Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9API4_LEIMU

TriTrypDb:

LmxM.13.1600

Length:

1212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9API4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9API4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1000	1004	PF00656	0.469
CLV_C14_Caspase3-7	238	242	PF00656	0.489
CLV_C14_Caspase3-7	769	773	PF00656	0.410
CLV_NRD_NRD_1	180	182	PF00675	0.657
CLV_NRD_NRD_1	269	271	PF00675	0.665
CLV_NRD_NRD_1	391	393	PF00675	0.661
CLV_NRD_NRD_1	706	708	PF00675	0.677
CLV_NRD_NRD_1	882	884	PF00675	0.617
CLV_NRD_NRD_1	925	927	PF00675	0.562
CLV_PCSK_FUR_1	880	884	PF00082	0.605
CLV_PCSK_KEX2_1	1052	1054	PF00082	0.734
CLV_PCSK_KEX2_1	180	182	PF00082	0.673
CLV_PCSK_KEX2_1	269	271	PF00082	0.665
CLV_PCSK_KEX2_1	391	393	PF00082	0.661
CLV_PCSK_KEX2_1	706	708	PF00082	0.677
CLV_PCSK_KEX2_1	882	884	PF00082	0.617
CLV_PCSK_PC1ET2_1	1052	1054	PF00082	0.734
CLV_PCSK_PC7_1	878	884	PF00082	0.624
CLV_PCSK_SKI1_1	180	184	PF00082	0.680
CLV_PCSK_SKI1_1	225	229	PF00082	0.535
CLV_PCSK_SKI1_1	270	274	PF00082	0.663
CLV_PCSK_SKI1_1	278	282	PF00082	0.625
CLV_PCSK_SKI1_1	335	339	PF00082	0.611
CLV_PCSK_SKI1_1	536	540	PF00082	0.592
CLV_PCSK_SKI1_1	874	878	PF00082	0.681
CLV_PCSK_SKI1_1	882	886	PF00082	0.533
DEG_APCC_DBOX_1	334	342	PF00400	0.407
DEG_APCC_DBOX_1	749	757	PF00400	0.471
DEG_APCC_DBOX_1	788	796	PF00400	0.561
DEG_APCC_DBOX_1	877	885	PF00400	0.461
DEG_SPOP_SBC_1	1085	1089	PF00917	0.375
DEG_SPOP_SBC_1	147	151	PF00917	0.528
DEG_SPOP_SBC_1	243	247	PF00917	0.483
DEG_SPOP_SBC_1	33	37	PF00917	0.419
DOC_CYCLIN_yClb5_NLxxxL_5	219	227	PF00134	0.426
DOC_MAPK_gen_1	79	88	PF00069	0.467
DOC_MAPK_MEF2A_6	485	493	PF00069	0.498
DOC_USP7_MATH_1	1026	1030	PF00917	0.481
DOC_USP7_MATH_1	1166	1170	PF00917	0.666
DOC_USP7_MATH_1	1188	1192	PF00917	0.708
DOC_USP7_MATH_1	17	21	PF00917	0.578
DOC_USP7_MATH_1	193	197	PF00917	0.471
DOC_USP7_MATH_1	235	239	PF00917	0.469
DOC_USP7_MATH_1	242	246	PF00917	0.472
DOC_USP7_MATH_1	260	264	PF00917	0.412
DOC_USP7_MATH_1	309	313	PF00917	0.437
DOC_USP7_MATH_1	360	364	PF00917	0.517
DOC_USP7_MATH_1	396	400	PF00917	0.446
DOC_USP7_MATH_1	434	438	PF00917	0.458
DOC_USP7_MATH_1	639	643	PF00917	0.443
DOC_USP7_MATH_1	719	723	PF00917	0.546
DOC_USP7_MATH_1	745	749	PF00917	0.428
DOC_USP7_MATH_1	896	900	PF00917	0.493
DOC_USP7_MATH_1	974	978	PF00917	0.458
DOC_USP7_MATH_2	1168	1174	PF00917	0.672
DOC_USP7_UBL2_3	1199	1203	PF12436	0.649
DOC_USP7_UBL2_3	277	281	PF12436	0.426
DOC_WW_Pin1_4	117	122	PF00397	0.519
DOC_WW_Pin1_4	150	155	PF00397	0.491
DOC_WW_Pin1_4	361	366	PF00397	0.475
DOC_WW_Pin1_4	480	485	PF00397	0.451
