Squalene monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

squalene monooxygenase-like protein

Species:

Leishmania mexicana

UniProt:

E9API6_LEIMU

TriTrypDb:

LmxM.13.1620

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9API6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9API6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006694	steroid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008202	steroid metabolic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004497	monooxygenase activity	3	12
GO:0004506	squalene monooxygenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0071949	FAD binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.502
CLV_NRD_NRD_1	204	206	PF00675	0.484
CLV_NRD_NRD_1	563	565	PF00675	0.536
CLV_NRD_NRD_1	58	60	PF00675	0.304
CLV_PCSK_KEX2_1	548	550	PF00082	0.418
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.418
CLV_PCSK_SKI1_1	206	210	PF00082	0.316
CLV_PCSK_SKI1_1	548	552	PF00082	0.375
CLV_PCSK_SKI1_1	59	63	PF00082	0.274
CLV_PCSK_SKI1_1	66	70	PF00082	0.303
DEG_APCC_KENBOX_2	147	151	PF00400	0.286
DEG_MDM2_SWIB_1	530	537	PF02201	0.373
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DOC_CYCLIN_RxL_1	60	73	PF00134	0.330
DOC_MAPK_gen_1	122	130	PF00069	0.453
DOC_MAPK_gen_1	252	260	PF00069	0.385
DOC_MAPK_gen_1	562	569	PF00069	0.501
DOC_MAPK_MEF2A_6	206	215	PF00069	0.255
DOC_MAPK_MEF2A_6	517	525	PF00069	0.347
DOC_PP4_FxxP_1	536	539	PF00568	0.390
DOC_PP4_FxxP_1	69	72	PF00568	0.312
DOC_USP7_MATH_1	30	34	PF00917	0.364
DOC_USP7_MATH_1	334	338	PF00917	0.394
DOC_WW_Pin1_4	228	233	PF00397	0.339
DOC_WW_Pin1_4	25	30	PF00397	0.488
DOC_WW_Pin1_4	538	543	PF00397	0.430
LIG_14-3-3_CanoR_1	138	143	PF00244	0.172
LIG_14-3-3_CanoR_1	205	211	PF00244	0.400
LIG_14-3-3_CanoR_1	31	35	PF00244	0.475
LIG_14-3-3_CanoR_1	368	374	PF00244	0.343
LIG_14-3-3_CanoR_1	403	412	PF00244	0.308
LIG_14-3-3_CanoR_1	549	554	PF00244	0.313
LIG_Actin_WH2_2	11	28	PF00022	0.445
LIG_Actin_WH2_2	360	376	PF00022	0.329
LIG_Actin_WH2_2	415	431	PF00022	0.255
LIG_Actin_WH2_2	73	91	PF00022	0.386
LIG_AP2alpha_2	188	190	PF02296	0.316
LIG_BRCT_BRCA1_1	128	132	PF00533	0.270
LIG_BRCT_BRCA1_1	140	144	PF00533	0.273
LIG_BRCT_BRCA1_1	458	462	PF00533	0.195
LIG_FHA_1	12	18	PF00498	0.424
LIG_FHA_1	161	167	PF00498	0.332
LIG_FHA_1	207	213	PF00498	0.268
LIG_FHA_1	245	251	PF00498	0.355
LIG_FHA_1	255	261	PF00498	0.237
LIG_FHA_1	318	324	PF00498	0.274
LIG_FHA_1	538	544	PF00498	0.309
LIG_FHA_2	150	156	PF00498	0.305
LIG_FHA_2	176	182	PF00498	0.413
LIG_FHA_2	30	36	PF00498	0.351
LIG_FHA_2	68	74	PF00498	0.379
LIG_G3BP_FGDF_1	130	135	PF02136	0.307
LIG_HP1_1	211	215	PF01393	0.334
LIG_LIR_Apic_2	181	186	PF02991	0.392
LIG_LIR_Apic_2	281	285	PF02991	0.255
LIG_LIR_Apic_2	67	72	PF02991	0.312
LIG_LIR_Gen_1	311	319	PF02991	0.385
LIG_LIR_Gen_1	33	41	PF02991	0.279
LIG_LIR_Gen_1	430	437	PF02991	0.323
LIG_LIR_LC3C_4	209	214	PF02991	0.385
LIG_LIR_Nem_3	129	135	PF02991	0.277
