AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania mexicana

UniProt:

E9APH6_LEIMU

TriTrypDb:

LmxM.13.1520

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9APH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.471
CLV_C14_Caspase3-7	493	497	PF00656	0.597
CLV_C14_Caspase3-7	558	562	PF00656	0.329
CLV_C14_Caspase3-7	760	764	PF00656	0.166
CLV_C14_Caspase3-7	79	83	PF00656	0.442
CLV_NRD_NRD_1	131	133	PF00675	0.434
CLV_NRD_NRD_1	302	304	PF00675	0.470
CLV_NRD_NRD_1	377	379	PF00675	0.594
CLV_NRD_NRD_1	427	429	PF00675	0.657
CLV_NRD_NRD_1	432	434	PF00675	0.624
CLV_NRD_NRD_1	491	493	PF00675	0.555
CLV_NRD_NRD_1	532	534	PF00675	0.622
CLV_NRD_NRD_1	537	539	PF00675	0.639
CLV_NRD_NRD_1	73	75	PF00675	0.486
CLV_NRD_NRD_1	757	759	PF00675	0.179
CLV_NRD_NRD_1	927	929	PF00675	0.499
CLV_PCSK_KEX2_1	131	133	PF00082	0.428
CLV_PCSK_KEX2_1	266	268	PF00082	0.529
CLV_PCSK_KEX2_1	432	434	PF00082	0.662
CLV_PCSK_KEX2_1	491	493	PF00082	0.615
CLV_PCSK_KEX2_1	532	534	PF00082	0.665
CLV_PCSK_KEX2_1	614	616	PF00082	0.601
CLV_PCSK_KEX2_1	73	75	PF00082	0.465
CLV_PCSK_KEX2_1	757	759	PF00082	0.330
CLV_PCSK_KEX2_1	927	929	PF00082	0.499
CLV_PCSK_KEX2_1	943	945	PF00082	0.591
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.529
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.693
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.578
CLV_PCSK_PC1ET2_1	943	945	PF00082	0.546
CLV_PCSK_PC7_1	428	434	PF00082	0.777
CLV_PCSK_SKI1_1	132	136	PF00082	0.536
CLV_PCSK_SKI1_1	188	192	PF00082	0.476
CLV_PCSK_SKI1_1	250	254	PF00082	0.519
CLV_PCSK_SKI1_1	257	261	PF00082	0.464
CLV_PCSK_SKI1_1	293	297	PF00082	0.354
CLV_PCSK_SKI1_1	323	327	PF00082	0.603
CLV_PCSK_SKI1_1	541	545	PF00082	0.745
CLV_PCSK_SKI1_1	614	618	PF00082	0.536
CLV_PCSK_SKI1_1	694	698	PF00082	0.358
CLV_PCSK_SKI1_1	770	774	PF00082	0.298
CLV_PCSK_SKI1_1	78	82	PF00082	0.379
CLV_PCSK_SKI1_1	824	828	PF00082	0.410
DEG_SCF_FBW7_2	844	849	PF00400	0.496
DEG_SPOP_SBC_1	792	796	PF00917	0.427
DOC_ANK_TNKS_1	431	438	PF00023	0.642
DOC_ANK_TNKS_1	491	498	PF00023	0.448
DOC_CYCLIN_RxL_1	204	213	PF00134	0.574
DOC_CYCLIN_yClb5_NLxxxL_5	515	524	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.431
DOC_MAPK_DCC_7	572	582	PF00069	0.529
DOC_MAPK_gen_1	216	226	PF00069	0.513