DOC_WW_Pin1_4	552	557	PF00397	0.564
DOC_WW_Pin1_4	585	590	PF00397	0.480
DOC_WW_Pin1_4	591	596	PF00397	0.417
DOC_WW_Pin1_4	689	694	PF00397	0.480
DOC_WW_Pin1_4	7	12	PF00397	0.477
DOC_WW_Pin1_4	853	858	PF00397	0.444
LIG_14-3-3_CanoR_1	25	31	PF00244	0.461
LIG_14-3-3_CanoR_1	316	324	PF00244	0.388
LIG_14-3-3_CanoR_1	353	357	PF00244	0.475
LIG_14-3-3_CanoR_1	531	538	PF00244	0.472
LIG_14-3-3_CanoR_1	750	754	PF00244	0.507
LIG_14-3-3_CanoR_1	760	765	PF00244	0.470
LIG_14-3-3_CanoR_1	789	799	PF00244	0.425
LIG_14-3-3_CanoR_1	872	881	PF00244	0.423
LIG_14-3-3_CanoR_1	882	891	PF00244	0.319
LIG_14-3-3_CanoR_1	926	931	PF00244	0.370
LIG_Actin_WH2_2	254	271	PF00022	0.417
LIG_Actin_WH2_2	337	355	PF00022	0.476
LIG_Actin_WH2_2	435	452	PF00022	0.508
LIG_Actin_WH2_2	84	101	PF00022	0.417
LIG_AP2alpha_1	757	761	PF02296	0.433
LIG_APCC_ABBA_1	401	406	PF00400	0.445
LIG_BRCT_BRCA1_1	731	735	PF00533	0.450
LIG_CtBP_PxDLS_1	643	648	PF00389	0.377
LIG_DLG_GKlike_1	760	768	PF00625	0.386
LIG_eIF4E_1	1155	1161	PF01652	0.312
LIG_FHA_1	1076	1082	PF00498	0.342
LIG_FHA_1	1105	1111	PF00498	0.455
LIG_FHA_1	1117	1123	PF00498	0.503
LIG_FHA_1	1128	1134	PF00498	0.485
LIG_FHA_1	181	187	PF00498	0.478
LIG_FHA_1	263	269	PF00498	0.409
LIG_FHA_1	271	277	PF00498	0.410
LIG_FHA_1	422	428	PF00498	0.494
LIG_FHA_1	473	479	PF00498	0.470
LIG_FHA_1	557	563	PF00498	0.471
LIG_FHA_1	565	571	PF00498	0.394
LIG_FHA_1	586	592	PF00498	0.510
LIG_FHA_1	628	634	PF00498	0.447
LIG_FHA_1	716	722	PF00498	0.520
LIG_FHA_1	763	769	PF00498	0.434
LIG_FHA_1	8	14	PF00498	0.527
LIG_FHA_1	827	833	PF00498	0.446
LIG_FHA_1	883	889	PF00498	0.408
LIG_FHA_1	987	993	PF00498	0.422
LIG_FHA_2	1113	1119	PF00498	0.521
LIG_FHA_2	1187	1193	PF00498	0.710
LIG_FHA_2	232	238	PF00498	0.539
LIG_FHA_2	244	250	PF00498	0.411
LIG_FHA_2	283	289	PF00498	0.521
LIG_FHA_2	293	299	PF00498	0.404
LIG_FHA_2	316	322	PF00498	0.390
LIG_FHA_2	35	41	PF00498	0.431
LIG_FHA_2	439	445	PF00498	0.472
LIG_FHA_2	530	536	PF00498	0.465
LIG_FHA_2	564	570	PF00498	0.443
LIG_FHA_2	694	700	PF00498	0.442
LIG_FHA_2	73	79	PF00498	0.410
LIG_FHA_2	782	788	PF00498	0.479
LIG_GBD_Chelix_1	519	527	PF00786	0.690
LIG_LIR_Gen_1	29	34	PF02991	0.481
LIG_LIR_Gen_1	483	493	PF02991	0.443
LIG_LIR_Gen_1	759	768	PF02991	0.431
LIG_LIR_Nem_3	1152	1157	PF02991	0.312
LIG_LIR_Nem_3	29	33	PF02991	0.487
LIG_LIR_Nem_3	304	310	PF02991	0.480
LIG_LIR_Nem_3	483	489	PF02991	0.565
LIG_LIR_Nem_3	594	600	PF02991	0.420
LIG_LIR_Nem_3	759	764	PF02991	0.433
LIG_NRBOX	724	730	PF00104	0.335
LIG_PCNA_yPIPBox_3	179	189	PF02747	0.453
LIG_PCNA_yPIPBox_3	217	225	PF02747	0.387
LIG_Pex14_2	757	761	PF04695	0.433