LIG_LIR_Nem_3	225	230	PF02991	0.334
LIG_LIR_Nem_3	238	243	PF02991	0.119
LIG_LIR_Nem_3	311	316	PF02991	0.385
LIG_LIR_Nem_3	33	39	PF02991	0.284
LIG_LIR_Nem_3	416	420	PF02991	0.252
LIG_LIR_Nem_3	430	436	PF02991	0.240
LIG_LIR_Nem_3	459	464	PF02991	0.234
LIG_LIR_Nem_3	532	537	PF02991	0.347
LIG_MAD2	277	285	PF02301	0.304
LIG_MAD2	74	82	PF02301	0.292
LIG_MLH1_MIPbox_1	458	462	PF16413	0.195
LIG_MYND_3	287	291	PF01753	0.299
LIG_NBox_RRM_1	363	373	PF00076	0.385
LIG_PCNA_yPIPBox_3	393	402	PF02747	0.180
LIG_PDZ_Class_2	564	569	PF00595	0.416
LIG_Pex14_1	223	227	PF04695	0.385
LIG_Pex14_2	530	534	PF04695	0.332
LIG_PTB_Apo_2	525	532	PF02174	0.512
LIG_PTB_Phospho_1	525	531	PF10480	0.469
LIG_RPA_C_Fungi	15	27	PF08784	0.335
LIG_SH2_CRK	282	286	PF00017	0.255
LIG_SH2_CRK	36	40	PF00017	0.256
LIG_SH2_CRK	464	468	PF00017	0.385
LIG_SH2_NCK_1	177	181	PF00017	0.397
LIG_SH2_NCK_1	183	187	PF00017	0.455
LIG_SH2_NCK_1	230	234	PF00017	0.274
LIG_SH2_NCK_1	282	286	PF00017	0.221
LIG_SH2_PTP2	107	110	PF00017	0.310
LIG_SH2_PTP2	341	344	PF00017	0.255
LIG_SH2_SRC	234	237	PF00017	0.382
LIG_SH2_STAP1	34	38	PF00017	0.269
LIG_SH2_STAP1	482	486	PF00017	0.477
LIG_SH2_STAP1	555	559	PF00017	0.455
LIG_SH2_STAT3	555	558	PF00017	0.452
LIG_SH2_STAT5	107	110	PF00017	0.289
LIG_SH2_STAT5	142	145	PF00017	0.269
LIG_SH2_STAT5	177	180	PF00017	0.351
LIG_SH2_STAT5	230	233	PF00017	0.299
LIG_SH2_STAT5	3	6	PF00017	0.466
LIG_SH2_STAT5	341	344	PF00017	0.255
LIG_SH2_STAT5	401	404	PF00017	0.265
LIG_SH2_STAT5	406	409	PF00017	0.284
LIG_SH2_STAT5	435	438	PF00017	0.240
LIG_SH2_STAT5	464	467	PF00017	0.260
LIG_SH2_STAT5	513	516	PF00017	0.364
LIG_SH2_STAT5	555	558	PF00017	0.515
LIG_SH3_1	183	189	PF00018	0.374
LIG_SH3_1	196	202	PF00018	0.438
LIG_SH3_1	282	288	PF00018	0.255
LIG_SH3_1	330	336	PF00018	0.311
LIG_SH3_2	186	191	PF14604	0.456
LIG_SH3_3	114	120	PF00018	0.405
LIG_SH3_3	183	189	PF00018	0.409
LIG_SH3_3	196	202	PF00018	0.450
LIG_SH3_3	245	251	PF00018	0.325
LIG_SH3_3	282	288	PF00018	0.253
LIG_SH3_3	300	306	PF00018	0.180
LIG_SH3_3	330	336	PF00018	0.364
LIG_SH3_3	440	446	PF00018	0.240
LIG_SH3_3	518	524	PF00018	0.237
LIG_SH3_3	536	542	PF00018	0.419
LIG_SH3_5	232	236	PF00018	0.269
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.432
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.312
LIG_SUMO_SIM_par_1	60	65	PF11976	0.277
LIG_WRC_WIRS_1	498	503	PF05994	0.404
MOD_CDC14_SPxK_1	28	31	PF00782	0.468
MOD_CDK_SPxK_1	25	31	PF00069	0.484
MOD_CK1_1	126	132	PF00069	0.442
MOD_CK1_1	317	323	PF00069	0.316
MOD_CK1_1	378	384	PF00069	0.340
MOD_CK1_1	421	427	PF00069	0.385
MOD_CK2_1	143	149	PF00069	0.318
MOD_CK2_1	164	170	PF00069	0.453
MOD_CK2_1	175	181	PF00069	0.308
MOD_CK2_1	487	493	PF00069	0.531
MOD_Cter_Amidation	57	60	PF01082	0.392
MOD_GlcNHglycan	125	128	PF01048	0.427
MOD_GSK3_1	160	167	PF00069	0.435
MOD_GSK3_1	218	225	PF00069	0.334
MOD_GSK3_1	25	32	PF00069	0.500
MOD_GSK3_1	418	425	PF00069	0.385
MOD_GSK3_1	476	483	PF00069	0.237
