Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APJ4_LEIMU

TriTrypDb:

LmxM.13.1700

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	16
GO:0042995	cell projection	2	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0110165	cellular anatomical entity	1	16
GO:0120025	plasma membrane bounded cell projection	3	16
GO:0016020	membrane	2	1

Expansion

Sequence features

E9APJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.542
CLV_PCSK_KEX2_1	9	11	PF00082	0.401
CLV_PCSK_SKI1_1	135	139	PF00082	0.386
CLV_PCSK_SKI1_1	241	245	PF00082	0.399
CLV_PCSK_SKI1_1	370	374	PF00082	0.482
CLV_PCSK_SKI1_1	430	434	PF00082	0.380
CLV_PCSK_SKI1_1	78	82	PF00082	0.554
CLV_Separin_Metazoa	407	411	PF03568	0.459
DEG_APCC_DBOX_1	134	142	PF00400	0.334
DEG_APCC_DBOX_1	51	59	PF00400	0.646
DEG_APCC_DBOX_1	9	17	PF00400	0.296
DEG_Nend_UBRbox_2	1	3	PF02207	0.606
DOC_CDC14_PxL_1	170	178	PF14671	0.269
DOC_CDC14_PxL_1	199	207	PF14671	0.426
DOC_CDC14_PxL_1	333	341	PF14671	0.490
DOC_CDC14_PxL_1	378	386	PF14671	0.385
DOC_CDC14_PxL_1	423	431	PF14671	0.513
DOC_CYCLIN_RxL_1	278	287	PF00134	0.405
DOC_CYCLIN_RxL_1	72	85	PF00134	0.410
DOC_CYCLIN_yClb5_NLxxxL_5	46	55	PF00134	0.391
DOC_MAPK_gen_1	9	15	PF00069	0.293
DOC_MAPK_HePTP_8	69	81	PF00069	0.455
DOC_MAPK_MEF2A_6	112	119	PF00069	0.444
DOC_MAPK_MEF2A_6	72	81	PF00069	0.494
DOC_PP1_RVXF_1	316	322	PF00149	0.439
DOC_USP7_MATH_1	169	173	PF00917	0.483
DOC_USP7_MATH_1	175	179	PF00917	0.516
DOC_USP7_MATH_1	311	315	PF00917	0.356
DOC_USP7_MATH_1	326	330	PF00917	0.564
DOC_USP7_MATH_1	95	99	PF00917	0.458
DOC_WW_Pin1_4	373	378	PF00397	0.412
DOC_WW_Pin1_4	446	451	PF00397	0.548
DOC_WW_Pin1_4	457	462	PF00397	0.693
DOC_WW_Pin1_4	56	61	PF00397	0.537
LIG_14-3-3_CanoR_1	139	144	PF00244	0.532
LIG_14-3-3_CanoR_1	190	199	PF00244	0.430
LIG_14-3-3_CanoR_1	22	26	PF00244	0.493
LIG_14-3-3_CanoR_1	241	249	PF00244	0.341
LIG_14-3-3_CanoR_1	281	286	PF00244	0.491
LIG_14-3-3_CanoR_1	318	322	PF00244	0.451
LIG_14-3-3_CanoR_1	370	378	PF00244	0.369
LIG_14-3-3_CanoR_1	52	56	PF00244	0.582
LIG_14-3-3_CanoR_1	72	78	PF00244	0.302
LIG_Actin_WH2_2	326	342	PF00022	0.382
LIG_Actin_WH2_2	36	54	PF00022	0.553
LIG_APCC_ABBA_1	156	161	PF00400	0.284
LIG_BIR_III_4	93	97	PF00653	0.409
LIG_Clathr_ClatBox_1	157	161	PF01394	0.352
LIG_DLG_GKlike_1	139	146	PF00625	0.401
LIG_DLG_GKlike_1	281	288	PF00625	0.401
LIG_FHA_1	205	211	PF00498	0.455
LIG_FHA_1	271	277	PF00498	0.534
LIG_FHA_1	3	9	PF00498	0.548
LIG_FHA_1	361	367	PF00498	0.392
LIG_FHA_1	447	453	PF00498	0.426
LIG_FHA_1	74	80	PF00498	0.544
LIG_FHA_2	273	279	PF00498	0.389
LIG_GBD_Chelix_1	65	73	PF00786	0.419
LIG_Integrin_RGD_1	120	122	PF01839	0.427
LIG_LIR_Gen_1	168	177	PF02991	0.499
LIG_LIR_Gen_1	298	309	PF02991	0.246
LIG_LIR_Gen_1	388	397	PF02991	0.469
LIG_LIR_Gen_1	428	437	PF02991	0.247
LIG_LIR_Nem_3	168	173	PF02991	0.486
LIG_LIR_Nem_3	298	304	PF02991	0.412
LIG_LIR_Nem_3	388	394	PF02991	0.479
LIG_LIR_Nem_3	428	434	PF02991	0.314
LIG_NRBOX	64	70	PF00104	0.415
LIG_NRBOX	76	82	PF00104	0.353
LIG_RPA_C_Fungi	185	197	PF08784	0.343
LIG_SH2_CRK	200	204	PF00017	0.431
LIG_SH2_PTP2	431	434	PF00017	0.335
LIG_SH2_STAT5	431	434	PF00017	0.335
LIG_SH3_3	171	177	PF00018	0.510
LIG_SH3_3	22	28	PF00018	0.348
LIG_SUMO_SIM_anti_2	122	132	PF11976	0.402
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.466
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.407