LIG_SH2_PTP2	30	33	PF00017	0.486
LIG_SH2_SRC	30	33	PF00017	0.486
LIG_SH2_SRC	599	602	PF00017	0.416
LIG_SH2_STAP1	18	22	PF00017	0.535
LIG_SH2_STAP1	76	80	PF00017	0.476
LIG_SH2_STAT5	1155	1158	PF00017	0.312
LIG_SH2_STAT5	1207	1210	PF00017	0.662
LIG_SH2_STAT5	30	33	PF00017	0.486
LIG_SH2_STAT5	599	602	PF00017	0.436
LIG_SH3_1	8	14	PF00018	0.527
LIG_SH3_3	1162	1168	PF00018	0.528
LIG_SH3_3	462	468	PF00018	0.589
LIG_SH3_3	478	484	PF00018	0.441
LIG_SH3_3	671	677	PF00018	0.600
LIG_SH3_3	8	14	PF00018	0.473
LIG_SUMO_SIM_anti_2	29	38	PF11976	0.467
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.474
LIG_SUMO_SIM_par_1	1147	1152	PF11976	0.284
LIG_TRAF2_1	1109	1112	PF00917	0.504
LIG_TRAF2_1	1168	1171	PF00917	0.638
LIG_TRAF2_1	197	200	PF00917	0.449
LIG_TRAF2_1	252	255	PF00917	0.481
LIG_TRAF2_1	340	343	PF00917	0.431
LIG_TRAF2_1	543	546	PF00917	0.454
LIG_TRAF2_1	612	615	PF00917	0.433
LIG_TRAF2_1	838	841	PF00917	0.468
LIG_TRAF2_1	903	906	PF00917	0.381
LIG_UBA3_1	400	405	PF00899	0.489
LIG_WRC_WIRS_1	603	608	PF05994	0.463
MOD_CDK_SPK_2	480	485	PF00069	0.546
MOD_CDK_SPxxK_3	591	598	PF00069	0.529
MOD_CK1_1	1104	1110	PF00069	0.618
MOD_CK1_1	1116	1122	PF00069	0.672
MOD_CK1_1	148	154	PF00069	0.667
MOD_CK1_1	256	262	PF00069	0.672
MOD_CK1_1	282	288	PF00069	0.573
MOD_CK1_1	312	318	PF00069	0.603
MOD_CK1_1	354	360	PF00069	0.644
MOD_CK1_1	363	369	PF00069	0.616
MOD_CK1_1	395	401	PF00069	0.513
MOD_CK1_1	437	443	PF00069	0.637
MOD_CK1_1	514	520	PF00069	0.604
MOD_CK1_1	551	557	PF00069	0.620
MOD_CK1_1	602	608	PF00069	0.464
MOD_CK1_1	642	648	PF00069	0.707
MOD_CK1_1	736	742	PF00069	0.514
MOD_CK1_1	798	804	PF00069	0.641
MOD_CK1_1	889	895	PF00069	0.487
MOD_CK2_1	1028	1034	PF00069	0.617
MOD_CK2_1	1045	1051	PF00069	0.438
MOD_CK2_1	1105	1111	PF00069	0.444
MOD_CK2_1	1186	1192	PF00069	0.599
MOD_CK2_1	162	168	PF00069	0.584
MOD_CK2_1	193	199	PF00069	0.446
MOD_CK2_1	231	237	PF00069	0.645
MOD_CK2_1	282	288	PF00069	0.596
MOD_CK2_1	32	38	PF00069	0.536
MOD_CK2_1	529	535	PF00069	0.530
MOD_CK2_1	563	569	PF00069	0.553
MOD_CK2_1	609	615	PF00069	0.525
MOD_CK2_1	621	627	PF00069	0.444
MOD_CK2_1	656	662	PF00069	0.532
MOD_CK2_1	693	699	PF00069	0.522
MOD_CK2_1	781	787	PF00069	0.619
MOD_CK2_1	816	822	PF00069	0.594
MOD_GlcNHglycan	1030	1033	PF01048	0.663
MOD_GlcNHglycan	1047	1050	PF01048	0.485
MOD_GlcNHglycan	1088	1091	PF01048	0.527
MOD_GlcNHglycan	1107	1110	PF01048	0.741
MOD_GlcNHglycan	1170	1175	PF01048	0.608
MOD_GlcNHglycan	133	136	PF01048	0.401
MOD_GlcNHglycan	195	198	PF01048	0.656
MOD_GlcNHglycan	237	240	PF01048	0.583
MOD_GlcNHglycan	258	261	PF01048	0.583
