Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APH3_LEIMU

TriTrypDb:

LmxM.13.1490

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APH3

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031848	protection from non-homologous end joining at telomere	6	1
GO:0032200	telomere organization	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036297	interstrand cross-link repair	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043247	telomere maintenance in response to DNA damage	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0035312	5'-3' DNA exonuclease activity	7	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	580	584	PF00656	0.658
CLV_C14_Caspase3-7	764	768	PF00656	0.588
CLV_NRD_NRD_1	19	21	PF00675	0.537
CLV_NRD_NRD_1	219	221	PF00675	0.416
CLV_NRD_NRD_1	373	375	PF00675	0.436
CLV_NRD_NRD_1	590	592	PF00675	0.623
CLV_NRD_NRD_1	753	755	PF00675	0.500
CLV_PCSK_KEX2_1	19	21	PF00082	0.539
CLV_PCSK_KEX2_1	219	221	PF00082	0.416
CLV_PCSK_KEX2_1	373	375	PF00082	0.528
CLV_PCSK_KEX2_1	590	592	PF00082	0.623
CLV_PCSK_KEX2_1	701	703	PF00082	0.616
CLV_PCSK_KEX2_1	753	755	PF00082	0.500
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.632
CLV_PCSK_SKI1_1	149	153	PF00082	0.386
CLV_PCSK_SKI1_1	279	283	PF00082	0.355
CLV_PCSK_SKI1_1	303	307	PF00082	0.358
CLV_PCSK_SKI1_1	57	61	PF00082	0.341
CLV_PCSK_SKI1_1	734	738	PF00082	0.636
CLV_PCSK_SKI1_1	753	757	PF00082	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.409
DEG_SPOP_SBC_1	251	255	PF00917	0.586
DEG_SPOP_SBC_1	723	727	PF00917	0.526
DOC_CKS1_1	122	127	PF01111	0.441
DOC_CYCLIN_RxL_1	54	65	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.321
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.363
DOC_MAPK_DCC_7	400	409	PF00069	0.508
DOC_MAPK_DCC_7	590	600	PF00069	0.517
DOC_MAPK_gen_1	590	600	PF00069	0.561
DOC_MAPK_gen_1	68	76	PF00069	0.354
DOC_MAPK_gen_1	701	707	PF00069	0.569
DOC_MAPK_HePTP_8	496	508	PF00069	0.482
DOC_MAPK_MEF2A_6	2	10	PF00069	0.427
DOC_MAPK_MEF2A_6	264	273	PF00069	0.367
DOC_MAPK_MEF2A_6	400	409	PF00069	0.514
DOC_MAPK_MEF2A_6	499	508	PF00069	0.484
DOC_MAPK_MEF2A_6	68	76	PF00069	0.419
DOC_MAPK_MEF2A_6	701	709	PF00069	0.569
DOC_MAPK_RevD_3	4	20	PF00069	0.378
DOC_PP2B_LxvP_1	504	507	PF13499	0.504
DOC_PP2B_LxvP_1	72	75	PF13499	0.403
DOC_PP2B_PxIxI_1	404	410	PF00149	0.398
DOC_PP4_FxxP_1	112	115	PF00568	0.326
DOC_PP4_FxxP_1	634	637	PF00568	0.656
DOC_USP7_MATH_1	249	253	PF00917	0.616
DOC_USP7_MATH_1	390	394	PF00917	0.624
DOC_USP7_MATH_1	451	455	PF00917	0.457
DOC_USP7_MATH_1	522	526	PF00917	0.492
DOC_USP7_MATH_1	665	669	PF00917	0.777
DOC_USP7_UBL2_3	730	734	PF12436	0.526
DOC_WW_Pin1_4	121	126	PF00397	0.428
