLV_NRD_NRD_1	746	748	PF00675	0.467
CLV_NRD_NRD_1	902	904	PF00675	0.212
CLV_PCSK_KEX2_1	402	404	PF00082	0.556
CLV_PCSK_KEX2_1	428	430	PF00082	0.446
CLV_PCSK_KEX2_1	484	486	PF00082	0.519
CLV_PCSK_KEX2_1	550	552	PF00082	0.446
CLV_PCSK_KEX2_1	589	591	PF00082	0.450
CLV_PCSK_KEX2_1	746	748	PF00082	0.537
CLV_PCSK_KEX2_1	832	834	PF00082	0.251
CLV_PCSK_KEX2_1	902	904	PF00082	0.212
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.446
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.519
CLV_PCSK_PC1ET2_1	832	834	PF00082	0.251
CLV_PCSK_PC7_1	546	552	PF00082	0.446
CLV_PCSK_SKI1_1	149	153	PF00082	0.584
CLV_PCSK_SKI1_1	249	253	PF00082	0.468
CLV_PCSK_SKI1_1	300	304	PF00082	0.370
CLV_PCSK_SKI1_1	425	429	PF00082	0.446
CLV_PCSK_SKI1_1	444	448	PF00082	0.446
CLV_PCSK_SKI1_1	451	455	PF00082	0.452
CLV_PCSK_SKI1_1	546	550	PF00082	0.446
CLV_PCSK_SKI1_1	572	576	PF00082	0.537
CLV_PCSK_SKI1_1	609	613	PF00082	0.573
CLV_PCSK_SKI1_1	902	906	PF00082	0.279
CLV_PCSK_SKI1_1	930	934	PF00082	0.328
DEG_Nend_UBRbox_3	1	3	PF02207	0.317
DEG_SPOP_SBC_1	289	293	PF00917	0.337
DOC_ANK_TNKS_1	356	363	PF00023	0.319
DOC_CKS1_1	839	844	PF01111	0.446
DOC_CYCLIN_RxL_1	277	287	PF00134	0.264
DOC_CYCLIN_RxL_1	540	552	PF00134	0.246
DOC_CYCLIN_RxL_1	900	911	PF00134	0.412
DOC_MAPK_gen_1	355	363	PF00069	0.349
DOC_MAPK_gen_1	663	671	PF00069	0.279
DOC_MAPK_MEF2A_6	138	146	PF00069	0.319
DOC_MAPK_MEF2A_6	34	41	PF00069	0.409
DOC_MAPK_MEF2A_6	663	671	PF00069	0.297
DOC_MAPK_MEF2A_6	692	700	PF00069	0.261
DOC_MAPK_MEF2A_6	709	717	PF00069	0.193
DOC_MAPK_NFAT4_5	34	42	PF00069	0.415
DOC_PP1_RVXF_1	258	264	PF00149	0.268
DOC_PP1_RVXF_1	266	272	PF00149	0.221
DOC_PP1_RVXF_1	281	287	PF00149	0.310
DOC_PP1_RVXF_1	382	389	PF00149	0.379
DOC_PP1_RVXF_1	442	449	PF00149	0.264
DOC_PP4_FxxP_1	154	157	PF00568	0.438
DOC_PP4_FxxP_1	27	30	PF00568	0.325
DOC_PP4_FxxP_1	382	385	PF00568	0.331
DOC_SPAK_OSR1_1	680	684	PF12202	0.197
DOC_USP7_MATH_1	174	178	PF00917	0.491
DOC_USP7_MATH_1	19	23	PF00917	0.365
DOC_USP7_MATH_1	251	255	PF00917	0.337
DOC_USP7_MATH_1	401	405	PF00917	0.376
DOC_USP7_MATH_1	411	415	PF00917	0.403
DOC_USP7_UBL2_3	459	463	PF12436	0.287
DOC_USP7_UBL2_3	609	613	PF12436	0.277
DOC_USP7_UBL2_3	620	624	PF12436	0.309
DOC_USP7_UBL2_3	828	832	PF12436	0.446
DOC_USP7_UBL2_3	97	101	PF12436	0.246
