Leucine-rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania mexicana

UniProt:

E9APG7_LEIMU

TriTrypDb:

LmxM.13.1430

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

E9APG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.608
CLV_C14_Caspase3-7	295	299	PF00656	0.431
CLV_C14_Caspase3-7	459	463	PF00656	0.539
CLV_NRD_NRD_1	108	110	PF00675	0.650
CLV_NRD_NRD_1	323	325	PF00675	0.780
CLV_NRD_NRD_1	339	341	PF00675	0.536
CLV_NRD_NRD_1	522	524	PF00675	0.499
CLV_NRD_NRD_1	561	563	PF00675	0.694
CLV_PCSK_FUR_1	520	524	PF00082	0.547
CLV_PCSK_KEX2_1	108	110	PF00082	0.656
CLV_PCSK_KEX2_1	323	325	PF00082	0.806
CLV_PCSK_KEX2_1	339	341	PF00082	0.550
CLV_PCSK_KEX2_1	520	522	PF00082	0.488
CLV_PCSK_KEX2_1	561	563	PF00082	0.644
CLV_PCSK_SKI1_1	119	123	PF00082	0.677
DEG_SPOP_SBC_1	47	51	PF00917	0.614
DEG_SPOP_SBC_1	605	609	PF00917	0.691
DEG_SPOP_SBC_1	63	67	PF00917	0.478
DOC_CKS1_1	575	580	PF01111	0.583
DOC_PP4_FxxP_1	115	118	PF00568	0.662
DOC_USP7_MATH_1	243	247	PF00917	0.416
DOC_USP7_MATH_1	328	332	PF00917	0.629
DOC_USP7_MATH_1	350	354	PF00917	0.700
DOC_USP7_MATH_1	366	370	PF00917	0.609
DOC_USP7_MATH_1	383	387	PF00917	0.632
DOC_USP7_MATH_1	42	46	PF00917	0.701
DOC_USP7_MATH_1	429	433	PF00917	0.796
DOC_USP7_MATH_1	457	461	PF00917	0.609
DOC_USP7_MATH_1	465	469	PF00917	0.560
DOC_USP7_MATH_1	47	51	PF00917	0.699
DOC_USP7_MATH_1	54	58	PF00917	0.654
DOC_USP7_MATH_1	570	574	PF00917	0.642
DOC_USP7_MATH_1	591	595	PF00917	0.720
DOC_USP7_MATH_1	63	67	PF00917	0.612
DOC_USP7_UBL2_3	617	621	PF12436	0.687
DOC_WW_Pin1_4	362	367	PF00397	0.649
DOC_WW_Pin1_4	415	420	PF00397	0.723
DOC_WW_Pin1_4	425	430	PF00397	0.646
DOC_WW_Pin1_4	529	534	PF00397	0.471
DOC_WW_Pin1_4	574	579	PF00397	0.668
LIG_14-3-3_CanoR_1	108	117	PF00244	0.622
LIG_14-3-3_CanoR_1	119	129	PF00244	0.563
LIG_14-3-3_CanoR_1	273	278	PF00244	0.386
LIG_14-3-3_CanoR_1	323	330	PF00244	0.704
LIG_14-3-3_CanoR_1	340	346	PF00244	0.506
LIG_14-3-3_CanoR_1	349	355	PF00244	0.650
LIG_14-3-3_CanoR_1	382	388	PF00244	0.531
LIG_14-3-3_CanoR_1	434	442	PF00244	0.588
LIG_14-3-3_CanoR_1	508	514	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	602	606	PF00533	0.559
LIG_BRCT_BRCA1_1	96	100	PF00533	0.600
LIG_CaM_IQ_9	513	529	PF13499	0.553
LIG_Clathr_ClatBox_1	539	543	PF01394	0.504
LIG_deltaCOP1_diTrp_1	93	100	PF00928	0.474
LIG_FHA_1	130	136	PF00498	0.503
LIG_FHA_1	152	158	PF00498	0.433
LIG_FHA_1	475	481	PF00498	0.517
LIG_FHA_1	485	491	PF00498	0.461
LIG_FHA_1	534	540	PF00498	0.516