DOC_WW_Pin1_4	143	148	PF00397	0.359
DOC_WW_Pin1_4	180	185	PF00397	0.637
DOC_WW_Pin1_4	247	252	PF00397	0.605
DOC_WW_Pin1_4	428	433	PF00397	0.502
DOC_WW_Pin1_4	464	469	PF00397	0.386
DOC_WW_Pin1_4	481	486	PF00397	0.362
DOC_WW_Pin1_4	635	640	PF00397	0.607
DOC_WW_Pin1_4	77	82	PF00397	0.313
LIG_14-3-3_CanoR_1	303	308	PF00244	0.357
LIG_14-3-3_CanoR_1	443	451	PF00244	0.550
LIG_14-3-3_CanoR_1	479	484	PF00244	0.363
LIG_14-3-3_CanoR_1	675	680	PF00244	0.609
LIG_14-3-3_CanoR_1	753	762	PF00244	0.528
LIG_BIR_III_4	239	243	PF00653	0.525
LIG_BRCT_BRCA1_1	631	635	PF00533	0.588
LIG_Clathr_ClatBox_1	318	322	PF01394	0.374
LIG_eIF4E_1	541	547	PF01652	0.416
LIG_FHA_1	241	247	PF00498	0.534
LIG_FHA_1	290	296	PF00498	0.367
LIG_FHA_1	44	50	PF00498	0.434
LIG_FHA_1	526	532	PF00498	0.545
LIG_FHA_1	54	60	PF00498	0.305
LIG_FHA_1	542	548	PF00498	0.353
LIG_FHA_1	624	630	PF00498	0.582
LIG_FHA_1	640	646	PF00498	0.504
LIG_FHA_1	754	760	PF00498	0.660
LIG_FHA_1	78	84	PF00498	0.351
LIG_FHA_2	304	310	PF00498	0.364
LIG_FHA_2	465	471	PF00498	0.377
LIG_HCF-1_HBM_1	158	161	PF13415	0.336
LIG_KLC1_Yacidic_2	158	163	PF13176	0.333
LIG_LIR_Apic_2	621	625	PF02991	0.513
LIG_LIR_Apic_2	632	637	PF02991	0.576
LIG_LIR_Gen_1	163	174	PF02991	0.407
LIG_LIR_Gen_1	298	308	PF02991	0.364
LIG_LIR_Gen_1	473	481	PF02991	0.391
LIG_LIR_Gen_1	544	551	PF02991	0.345
LIG_LIR_Nem_3	11	16	PF02991	0.412
LIG_LIR_Nem_3	163	169	PF02991	0.356
LIG_LIR_Nem_3	298	304	PF02991	0.368
LIG_LIR_Nem_3	431	437	PF02991	0.384
LIG_LIR_Nem_3	439	444	PF02991	0.520
LIG_LIR_Nem_3	473	477	PF02991	0.393
LIG_LIR_Nem_3	544	548	PF02991	0.328
LIG_MLH1_MIPbox_1	631	635	PF16413	0.588
LIG_NRBOX	200	206	PF00104	0.439
LIG_PDZ_Class_2	766	771	PF00595	0.635
LIG_Pex14_2	29	33	PF04695	0.396
LIG_SH2_CRK	301	305	PF00017	0.365
LIG_SH2_CRK	434	438	PF00017	0.356
LIG_SH2_CRK	622	626	PF00017	0.462
LIG_SH2_NCK_1	622	626	PF00017	0.462
LIG_SH2_PTP2	105	108	PF00017	0.304
LIG_SH2_SRC	622	625	PF00017	0.460
LIG_SH2_STAP1	138	142	PF00017	0.458
LIG_SH2_STAP1	301	305	PF00017	0.365
LIG_SH2_STAT3	223	226	PF00017	0.444
LIG_SH2_STAT5	105	108	PF00017	0.309
LIG_SH2_STAT5	121	124	PF00017	0.406
LIG_SH2_STAT5	130	133	PF00017	0.352
LIG_SH2_STAT5	138	141	PF00017	0.443
LIG_SH2_STAT5	161	164	PF00017	0.333
LIG_SH2_STAT5	272	275	PF00017	0.385
LIG_SH2_STAT5	503	506	PF00017	0.413
LIG_SH2_STAT5	541	544	PF00017	0.453
LIG_SH2_STAT5	545	548	PF00017	0.451
LIG_SH2_STAT5	633	636	PF00017	0.658
LIG_SH2_STAT5	692	695	PF00017	0.561
LIG_SH3_1	537	543	PF00018	0.444
LIG_SH3_3	1	7	PF00018	0.375
LIG_SH3_3	243	249	PF00018	0.499
LIG_SH3_3	384	390	PF00018	0.629
LIG_SH3_3	537	543	PF00018	0.530
LIG_SH3_3	595	601	PF00018	0.509
