Tcp10_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal 4

Species:

Leishmania mexicana

UniProt:

E9API3_LEIMU

TriTrypDb:

LmxM.13.1590

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9API3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9API3

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0061511	centriole elongation	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.650
CLV_C14_Caspase3-7	320	324	PF00656	0.555
CLV_C14_Caspase3-7	54	58	PF00656	0.633
CLV_NRD_NRD_1	120	122	PF00675	0.744
CLV_NRD_NRD_1	22	24	PF00675	0.681
CLV_NRD_NRD_1	235	237	PF00675	0.675
CLV_NRD_NRD_1	316	318	PF00675	0.663
CLV_NRD_NRD_1	350	352	PF00675	0.595
CLV_NRD_NRD_1	385	387	PF00675	0.522
CLV_NRD_NRD_1	393	395	PF00675	0.539
CLV_NRD_NRD_1	459	461	PF00675	0.755
CLV_NRD_NRD_1	504	506	PF00675	0.604
CLV_NRD_NRD_1	515	517	PF00675	0.614
CLV_NRD_NRD_1	548	550	PF00675	0.662
CLV_NRD_NRD_1	55	57	PF00675	0.627
CLV_NRD_NRD_1	562	564	PF00675	0.536
CLV_NRD_NRD_1	583	585	PF00675	0.789
CLV_NRD_NRD_1	86	88	PF00675	0.744
CLV_PCSK_FUR_1	383	387	PF00082	0.503
CLV_PCSK_FUR_1	484	488	PF00082	0.643
CLV_PCSK_FUR_1	53	57	PF00082	0.687
CLV_PCSK_KEX2_1	120	122	PF00082	0.744
CLV_PCSK_KEX2_1	22	24	PF00082	0.738
CLV_PCSK_KEX2_1	235	237	PF00082	0.675
CLV_PCSK_KEX2_1	316	318	PF00082	0.663
CLV_PCSK_KEX2_1	350	352	PF00082	0.595
CLV_PCSK_KEX2_1	385	387	PF00082	0.503
CLV_PCSK_KEX2_1	393	395	PF00082	0.505
CLV_PCSK_KEX2_1	459	461	PF00082	0.755
CLV_PCSK_KEX2_1	486	488	PF00082	0.590
CLV_PCSK_KEX2_1	506	508	PF00082	0.347
CLV_PCSK_KEX2_1	517	519	PF00082	0.622
CLV_PCSK_KEX2_1	55	57	PF00082	0.627
CLV_PCSK_KEX2_1	562	564	PF00082	0.503
CLV_PCSK_KEX2_1	582	584	PF00082	0.758
CLV_PCSK_KEX2_1	597	599	PF00082	0.513
CLV_PCSK_KEX2_1	645	647	PF00082	0.316
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.622
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.347
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.579
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.765
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.669
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.316
CLV_PCSK_PC7_1	231	237	PF00082	0.673
CLV_PCSK_PC7_1	346	352	PF00082	0.589
CLV_PCSK_PC7_1	593	599	PF00082	0.598
CLV_PCSK_SKI1_1	350	354	PF00082	0.521
CLV_PCSK_SKI1_1	637	641	PF00082	0.511
CLV_PCSK_SKI1_1	656	660	PF00082	0.198
CLV_PCSK_SKI1_1	70	74	PF00082	0.669
CLV_PCSK_SKI1_1	720	724	PF00082	0.442
DEG_APCC_DBOX_1	359	367	PF00400	0.517
DOC_CKS1_1	161	166	PF01111	0.655
DOC_CKS1_1	569	574	PF01111	0.667
DOC_MAPK_gen_1	334	343	PF00069	0.492
DOC_MAPK_gen_1	459	469	PF00069	0.710
DOC_MAPK_gen_1	523	531	PF00069	0.643