DOC_MAPK_gen_1	353	361	PF00069	0.651
DOC_MAPK_gen_1	53	63	PF00069	0.508
DOC_MAPK_gen_1	735	744	PF00069	0.446
DOC_MAPK_MEF2A_6	219	228	PF00069	0.548
DOC_MAPK_NFAT4_5	221	229	PF00069	0.576
DOC_PP2B_LxvP_1	119	122	PF13499	0.413
DOC_PP2B_LxvP_1	30	33	PF13499	0.442
DOC_PP2B_LxvP_1	573	576	PF13499	0.421
DOC_PP2B_LxvP_1	816	819	PF13499	0.477
DOC_PP4_FxxP_1	585	588	PF00568	0.534
DOC_USP7_MATH_1	164	168	PF00917	0.633
DOC_USP7_MATH_1	237	241	PF00917	0.383
DOC_USP7_MATH_1	286	290	PF00917	0.574
DOC_USP7_MATH_1	383	387	PF00917	0.743
DOC_USP7_MATH_1	391	395	PF00917	0.737
DOC_USP7_MATH_1	427	431	PF00917	0.773
DOC_USP7_MATH_1	439	443	PF00917	0.511
DOC_USP7_MATH_1	668	672	PF00917	0.364
DOC_USP7_MATH_1	702	706	PF00917	0.414
DOC_USP7_MATH_1	848	852	PF00917	0.502
DOC_USP7_UBL2_3	528	532	PF12436	0.569
DOC_USP7_UBL2_3	535	539	PF12436	0.599
DOC_USP7_UBL2_3	544	548	PF12436	0.571
DOC_USP7_UBL2_3	607	611	PF12436	0.619
DOC_USP7_UBL2_3	721	725	PF12436	0.416
DOC_USP7_UBL2_3	770	774	PF12436	0.323
DOC_WW_Pin1_4	112	117	PF00397	0.515
DOC_WW_Pin1_4	710	715	PF00397	0.304
DOC_WW_Pin1_4	842	847	PF00397	0.605
LIG_14-3-3_CanoR_1	293	299	PF00244	0.352
LIG_14-3-3_CanoR_1	323	331	PF00244	0.542
LIG_14-3-3_CanoR_1	428	432	PF00244	0.758
LIG_14-3-3_CanoR_1	581	586	PF00244	0.564
LIG_14-3-3_CanoR_1	601	606	PF00244	0.338
LIG_14-3-3_CanoR_1	658	668	PF00244	0.421
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_CaM_IQ_9	206	222	PF13499	0.485
LIG_CaM_IQ_9	599	614	PF13499	0.638
LIG_Clathr_ClatBox_1	512	516	PF01394	0.431
LIG_deltaCOP1_diTrp_1	610	620	PF00928	0.589
LIG_EVH1_1	179	183	PF00568	0.710
LIG_EVH1_2	448	452	PF00568	0.583
LIG_FHA_1	123	129	PF00498	0.500
LIG_FHA_1	174	180	PF00498	0.695
LIG_FHA_1	282	288	PF00498	0.556
LIG_FHA_1	331	337	PF00498	0.597
LIG_FHA_1	367	373	PF00498	0.606
LIG_FHA_1	600	606	PF00498	0.667
LIG_FHA_1	680	686	PF00498	0.374
LIG_FHA_1	718	724	PF00498	0.324
LIG_FHA_1	784	790	PF00498	0.304
LIG_FHA_1	801	807	PF00498	0.304
LIG_FHA_1	874	880	PF00498	0.443
LIG_FHA_1	902	908	PF00498	0.505
LIG_FHA_2	106	112	PF00498	0.516
LIG_FHA_2	150	156	PF00498	0.470
LIG_FHA_2	182	188	PF00498	0.744
LIG_FHA_2	189	195	PF00498	0.646
LIG_FHA_2	244	250	PF00498	0.521
LIG_FHA_2	361	367	PF00498	0.493
LIG_FHA_2	472	478	PF00498	0.652
LIG_FHA_2	553	559	PF00498	0.598
