Programmed cell death 6 protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

programmed cell death 6 protein-like protein

Species:

Leishmania mexicana

UniProt:

E9APH0_LEIMU

TriTrypDb:

LmxM.13.1460

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APH0

PDB structure(s): 1y1x_A , 1y1x_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.378
CLV_NRD_NRD_1	142	144	PF00675	0.460
CLV_NRD_NRD_1	178	180	PF00675	0.376
CLV_NRD_NRD_1	185	187	PF00675	0.358
CLV_PCSK_FUR_1	183	187	PF00082	0.358
CLV_PCSK_KEX2_1	144	146	PF00082	0.459
CLV_PCSK_KEX2_1	185	187	PF00082	0.346
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.363
CLV_PCSK_SKI1_1	159	163	PF00082	0.358
CLV_PCSK_SKI1_1	205	209	PF00082	0.610
DOC_CKS1_1	33	38	PF01111	0.808
DOC_MAPK_gen_1	183	191	PF00069	0.353
DOC_MAPK_gen_1	213	221	PF00069	0.663
DOC_USP7_MATH_1	161	165	PF00917	0.293
DOC_USP7_MATH_1	95	99	PF00917	0.458
DOC_WW_Pin1_4	32	37	PF00397	0.682
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_1	1	5	PF00653	0.612
LIG_BIR_III_3	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	187	191	PF00533	0.365
LIG_FHA_1	106	112	PF00498	0.353
LIG_FHA_1	214	220	PF00498	0.656
LIG_FHA_1	32	38	PF00498	0.788
LIG_FHA_2	122	128	PF00498	0.412
LIG_FHA_2	41	47	PF00498	0.500
LIG_LIR_Apic_2	16	21	PF02991	0.776
LIG_LIR_Gen_1	122	131	PF02991	0.381
LIG_LIR_Gen_1	171	181	PF02991	0.353
LIG_LIR_Gen_1	192	201	PF02991	0.353
LIG_LIR_Gen_1	220	231	PF02991	0.580
LIG_LIR_Nem_3	122	128	PF02991	0.381
LIG_LIR_Nem_3	171	177	PF02991	0.390
LIG_LIR_Nem_3	188	194	PF02991	0.269
LIG_LIR_Nem_3	220	226	PF02991	0.568
LIG_LIR_Nem_3	43	48	PF02991	0.720
LIG_LIR_Nem_3	74	79	PF02991	0.433
LIG_PCNA_yPIPBox_3	64	76	PF02747	0.738
LIG_PDZ_Class_1	229	234	PF00595	0.552
LIG_Rb_pABgroove_1	109	117	PF01858	0.339
LIG_SH2_CRK	11	15	PF00017	0.707
LIG_SH2_CRK	18	22	PF00017	0.723
LIG_SH2_CRK	45	49	PF00017	0.559
LIG_SH2_NCK_1	11	15	PF00017	0.791
LIG_SH2_PTP2	194	197	PF00017	0.369
LIG_SH2_SRC	59	62	PF00017	0.743
LIG_SH2_STAT3	39	42	PF00017	0.740
LIG_SH2_STAT5	11	14	PF00017	0.704
LIG_SH2_STAT5	194	197	PF00017	0.367
LIG_SH3_3	30	36	PF00018	0.782
LIG_SH3_3	45	51	PF00018	0.655
LIG_SH3_3	55	61	PF00018	0.637
LIG_TYR_ITSM	41	48	PF00017	0.501
LIG_UBA3_1	111	117	PF00899	0.462
LIG_UBA3_1	135	139	PF00899	0.603
LIG_WRC_WIRS_1	223	228	PF05994	0.632
MOD_CK1_1	104	110	PF00069	0.378
MOD_CK1_1	170	176	PF00069	0.418
MOD_CK2_1	121	127	PF00069	0.441
MOD_CK2_1	134	140	PF00069	0.621
MOD_CK2_1	85	91	PF00069	0.419
MOD_GlcNHglycan	119	122	PF01048	0.436
MOD_GlcNHglycan	146	150	PF01048	0.379