DOC_PP2B_LxvP_1	145	148	PF13499	0.719
DOC_PP4_FxxP_1	161	164	PF00568	0.500
DOC_USP7_MATH_1	14	18	PF00917	0.760
DOC_USP7_MATH_1	148	152	PF00917	0.624
DOC_USP7_MATH_1	174	178	PF00917	0.710
DOC_USP7_MATH_1	223	227	PF00917	0.711
DOC_USP7_MATH_1	244	248	PF00917	0.748
DOC_USP7_MATH_1	252	256	PF00917	0.686
DOC_USP7_MATH_1	413	417	PF00917	0.629
DOC_USP7_MATH_1	476	480	PF00917	0.651
DOC_USP7_MATH_1	555	559	PF00917	0.707
DOC_USP7_MATH_1	576	580	PF00917	0.706
DOC_USP7_MATH_1	585	589	PF00917	0.727
DOC_USP7_MATH_1	716	720	PF00917	0.557
DOC_USP7_MATH_1	734	738	PF00917	0.627
DOC_USP7_UBL2_3	11	15	PF12436	0.648
DOC_USP7_UBL2_3	272	276	PF12436	0.566
DOC_WW_Pin1_4	139	144	PF00397	0.745
DOC_WW_Pin1_4	160	165	PF00397	0.660
DOC_WW_Pin1_4	199	204	PF00397	0.721
DOC_WW_Pin1_4	221	226	PF00397	0.682
DOC_WW_Pin1_4	248	253	PF00397	0.781
DOC_WW_Pin1_4	34	39	PF00397	0.695
DOC_WW_Pin1_4	470	475	PF00397	0.707
DOC_WW_Pin1_4	535	540	PF00397	0.423
DOC_WW_Pin1_4	568	573	PF00397	0.658
LIG_14-3-3_CanoR_1	212	217	PF00244	0.717
LIG_14-3-3_CanoR_1	27	31	PF00244	0.672
LIG_14-3-3_CanoR_1	3	7	PF00244	0.672
LIG_14-3-3_CanoR_1	329	335	PF00244	0.498
LIG_14-3-3_CanoR_1	350	359	PF00244	0.620
LIG_14-3-3_CanoR_1	420	429	PF00244	0.780
LIG_14-3-3_CanoR_1	437	443	PF00244	0.532
LIG_14-3-3_CanoR_1	526	532	PF00244	0.398
LIG_14-3-3_CanoR_1	584	594	PF00244	0.688
LIG_14-3-3_CanoR_1	70	78	PF00244	0.643
LIG_APCC_ABBAyCdc20_2	720	726	PF00400	0.457
LIG_APCC_Cbox_1	510	516	PF00515	0.504
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BRCT_BRCA1_1	16	20	PF00533	0.744
LIG_eIF4E_1	742	748	PF01652	0.352
LIG_FHA_1	422	428	PF00498	0.591
LIG_FHA_1	614	620	PF00498	0.663
LIG_FHA_1	652	658	PF00498	0.525
LIG_FHA_1	91	97	PF00498	0.746
LIG_FHA_2	359	365	PF00498	0.640
LIG_FHA_2	367	373	PF00498	0.547
LIG_FHA_2	601	607	PF00498	0.496
LIG_FHA_2	667	673	PF00498	0.501
LIG_LIR_Apic_2	133	137	PF02991	0.694
LIG_LIR_Apic_2	158	164	PF02991	0.704
LIG_LIR_Nem_3	16	21	PF02991	0.745
LIG_LIR_Nem_3	332	338	PF02991	0.561
LIG_LIR_Nem_3	726	732	PF02991	0.456
LIG_Rb_LxCxE_1	404	424	PF01857	0.657
LIG_Rb_LxCxE_1	603	623	PF01857	0.381
LIG_SH2_CRK	198	202	PF00017	0.806
LIG_SH2_CRK	729	733	PF00017	0.455
LIG_SH2_GRB2like	650	653	PF00017	0.501
LIG_SH2_NCK_1	30	34	PF00017	0.767
LIG_SH2_NCK_1	686	690	PF00017	0.474
LIG_SH2_SRC	218	221	PF00017	0.676
LIG_SH2_SRC	281	284	PF00017	0.574
LIG_SH2_SRC	443	446	PF00017	0.718
LIG_SH2_SRC	650	653	PF00017	0.485
LIG_SH2_STAP1	165	169	PF00017	0.570
LIG_SH2_STAT5	160	163	PF00017	0.725
LIG_SH2_STAT5	233	236	PF00017	0.779
LIG_SH2_STAT5	512	515	PF00017	0.602
LIG_SH3_2	592	597	PF14604	0.715