LIG_FHA_2	565	571	PF00498	0.491
LIG_FHA_2	758	764	PF00498	0.166
LIG_FHA_2	77	83	PF00498	0.391
LIG_FHA_2	792	798	PF00498	0.382
LIG_Integrin_RGD_1	74	76	PF01839	0.520
LIG_LIR_Apic_2	583	588	PF02991	0.542
LIG_LIR_Gen_1	101	109	PF02991	0.428
LIG_LIR_Gen_1	662	669	PF02991	0.366
LIG_LIR_LC3C_4	787	792	PF02991	0.446
LIG_LIR_Nem_3	101	105	PF02991	0.414
LIG_LIR_Nem_3	49	54	PF02991	0.346
LIG_LIR_Nem_3	610	616	PF02991	0.574
LIG_LIR_Nem_3	662	667	PF02991	0.366
LIG_NRP_CendR_1	943	945	PF00754	0.749
LIG_Pex14_1	467	471	PF04695	0.471
LIG_Pex14_1	47	51	PF04695	0.359
LIG_SH2_CRK	10	14	PF00017	0.498
LIG_SH2_CRK	664	668	PF00017	0.340
LIG_SH2_CRK	687	691	PF00017	0.372
LIG_SH2_GRB2like	569	572	PF00017	0.485
LIG_SH2_NCK_1	699	703	PF00017	0.446
LIG_SH2_PTP2	102	105	PF00017	0.543
LIG_SH2_PTP2	54	57	PF00017	0.450
LIG_SH2_SRC	485	488	PF00017	0.545
LIG_SH2_SRC	699	702	PF00017	0.446
LIG_SH2_SRC	743	746	PF00017	0.275
LIG_SH2_STAP1	485	489	PF00017	0.584
LIG_SH2_STAP1	569	573	PF00017	0.536
LIG_SH2_STAP1	732	736	PF00017	0.416
LIG_SH2_STAT3	262	265	PF00017	0.586
LIG_SH2_STAT3	42	45	PF00017	0.492
LIG_SH2_STAT3	6	9	PF00017	0.463
LIG_SH2_STAT5	102	105	PF00017	0.504
LIG_SH2_STAT5	126	129	PF00017	0.408
LIG_SH2_STAT5	141	144	PF00017	0.409
LIG_SH2_STAT5	26	29	PF00017	0.565
LIG_SH2_STAT5	262	265	PF00017	0.461
LIG_SH2_STAT5	43	46	PF00017	0.253
LIG_SH2_STAT5	51	54	PF00017	0.343
LIG_SH2_STAT5	732	735	PF00017	0.377
LIG_SH2_STAT5	743	746	PF00017	0.304
LIG_SH3_1	177	183	PF00018	0.710
LIG_SH3_3	118	124	PF00018	0.420
LIG_SH3_3	177	183	PF00018	0.686
LIG_SH3_3	492	498	PF00018	0.449
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.577
LIG_SUMO_SIM_anti_2	369	374	PF11976	0.584
LIG_SUMO_SIM_anti_2	786	797	PF11976	0.306
LIG_SUMO_SIM_par_1	786	797	PF11976	0.348
LIG_TRAF2_1	108	111	PF00917	0.541
LIG_TRAF2_1	201	204	PF00917	0.584
LIG_TRAF2_1	893	896	PF00917	0.489
LIG_TRFH_1	710	714	PF08558	0.347
LIG_TYR_ITIM	52	57	PF00017	0.458
LIG_WRC_WIRS_1	582	587	PF05994	0.529
LIG_WRC_WIRS_1	828	833	PF05994	0.525
LIG_WW_2	121	124	PF00397	0.516
MOD_CK1_1	2	8	PF00069	0.430
MOD_CK1_1	405	411	PF00069	0.732
MOD_CK1_1	442	448	PF00069	0.565
MOD_CK1_1	457	463	PF00069	0.413
MOD_CK1_1	692	698	PF00069	0.321
MOD_CK1_1	860	866	PF00069	0.529
MOD_CK2_1	105	111	PF00069	0.533