MOD_GlcNHglycan	262	265	PF01048	0.511
MOD_GlcNHglycan	284	288	PF01048	0.557
MOD_GlcNHglycan	372	375	PF01048	0.592
MOD_GlcNHglycan	393	397	PF01048	0.577
MOD_GlcNHglycan	436	439	PF01048	0.660
MOD_GlcNHglycan	532	535	PF01048	0.575
MOD_GlcNHglycan	641	644	PF01048	0.550
MOD_GlcNHglycan	736	739	PF01048	0.594
MOD_GlcNHglycan	784	787	PF01048	0.546
MOD_GlcNHglycan	818	821	PF01048	0.633
MOD_GlcNHglycan	892	895	PF01048	0.568
MOD_GlcNHglycan	898	901	PF01048	0.539
MOD_GlcNHglycan	989	992	PF01048	0.540
MOD_GSK3_1	1034	1041	PF00069	0.561
MOD_GSK3_1	1061	1068	PF00069	0.570
MOD_GSK3_1	1071	1078	PF00069	0.462
MOD_GSK3_1	1080	1087	PF00069	0.413
MOD_GSK3_1	1101	1108	PF00069	0.588
MOD_GSK3_1	111	118	PF00069	0.657
MOD_GSK3_1	1112	1119	PF00069	0.677
MOD_GSK3_1	1123	1130	PF00069	0.672
MOD_GSK3_1	1166	1173	PF00069	0.627
MOD_GSK3_1	142	149	PF00069	0.682
MOD_GSK3_1	231	238	PF00069	0.454
MOD_GSK3_1	256	263	PF00069	0.510
MOD_GSK3_1	279	286	PF00069	0.509
MOD_GSK3_1	351	358	PF00069	0.611
MOD_GSK3_1	392	399	PF00069	0.535
MOD_GSK3_1	417	424	PF00069	0.530
MOD_GSK3_1	434	441	PF00069	0.566
MOD_GSK3_1	511	518	PF00069	0.556
MOD_GSK3_1	548	555	PF00069	0.513
MOD_GSK3_1	609	616	PF00069	0.551
MOD_GSK3_1	621	628	PF00069	0.409
MOD_GSK3_1	689	696	PF00069	0.621
MOD_GSK3_1	715	722	PF00069	0.527
MOD_GSK3_1	729	736	PF00069	0.557
MOD_GSK3_1	745	752	PF00069	0.498
MOD_GSK3_1	760	767	PF00069	0.663
MOD_GSK3_1	791	798	PF00069	0.570
MOD_GSK3_1	814	821	PF00069	0.687
MOD_GSK3_1	882	889	PF00069	0.603
MOD_GSK3_1	892	899	PF00069	0.573
MOD_GSK3_1	937	944	PF00069	0.461
MOD_GSK3_1	987	994	PF00069	0.528
MOD_LATS_1	1059	1065	PF00433	0.510
MOD_N-GLC_1	1045	1050	PF02516	0.542
MOD_N-GLC_1	591	596	PF02516	0.609
MOD_N-GLC_1	616	621	PF02516	0.600
MOD_N-GLC_1	81	86	PF02516	0.398
MOD_N-GLC_1	987	992	PF02516	0.534
MOD_NEK2_1	1002	1007	PF00069	0.504
MOD_NEK2_1	1122	1127	PF00069	0.692
MOD_NEK2_1	167	172	PF00069	0.565
MOD_NEK2_1	268	273	PF00069	0.572
MOD_NEK2_1	352	357	PF00069	0.605
MOD_NEK2_1	613	618	PF00069	0.600
MOD_NEK2_1	625	630	PF00069	0.404
MOD_NEK2_1	72	77	PF00069	0.529
MOD_NEK2_1	814	819	PF00069	0.720
MOD_PIKK_1	1008	1014	PF00454	0.590
MOD_PIKK_1	1113	1119	PF00454	0.650
MOD_PIKK_1	206	212	PF00454	0.414
MOD_PIKK_1	310	316	PF00454	0.525
MOD_PIKK_1	467	473	PF00454	0.669
MOD_PIKK_1	580	586	PF00454	0.622
MOD_PIKK_1	762	768	PF00454	0.604
MOD_PIKK_1	800	806	PF00454	0.513
MOD_PIKK_1	882	888	PF00454	0.668
MOD_PIKK_1	959	965	PF00454	0.597
MOD_PK_1	1094	1100	PF00069	0.541
MOD_PK_1	926	932	PF00069	0.450
MOD_PKA_1	180	186	PF00069	0.600
MOD_PKA_1	882	888	PF00069	0.520
MOD_PKA_1	926	932	PF00069	0.450