DOC_WW_Pin1_4	484	489	PF00397	0.317
DOC_WW_Pin1_4	588	593	PF00397	0.319
DOC_WW_Pin1_4	838	843	PF00397	0.436
DOC_WW_Pin1_4	850	855	PF00397	0.440
LIG_14-3-3_CanoR_1	283	289	PF00244	0.278
LIG_14-3-3_CanoR_1	300	308	PF00244	0.290
LIG_14-3-3_CanoR_1	402	406	PF00244	0.328
LIG_14-3-3_CanoR_1	550	554	PF00244	0.264
LIG_14-3-3_CanoR_1	627	631	PF00244	0.326
LIG_14-3-3_CanoR_1	638	642	PF00244	0.220
LIG_14-3-3_CanoR_1	68	76	PF00244	0.432
LIG_14-3-3_CanoR_1	86	96	PF00244	0.191
LIG_14-3-3_CanoR_1	871	881	PF00244	0.495
LIG_Actin_WH2_2	182	198	PF00022	0.214
LIG_Actin_WH2_2	414	430	PF00022	0.297
LIG_Actin_WH2_2	888	904	PF00022	0.493
LIG_AP2alpha_1	635	639	PF02296	0.214
LIG_BRCT_BRCA1_1	323	327	PF00533	0.290
LIG_BRCT_BRCA1_1	661	665	PF00533	0.335
LIG_BRCT_BRCA1_1	852	856	PF00533	0.537
LIG_Clathr_ClatBox_1	471	475	PF01394	0.337
LIG_Clathr_ClatBox_1	813	817	PF01394	0.446
LIG_deltaCOP1_diTrp_1	3	7	PF00928	0.372
LIG_eIF4E_1	121	127	PF01652	0.246
LIG_eIF4E_1	477	483	PF01652	0.264
LIG_eIF4E_1	602	608	PF01652	0.271
LIG_FHA_1	103	109	PF00498	0.337
LIG_FHA_1	153	159	PF00498	0.311
LIG_FHA_1	179	185	PF00498	0.436
LIG_FHA_1	291	297	PF00498	0.337
LIG_FHA_1	372	378	PF00498	0.339
LIG_FHA_1	638	644	PF00498	0.269
LIG_FHA_1	695	701	PF00498	0.246
LIG_FHA_1	790	796	PF00498	0.299
LIG_FHA_2	301	307	PF00498	0.298
LIG_FHA_2	438	444	PF00498	0.169
LIG_FHA_2	573	579	PF00498	0.337
LIG_FHA_2	743	749	PF00498	0.287
LIG_FHA_2	77	83	PF00498	0.301
LIG_FHA_2	892	898	PF00498	0.563
LIG_FHA_2	908	914	PF00498	0.474
LIG_Integrin_RGD_1	50	52	PF01839	0.516
LIG_IRF3_LxIS_1	201	207	PF10401	0.388
LIG_LIR_Apic_2	152	157	PF02991	0.428
LIG_LIR_Gen_1	337	346	PF02991	0.170
LIG_LIR_Gen_1	499	507	PF02991	0.264
LIG_LIR_Gen_1	538	549	PF02991	0.170
LIG_LIR_Gen_1	6	15	PF02991	0.322
LIG_LIR_Gen_1	678	685	PF02991	0.293
LIG_LIR_Gen_1	935	941	PF02991	0.515
LIG_LIR_Gen_1	94	100	PF02991	0.337
LIG_LIR_LC3C_4	504	507	PF02991	0.246
LIG_LIR_Nem_3	220	226	PF02991	0.299
LIG_LIR_Nem_3	3	7	PF02991	0.394
LIG_LIR_Nem_3	337	341	PF02991	0.264
LIG_LIR_Nem_3	376	382	PF02991	0.289
LIG_LIR_Nem_3	499	505	PF02991	0.280
LIG_LIR_Nem_3	538	544	PF02991	0.217
LIG_LIR_Nem_3	678	684	PF02991	0.296
LIG_LIR_Nem_3	817	821	PF02991	0.446
LIG_LIR_Nem_3	853	859	PF02991	0.446
LIG_LIR_Nem_3	915	921	PF02991	0.539