MOD_GlcNHglycan	164	167	PF01048	0.254
MOD_GlcNHglycan	61	64	PF01048	0.713
MOD_GlcNHglycan	82	86	PF01048	0.386
MOD_GlcNHglycan	97	100	PF01048	0.336
MOD_GSK3_1	101	108	PF00069	0.259
MOD_GSK3_1	117	124	PF00069	0.353
MOD_GSK3_1	195	202	PF00069	0.549
MOD_GSK3_1	213	220	PF00069	0.649
MOD_GSK3_1	81	88	PF00069	0.491
MOD_GSK3_1	9	16	PF00069	0.738
MOD_N-GLC_1	117	122	PF02516	0.453
MOD_NEK2_1	134	139	PF00069	0.614
MOD_NEK2_1	162	167	PF00069	0.388
MOD_PIKK_1	9	15	PF00454	0.791
MOD_PKA_1	144	150	PF00069	0.446
MOD_PKA_1	185	191	PF00069	0.358
MOD_PKA_2	144	150	PF00069	0.350
MOD_PKA_2	185	191	PF00069	0.354
MOD_PKB_1	143	151	PF00069	0.368
MOD_PKB_1	183	191	PF00069	0.416
MOD_Plk_1	121	127	PF00069	0.363
MOD_Plk_1	170	176	PF00069	0.374
MOD_Plk_1	195	201	PF00069	0.541
MOD_Plk_4	195	201	PF00069	0.557
MOD_Plk_4	222	228	PF00069	0.615
MOD_ProDKin_1	32	38	PF00069	0.675
MOD_SUMO_rev_2	122	131	PF00179	0.363
TRG_DiLeu_BaEn_2	195	201	PF01217	0.541
TRG_ENDOCYTIC_2	194	197	PF00928	0.353
TRG_ENDOCYTIC_2	45	48	PF00928	0.737
TRG_ER_diArg_1	142	145	PF00400	0.368
TRG_ER_diArg_1	183	186	PF00400	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P882	Leptomonas seymouri	75%	100%
A0A0N0P8K6	Leptomonas seymouri	45%	100%
A0A0S4JBG2	Bodo saltans	56%	82%
A0A1X0NJH7	Trypanosomatidae	52%	96%
A0A3Q8I9P0	Leishmania donovani	94%	100%
A0A3Q8IW81	Leishmania donovani	31%	100%
A0A422P491	Trypanosoma rangeli	42%	96%
A4H7C7	Leishmania braziliensis	80%	100%
A4HPN5	Leishmania braziliensis	30%	100%
A4HVS3	Leishmania infantum	94%	100%
A4ID29	Leishmania infantum	31%	100%
E9APG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
G3V7W1	Rattus norvegicus	33%	100%
O75340	Homo sapiens	34%	100%
P05434	Chlamydomonas reinhardtii	25%	100%
P12815	Mus musculus	34%	100%
P25070	Arabidopsis thaliana	25%	100%
P28676	Homo sapiens	29%	100%
P53238	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	70%
Q03975	Lytechinus pictus	26%	96%
Q0JC44	Oryza sativa subsp. japonica	24%	94%
Q12798	Homo sapiens	25%	100%
Q24956	Giardia intestinalis	26%	100%
Q2QY10	Oryza sativa subsp. japonica	29%	80%
Q4Q148	Leishmania major	31%	100%
Q4QG08	Leishmania major	91%	100%
Q4QG09	Leishmania major	54%	100%
Q5PQ53	Xenopus laevis	29%	83%
Q641Z8	Rattus norvegicus	30%	83%
Q6DC93	Danio rerio	30%	87%
Q8BFY6	Mus musculus	29%	85%
Q8VC88	Mus musculus	27%	100%
Q8W4L0	Arabidopsis thaliana	29%	70%
Q94743	Schistosoma japonicum	35%	100%
Q9FYE4	Arabidopsis thaliana	30%	66%
Q9UBV8	Homo sapiens	29%	82%
Q9ZQH1	Arabidopsis thaliana	24%	100%
V5BM44	Trypanosoma cruzi	44%	100%