MOD_PKA_2	1018	1024	PF00069	0.613
MOD_PKA_2	1104	1110	PF00069	0.618
MOD_PKA_2	1177	1183	PF00069	0.572
MOD_PKA_2	180	186	PF00069	0.603
MOD_PKA_2	231	237	PF00069	0.595
MOD_PKA_2	268	274	PF00069	0.569
MOD_PKA_2	315	321	PF00069	0.472
MOD_PKA_2	352	358	PF00069	0.650
MOD_PKA_2	530	536	PF00069	0.632
MOD_PKA_2	656	662	PF00069	0.609
MOD_PKA_2	749	755	PF00069	0.587
MOD_PKA_2	759	765	PF00069	0.474
MOD_PKA_2	779	785	PF00069	0.451
MOD_PKA_2	814	820	PF00069	0.552
MOD_PKA_2	882	888	PF00069	0.520
MOD_PKA_2	925	931	PF00069	0.550
MOD_PKB_1	872	880	PF00069	0.668
MOD_Plk_1	1002	1008	PF00069	0.507
MOD_Plk_1	1062	1068	PF00069	0.487
MOD_Plk_1	1075	1081	PF00069	0.475
MOD_Plk_1	206	212	PF00069	0.407
MOD_Plk_1	253	259	PF00069	0.597
MOD_Plk_1	487	493	PF00069	0.621
MOD_Plk_1	609	615	PF00069	0.513
MOD_Plk_1	719	725	PF00069	0.536
MOD_Plk_2-3	609	615	PF00069	0.513
MOD_Plk_4	1002	1008	PF00069	0.507
MOD_Plk_4	1149	1155	PF00069	0.291
MOD_Plk_4	26	32	PF00069	0.615
MOD_Plk_4	396	402	PF00069	0.509
MOD_Plk_4	599	605	PF00069	0.494
MOD_Plk_4	720	726	PF00069	0.511
MOD_Plk_4	937	943	PF00069	0.543
MOD_Plk_4	974	980	PF00069	0.579
MOD_ProDKin_1	117	123	PF00069	0.648
MOD_ProDKin_1	150	156	PF00069	0.610
MOD_ProDKin_1	361	367	PF00069	0.596
MOD_ProDKin_1	480	486	PF00069	0.560
MOD_ProDKin_1	552	558	PF00069	0.710
MOD_ProDKin_1	585	591	PF00069	0.599
MOD_ProDKin_1	689	695	PF00069	0.595
MOD_ProDKin_1	7	13	PF00069	0.593
MOD_ProDKin_1	853	859	PF00069	0.544
MOD_SUMO_for_1	1060	1063	PF00179	0.533
MOD_SUMO_for_1	538	541	PF00179	0.609
MOD_SUMO_for_1	607	610	PF00179	0.502
MOD_SUMO_rev_2	1029	1038	PF00179	0.631
TRG_DiLeu_BaEn_1	920	925	PF01217	0.515
TRG_DiLeu_BaLyEn_6	1050	1055	PF01217	0.611
TRG_DiLeu_BaLyEn_6	1139	1144	PF01217	0.315
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.396
TRG_DiLeu_BaLyEn_6	854	859	PF01217	0.418
TRG_ENDOCYTIC_2	1154	1157	PF00928	0.312
TRG_ENDOCYTIC_2	30	33	PF00928	0.608
TRG_ENDOCYTIC_2	597	600	PF00928	0.519
TRG_ER_diArg_1	180	182	PF00400	0.549
TRG_ER_diArg_1	268	270	PF00400	0.569
TRG_ER_diArg_1	390	392	PF00400	0.576
TRG_ER_diArg_1	705	707	PF00400	0.603
TRG_ER_diArg_1	871	874	PF00400	0.600
TRG_ER_diArg_1	880	883	PF00400	0.466
TRG_NES_CRM1_1	48	62	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	536	541	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	915	919	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	955	959	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P568	Leptomonas seymouri	44%	88%
A0A3Q8I9Q1	Leishmania donovani	90%	100%
A4H7F0	Leishmania braziliensis	74%	100%
A4HVT8	Leishmania infantum	90%	100%
Q4QFZ4	Leishmania major	88%	100%