LIG_LIR_Nem_3	935	939	PF02991	0.371
LIG_MLH1_MIPbox_1	323	327	PF16413	0.337
LIG_PCNA_APIM_2	544	550	PF02747	0.246
LIG_PCNA_yPIPBox_3	550	563	PF02747	0.319
LIG_Pex14_1	470	474	PF04695	0.246
LIG_Pex14_1	763	767	PF04695	0.246
LIG_Pex14_2	375	379	PF04695	0.319
LIG_Pex14_2	635	639	PF04695	0.362
LIG_Pex14_2	681	685	PF04695	0.258
LIG_Pex14_2	814	818	PF04695	0.446
LIG_Pex14_2	821	825	PF04695	0.446
LIG_SH2_CRK	338	342	PF00017	0.277
LIG_SH2_CRK	433	437	PF00017	0.319
LIG_SH2_CRK	541	545	PF00017	0.287
LIG_SH2_CRK	720	724	PF00017	0.246
LIG_SH2_CRK	867	871	PF00017	0.486
LIG_SH2_CRK	918	922	PF00017	0.551
LIG_SH2_NCK_1	788	792	PF00017	0.310
LIG_SH2_PTP2	936	939	PF00017	0.506
LIG_SH2_SRC	119	122	PF00017	0.246
LIG_SH2_SRC	844	847	PF00017	0.519
LIG_SH2_SRC	936	939	PF00017	0.506
LIG_SH2_STAP1	338	342	PF00017	0.319
LIG_SH2_STAP1	502	506	PF00017	0.298
LIG_SH2_STAP1	541	545	PF00017	0.319
LIG_SH2_STAT3	121	124	PF00017	0.319
LIG_SH2_STAT3	597	600	PF00017	0.281
LIG_SH2_STAT5	119	122	PF00017	0.264
LIG_SH2_STAT5	163	166	PF00017	0.386
LIG_SH2_STAT5	223	226	PF00017	0.269
LIG_SH2_STAT5	231	234	PF00017	0.276
LIG_SH2_STAT5	350	353	PF00017	0.326
LIG_SH2_STAT5	438	441	PF00017	0.170
LIG_SH2_STAT5	514	517	PF00017	0.292
LIG_SH2_STAT5	562	565	PF00017	0.246
LIG_SH2_STAT5	566	569	PF00017	0.246
LIG_SH2_STAT5	597	600	PF00017	0.281
LIG_SH2_STAT5	602	605	PF00017	0.275
LIG_SH2_STAT5	61	64	PF00017	0.337
LIG_SH2_STAT5	788	791	PF00017	0.299
LIG_SH2_STAT5	793	796	PF00017	0.299
LIG_SH2_STAT5	844	847	PF00017	0.456
LIG_SH2_STAT5	858	861	PF00017	0.421
LIG_SH2_STAT5	936	939	PF00017	0.494
LIG_SH3_2	12	17	PF14604	0.484
LIG_SH3_3	142	148	PF00018	0.305
LIG_SH3_3	27	33	PF00018	0.205
LIG_SH3_3	374	380	PF00018	0.336
LIG_SH3_3	383	389	PF00018	0.280
LIG_SH3_3	9	15	PF00018	0.470
LIG_SH3_4	317	324	PF00018	0.170
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.337
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.246
LIG_SUMO_SIM_par_1	881	887	PF11976	0.446
LIG_TRAF2_1	303	306	PF00917	0.263
LIG_TRAF2_1	910	913	PF00917	0.501
LIG_TYR_ITIM	431	436	PF00017	0.400
LIG_TYR_ITIM	718	723	PF00017	0.324
LIG_UBA3_1	527	535	PF00899	0.393
LIG_UBA3_1	583	589	PF00899	0.363
LIG_UBA3_1	700	709	PF00899	0.299
LIG_WW_2	30	33	PF00397	0.302
MOD_CDC14_SPxK_1	591	594	PF00782	0.465
MOD_CDK_SPxK_1	588	594	PF00069	0.400