LIG_FHA_1	546	552	PF00498	0.474
LIG_FHA_2	435	441	PF00498	0.528
LIG_FHA_2	471	477	PF00498	0.493
LIG_FHA_2	5	11	PF00498	0.486
LIG_Integrin_RGD_1	474	476	PF01839	0.479
LIG_LIR_Gen_1	221	230	PF02991	0.444
LIG_LIR_Nem_3	221	225	PF02991	0.434
LIG_NRP_CendR_1	632	633	PF00754	0.714
LIG_PCNA_PIPBox_1	496	505	PF02747	0.502
LIG_Pex14_1	96	100	PF04695	0.479
LIG_PTB_Apo_2	480	487	PF02174	0.465
LIG_RPA_C_Fungi	344	356	PF08784	0.565
LIG_SH2_CRK	14	18	PF00017	0.597
LIG_SH2_CRK	481	485	PF00017	0.510
LIG_SH2_GRB2like	481	484	PF00017	0.420
LIG_SH2_SRC	222	225	PF00017	0.438
LIG_SH2_STAP1	535	539	PF00017	0.483
LIG_SH2_STAT5	180	183	PF00017	0.387
LIG_SH2_STAT5	222	225	PF00017	0.438
LIG_SH2_STAT5	277	280	PF00017	0.501
LIG_SH2_STAT5	535	538	PF00017	0.545
LIG_SH3_1	621	627	PF00018	0.703
LIG_SH3_2	627	632	PF14604	0.688
LIG_SH3_3	154	160	PF00018	0.500
LIG_SH3_3	413	419	PF00018	0.637
LIG_SH3_3	572	578	PF00018	0.718
LIG_SH3_3	610	616	PF00018	0.821
LIG_SH3_3	621	627	PF00018	0.647
LIG_SH3_CIN85_PxpxPR_1	627	632	PF14604	0.688
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.458
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.542
LIG_SUMO_SIM_par_1	536	543	PF11976	0.506
LIG_TRAF2_1	7	10	PF00917	0.538
LIG_TYR_ITIM	220	225	PF00017	0.440
LIG_WW_3	629	633	PF00397	0.691
MOD_CDK_SPK_2	415	420	PF00069	0.560
MOD_CK1_1	120	126	PF00069	0.592
MOD_CK1_1	162	168	PF00069	0.395
MOD_CK1_1	246	252	PF00069	0.583
MOD_CK1_1	306	312	PF00069	0.706
MOD_CK1_1	371	377	PF00069	0.685
MOD_CK1_1	432	438	PF00069	0.748
MOD_CK1_1	460	466	PF00069	0.499
MOD_CK1_1	607	613	PF00069	0.664
MOD_CK2_1	305	311	PF00069	0.632
MOD_CK2_1	340	346	PF00069	0.486
MOD_CK2_1	4	10	PF00069	0.489
MOD_CK2_1	75	81	PF00069	0.658
MOD_GlcNHglycan	110	113	PF01048	0.651
MOD_GlcNHglycan	119	122	PF01048	0.588
MOD_GlcNHglycan	332	335	PF01048	0.569
MOD_GlcNHglycan	368	371	PF01048	0.707
MOD_GlcNHglycan	373	376	PF01048	0.685
MOD_GlcNHglycan	378	382	PF01048	0.608
MOD_GlcNHglycan	42	45	PF01048	0.712
MOD_GlcNHglycan	425	428	PF01048	0.724
MOD_GlcNHglycan	459	462	PF01048	0.543
MOD_GlcNHglycan	466	470	PF01048	0.543
MOD_GlcNHglycan	54	57	PF01048	0.688
MOD_GlcNHglycan	572	575	PF01048	0.639
MOD_GlcNHglycan	593	596	PF01048	0.582
MOD_GSK3_1	104	111	PF00069	0.599
MOD_GSK3_1	120	127	PF00069	0.666
MOD_GSK3_1	159	166	PF00069	0.405
MOD_GSK3_1	246	253	PF00069	0.573
MOD_GSK3_1	303	310	PF00069	0.724
MOD_GSK3_1	330	337	PF00069	0.536
MOD_GSK3_1	362	369	PF00069	0.544
MOD_GSK3_1	411	418	PF00069	0.684