LIG_SH3_3	606	612	PF00018	0.502
LIG_SUMO_SIM_anti_2	473	479	PF11976	0.394
LIG_SUMO_SIM_par_1	303	309	PF11976	0.430
LIG_SUMO_SIM_par_1	405	412	PF11976	0.373
LIG_SUMO_SIM_par_1	479	484	PF11976	0.342
LIG_SUMO_SIM_par_1	5	12	PF11976	0.418
LIG_SUMO_SIM_par_1	756	764	PF11976	0.584
LIG_TRAF2_1	310	313	PF00917	0.384
LIG_TRAF2_1	337	340	PF00917	0.418
LIG_TRAF2_1	467	470	PF00917	0.392
LIG_TRAF2_1	584	587	PF00917	0.663
LIG_TYR_ITIM	103	108	PF00017	0.343
LIG_TYR_ITIM	299	304	PF00017	0.299
LIG_TYR_ITSM	429	436	PF00017	0.445
LIG_WRC_WIRS_1	148	153	PF05994	0.380
LIG_WRC_WIRS_1	360	365	PF05994	0.392
MOD_CDC14_SPxK_1	146	149	PF00782	0.341
MOD_CDK_SPxK_1	143	149	PF00069	0.362
MOD_CK1_1	126	132	PF00069	0.363
MOD_CK1_1	250	256	PF00069	0.610
MOD_CK1_1	412	418	PF00069	0.496
MOD_CK1_1	43	49	PF00069	0.397
MOD_CK1_1	525	531	PF00069	0.482
MOD_CK1_1	563	569	PF00069	0.457
MOD_CK1_1	638	644	PF00069	0.627
MOD_CK1_1	664	670	PF00069	0.749
MOD_CK1_1	691	697	PF00069	0.565
MOD_CK1_1	95	101	PF00069	0.474
MOD_CK2_1	20	26	PF00069	0.476
MOD_CK2_1	303	309	PF00069	0.366
MOD_CK2_1	334	340	PF00069	0.445
MOD_CK2_1	343	349	PF00069	0.395
MOD_CK2_1	464	470	PF00069	0.384
MOD_CK2_1	488	494	PF00069	0.471
MOD_CK2_1	581	587	PF00069	0.542
MOD_CK2_1	611	617	PF00069	0.624
MOD_Cter_Amidation	17	20	PF01082	0.498
MOD_Cter_Amidation	217	220	PF01082	0.409
MOD_Cter_Amidation	699	702	PF01082	0.685
MOD_GlcNHglycan	116	119	PF01048	0.321
MOD_GlcNHglycan	125	128	PF01048	0.398
MOD_GlcNHglycan	195	198	PF01048	0.528
MOD_GlcNHglycan	20	23	PF01048	0.501
MOD_GlcNHglycan	254	257	PF01048	0.654
MOD_GlcNHglycan	261	264	PF01048	0.467
MOD_GlcNHglycan	336	339	PF01048	0.538
MOD_GlcNHglycan	345	348	PF01048	0.374
MOD_GlcNHglycan	392	395	PF01048	0.633
MOD_GlcNHglycan	424	427	PF01048	0.544
MOD_GlcNHglycan	438	441	PF01048	0.402
MOD_GlcNHglycan	453	456	PF01048	0.529
MOD_GlcNHglycan	557	560	PF01048	0.616
MOD_GlcNHglycan	565	568	PF01048	0.522
MOD_GlcNHglycan	613	616	PF01048	0.628
MOD_GlcNHglycan	662	666	PF01048	0.552
MOD_GlcNHglycan	667	670	PF01048	0.567
MOD_GlcNHglycan	697	700	PF01048	0.627
MOD_GlcNHglycan	730	733	PF01048	0.716
MOD_GlcNHglycan	83	86	PF01048	0.480
MOD_GlcNHglycan	94	97	PF01048	0.557
MOD_GSK3_1	126	133	PF00069	0.360
MOD_GSK3_1	143	150	PF00069	0.388
MOD_GSK3_1	18	25	PF00069	0.545
MOD_GSK3_1	247	254	PF00069	0.602
MOD_GSK3_1	28	35	PF00069	0.277
MOD_GSK3_1	39	46	PF00069	0.397
MOD_GSK3_1	408	415	PF00069	0.340
MOD_GSK3_1	459	466	PF00069	0.397
MOD_GSK3_1	49	56	PF00069	0.308
MOD_GSK3_1	551	558	PF00069	0.573
MOD_GSK3_1	607	614	PF00069	0.641
MOD_GSK3_1	623	630	PF00069	0.564
MOD_GSK3_1	635	642	PF00069	0.573
MOD_GSK3_1	660	667	PF00069	0.803