MOD_CDK_SPxxK_3	850	857	PF00069	0.400
MOD_CK1_1	176	182	PF00069	0.620
MOD_CK1_1	256	262	PF00069	0.250
MOD_CK1_1	404	410	PF00069	0.284
MOD_CK1_1	552	558	PF00069	0.310
MOD_CK1_1	6	12	PF00069	0.495
MOD_CK1_1	67	73	PF00069	0.563
MOD_CK2_1	10	16	PF00069	0.591
MOD_CK2_1	300	306	PF00069	0.348
MOD_CK2_1	416	422	PF00069	0.316
MOD_CK2_1	43	49	PF00069	0.515
MOD_CK2_1	516	522	PF00069	0.299
MOD_CK2_1	572	578	PF00069	0.305
MOD_CK2_1	721	727	PF00069	0.356
MOD_CK2_1	742	748	PF00069	0.400
MOD_CK2_1	769	775	PF00069	0.192
MOD_CK2_1	88	94	PF00069	0.425
MOD_CK2_1	907	913	PF00069	0.382
MOD_GlcNHglycan	206	209	PF01048	0.550
MOD_GlcNHglycan	389	392	PF01048	0.499
MOD_GlcNHglycan	465	468	PF01048	0.388
MOD_GlcNHglycan	541	544	PF01048	0.299
MOD_GlcNHglycan	686	689	PF01048	0.400
MOD_GlcNHglycan	710	713	PF01048	0.425
MOD_GlcNHglycan	874	877	PF01048	0.425
MOD_GSK3_1	173	180	PF00069	0.594
MOD_GSK3_1	269	276	PF00069	0.365
MOD_GSK3_1	284	291	PF00069	0.157
MOD_GSK3_1	296	303	PF00069	0.299
MOD_GSK3_1	367	374	PF00069	0.482
MOD_GSK3_1	438	445	PF00069	0.363
MOD_GSK3_1	535	542	PF00069	0.192
MOD_GSK3_1	6	13	PF00069	0.545
MOD_GSK3_1	64	71	PF00069	0.336
MOD_N-GLC_1	572	577	PF02516	0.299
MOD_N-GLC_1	742	747	PF02516	0.299
MOD_N-GLC_1	907	912	PF02516	0.453
MOD_N-GLC_2	371	373	PF02516	0.515
MOD_NEK2_1	204	209	PF00069	0.525
MOD_NEK2_1	284	289	PF00069	0.311
MOD_NEK2_1	327	332	PF00069	0.356
MOD_NEK2_1	549	554	PF00069	0.299
MOD_NEK2_1	626	631	PF00069	0.501
MOD_NEK2_1	667	672	PF00069	0.223
MOD_NEK2_1	703	708	PF00069	0.299
MOD_NEK2_1	781	786	PF00069	0.299
MOD_NEK2_1	848	853	PF00069	0.387
MOD_NEK2_1	87	92	PF00069	0.321
MOD_NEK2_1	883	888	PF00069	0.309
MOD_NEK2_2	53	58	PF00069	0.500
MOD_NEK2_2	866	871	PF00069	0.192
MOD_PIKK_1	120	126	PF00454	0.372
MOD_PIKK_1	330	336	PF00454	0.425
MOD_PKA_1	832	838	PF00069	0.299
MOD_PKA_2	159	165	PF00069	0.571
MOD_PKA_2	216	222	PF00069	0.511
MOD_PKA_2	401	407	PF00069	0.373
MOD_PKA_2	549	555	PF00069	0.324
MOD_PKA_2	626	632	PF00069	0.416
MOD_PKA_2	637	643	PF00069	0.272
MOD_PKA_2	67	73	PF00069	0.559
MOD_PKA_2	832	838	PF00069	0.299
MOD_PKA_2	85	91	PF00069	0.222
MOD_Plk_1	149	155	PF00069	0.495
MOD_Plk_1	442	448	PF00069	0.366
MOD_Plk_1	572	578	PF00069	0.300
MOD_Plk_2-3	516	522	PF00069	0.400
MOD_Plk_2-3	891	897	PF00069	0.470
MOD_Plk_4	149	155	PF00069	0.463