MOD_GSK3_1	42	49	PF00069	0.726
MOD_GSK3_1	421	428	PF00069	0.621
MOD_GSK3_1	429	436	PF00069	0.536
MOD_GSK3_1	465	472	PF00069	0.571
MOD_GSK3_1	484	491	PF00069	0.617
MOD_GSK3_1	529	536	PF00069	0.593
MOD_GSK3_1	570	577	PF00069	0.509
MOD_GSK3_1	600	607	PF00069	0.682
MOD_GSK3_1	95	102	PF00069	0.607
MOD_N-GLC_1	174	179	PF02516	0.374
MOD_N-GLC_1	228	233	PF02516	0.514
MOD_N-GLC_1	250	255	PF02516	0.490
MOD_N-GLC_2	259	261	PF02516	0.425
MOD_NEK2_1	100	105	PF00069	0.626
MOD_NEK2_1	174	179	PF00069	0.398
MOD_NEK2_1	223	228	PF00069	0.384
MOD_NEK2_1	250	255	PF00069	0.487
MOD_NEK2_1	430	435	PF00069	0.564
MOD_NEK2_1	470	475	PF00069	0.576
MOD_NEK2_1	52	57	PF00069	0.541
MOD_NEK2_1	606	611	PF00069	0.571
MOD_NEK2_1	64	69	PF00069	0.559
MOD_NEK2_2	13	18	PF00069	0.544
MOD_NEK2_2	334	339	PF00069	0.626
MOD_PIKK_1	129	135	PF00454	0.558
MOD_PIKK_1	159	165	PF00454	0.358
MOD_PIKK_1	193	199	PF00454	0.468
MOD_PIKK_1	328	334	PF00454	0.573
MOD_PIKK_1	484	490	PF00454	0.499
MOD_PIKK_1	545	551	PF00454	0.399
MOD_PK_1	622	628	PF00069	0.655
MOD_PKA_1	108	114	PF00069	0.704
MOD_PKA_1	323	329	PF00069	0.520
MOD_PKA_2	108	114	PF00069	0.623
MOD_PKA_2	322	328	PF00069	0.626
MOD_PKA_2	433	439	PF00069	0.635
MOD_PKA_2	543	549	PF00069	0.600
MOD_PKA_2	554	560	PF00069	0.606
MOD_Plk_1	174	180	PF00069	0.397
MOD_Plk_1	465	471	PF00069	0.552
MOD_Plk_1	504	510	PF00069	0.515
MOD_Plk_2-3	218	224	PF00069	0.430
MOD_Plk_4	218	224	PF00069	0.548
MOD_Plk_4	368	374	PF00069	0.580
MOD_Plk_4	48	54	PF00069	0.536
MOD_Plk_4	535	541	PF00069	0.551
MOD_ProDKin_1	362	368	PF00069	0.646
MOD_ProDKin_1	415	421	PF00069	0.727
MOD_ProDKin_1	425	431	PF00069	0.646
MOD_ProDKin_1	529	535	PF00069	0.466
MOD_ProDKin_1	574	580	PF00069	0.669
MOD_SUMO_rev_2	450	457	PF00179	0.682
TRG_DiLeu_BaEn_1	190	195	PF01217	0.500
TRG_DiLeu_BaEn_1	398	403	PF01217	0.560
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.516
TRG_ENDOCYTIC_2	14	17	PF00928	0.576
TRG_ENDOCYTIC_2	222	225	PF00928	0.438
TRG_ENDOCYTIC_2	481	484	PF00928	0.453
TRG_ER_diArg_1	108	110	PF00400	0.652
TRG_ER_diArg_1	126	129	PF00400	0.529
TRG_ER_diArg_1	338	340	PF00400	0.633
TRG_ER_diArg_1	520	523	PF00400	0.519
TRG_ER_diArg_1	631	633	PF00400	0.703
TRG_NES_CRM1_1	193	207	PF08389	0.593
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P881	Leptomonas seymouri	43%	100%
A0A3S7WSM9	Leishmania donovani	84%	100%
A0A422P4A5	Trypanosoma rangeli	29%	100%
A4H7C5	Leishmania braziliensis	65%	98%
A4HVS1	Leishmania infantum	84%	100%
Q4QG11	Leishmania major	84%	100%