LIG_SH3_3	126	132	PF00018	0.748
LIG_SH3_3	134	140	PF00018	0.645
LIG_SH3_3	150	156	PF00018	0.700
LIG_SH3_3	566	572	PF00018	0.687
LIG_SH3_3	589	595	PF00018	0.724
LIG_SH3_3	654	660	PF00018	0.525
LIG_SH3_3	80	86	PF00018	0.723
LIG_SH3_3	93	99	PF00018	0.686
LIG_SH3_4	11	18	PF00018	0.726
LIG_SUMO_SIM_par_1	465	471	PF11976	0.700
LIG_TRAF2_1	257	260	PF00917	0.598
LIG_TRAF2_1	330	333	PF00917	0.555
LIG_TRAF2_1	501	504	PF00917	0.672
LIG_TRAF2_1	603	606	PF00917	0.518
LIG_UBA3_1	263	272	PF00899	0.648
LIG_UBA3_1	398	403	PF00899	0.586
MOD_CDC14_SPxK_1	37	40	PF00782	0.770
MOD_CDK_SPK_2	199	204	PF00069	0.721
MOD_CDK_SPK_2	470	475	PF00069	0.718
MOD_CDK_SPK_2	568	573	PF00069	0.658
MOD_CDK_SPxK_1	34	40	PF00069	0.772
MOD_CDK_SPxK_1	535	541	PF00069	0.428
MOD_CK1_1	106	112	PF00069	0.784
MOD_CK1_1	185	191	PF00069	0.707
MOD_CK1_1	2	8	PF00069	0.703
MOD_CK1_1	221	227	PF00069	0.529
MOD_CK1_1	31	37	PF00069	0.773
MOD_CK1_1	358	364	PF00069	0.581
MOD_CK1_1	39	45	PF00069	0.743
MOD_CK1_1	416	422	PF00069	0.768
MOD_CK1_1	425	431	PF00069	0.693
MOD_CK1_1	439	445	PF00069	0.594
MOD_CK1_1	661	667	PF00069	0.560
MOD_CK1_1	679	685	PF00069	0.396
MOD_CK1_1	737	743	PF00069	0.564
MOD_CK2_1	104	110	PF00069	0.779
MOD_CK2_1	148	154	PF00069	0.777
MOD_CK2_1	254	260	PF00069	0.647
MOD_CK2_1	358	364	PF00069	0.638
MOD_CK2_1	366	372	PF00069	0.549
MOD_CK2_1	555	561	PF00069	0.674
MOD_CK2_1	600	606	PF00069	0.479
MOD_Cter_Amidation	643	646	PF01082	0.301
MOD_GlcNHglycan	106	109	PF01048	0.640
MOD_GlcNHglycan	169	172	PF01048	0.793
MOD_GlcNHglycan	177	180	PF01048	0.677
MOD_GlcNHglycan	204	207	PF01048	0.743
MOD_GlcNHglycan	219	224	PF01048	0.575
MOD_GlcNHglycan	30	33	PF01048	0.714
MOD_GlcNHglycan	338	341	PF01048	0.627
MOD_GlcNHglycan	413	416	PF01048	0.707
MOD_GlcNHglycan	432	436	PF01048	0.730
MOD_GlcNHglycan	439	442	PF01048	0.746
MOD_GlcNHglycan	564	567	PF01048	0.707
MOD_GlcNHglycan	587	590	PF01048	0.659
MOD_GlcNHglycan	642	645	PF01048	0.332
MOD_GlcNHglycan	660	663	PF01048	0.283
MOD_GlcNHglycan	678	681	PF01048	0.444
MOD_GlcNHglycan	96	99	PF01048	0.824
MOD_GSK3_1	100	107	PF00069	0.579
MOD_GSK3_1	163	170	PF00069	0.739
MOD_GSK3_1	219	226	PF00069	0.714
MOD_GSK3_1	244	251	PF00069	0.740
MOD_GSK3_1	39	46	PF00069	0.653
MOD_GSK3_1	416	423	PF00069	0.662
MOD_GSK3_1	427	434	PF00069	0.708
MOD_GSK3_1	658	665	PF00069	0.560
MOD_GSK3_1	676	683	PF00069	0.429
MOD_GSK3_1	704	711	PF00069	0.557
MOD_GSK3_1	90	97	PF00069	0.761
MOD_N-GLC_1	103	108	PF02516	0.783
MOD_N-GLC_1	336	341	PF02516	0.643
MOD_N-GLC_1	355	360	PF02516	0.373
MOD_N-GLC_1	43	48	PF02516	0.622
MOD_N-GLC_1	651	656	PF02516	0.285
MOD_NEK2_1	28	33	PF00069	0.676