MOD_CK2_1	149	155	PF00069	0.567
MOD_CK2_1	181	187	PF00069	0.729
MOD_CK2_1	198	204	PF00069	0.582
MOD_CK2_1	471	477	PF00069	0.625
MOD_CK2_1	552	558	PF00069	0.588
MOD_CK2_1	564	570	PF00069	0.451
MOD_CK2_1	650	656	PF00069	0.510
MOD_CK2_1	791	797	PF00069	0.382
MOD_CK2_1	848	854	PF00069	0.584
MOD_CK2_1	935	941	PF00069	0.720
MOD_Cter_Amidation	530	533	PF01082	0.583
MOD_Cter_Amidation	536	539	PF01082	0.614
MOD_Cter_Amidation	755	758	PF01082	0.373
MOD_Cter_Amidation	768	771	PF01082	0.218
MOD_GlcNHglycan	166	169	PF01048	0.680
MOD_GlcNHglycan	196	199	PF01048	0.592
MOD_GlcNHglycan	27	30	PF01048	0.485
MOD_GlcNHglycan	381	384	PF01048	0.693
MOD_GlcNHglycan	390	394	PF01048	0.623
MOD_GlcNHglycan	412	415	PF01048	0.552
MOD_GlcNHglycan	441	444	PF01048	0.723
MOD_GlcNHglycan	456	459	PF01048	0.320
MOD_GlcNHglycan	527	531	PF01048	0.515
MOD_GlcNHglycan	591	594	PF01048	0.561
MOD_GlcNHglycan	651	655	PF01048	0.458
MOD_GlcNHglycan	691	694	PF01048	0.323
MOD_GlcNHglycan	704	707	PF01048	0.251
MOD_GlcNHglycan	866	869	PF01048	0.385
MOD_GSK3_1	194	201	PF00069	0.673
MOD_GSK3_1	237	244	PF00069	0.643
MOD_GSK3_1	315	322	PF00069	0.407
MOD_GSK3_1	379	386	PF00069	0.674
MOD_GSK3_1	391	398	PF00069	0.622
MOD_GSK3_1	399	406	PF00069	0.523
MOD_GSK3_1	416	423	PF00069	0.539
MOD_GSK3_1	559	566	PF00069	0.450
MOD_GSK3_1	76	83	PF00069	0.397
MOD_GSK3_1	779	786	PF00069	0.377
MOD_GSK3_1	835	842	PF00069	0.547
MOD_GSK3_1	860	867	PF00069	0.381
MOD_GSK3_1	873	880	PF00069	0.395
MOD_N-GLC_1	399	404	PF02516	0.757
MOD_N-GLC_1	564	569	PF02516	0.535
MOD_N-GLC_1	702	707	PF02516	0.300
MOD_N-GLC_1	710	715	PF02516	0.287
MOD_NEK2_1	279	284	PF00069	0.620
MOD_NEK2_1	319	324	PF00069	0.335
MOD_NEK2_1	373	378	PF00069	0.598
MOD_NEK2_1	399	404	PF00069	0.722
MOD_NEK2_1	471	476	PF00069	0.563
MOD_NEK2_1	564	569	PF00069	0.427
MOD_NEK2_1	589	594	PF00069	0.584
MOD_NEK2_1	599	604	PF00069	0.554
MOD_NEK2_1	717	722	PF00069	0.420
MOD_NEK2_1	80	85	PF00069	0.389
MOD_NEK2_1	827	832	PF00069	0.462
MOD_NEK2_1	901	906	PF00069	0.569
MOD_NEK2_1	918	923	PF00069	0.414
MOD_NEK2_2	427	432	PF00069	0.796
MOD_NEK2_2	46	51	PF00069	0.369
MOD_PIKK_1	324	330	PF00454	0.571
MOD_PIKK_1	420	426	PF00454	0.486
MOD_PIKK_1	599	605	PF00454	0.604
MOD_PIKK_1	668	674	PF00454	0.370
MOD_PIKK_1	873	879	PF00454	0.531