LIG_SUMO_SIM_anti_2	272	278	PF11976	0.429
LIG_SUMO_SIM_anti_2	405	410	PF11976	0.515
LIG_SUMO_SIM_par_1	206	212	PF11976	0.381
LIG_SUMO_SIM_par_1	272	278	PF11976	0.467
LIG_SUMO_SIM_par_1	280	287	PF11976	0.513
LIG_TRAF2_2	228	233	PF00917	0.465
LIG_TYR_ITIM	429	434	PF00017	0.338
MOD_CDK_SPK_2	446	451	PF00069	0.412
MOD_CDK_SPK_2	56	61	PF00069	0.467
MOD_CDK_SPxxK_3	56	63	PF00069	0.554
MOD_CK1_1	178	184	PF00069	0.359
MOD_CK1_1	204	210	PF00069	0.439
MOD_CK1_1	245	251	PF00069	0.401
MOD_CK1_1	257	263	PF00069	0.306
MOD_CK1_1	270	276	PF00069	0.383
MOD_CK1_1	284	290	PF00069	0.401
MOD_CK1_1	302	308	PF00069	0.338
MOD_CK1_1	390	396	PF00069	0.506
MOD_CK1_1	446	452	PF00069	0.491
MOD_CK2_1	311	317	PF00069	0.353
MOD_GlcNHglycan	192	195	PF01048	0.528
MOD_GlcNHglycan	244	247	PF01048	0.463
MOD_GlcNHglycan	256	259	PF01048	0.426
MOD_GlcNHglycan	262	265	PF01048	0.362
MOD_GlcNHglycan	301	304	PF01048	0.502
MOD_GlcNHglycan	346	349	PF01048	0.335
MOD_GSK3_1	124	131	PF00069	0.543
MOD_GSK3_1	17	24	PF00069	0.542
MOD_GSK3_1	241	248	PF00069	0.381
MOD_GSK3_1	293	300	PF00069	0.438
MOD_GSK3_1	360	367	PF00069	0.357
MOD_N-GLC_1	220	225	PF02516	0.458
MOD_NEK2_1	128	133	PF00069	0.526
MOD_NEK2_1	242	247	PF00069	0.464
MOD_NEK2_1	252	257	PF00069	0.454
MOD_NEK2_1	283	288	PF00069	0.584
MOD_NEK2_1	293	298	PF00069	0.408
MOD_NEK2_1	364	369	PF00069	0.351
MOD_NEK2_1	51	56	PF00069	0.650
MOD_NEK2_1	68	73	PF00069	0.611
MOD_NEK2_1	81	86	PF00069	0.326
MOD_PIKK_1	175	181	PF00454	0.412
MOD_PK_1	295	301	PF00069	0.402
MOD_PKA_2	189	195	PF00069	0.509
MOD_PKA_2	21	27	PF00069	0.504
MOD_PKA_2	252	258	PF00069	0.538
MOD_PKA_2	317	323	PF00069	0.473
MOD_PKA_2	51	57	PF00069	0.649
MOD_Plk_1	121	127	PF00069	0.507
MOD_Plk_1	17	23	PF00069	0.463
MOD_Plk_1	220	226	PF00069	0.522
MOD_Plk_1	387	393	PF00069	0.427
MOD_Plk_1	81	87	PF00069	0.610
MOD_Plk_2-3	317	323	PF00069	0.463
MOD_Plk_4	121	127	PF00069	0.584
MOD_Plk_4	141	147	PF00069	0.342
MOD_Plk_4	21	27	PF00069	0.419
MOD_Plk_4	257	263	PF00069	0.515
MOD_Plk_4	272	278	PF00069	0.497
MOD_Plk_4	82	88	PF00069	0.424
MOD_Plk_4	95	101	PF00069	0.536
MOD_ProDKin_1	373	379	PF00069	0.416
MOD_ProDKin_1	446	452	PF00069	0.543
MOD_ProDKin_1	56	62	PF00069	0.528
MOD_SUMO_rev_2	209	214	PF00179	0.395
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.263
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.564
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.407
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.534
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.519
TRG_ENDOCYTIC_2	431	434	PF00928	0.335
TRG_ER_diArg_1	133	136	PF00400	0.516
TRG_ER_diArg_1	337	340	PF00400	0.482
TRG_ER_diArg_1	382	385	PF00400	0.386
TRG_ER_diArg_1	8	10	PF00400	0.403
TRG_NES_CRM1_1	201	211	PF08389	0.373
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	33%	88%
A0A0N0P8N9	Leptomonas seymouri	31%	70%
A0A0N1I0W0	Leptomonas seymouri	26%	90%
A0A0N1I1E8	Leptomonas seymouri	27%	100%
A0A1X0NG16	Trypanosomatidae	26%	79%
A0A3Q8I8N4	Leishmania donovani	89%	100%
A0A3S5H5M6	Leishmania donovani	24%	86%
A4H3R1	Leishmania braziliensis	32%	67%
A4H4H0	Leishmania braziliensis	23%	100%
A4H7G0	Leishmania braziliensis	76%	100%
A4HSP5	Leishmania infantum	24%	86%
E9AGK6	Leishmania infantum	88%	100%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QFY4	Leishmania major	89%	100%