MOD_GSK3_1	675	682	PF00069	0.486
MOD_GSK3_1	688	695	PF00069	0.524
MOD_GSK3_1	724	731	PF00069	0.590
MOD_GSK3_1	749	756	PF00069	0.629
MOD_GSK3_1	77	84	PF00069	0.347
MOD_GSK3_1	92	99	PF00069	0.545
MOD_LATS_1	37	43	PF00433	0.441
MOD_N-GLC_1	240	245	PF02516	0.640
MOD_N-GLC_1	398	403	PF02516	0.482
MOD_NEK2_1	151	156	PF00069	0.380
MOD_NEK2_1	162	167	PF00069	0.343
MOD_NEK2_1	28	33	PF00069	0.332
MOD_NEK2_1	41	46	PF00069	0.394
MOD_NEK2_1	49	54	PF00069	0.369
MOD_NEK2_1	546	551	PF00069	0.418
MOD_NEK2_1	674	679	PF00069	0.614
MOD_NEK2_1	688	693	PF00069	0.518
MOD_NEK2_1	83	88	PF00069	0.345
MOD_NEK2_2	147	152	PF00069	0.379
MOD_PIKK_1	233	239	PF00454	0.518
MOD_PIKK_1	361	367	PF00454	0.397
MOD_PIKK_1	443	449	PF00454	0.596
MOD_PIKK_1	546	552	PF00454	0.509
MOD_PIKK_1	686	692	PF00454	0.611
MOD_PK_1	479	485	PF00069	0.341
MOD_PKA_1	753	759	PF00069	0.497
MOD_PKA_2	18	24	PF00069	0.460
MOD_PKA_2	343	349	PF00069	0.395
MOD_PKA_2	412	418	PF00069	0.556
MOD_PKA_2	488	494	PF00069	0.450
MOD_PKA_2	525	531	PF00069	0.521
MOD_PKA_2	674	680	PF00069	0.611
MOD_PKA_2	753	759	PF00069	0.625
MOD_PKA_2	92	98	PF00069	0.471
MOD_Plk_1	162	168	PF00069	0.349
MOD_Plk_4	104	110	PF00069	0.339
MOD_Plk_4	126	132	PF00069	0.363
MOD_Plk_4	162	168	PF00069	0.349
MOD_Plk_4	303	309	PF00069	0.430
MOD_Plk_4	541	547	PF00069	0.312
MOD_Plk_4	629	635	PF00069	0.661
MOD_Plk_4	675	681	PF00069	0.626
MOD_Plk_4	688	694	PF00069	0.498
MOD_ProDKin_1	121	127	PF00069	0.433
MOD_ProDKin_1	143	149	PF00069	0.362
MOD_ProDKin_1	180	186	PF00069	0.638
MOD_ProDKin_1	247	253	PF00069	0.601
MOD_ProDKin_1	428	434	PF00069	0.495
MOD_ProDKin_1	464	470	PF00069	0.384
MOD_ProDKin_1	481	487	PF00069	0.370
MOD_ProDKin_1	635	641	PF00069	0.607
MOD_ProDKin_1	77	83	PF00069	0.312
MOD_SUMO_rev_2	580	589	PF00179	0.654
MOD_SUMO_rev_2	731	739	PF00179	0.517
TRG_DiLeu_BaEn_1	314	319	PF01217	0.334
TRG_DiLeu_BaEn_2	469	475	PF01217	0.438
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.361
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.440
TRG_ENDOCYTIC_2	105	108	PF00928	0.304
TRG_ENDOCYTIC_2	301	304	PF00928	0.360
TRG_ENDOCYTIC_2	433	436	PF00928	0.358
TRG_ENDOCYTIC_2	503	506	PF00928	0.478
TRG_ENDOCYTIC_2	545	548	PF00928	0.378
TRG_ER_diArg_1	219	221	PF00400	0.416
TRG_ER_diArg_1	290	293	PF00400	0.390
TRG_ER_diArg_1	373	375	PF00400	0.535
TRG_ER_diArg_1	589	591	PF00400	0.656
TRG_ER_diArg_1	593	596	PF00400	0.669
TRG_ER_diArg_1	67	70	PF00400	0.375
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAX7	Leptomonas seymouri	48%	100%
A0A3S5H6Q1	Leishmania donovani	86%	100%
A4H7D0	Leishmania braziliensis	72%	100%
A4HVS7	Leishmania infantum	86%	100%
Q4QG05	Leishmania major	85%	100%