MOD_NEK2_1	366	371	PF00069	0.550
MOD_NEK2_1	640	645	PF00069	0.489
MOD_NEK2_1	666	671	PF00069	0.501
MOD_NEK2_1	705	710	PF00069	0.487
MOD_NEK2_2	14	19	PF00069	0.714
MOD_NEK2_2	651	656	PF00069	0.554
MOD_NEK2_2	662	667	PF00069	0.569
MOD_NEK2_2	688	693	PF00069	0.524
MOD_PIKK_1	350	356	PF00454	0.549
MOD_PIKK_1	358	364	PF00454	0.549
MOD_PIKK_1	623	629	PF00454	0.514
MOD_PIKK_1	691	697	PF00454	0.464
MOD_PK_1	583	589	PF00069	0.605
MOD_PKA_1	350	356	PF00069	0.516
MOD_PKA_1	459	465	PF00069	0.743
MOD_PKA_1	55	61	PF00069	0.580
MOD_PKA_1	562	568	PF00069	0.667
MOD_PKA_1	583	589	PF00069	0.796
MOD_PKA_2	185	191	PF00069	0.756
MOD_PKA_2	2	8	PF00069	0.697
MOD_PKA_2	26	32	PF00069	0.700
MOD_PKA_2	315	321	PF00069	0.553
MOD_PKA_2	328	334	PF00069	0.522
MOD_PKA_2	345	351	PF00069	0.376
MOD_PKA_2	419	425	PF00069	0.773
MOD_PKA_2	436	442	PF00069	0.527
MOD_PKA_2	459	465	PF00069	0.719
MOD_PKA_2	527	533	PF00069	0.399
MOD_PKA_2	55	61	PF00069	0.580
MOD_PKA_2	562	568	PF00069	0.503
MOD_PKA_2	583	589	PF00069	0.796
MOD_PKA_2	705	711	PF00069	0.561
MOD_PKB_1	53	61	PF00069	0.669
MOD_Plk_1	355	361	PF00069	0.450
MOD_Plk_1	737	743	PF00069	0.483
MOD_Plk_4	2	8	PF00069	0.784
MOD_Plk_4	527	533	PF00069	0.399
MOD_Plk_4	680	686	PF00069	0.438
MOD_Plk_4	737	743	PF00069	0.483
MOD_ProDKin_1	139	145	PF00069	0.748
MOD_ProDKin_1	160	166	PF00069	0.656
MOD_ProDKin_1	199	205	PF00069	0.719
MOD_ProDKin_1	221	227	PF00069	0.682
MOD_ProDKin_1	248	254	PF00069	0.780
MOD_ProDKin_1	34	40	PF00069	0.696
MOD_ProDKin_1	470	476	PF00069	0.703
MOD_ProDKin_1	535	541	PF00069	0.428
MOD_ProDKin_1	568	574	PF00069	0.660
MOD_SUMO_for_1	216	219	PF00179	0.716
MOD_SUMO_rev_2	266	274	PF00179	0.644
MOD_SUMO_rev_2	519	525	PF00179	0.586
MOD_SUMO_rev_2	54	61	PF00179	0.660
MOD_SUMO_rev_2	738	748	PF00179	0.336
TRG_DiLeu_BaEn_1	259	264	PF01217	0.567
TRG_DiLeu_BaEn_2	15	21	PF01217	0.745
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.695
TRG_ENDOCYTIC_2	198	201	PF00928	0.780
TRG_ENDOCYTIC_2	729	732	PF00928	0.448
TRG_ER_diArg_1	21	23	PF00400	0.747
TRG_ER_diArg_1	234	236	PF00400	0.679
TRG_ER_diArg_1	316	319	PF00400	0.665
TRG_ER_diArg_1	350	352	PF00400	0.595
TRG_ER_diArg_1	383	386	PF00400	0.506
TRG_ER_diArg_1	526	529	PF00400	0.609
TRG_ER_diArg_1	562	564	PF00400	0.547
TRG_ER_diArg_1	583	585	PF00400	0.793
TRG_NLS_MonoExtC_3	729	734	PF00514	0.307
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW13	Leptomonas seymouri	55%	98%
A0A1X0NJT3	Trypanosomatidae	35%	82%
A0A3Q8I9S9	Leishmania donovani	93%	100%
A4H7E9	Leishmania braziliensis	77%	99%
A4HVT7	Leishmania infantum	93%	100%
Q4QFZ5	Leishmania major	90%	100%
V5B213	Trypanosoma cruzi	43%	98%