MOD_PK_1	737	743	PF00069	0.446
MOD_PKA_1	757	763	PF00069	0.166
MOD_PKA_2	374	380	PF00069	0.680
MOD_PKA_2	410	416	PF00069	0.635
MOD_PKA_2	427	433	PF00069	0.716
MOD_PKA_2	580	586	PF00069	0.560
MOD_PKA_2	757	763	PF00069	0.166
MOD_Plk_1	105	111	PF00069	0.561
MOD_Plk_1	564	570	PF00069	0.539
MOD_Plk_1	848	854	PF00069	0.564
MOD_Plk_2-3	76	82	PF00069	0.381
MOD_Plk_4	122	128	PF00069	0.496
MOD_Plk_4	250	256	PF00069	0.498
MOD_Plk_4	447	453	PF00069	0.477
MOD_Plk_4	46	52	PF00069	0.346
MOD_Plk_4	564	570	PF00069	0.431
MOD_Plk_4	581	587	PF00069	0.527
MOD_Plk_4	634	640	PF00069	0.485
MOD_Plk_4	644	650	PF00069	0.481
MOD_Plk_4	692	698	PF00069	0.347
MOD_Plk_4	737	743	PF00069	0.304
MOD_Plk_4	857	863	PF00069	0.512
MOD_ProDKin_1	112	118	PF00069	0.514
MOD_ProDKin_1	710	716	PF00069	0.304
MOD_ProDKin_1	842	848	PF00069	0.595
MOD_SUMO_for_1	772	775	PF00179	0.304
MOD_SUMO_rev_2	106	115	PF00179	0.410
MOD_SUMO_rev_2	297	305	PF00179	0.479
MOD_SUMO_rev_2	933	938	PF00179	0.686
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.672
TRG_ENDOCYTIC_2	10	13	PF00928	0.502
TRG_ENDOCYTIC_2	102	105	PF00928	0.517
TRG_ENDOCYTIC_2	347	350	PF00928	0.485
TRG_ENDOCYTIC_2	54	57	PF00928	0.408
TRG_ENDOCYTIC_2	664	667	PF00928	0.340
TRG_ENDOCYTIC_2	915	918	PF00928	0.507
TRG_ER_diArg_1	267	270	PF00400	0.441
TRG_ER_diArg_1	306	309	PF00400	0.478
TRG_ER_diArg_1	431	433	PF00400	0.716
TRG_ER_diArg_1	490	492	PF00400	0.560
TRG_ER_diArg_1	926	928	PF00400	0.483
TRG_NES_CRM1_1	503	516	PF08389	0.453
TRG_NLS_Bipartite_1	532	551	PF00514	0.660
TRG_NLS_Bipartite_1	757	774	PF00514	0.321
TRG_NLS_MonoCore_2	531	536	PF00514	0.620
TRG_NLS_MonoCore_2	546	551	PF00514	0.574
TRG_NLS_MonoExtC_3	537	542	PF00514	0.625
TRG_NLS_MonoExtC_3	769	774	PF00514	0.377
TRG_NLS_MonoExtN_4	532	537	PF00514	0.625
TRG_NLS_MonoExtN_4	538	545	PF00514	0.639
TRG_NLS_MonoExtN_4	768	774	PF00514	0.338
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P878	Leptomonas seymouri	61%	96%
A0A1X0NLC0	Trypanosomatidae	42%	100%
A0A3S7WSN9	Leishmania donovani	92%	100%
A0A422P4A2	Trypanosoma rangeli	44%	100%
A4HVT1	Leishmania infantum	92%	100%
D0A6G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QG02	Leishmania major	92%	100%
Q9CUL5	Mus musculus	25%	100%
V5B216	Trypanosoma cruzi	43%	78%