Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APH8_LEIMU

TriTrypDb:

LmxM.13.1540

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.728
CLV_C14_Caspase3-7	144	148	PF00656	0.627
CLV_C14_Caspase3-7	379	383	PF00656	0.833
CLV_NRD_NRD_1	345	347	PF00675	0.691
CLV_NRD_NRD_1	482	484	PF00675	0.644
CLV_PCSK_FUR_1	480	484	PF00082	0.635
CLV_PCSK_KEX2_1	345	347	PF00082	0.684
CLV_PCSK_KEX2_1	482	484	PF00082	0.648
CLV_PCSK_SKI1_1	256	260	PF00082	0.527
CLV_PCSK_SKI1_1	9	13	PF00082	0.572
CLV_Separin_Metazoa	15	19	PF03568	0.414
DEG_APCC_DBOX_1	235	243	PF00400	0.528
DEG_Nend_UBRbox_1	1	4	PF02207	0.713
DOC_CKS1_1	393	398	PF01111	0.728
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.766
DOC_MAPK_DCC_7	385	393	PF00069	0.530
DOC_PP2B_LxvP_1	174	177	PF13499	0.768
DOC_PP2B_LxvP_1	413	416	PF13499	0.616
DOC_PP2B_LxvP_1	466	469	PF13499	0.628
DOC_PP4_FxxP_1	169	172	PF00568	0.719
DOC_USP7_MATH_1	114	118	PF00917	0.672
DOC_USP7_MATH_1	238	242	PF00917	0.532
DOC_USP7_MATH_1	280	284	PF00917	0.495
DOC_USP7_MATH_1	359	363	PF00917	0.518
DOC_USP7_MATH_1	380	384	PF00917	0.786
DOC_USP7_MATH_1	475	479	PF00917	0.468
DOC_WW_Pin1_4	124	129	PF00397	0.731
DOC_WW_Pin1_4	134	139	PF00397	0.782
DOC_WW_Pin1_4	163	168	PF00397	0.654
DOC_WW_Pin1_4	219	224	PF00397	0.492
DOC_WW_Pin1_4	234	239	PF00397	0.509
DOC_WW_Pin1_4	386	391	PF00397	0.726
DOC_WW_Pin1_4	392	397	PF00397	0.725
DOC_WW_Pin1_4	441	446	PF00397	0.612
DOC_WW_Pin1_4	70	75	PF00397	0.765
LIG_14-3-3_CanoR_1	236	244	PF00244	0.504
LIG_14-3-3_CanoR_1	314	324	PF00244	0.486
LIG_14-3-3_CterR_2	482	486	PF00244	0.816
LIG_APCC_ABBA_1	203	208	PF00400	0.699
LIG_BRCT_BRCA1_1	165	169	PF00533	0.668
LIG_Clathr_ClatBox_1	225	229	PF01394	0.466
LIG_FHA_1	102	108	PF00498	0.724
LIG_FHA_1	166	172	PF00498	0.517
LIG_FHA_1	250	256	PF00498	0.634
LIG_FHA_1	318	324	PF00498	0.551
LIG_FHA_1	393	399	PF00498	0.785
LIG_FHA_1	410	416	PF00498	0.609
LIG_FHA_1	419	425	PF00498	0.476
LIG_FHA_2	104	110	PF00498	0.542
LIG_FHA_2	249	255	PF00498	0.644
LIG_FHA_2	316	322	PF00498	0.533
LIG_FHA_2	370	376	PF00498	0.732
LIG_FHA_2	5	11	PF00498	0.754
LIG_FHA_2	56	62	PF00498	0.568
LIG_FHA_2	90	96	PF00498	0.696
LIG_GBD_Chelix_1	226	234	PF00786	0.571
LIG_GBD_Chelix_1	302	310	PF00786	0.498
LIG_Integrin_RGD_1	99	101	PF01839	0.531
LIG_LIR_Apic_2	166	172	PF02991	0.723
LIG_LIR_Gen_1	150	160	PF02991	0.680
LIG_LIR_Gen_1	19	29	PF02991	0.396
LIG_LIR_LC3C_4	222	227	PF02991	0.468
LIG_LIR_Nem_3	150	156	PF02991	0.621
LIG_LIR_Nem_3	19	24	PF02991	0.522
LIG_NRBOX	461	467	PF00104	0.644
LIG_PDZ_Class_1	481	486	PF00595	0.819
LIG_Pex14_2	264	268	PF04695	0.399
LIG_Rb_pABgroove_1	147	155	PF01858	0.703
LIG_SH2_CRK	21	25	PF00017	0.573
LIG_SH2_CRK	217	221	PF00017	0.743
LIG_SH2_CRK	40	44	PF00017	0.684
LIG_SH2_STAP1	21	25	PF00017	0.381
LIG_SH2_STAP1	217	221	PF00017	0.734
LIG_SH2_STAP1	400	404	PF00017	0.703
LIG_SH2_STAT3	337	340	PF00017	0.583
LIG_SH2_STAT5	316	319	PF00017	0.511
LIG_SH2_STAT5	456	459	PF00017	0.344
LIG_SH3_3	108	114	PF00018	0.753
LIG_SH3_3	217	223	PF00018	0.713
LIG_SH3_3	306	312	PF00018	0.499
LIG_SH3_3	321	327	PF00018	0.423