MOD_Plk_4	159	165	PF00069	0.495
MOD_Plk_4	321	327	PF00069	0.449
MOD_Plk_4	442	448	PF00069	0.457
MOD_Plk_4	703	709	PF00069	0.299
MOD_Plk_4	789	795	PF00069	0.299
MOD_Plk_4	809	815	PF00069	0.115
MOD_Plk_4	88	94	PF00069	0.192
MOD_ProDKin_1	484	490	PF00069	0.397
MOD_ProDKin_1	588	594	PF00069	0.400
MOD_ProDKin_1	838	844	PF00069	0.285
MOD_ProDKin_1	850	856	PF00069	0.290
MOD_SUMO_for_1	211	214	PF00179	0.412
MOD_SUMO_for_1	534	537	PF00179	0.299
MOD_SUMO_for_1	831	834	PF00179	0.299
MOD_SUMO_for_1	96	99	PF00179	0.192
MOD_SUMO_rev_2	141	151	PF00179	0.425
MOD_SUMO_rev_2	441	446	PF00179	0.414
MOD_SUMO_rev_2	653	660	PF00179	0.464
MOD_SUMO_rev_2	94	102	PF00179	0.192
TRG_DiLeu_BaEn_1	478	483	PF01217	0.324
TRG_DiLeu_BaEn_1	578	583	PF01217	0.299
TRG_DiLeu_BaEn_2	833	839	PF01217	0.299
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.204
TRG_ENDOCYTIC_2	223	226	PF00928	0.331
TRG_ENDOCYTIC_2	338	341	PF00928	0.342
TRG_ENDOCYTIC_2	433	436	PF00928	0.400
TRG_ENDOCYTIC_2	502	505	PF00928	0.356
TRG_ENDOCYTIC_2	541	544	PF00928	0.356
TRG_ENDOCYTIC_2	720	723	PF00928	0.313
TRG_ENDOCYTIC_2	867	870	PF00928	0.362
TRG_ENDOCYTIC_2	918	921	PF00928	0.434
TRG_ENDOCYTIC_2	936	939	PF00928	0.233
TRG_ER_diArg_1	483	485	PF00400	0.425
TRG_ER_diArg_1	549	551	PF00400	0.324
TRG_ER_diArg_1	901	903	PF00400	0.249
TRG_NES_CRM1_1	422	434	PF08389	0.425
TRG_NES_CRM1_1	522	537	PF08389	0.324
TRG_NES_CRM1_1	689	702	PF08389	0.299
TRG_NES_CRM1_1	896	911	PF08389	0.359
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.209
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	930	935	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K344	Rattus norvegicus	33%	88%
A0A0N1I4K0	Leptomonas seymouri	75%	90%
A0A1X0NPD0	Trypanosomatidae	56%	89%
A0A3R7MRK8	Trypanosoma rangeli	54%	89%
A0A3S7WSQ8	Leishmania donovani	89%	90%
A4HVU4	Leishmania infantum	89%	90%
O00329	Homo sapiens	34%	90%
O02697	Sus scrofa	33%	85%
O35904	Mus musculus	34%	90%
P0C5E7	Caenorhabditis briggsae	28%	81%
P32871	Bos taurus	33%	88%
P42336	Homo sapiens	33%	88%
P42337	Mus musculus	33%	88%
P42338	Homo sapiens	35%	88%
P48736	Homo sapiens	34%	85%
Q8BTI9	Mus musculus	35%	89%
Q94125	Caenorhabditis elegans	28%	80%
Q9JHG7	Mus musculus	33%	85%
Q9Z1L0	Rattus norvegicus	34%	88%
V5AXQ0	Trypanosoma cruzi	54%	89%