MOD_GSK3_1	489	496	PF00069	0.317
MOD_GSK3_1	549	556	PF00069	0.512
MOD_N-GLC_1	149	154	PF02516	0.343
MOD_N-GLC_1	18	23	PF02516	0.319
MOD_N-GLC_1	544	549	PF02516	0.381
MOD_NEK2_1	18	23	PF00069	0.370
MOD_NEK2_1	260	265	PF00069	0.283
MOD_NEK2_1	369	374	PF00069	0.312
MOD_NEK2_1	404	409	PF00069	0.210
MOD_NEK2_1	476	481	PF00069	0.256
MOD_NEK2_1	553	558	PF00069	0.514
MOD_NEK2_2	418	423	PF00069	0.355
MOD_PIKK_1	422	428	PF00454	0.141
MOD_PKA_2	254	260	PF00069	0.387
MOD_PKA_2	30	36	PF00069	0.362
MOD_PKA_2	314	320	PF00069	0.394
MOD_PKA_2	404	410	PF00069	0.305
MOD_PKA_2	441	447	PF00069	0.141
MOD_Plk_1	149	155	PF00069	0.353
MOD_Plk_1	175	181	PF00069	0.355
MOD_Plk_1	18	24	PF00069	0.325
MOD_Plk_1	64	70	PF00069	0.311
MOD_Plk_2-3	149	155	PF00069	0.224
MOD_Plk_2-3	164	170	PF00069	0.449
MOD_Plk_4	11	17	PF00069	0.388
MOD_Plk_4	149	155	PF00069	0.333
MOD_Plk_4	254	260	PF00069	0.227
MOD_Plk_4	418	424	PF00069	0.385
MOD_Plk_4	456	462	PF00069	0.207
MOD_Plk_4	497	503	PF00069	0.368
MOD_Plk_4	529	535	PF00069	0.331
MOD_Plk_4	549	555	PF00069	0.236
MOD_ProDKin_1	228	234	PF00069	0.339
MOD_ProDKin_1	25	31	PF00069	0.484
MOD_ProDKin_1	538	544	PF00069	0.429
MOD_SUMO_for_1	526	529	PF00179	0.460
MOD_SUMO_rev_2	317	323	PF00179	0.305
MOD_SUMO_rev_2	385	394	PF00179	0.301
TRG_DiLeu_BaEn_1	275	280	PF01217	0.240
TRG_DiLeu_BaEn_2	94	100	PF01217	0.200
TRG_ENDOCYTIC_2	107	110	PF00928	0.274
TRG_ENDOCYTIC_2	341	344	PF00928	0.247
TRG_ENDOCYTIC_2	36	39	PF00928	0.257
TRG_ENDOCYTIC_2	401	404	PF00928	0.292
TRG_ENDOCYTIC_2	420	423	PF00928	0.222
TRG_ENDOCYTIC_2	464	467	PF00928	0.240
TRG_ER_diArg_1	24	27	PF00400	0.459
TRG_NES_CRM1_1	493	504	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K9	Leptomonas seymouri	80%	100%
A0A0S4IT90	Bodo saltans	55%	87%
A0A1X0NLC9	Trypanosomatidae	61%	100%
A0A3S7WSP8	Leishmania donovani	92%	100%
A0A422P4A3	Trypanosoma rangeli	60%	100%
A4H7F2	Leishmania braziliensis	86%	100%
A4HVU0	Leishmania infantum	91%	100%
B7TWW5	Panax ginseng	35%	100%
D0A6E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	98%
E9R5G2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	100%
I1RQ76	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
O13306	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
O48651	Panax ginseng	33%	100%
O65402	Arabidopsis thaliana	27%	100%
O65403	Arabidopsis thaliana	26%	100%
O65404	Arabidopsis thaliana	26%	100%
O65726	Brassica napus	27%	100%
O65727	Brassica napus	27%	100%
O81000	Arabidopsis thaliana	36%	97%
P32476	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P52019	Mus musculus	35%	99%
P52020	Rattus norvegicus	33%	99%
Q14534	Homo sapiens	34%	99%
Q4QFZ2	Leishmania major	92%	100%
Q75F69	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	100%
Q8VYH2	Arabidopsis thaliana	35%	100%
Q92206	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	100%
Q9C1W3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9SM02	Arabidopsis thaliana	34%	100%
V5BRL1	Trypanosoma cruzi	58%	99%