EF hand-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF hand-like protein

Species:

Leishmania mexicana

UniProt:

E9APG9_LEIMU

TriTrypDb:

LmxM.13.1450

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APG9

PDB structure(s): 1y1x_A , 1y1x_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.340
CLV_NRD_NRD_1	161	163	PF00675	0.335
CLV_PCSK_SKI1_1	188	192	PF00082	0.439
CLV_PCSK_SKI1_1	93	97	PF00082	0.213
DOC_MAPK_gen_1	166	174	PF00069	0.302
DOC_MAPK_gen_1	196	204	PF00069	0.505
DOC_USP7_MATH_1	61	65	PF00917	0.318
DOC_USP7_MATH_1	78	82	PF00917	0.406
DOC_USP7_MATH_2	52	58	PF00917	0.473
LIG_14-3-3_CanoR_1	85	89	PF00244	0.245
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	170	174	PF00533	0.327
LIG_BRCT_BRCA1_1	80	84	PF00533	0.228
LIG_Clathr_ClatBox_1	203	207	PF01394	0.329
LIG_CtBP_PxDLS_1	52	56	PF00389	0.343
LIG_FHA_1	41	47	PF00498	0.497
LIG_FHA_1	89	95	PF00498	0.315
LIG_FHA_2	105	111	PF00498	0.350
LIG_FHA_2	128	134	PF00498	0.233
LIG_FHA_2	94	100	PF00498	0.355
LIG_Integrin_isoDGR_2	67	69	PF01839	0.228
LIG_LIR_Gen_1	109	118	PF02991	0.402
LIG_LIR_Gen_1	154	164	PF02991	0.315
LIG_LIR_Gen_1	175	185	PF02991	0.315
LIG_LIR_Gen_1	57	65	PF02991	0.158
LIG_LIR_Nem_3	109	114	PF02991	0.321
LIG_LIR_Nem_3	154	160	PF02991	0.352
LIG_LIR_Nem_3	171	177	PF02991	0.228
LIG_LIR_Nem_3	189	194	PF02991	0.454
LIG_LIR_Nem_3	3	8	PF02991	0.475
LIG_LIR_Nem_3	57	62	PF02991	0.421
LIG_Pex14_2	84	88	PF04695	0.158
LIG_PTB_Apo_2	18	25	PF02174	0.440
LIG_PTB_Phospho_1	18	24	PF10480	0.433
LIG_SH2_CRK	49	53	PF00017	0.467
LIG_SH2_PTP2	177	180	PF00017	0.331
LIG_SH2_STAT3	24	27	PF00017	0.673
LIG_SH2_STAT5	177	180	PF00017	0.329
LIG_SH3_3	9	15	PF00018	0.479
LIG_TRAF2_1	107	110	PF00917	0.362
LIG_WRC_WIRS_1	206	211	PF05994	0.488
MOD_CK1_1	138	144	PF00069	0.342
MOD_CK1_1	87	93	PF00069	0.328
MOD_CK2_1	104	110	PF00069	0.400
MOD_GlcNHglycan	101	105	PF01048	0.431
MOD_GlcNHglycan	129	133	PF01048	0.327
MOD_GlcNHglycan	147	150	PF01048	0.206
MOD_GlcNHglycan	197	201	PF01048	0.284
MOD_GlcNHglycan	80	83	PF01048	0.284
MOD_GSK3_1	100	107	PF00069	0.315
MOD_GSK3_1	205	212	PF00069	0.444
MOD_GSK3_1	28	35	PF00069	0.722
MOD_GSK3_1	84	91	PF00069	0.313
MOD_NEK2_1	100	105	PF00069	0.205
MOD_NEK2_1	145	150	PF00069	0.350
MOD_NEK2_1	209	214	PF00069	0.402
MOD_NEK2_1	84	89	PF00069	0.254
MOD_PKA_2	127	133	PF00069	0.313
MOD_PKA_2	138	144	PF00069	0.338
MOD_PKA_2	145	151	PF00069	0.408
MOD_PKA_2	168	174	PF00069	0.317
MOD_PKA_2	84	90	PF00069	0.303
MOD_PKB_1	126	134	PF00069	0.330
MOD_Plk_1	153	159	PF00069	0.337
MOD_Plk_1	178	184	PF00069	0.351
MOD_Plk_4	178	184	PF00069	0.380
MOD_Plk_4	205	211	PF00069	0.457
MOD_Plk_4	54	60	PF00069	0.262
TRG_DiLeu_BaEn_2	178	184	PF01217	0.364
TRG_DiLeu_BaEn_4	109	115	PF01217	0.362
TRG_ENDOCYTIC_2	177	180	PF00928	0.315
TRG_ER_diArg_1	125	128	PF00400	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P882	Leptomonas seymouri	54%	93%
A0A0N0P8K6	Leptomonas seymouri	55%	94%
A0A0S4JBG2	Bodo saltans	56%	76%
A0A1X0NJH7	Trypanosomatidae	51%	89%
A0A3Q8I9P0	Leishmania donovani	56%	93%
A0A3Q8IW81	Leishmania donovani	32%	100%
A0A422P491	Trypanosoma rangeli	38%	89%
A4H7C7	Leishmania braziliensis	55%	100%
A4HPN5	Leishmania braziliensis	30%	100%
A4HVS3	Leishmania infantum	56%	93%
A4ID29	Leishmania infantum	32%	100%
E9APH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	93%
G3V7W1	Rattus norvegicus	32%	100%
O23184	Arabidopsis thaliana	24%	100%
O75340	Homo sapiens	32%	100%
O82659	Arabidopsis thaliana	27%	100%
P02586	Oryctolagus cuniculus	26%	100%
P02587	Sus scrofa	26%	100%
P05044	Cricetulus griseus	28%	100%
P12815	Mus musculus	32%	100%
P20801	Mus musculus	27%	100%
P28676	Homo sapiens	27%	100%
P30626	Homo sapiens	28%	100%
P41210	Atriplex nummularia	26%	100%
Q24956	Giardia intestinalis	25%	100%
Q2QY10	Oryza sativa subsp. japonica	27%	74%
Q4Q148	Leishmania major	32%	100%
Q4QG08	Leishmania major	55%	100%
Q4QG09	Leishmania major	89%	100%
Q5PQ53	Xenopus laevis	30%	77%
Q5R4U9	Pongo abelii	28%	100%
Q5RAI6	Pongo abelii	26%	100%
Q641Z8	Rattus norvegicus	27%	77%
Q6DC93	Danio rerio	28%	80%
Q6P069	Mus musculus	29%	100%
Q8BFY6	Mus musculus	27%	79%
Q8VC88	Mus musculus	29%	99%
Q94743	Schistosoma japonicum	33%	100%
Q95YL4	Dictyostelium discoideum	32%	100%
Q95YL5	Dictyostelium discoideum	31%	100%
Q9UBV8	Homo sapiens	28%	76%
Q9ZQH1	Arabidopsis thaliana	23%	95%
V5BM44	Trypanosoma cruzi	45%	100%