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.414
LIG_SUMO_SIM_anti_2	420	429	PF11976	0.535
LIG_SUMO_SIM_par_1	103	110	PF11976	0.629
LIG_SUMO_SIM_par_1	222	229	PF11976	0.492
LIG_SUMO_SIM_par_1	420	429	PF11976	0.535
MOD_CK1_1	117	123	PF00069	0.659
MOD_CK1_1	129	135	PF00069	0.759
MOD_CK1_1	237	243	PF00069	0.643
MOD_CK1_1	383	389	PF00069	0.709
MOD_CK1_1	454	460	PF00069	0.350
MOD_CK1_1	478	484	PF00069	0.515
MOD_CK1_1	91	97	PF00069	0.498
MOD_CK2_1	184	190	PF00069	0.754
MOD_CK2_1	248	254	PF00069	0.654
MOD_CK2_1	280	286	PF00069	0.515
MOD_CK2_1	294	300	PF00069	0.528
MOD_CK2_1	369	375	PF00069	0.732
MOD_CK2_1	4	10	PF00069	0.724
MOD_CK2_1	55	61	PF00069	0.622
MOD_CK2_1	70	76	PF00069	0.660
MOD_CK2_1	89	95	PF00069	0.690
MOD_GlcNHglycan	143	146	PF01048	0.660
MOD_GlcNHglycan	212	215	PF01048	0.768
MOD_GlcNHglycan	451	454	PF01048	0.525
MOD_GlcNHglycan	477	480	PF01048	0.587
MOD_GSK3_1	103	110	PF00069	0.814
MOD_GSK3_1	114	121	PF00069	0.523
MOD_GSK3_1	159	166	PF00069	0.675
MOD_GSK3_1	230	237	PF00069	0.571
MOD_GSK3_1	374	381	PF00069	0.598
MOD_GSK3_1	478	485	PF00069	0.791
MOD_GSK3_1	5	12	PF00069	0.662
MOD_N-GLC_1	117	122	PF02516	0.706
MOD_N-GLC_1	408	413	PF02516	0.474
MOD_N-GLC_2	371	373	PF02516	0.643
MOD_NEK2_1	107	112	PF00069	0.665
MOD_NEK2_1	230	235	PF00069	0.421
MOD_NEK2_1	451	456	PF00069	0.579
MOD_NEK2_1	88	93	PF00069	0.682
MOD_NEK2_2	380	385	PF00069	0.830
MOD_PIKK_1	184	190	PF00454	0.754
MOD_PIKK_1	270	276	PF00454	0.403
MOD_PIKK_1	359	365	PF00454	0.568
MOD_PIKK_1	77	83	PF00454	0.623
MOD_PKA_2	366	372	PF00069	0.599
MOD_PKA_2	475	481	PF00069	0.484
MOD_Plk_1	160	166	PF00069	0.713
MOD_Plk_1	194	200	PF00069	0.570
MOD_Plk_1	400	406	PF00069	0.499
MOD_Plk_1	408	414	PF00069	0.455
MOD_Plk_1	9	15	PF00069	0.558
MOD_Plk_4	107	113	PF00069	0.677
MOD_Plk_4	19	25	PF00069	0.532
MOD_Plk_4	216	222	PF00069	0.707
MOD_Plk_4	230	236	PF00069	0.367
MOD_Plk_4	409	415	PF00069	0.750
MOD_Plk_4	451	457	PF00069	0.524
MOD_Plk_4	55	61	PF00069	0.539
MOD_ProDKin_1	124	130	PF00069	0.731
MOD_ProDKin_1	134	140	PF00069	0.770
MOD_ProDKin_1	163	169	PF00069	0.655
MOD_ProDKin_1	219	225	PF00069	0.479
MOD_ProDKin_1	234	240	PF00069	0.516
MOD_ProDKin_1	386	392	PF00069	0.723
MOD_ProDKin_1	441	447	PF00069	0.610
MOD_ProDKin_1	70	76	PF00069	0.762
TRG_DiLeu_BaEn_1	351	356	PF01217	0.542
TRG_DiLeu_BaEn_1	461	466	PF01217	0.642
TRG_DiLeu_BaEn_2	18	24	PF01217	0.599
TRG_DiLeu_BaEn_4	351	357	PF01217	0.454
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.736
TRG_DiLeu_LyEn_5	351	356	PF01217	0.542
TRG_ENDOCYTIC_2	21	24	PF00928	0.543
TRG_ENDOCYTIC_2	217	220	PF00928	0.744
TRG_ENDOCYTIC_2	40	43	PF00928	0.681
TRG_ER_diArg_1	209	212	PF00400	0.754
TRG_ER_diArg_1	480	483	PF00400	0.688
TRG_NES_CRM1_1	147	161	PF08389	0.615
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.600
TRG_PTS1	483	486	PF00515	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K4	Leptomonas seymouri	48%	83%
A0A3S7WSN4	Leishmania donovani	88%	100%
A4H7E3	Leishmania braziliensis	73%	100%
A4HVT3	Leishmania infantum	88%	100%
Q4QG00	Leishmania major	88%	100%